Published in Immunity on August 15, 2013
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity (2013) 2.05
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat Immunol (2015) 1.31
Treg functional stability and its responsiveness to the microenvironment. Immunol Rev (2014) 1.01
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat Immunol (2016) 0.96
β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med (2014) 0.96
TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest (2015) 0.96
Transcriptional regulatory networks for CD4 T cell differentiation. Curr Top Microbiol Immunol (2014) 0.86
Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease. J Mol Cell Biol (2014) 0.85
Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease. Cell Rep (2015) 0.83
Dickkopf-3, a tissue-derived modulator of local T-cell responses. Front Immunol (2015) 0.83
The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation. Immunity (2016) 0.82
Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions. PLoS One (2014) 0.82
A critical role for the regulated wnt-myc pathway in naive T cell survival. J Immunol (2014) 0.80
Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases. J Immunol Res (2016) 0.80
Lrp5/β-catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis. Am J Respir Cell Mol Biol (2016) 0.79
Mycobacteria-responsive sonic hedgehog signaling mediates programmed death-ligand 1- and prostaglandin E2-induced regulatory T cell expansion. Sci Rep (2016) 0.78
Blockade of Wnt/β-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses. Mediators Inflamm (2016) 0.77
Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation. J Biol Chem (2015) 0.77
Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes. Philos Trans R Soc Lond B Biol Sci (2018) 0.76
FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2. Oncogene (2015) 0.76
Ubiquitous points of control over regulatory T cells. J Mol Med (Berl) (2014) 0.76
Spontaneous Intestinal Tumorigenesis in Apc (/Min+) Mice Requires Altered T Cell Development with IL-17A. J Immunol Res (2015) 0.76
Colorectal cancer cells suppress CD4+ T cells immunity through canonical Wnt signaling. Oncotarget (2017) 0.75
WNT5A transforms intestinal CD8αα(+) IELs into an unconventional phenotype with pro-inflammatory features. BMC Gastroenterol (2015) 0.75
MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway. PLoS One (2016) 0.75
Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis. Drug Des Devel Ther (2016) 0.75
Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis. JCI Insight (2016) 0.75
Dickkopf-3 Contributes to the Regulation of Anti-Tumor Immune Responses by Mesenchymal Stem Cells. Front Immunol (2015) 0.75
Membrane-bound Dickkopf-1 in Foxp3(+) regulatory T cells suppresses T cell-mediated autoimmune colitis. Immunology (2017) 0.75
Active GSK3β and an intact β-catenin TCF complex are essential for the differentiation of human myogenic progenitor cells. Sci Rep (2017) 0.75
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell (2010) 12.23
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell (2009) 7.08
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest (2008) 7.05
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (2012) 6.55
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol (2002) 4.85
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31
Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes (2004) 4.24
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology (2009) 4.16
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat Cell Biol (2006) 4.14
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol (2003) 3.70
WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol (2008) 3.46
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem (2003) 3.41
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J Clin Invest (2007) 3.28
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci (2009) 3.18
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell (2012) 3.03
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. Cancer Cell (2011) 2.89
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol (2002) 2.86
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol Cell Biol (2002) 2.84
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. J Clin Invest (2007) 2.80
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2. Mol Cell (2005) 2.76
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature (2012) 2.76
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64
Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells. Hum Immunol (2005) 2.53
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood (2009) 2.49
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med (2005) 2.44
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell (2009) 2.40
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex. Nat Cell Biol (2008) 2.38
Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation. Blood (2008) 2.37
Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays. BMC Immunol (2009) 2.27
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol (2011) 2.21
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion. Cell Stem Cell (2011) 2.18
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell (2010) 2.13
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10
Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies. J Immunol Methods (2005) 2.09
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity (2013) 2.05
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem (2009) 2.05
Controlled gene expression in primary Lgr5 organoid cultures. Nat Methods (2011) 1.98
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood (2006) 1.98
Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study. Ann Rheum Dis (2006) 1.95
Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis. Lancet (2005) 1.93
A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nat Med (2013) 1.87
Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples. Nat Methods (2010) 1.77
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity (2013) 1.75
A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry (2008) 1.66
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences. Mol Ther (2004) 1.65
Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. Clin Cancer Res (2011) 1.64
Bone regeneration is regulated by wnt signaling. J Bone Miner Res (2007) 1.63
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol (2012) 1.63
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol Cell Biol (2004) 1.63
Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression. J Immunol (2005) 1.61
Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy. Blood (2012) 1.61
MAPK signaling pathways in the regulation of hematopoiesis. J Leukoc Biol (2009) 1.60
The role of the PI3K-PKB signaling module in regulation of hematopoiesis. Cell Cycle (2009) 1.55
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood (2008) 1.54
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol (2004) 1.51
Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Obesity (Silver Spring) (2011) 1.50
The extending network of FOXO transcriptional target genes. Antioxid Redox Signal (2010) 1.49
Posttranslational modifications of PPAR-gamma: fine-tuning the metabolic master regulator. Obesity (Silver Spring) (2009) 1.44
FOXO transcription factors as regulators of immune homeostasis: molecules to die for? J Immunol (2003) 1.44
Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. J Immunol (2010) 1.44
A new PCR followed by MboI digestion for the detection of all variants of the Clostridium perfringens cpb2 gene. Vet Microbiol (2007) 1.41
Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion. J Immunol (2004) 1.41
FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1. J Biol Chem (2006) 1.40