Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma.

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Published in Mol Cell Ther on December 13, 2013

Authors

Chikako Shibata1, Motoyuki Otsuka2, Takahiro Kishikawa1, Takeshi Yoshikawa1, Motoko Ohno1, Akemi Takata1, Kazuhiko Koike1

Author Affiliations

1: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655 Japan.
2: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655 Japan ; Japan Science and Technology Agency, PRESTO, Kawaguchi, Saitama, 332-0012 Japan.

Associated clinical trials:

A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection | NCT01829971

Multiple Ascending Dose Study of Miravirsen in Treatment-Naïve Chronic Hepatitis C Subjects | NCT01200420

Safety Study of SPC3649 in Healthy Men | NCT00688012

Miravirsen Study in Null Responder to Pegylated Interferon Alpha Plus Ribavirin Subjects With Chronic Hepatitis C | NCT01727934

Miravirsen in Combination With Telaprevir and Ribavirin in Null Responder to Pegylated-Interferon Alpha Plus Ribavirin Subjects With Chronic Hepatitis C Virus Infection | NCT01872936

Drug Interaction Study to Assess the Effect of Co-Administered Miravirsen and Telaprevir in Healthy Subjects | NCT01646489

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