Published in Nature on December 23, 2015
Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature (2015) 2.58
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Control of stress-dependent cardiac growth and gene expression by a microRNA. Science (2007) 12.08
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet (2008) 10.87
A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A (2006) 10.09
The Atlas genome assembly system. Genome Res (2004) 9.78
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 9.14
Transient regenerative potential of the neonatal mouse heart. Science (2011) 9.02
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26
International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology (2012) 7.22
Performance comparison of exome DNA sequencing technologies. Nat Biotechnol (2011) 7.11
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J Infect Dis (2008) 6.43
Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A (2007) 5.95
Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med (2008) 5.82
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell (2004) 5.80
Performance comparison of whole-genome sequencing platforms. Nat Biotechnol (2011) 5.79
Loss to care and death before antiretroviral therapy in Durban, South Africa. J Acquir Immune Defic Syndr (2009) 5.40
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev (2008) 5.39
A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell (2009) 5.28
Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17
Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa. Clin Infect Dis (2008) 5.14
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell (2010) 5.07
High-precision, whole-genome sequencing of laboratory strains facilitates genetic studies. PLoS Genet (2008) 4.86
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev (2009) 4.62
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev (2007) 4.50
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol (2004) 4.24
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet (2003) 3.78
Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A (2002) 3.74
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell (2010) 3.72
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science (2009) 3.64
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci U S A (2007) 3.62
Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance. Cell Cycle (2009) 3.60
Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature (2002) 3.60
Targeted access to the genomes of low-abundance organisms in complex microbial communities. Appl Environ Microbiol (2007) 3.55
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med (2012) 3.53
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem (2002) 3.52
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell (2003) 3.40
The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2003) 3.40
CD4 decline and incidence of opportunistic infections in Cape Town, South Africa: implications for prophylaxis and treatment. J Acquir Immune Defic Syndr (2006) 3.39
Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med (2002) 3.31
Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A (2005) 3.30
Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A (2002) 3.27
TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res (2006) 3.21
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem (2005) 3.19
Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest (2007) 3.19
Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell (2006) 3.07
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A (2006) 3.05
optix drives the repeated convergent evolution of butterfly wing pattern mimicry. Science (2011) 2.99
Analysis of the human endogenous coregulator complexome. Cell (2011) 2.97
MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell (2007) 2.96
Routine voluntary HIV testing in Durban, South Africa: the experience from an outpatient department. J Acquir Immune Defic Syndr (2007) 2.91
Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev Biol (2004) 2.89
Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease. Hepatology (2015) 2.81
Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) 2.76
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest (2006) 2.74
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron (2003) 2.73
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med (2006) 2.67
Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc Natl Acad Sci U S A (2012) 2.66
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A (2009) 2.66
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development (2004) 2.61
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell (2002) 2.53
Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. Am J Hum Genet (2008) 2.53
Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486. Proc Natl Acad Sci U S A (2010) 2.47
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet (2012) 2.47
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab (2005) 2.42
A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature. Blood (2007) 2.39
Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal (2011) 2.38
A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A (2006) 2.32
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest (2008) 2.31
Predictors of mortality in patients initiating antiretroviral therapy in Durban, South Africa. S Afr Med J (2008) 2.30
Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol (2005) 2.30
Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci U S A (2009) 2.27
The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Cell (2006) 2.26
The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Genome Res (2010) 2.25
Environmental whole-genome amplification to access microbial populations in contaminated sediments. Appl Environ Microbiol (2006) 2.24
The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest (2008) 2.24
Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell (2010) 2.22
The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery. Anesth Analg (2002) 2.20
Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations. PLoS One (2010) 2.19
Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan. J Gastroenterol (2010) 2.18
Conserved developmental transcriptomes in evolutionarily divergent species. Genome Biol (2010) 2.16