Published in Small GTPases on June 23, 2015
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Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities. Expert Rev Mol Med (2015) 0.78
Rho GTPases at the crossroad of signaling networks in mammals. Small GTPases (2015) 0.76
Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression. F1000Res (2016) 0.75
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 18.40
Mutational landscape and significance across 12 major cancer types. Nature (2013) 14.91
A landscape of driver mutations in melanoma. Cell (2012) 12.61
Comprehensive molecular characterization of gastric adenocarcinoma. Nature (2014) 11.93
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
TGF-beta signaling in tumor suppression and cancer progression. Nat Genet (2001) 11.64
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature (2012) 10.39
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol (2001) 10.32
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science (2004) 10.23
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
RHO-GTPases and cancer. Nat Rev Cancer (2002) 8.03
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol (2003) 7.93
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 7.57
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A (2004) 7.24
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol (2007) 7.20
Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst (2007) 7.10
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet (2012) 7.00
Localized Rac activation dynamics visualized in living cells. Science (2000) 7.00
Spatiotemporal dynamics of RhoA activity in migrating cells. Nature (2006) 6.84
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature (2001) 6.70
Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature (2010) 4.85
Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev (1998) 4.71
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol (2003) 4.24
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol (2003) 3.85
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Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest (1996) 3.44
VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn (2006) 3.38
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut (2012) 3.13
The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell (2012) 3.10
Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev (2013) 3.07
Rho kinases in cardiovascular physiology and pathophysiology. Circ Res (2006) 2.97
Rho signaling pathway targeted to promote spinal cord repair. J Neurosci (2002) 2.90
ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma. Cancer Cell (2011) 2.77
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med (2004) 2.71
Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal (2010) 2.56
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol (2005) 2.50
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer (2002) 2.38
Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J Cell Biol (2005) 2.38
Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Oncogene (2005) 2.35
RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol (2003) 2.34
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. Nat Genet (2014) 2.34
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell (2013) 2.32
Asef, a link between the tumor suppressor APC and G-protein signaling. Science (2000) 2.25
RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat Rev Mol Cell Biol (2004) 2.24
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem (2007) 2.20
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet (2014) 2.14
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev Cell (2004) 2.13
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol (2003) 2.07
A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nat Cell Biol (2009) 2.05
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol (2009) 1.99
Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α. J Natl Cancer Inst (2011) 1.84
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2010) 1.81
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Res (2004) 1.81
Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity. Curr Biol (2001) 1.81
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J Cell Biol (2010) 1.79
Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial. J Neurosurg (1992) 1.77
Cell type-specific regulation of RhoA activity during cytokinesis. J Biol Chem (2004) 1.76
Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res (2009) 1.74
Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene (2006) 1.73
Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature (1985) 1.68
Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice. J Cell Sci (2001) 1.67
P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer. Oncogene (2010) 1.66
Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Rep (2012) 1.66
Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma. Hepatology (2013) 1.65
Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell (2003) 1.61
Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J Biol Chem (2003) 1.60
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res (2004) 1.58
Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates. Oncogene (2009) 1.54
Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma: analysis of the international peripheral T-cell lymphoma project. J Clin Oncol (2012) 1.53
Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells. Cancer Res (1999) 1.48
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer. Int J Oncol (2008) 1.32
Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy. J Biophotonics (2010) 1.30
Integration of non-SMAD and SMAD signaling in TGF-beta1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells. Thromb Haemost (2008) 1.30
Targeting Ras and Rho GTPases as opportunities for cancer therapeutics. Curr Opin Genet Dev (2005) 1.28
Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis. Cancer Res (2007) 1.27
Targeting the tumor microenvironment: from understanding pathways to effective clinical trials. Cancer Res (2013) 1.26
Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. Oncogene (1994) 1.24
The role of Rho protein signaling in hypertension. Nat Rev Cardiol (2010) 1.23
Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. J Cell Biol (2012) 1.20
The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism. Brain (2007) 1.19
Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther (2006) 1.17
Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. Proc Natl Acad Sci U S A (2009) 1.17
p38γ promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior. Cancer Res (2011) 1.15
The R(h)oads to Stat3: Stat3 activation by the Rho GTPases. Exp Cell Res (2011) 1.12
Rho GTPases modulate malignant transformation of tumor cells. Small GTPases (2014) 1.12
Developments in preclinical cancer imaging: innovating the discovery of therapeutics. Nat Rev Cancer (2014) 1.10
Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma. Oncogene (2000) 1.10
Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. Oncogene (2013) 1.10
Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules. Curr Biol (2013) 1.09
B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival. Gastroenterology (2008) 1.08
A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat. Brain Res (2003) 1.08
Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption. Cell Signal (2009) 1.08
RAC1P29S is a spontaneously activating cancer-associated GTPase. Proc Natl Acad Sci U S A (2013) 1.05
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion. J Cell Sci (2012) 1.05
Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity. PLoS One (2012) 1.02
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell (2013) 2.32
Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater. J Clin Oncol (2013) 2.26
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell (2011) 1.87
A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol (2004) 1.81
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2010) 1.81
Safety and efficacy of prophylactic anticoagulation in patients with traumatic brain injury. J Am Coll Surg (2011) 1.67
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. J Cell Biol (2012) 1.45
Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development. Cancer Res (2009) 1.25
Inhibition of autophagy impairs tumor cell invasion in an organotypic model. Cell Cycle (2012) 1.14
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res (2010) 1.12
Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex. Cell Motil Cytoskeleton (2006) 1.10
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J (2008) 1.06
Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Curr Biol (2012) 1.05
Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer. Cancer Res (2013) 0.99
Neuropathic pain associated with non-surgical treatment of breast cancer. Pain (2005) 0.90
Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Mol Biol Cell (2007) 0.89
Clinical and pathologic features of familial pancreatic cancer. Cancer (2014) 0.86
FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion. Small GTPases (2011) 0.84
Regulation of Tbx22 during facial and palatal development. Dev Dyn (2010) 0.83
Live cell in vitro and in vivo imaging applications: accelerating drug discovery. Pharmaceutics (2011) 0.79
Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging. Cell Adh Migr (2014) 0.78
Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions. Biochem J (2012) 0.78
Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue. FEBS J (2013) 0.77
Role of FDG-PET in surgical management of patients with colorectal liver metastases. ANZ J Surg (2004) 0.76
Database choices in endocrine systematic reviews. J Med Libr Assoc (2015) 0.76
Imaging fibrosis in pancreatic cancer using second harmonic generation. Pancreatology (2015) 0.75