β-Blockers are associated with a reduction in COPD exacerbations.

PubWeight™: 1.48‹?› | Rank: Top 4%

🔗 View Article (PMID 26283710)

Published in Thorax on August 17, 2015

Authors

Surya P Bhatt1, James M Wells1, Gregory L Kinney2, George R Washko3, Matthew Budoff4, Young-Il Kim5, William C Bailey1, Hrudaya Nath6, John E Hokanson2, Edwin K Silverman7, James Crapo8, Mark T Dransfield9, COPDGene Investigators

Author Affiliations

1: Division of Pulmonary, Allergy and Critical Care Medicine, UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
2: Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
3: Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
4: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
5: Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
6: Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
7: Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
8: Division of Pulmonary and Critical Care, National Jewish Health, Denver, Colorado, USA.
9: Division of Pulmonary, Allergy and Critical Care Medicine, UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, USA Birmingham VA Medical Center, Birmingham, Alabama, USA.

Associated clinical trials:

Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD) (COPDGene) | NCT00608764

Articles cited by this

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2012) 22.96

An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Multivariate Behav Res (2011) 13.63

Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67

Effect of beta-blockade on mortality among high-risk and low-risk patients after myocardial infarction. N Engl J Med (1998) 6.14

Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54

Re-examining the efficacy of beta-blockers for the treatment of hypertension: a meta-analysis. CMAJ (2006) 5.03

GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med (2012) 3.98

Use of beta blockers and the risk of death in hospitalised patients with acute exacerbations of COPD. Thorax (2007) 3.39

Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30

Cardioselective beta-blockers for chronic obstructive pulmonary disease. Cochrane Database Syst Rev (2005) 3.08

Calcium density of coronary artery plaque and risk of incident cardiovascular events. JAMA (2014) 3.06

Prediction of the clinical course of chronic obstructive pulmonary disease, using the new GOLD classification: a study of the general population. Am J Respir Crit Care Med (2012) 3.00

Effect of beta blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort study. BMJ (2011) 2.88

Beta-blockers may reduce mortality and risk of exacerbations in patients with chronic obstructive pulmonary disease. Arch Intern Med (2010) 2.82

Biochemical markers of cardiac dysfunction predict mortality in acute exacerbations of COPD. Thorax (2011) 2.39

Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol (2007) 2.24

Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality. Proc Am Thorac Soc (2005) 2.17

Prognostic value of coronary CT angiography and calcium score for major adverse cardiac events in outpatients. JACC Cardiovasc Imaging (2012) 2.17

Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest (2009) 2.16

Under-use of beta-blockers in patients with ischaemic heart disease and concomitant chronic obstructive pulmonary disease. QJM (2005) 1.94

Coronary artery and thoracic calcium on noncontrast thoracic CT scans: comparison of ungated and gated examinations in patients from the COPD Gene cohort. J Cardiovasc Comput Tomogr (2010) 1.91

Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma. Proc Natl Acad Sci U S A (2004) 1.85

2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2013) 1.76

Association between β-blocker therapy and outcomes in patients hospitalised with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension. Thorax (2012) 1.49

Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study. Am J Respir Crit Care Med (2015) 1.48

Inhaled drugs to reduce exacerbations in patients with chronic obstructive pulmonary disease: a network meta-analysis. BMC Med (2009) 1.37

Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers. Chest (2005) 1.33

Effectiveness of beta-blocker therapy after acute myocardial infarction in elderly patients with chronic obstructive pulmonary disease or asthma. J Am Coll Cardiol (2001) 1.26

Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest (2002) 1.26

Beta-blocker treatment of patients with diastolic heart failure and arterial hypertension. A prospective, randomized, comparison of the long-term effects of atenolol vs. nebivolol. Eur J Heart Fail (2003) 1.25

Chronic obstructive pulmonary disease and cardiovascular disease. Transl Res (2013) 1.18

Impact of cardioselective beta-blockers on mortality in patients with chronic obstructive pulmonary disease and atherosclerosis. Am J Respir Crit Care Med (2008) 1.16

Effects of cardiovascular drugs on mortality in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.12

Beta-blockers as single-agent therapy for hypertension and the risk of mortality among patients with chronic obstructive pulmonary disease. Am J Med (2004) 1.06

Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality. Thorax (2014) 1.02

Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. Am J Physiol Lung Cell Mol Physiol (2000) 0.98

Rates of hospitalizations and emergency department visits in patients with asthma and chronic obstructive pulmonary disease taking beta-blockers. Pharmacotherapy (2007) 0.93

Beta-blockers reduced the risk of mortality and exacerbation in patients with COPD: a meta-analysis of observational studies. PLoS One (2014) 0.89

Multicentric study on the beta-blocker use and relation with exacerbations in COPD. Respir Med (2014) 0.85

Arrhythmias as trigger for acute exacerbations of chronic obstructive pulmonary disease. Respir Med (2012) 0.83

β-Blocker use and incidence of chronic obstructive pulmonary disease exacerbations. Ann Pharmacother (2013) 0.83

Arrhythmogenesis in patients with stable chronic obstructive pulmonary disease. J Cardiovasc Med (Hagerstown) (2008) 0.81

Pulmonary effects of nebivolol. Ther Adv Cardiovasc Dis (2009) 0.81

Articles by these authors

Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54

Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75

Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30

Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax (2013) 2.88

The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29

Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax (2012) 2.15

The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. Chest (2011) 2.14

Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98

Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med (2012) 1.80

Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med (2011) 1.76

Racial differences in quality of life in patients with COPD. Chest (2011) 1.64

Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA (2016) 1.61

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med (2014) 1.57

Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc (2015) 1.54

Radiological correlates and clinical implications of the paradoxical lung function response to β₂ agonists: an observational study. Lancet Respir Med (2014) 1.41

Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol (2012) 1.41

Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med (2012) 1.27

The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med (2013) 1.23

Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18

Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 1.07

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res (2014) 1.06

Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest (2011) 1.03

Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. Chest (2011) 1.03

Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res (2013) 1.00

Family history is a risk factor for COPD. Chest (2011) 0.96

Racial differences in CT phenotypes in COPD. COPD (2013) 0.95

Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.92

Pulmonary function reduction in diabetes with and without chronic obstructive pulmonary disease. Diabetes Care (2013) 0.89

Association between occupational exposure and lung function, respiratory symptoms, and high-resolution computed tomography imaging in COPDGene. Am J Respir Crit Care Med (2014) 0.89

Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study. BMC Pulm Med (2016) 0.87

Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc (2016) 0.87

Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes. Chest (2013) 0.86

Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. BMC Pulm Med (2016) 0.86

Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans. Chronic Obstr Pulm Dis (2015) 0.85

Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene. Ann Am Thorac Soc (2015) 0.85

Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. Respir Res (2014) 0.84

Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study. Respir Res (2015) 0.84

Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study. Genet Epidemiol (2014) 0.82

Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.81

Cardiovascular disease is associated with COPD severity and reduced functional status and quality of life. COPD (2014) 0.81

Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc (2016) 0.80

Obesity is Associated with Increased Morbidity in Moderate to Severe COPD. Chest (2016) 0.79

Effect of Emphysema Severity on the Apnea-Hypopnea Index in Smokers with Obstructive Sleep Apnea. Ann Am Thorac Soc (2016) 0.79

Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med (2014) 0.78

β-Blockers for the prevention of acute exacerbations of chronic obstructive pulmonary disease (βLOCK COPD): a randomised controlled study protocol. BMJ Open (2016) 0.78

CT-derived Biomechanical Metrics Improve Agreement Between Spirometry and Emphysema. Acad Radiol (2016) 0.78

Airway wall thickness is increased in COPD patients with bronchodilator responsiveness. Respir Res (2014) 0.78

Lung Mass in Smokers. Acad Radiol (2016) 0.77

Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc (2014) 0.77

Current Smoking Status Is Associated With Lower Quantitative CT Measures of Emphysema and Gas Trapping. J Thorac Imaging (2016) 0.77

A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet (2015) 0.77

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet (2016) 0.77

Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction: authors' response. Thorax (2014) 0.77

Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction. Ann Am Thorac Soc (2014) 0.77

Biomechanical CT metrics are associated with patient outcomes in COPD. Thorax (2017) 0.77

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet (2017) 0.76

Multiplanar MDCT measurement of esophageal hiatus surface area: association with hiatal hernia and GERD. Surg Endosc (2015) 0.76

Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J (2015) 0.76

Acute Exacerbations and Lung Function Loss in Smokers With and Without COPD. Am J Respir Crit Care Med (2016) 0.75

GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. Respir Res (2017) 0.75

Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. Am J Respir Cell Mol Biol (2017) 0.75

Post-imaging pulmonary nodule mathematical prediction models: are they clinically relevant? Eur Radiol (2019) 0.75

Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers. Chest (2017) 0.75

Signs of Gas Trapping in Normal Lung Density Regions in Smokers. Am J Respir Crit Care Med (2017) 0.75

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest (2017) 0.75

Ventricular Geometry From Non-contrast Non-ECG-gated CT Scans: An Imaging Marker of Cardiopulmonary Disease in Smokers. Acad Radiol (2017) 0.75

CT Measure of Lung At-risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2017) 0.75

Handgrip Strength in Chronic Obstructive Pulmonary Disease. Associations with Acute Exacerbations and Body Composition. Ann Am Thorac Soc (2017) 0.75