Published in Am J Respir Crit Care Med on June 15, 2016
Extreme Trait Whole Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. Am J Respir Crit Care Med (2017) 0.78
Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees. Am J Hum Genet (2016) 0.77
The Advent of High-Throughput Sequencing Studies of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.75
Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol (2017) 0.75
Boosting Gene Mapping Power and Efficiency with Efficient Exact Variance Component Tests of SNP Sets. Genetics (2016) 0.75
Whole-Genome Sequencing in Common Respiratory Diseases. Ready, Set, Go! Am J Respir Crit Care Med (2017) 0.75
Using omics approaches to understand pulmonary diseases. Respir Res (2017) 0.75
Exome sequencing identifies the cause of a mendelian disorder. Nat Genet (2009) 32.06
STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res (2008) 20.62
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) (2012) 20.08
A general framework for estimating the relative pathogenicity of human genetic variants. Nat Genet (2014) 14.56
Exome sequencing as a tool for Mendelian disease gene discovery. Nat Rev Genet (2011) 14.29
Improved scoring of functional groups from gene expression data by decorrelating GO graph structure. Bioinformatics (2006) 11.33
Proteomics. Tissue-based map of the human proteome. Science (2015) 10.21
Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel. Am J Hum Genet (2011) 8.53
Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
A general framework for detecting disease associations with rare variants in sequencing studies. Am J Hum Genet (2011) 4.52
Loss-of-function mutations in APOC3 and risk of ischemic vascular disease. N Engl J Med (2014) 4.41
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet (2014) 4.24
A novel channelopathy in pulmonary arterial hypertension. N Engl J Med (2013) 4.23
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med (1998) 3.83
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Exome sequencing identifies WDR35 variants involved in Sensenbrenner syndrome. Am J Hum Genet (2010) 3.47
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med (2015) 3.29
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Chronic obstructive pulmonary disease surveillance--United States, 1971-2000. Respir Care (2002) 3.02
Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene. Nat Genet (2013) 2.91
Aminoacyl tRNA synthetases and their connections to disease. Proc Natl Acad Sci U S A (2008) 2.41
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28
Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J Exp Med (1995) 2.24
Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Nat Genet (2012) 2.14
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function. Am J Respir Crit Care Med (2013) 1.93
Transcriptomic analysis of human lung development. Am J Respir Crit Care Med (2009) 1.87
GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5. J Cell Biol (1999) 1.82
New anti-inflammatory targets for chronic obstructive pulmonary disease. Nat Rev Drug Discov (2013) 1.69
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med (2013) 1.67
Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia. Am J Hum Genet (2012) 1.65
Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Nat Genet (2003) 1.57
Finding disease variants in Mendelian disorders by using sequence data: methods and applications. Am J Hum Genet (2011) 1.40
Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity. Cancer Res (2005) 1.36
A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data. Nat Biotechnol (2014) 1.36
Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration. FEBS Lett (2006) 1.34
Heterogeneity of barrier function in the lung reflects diversity in endothelial cell junctions. Microvasc Res (2007) 1.13
Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res (2014) 1.06
Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment. FEBS Lett (1997) 1.03
Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med (2014) 0.99
Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. PLoS Genet (2014) 0.91
GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production. Mol Biol Cell (2012) 0.86
Impact of heterozygote CFTR mutations in COPD patients with chronic bronchitis. Respir Res (2014) 0.84
Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature (2012) 8.91
Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54
Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75
Copy number variation detection and genotyping from exome sequence data. Genome Res (2012) 4.44
Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature (2014) 3.29
Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax (2013) 2.88
Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders. Neuron (2013) 2.45
The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29
Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax (2012) 2.15
Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Nat Genet (2012) 2.14
The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. Chest (2011) 2.14
Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med (2012) 1.80
Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med (2011) 1.76
Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project. Blood (2013) 1.69
Racial differences in quality of life in patients with COPD. Chest (2011) 1.64
Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA (2016) 1.61
Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med (2014) 1.57
Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc (2015) 1.54
β-Blockers are associated with a reduction in COPD exacerbations. Thorax (2015) 1.48
Radiological correlates and clinical implications of the paradoxical lung function response to β₂ agonists: an observational study. Lancet Respir Med (2014) 1.41
Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol (2012) 1.41
Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results. Am J Hum Genet (2014) 1.35
Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med (2012) 1.27
The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med (2013) 1.23
Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18
Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 1.07
Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res (2014) 1.06
Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest (2011) 1.03
Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. Chest (2011) 1.03
Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res (2013) 1.00
Family history is a risk factor for COPD. Chest (2011) 0.96
Racial differences in CT phenotypes in COPD. COPD (2013) 0.95
Association between occupational exposure and lung function, respiratory symptoms, and high-resolution computed tomography imaging in COPDGene. Am J Respir Crit Care Med (2014) 0.89
Pulmonary function reduction in diabetes with and without chronic obstructive pulmonary disease. Diabetes Care (2013) 0.89
Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study. BMC Pulm Med (2016) 0.87
Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc (2016) 0.87
Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes. Chest (2013) 0.86
Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. BMC Pulm Med (2016) 0.86
Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene. Ann Am Thorac Soc (2015) 0.85
Smoking-Associated Site-Specific Differential Methylation in Buccal Mucosa in the COPDGene Study. Am J Respir Cell Mol Biol (2015) 0.84
Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study. Respir Res (2015) 0.84
Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. Respir Res (2014) 0.84
Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study. Genet Epidemiol (2014) 0.82
Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.81
Cardiovascular disease is associated with COPD severity and reduced functional status and quality of life. COPD (2014) 0.81
Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res (2014) 0.80
Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc (2016) 0.80
Obesity is Associated with Increased Morbidity in Moderate to Severe COPD. Chest (2016) 0.79
Effect of Emphysema Severity on the Apnea-Hypopnea Index in Smokers with Obstructive Sleep Apnea. Ann Am Thorac Soc (2016) 0.79
CT-derived Biomechanical Metrics Improve Agreement Between Spirometry and Emphysema. Acad Radiol (2016) 0.78
Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med (2014) 0.78
Airway wall thickness is increased in COPD patients with bronchodilator responsiveness. Respir Res (2014) 0.78
Lung Mass in Smokers. Acad Radiol (2016) 0.77
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet (2015) 0.77
Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc (2014) 0.77
Current Smoking Status Is Associated With Lower Quantitative CT Measures of Emphysema and Gas Trapping. J Thorac Imaging (2016) 0.77
Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction. Ann Am Thorac Soc (2014) 0.77
Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet (2016) 0.77
Biomechanical CT metrics are associated with patient outcomes in COPD. Thorax (2017) 0.77
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet (2017) 0.76
Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J (2015) 0.76
Multiplanar MDCT measurement of esophageal hiatus surface area: association with hiatal hernia and GERD. Surg Endosc (2015) 0.76
Acute Exacerbations and Lung Function Loss in Smokers With and Without COPD. Am J Respir Crit Care Med (2016) 0.75
GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. Respir Res (2017) 0.75
CT Measure of Lung At-risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2017) 0.75
Handgrip Strength in Chronic Obstructive Pulmonary Disease. Associations with Acute Exacerbations and Body Composition. Ann Am Thorac Soc (2017) 0.75
Post-imaging pulmonary nodule mathematical prediction models: are they clinically relevant? Eur Radiol (2019) 0.75
Ventricular Geometry From Non-contrast Non-ECG-gated CT Scans: An Imaging Marker of Cardiopulmonary Disease in Smokers. Acad Radiol (2017) 0.75
Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest (2017) 0.75
Signs of Gas Trapping in Normal Lung Density Regions in Smokers. Am J Respir Crit Care Med (2017) 0.75
Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. Am J Respir Cell Mol Biol (2017) 0.75
Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers. Chest (2017) 0.75