Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.

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🔗 View Article (PMID 26752265)

Published in Nat Genet on January 11, 2016

Authors

Jessica N Cooke Bailey¹, Stephanie J Loomis², Jae H Kang³, R Rand Allingham⁴, Puya Gharahkhani⁵, Chiea Chuen Khor⁶^,7, Kathryn P Burdon⁸^,9, Hugues Aschard¹⁰, Daniel I Chasman¹¹, Robert P Igo¹², Pirro G Hysi¹³, Craig A Glastonbury¹³, Allison Ashley-Koch¹⁴, Murray Brilliant¹⁵, Andrew A Brown¹⁶, Donald L Budenz¹⁷, Alfonso Buil¹⁶, Ching-Yu Cheng⁷^,18^,19, Hyon Choi²⁰, William G Christen¹¹, Gary Curhan³^,21, Immaculata De Vivo³, John H Fingert²²^,23, Paul J Foster²⁴^,25, Charles Fuchs³^,26, Douglas Gaasterland²⁷, Terry Gaasterland²⁸, Alex W Hewitt²⁹^,30, Frank Hu¹⁰^,31, David J Hunter¹⁰^,32, Anthony P Khawaja³³, Richard K Lee³⁴, Zheng Li⁶, Paul R Lichter³⁵, David A Mackey³⁶^,37, Peter McGuffin³⁸, Paul Mitchell³⁹, Sayoko E Moroi³⁵, Shamira A Perera¹⁸^,40, Keating W Pepper⁴¹, Qibin Qi⁴², Tony Realini⁴³, Julia E Richards³⁵^,44, Paul M Ridker¹¹, Eric Rimm³^,10^,31, Robert Ritch⁴⁵, Marylyn Ritchie⁴⁶, Joel S Schuman⁴⁷, William K Scott⁴⁸, Kuldev Singh⁴⁹, Arthur J Sit⁵⁰, Yeunjoo E Song¹², Rulla M Tamimi³, Fotis Topouzis⁵¹, Ananth C Viswanathan²⁴, Shefali Setia Verma⁴⁶, Douglas Vollrath⁵², Jie Jin Wang³⁹, Nicole Weisschuh⁵³, Bernd Wissinger⁵³, Gadi Wollstein⁴⁷, Tien Y Wong⁷^,18, Brian L Yaspan⁵⁴, Donald J Zack⁵⁵, Kang Zhang⁵⁶, Epic-Norfolk Eye Study⁵⁷, ANZRAG Consortium, Robert N Weinreb⁵⁶, Margaret A Pericak-Vance⁴⁸, Kerrin Small¹³, C J Hammond⁵⁸^,13, Tin Aung¹⁸^,19, Yutao Liu⁵⁷^,59, Eranga N Vithana¹⁸^,19, Stuart MacGregor⁵, Jamie E Craig⁶⁰, Peter Kraft¹⁰^,32, Gareth Howell⁴¹, Michael A Hauser⁴^,14, Louis R Pasquale²^,3, Jonathan L Haines¹², Janey L Wiggs²

Author Affiliations

1: Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
2: Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
3: Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
4: Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA.
5: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
6: Division of Human Genetics, Genome Institute of Singapore, Singapore.
7: Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
8: Department of Ophthalmology, Flinders Medical Centre, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia. Kathryn.burdon@utas.edu.au.
9: Menzies Institute for Medical Research, University of Tasmania, Private bag 23, Hobart, TAS, 7000, Australia. Kathryn.burdon@utas.edu.au.
10: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
11: Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
12: Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
13: Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
14: Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
15: Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA.
16: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
17: Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina, USA.
18: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
19: Eye Academic Clinical Program, Duke-National University of Singapore Graduate Medical School, Singapore.
20: Section of Rheumatology and Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA.
21: Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
22: Department of Ophthalmology, University of Iowa, College of Medicine, Iowa City, Iowa, USA.
23: Department of Anatomy and Cell Biology, University of Iowa, College of Medicine, Iowa City, Iowa, USA.
24: National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital, London, UK.
25: Department of Ophthalmology, University College London, London, UK.
26: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
27: Eye Doctors of Washington, Chevy Chase, Maryland, USA.
28: Scripps Genome Center, University of California at San Diego, San Diego, California, USA.
29: Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.
30: Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
31: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
32: Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA.
33: Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.
34: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
35: Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.
36: Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
37: Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia.
38: Medical Research Council Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, London, UK.
39: Centre for Vision Research, Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia.
40: Duke-National University of Singapore Graduate Medical School, Singapore.
41: The Jackson Laboratory, Bar Harbor, Maine, USA.
42: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
43: Department of Ophthalmology, West Virginia University Eye Institute, Morgantown, West Virginia, USA.
44: Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
45: Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.
46: Center for Systems Genomics, Pennsylvania State University, University Park, Pennsylvania, USA.
47: Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
48: Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
49: Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
50: Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
51: Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
52: Department of Genetics, Stanford University School of Medicine, Palo Alto, California, USA.
53: Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
54: Genentech, San Francisco, California, USA.
55: Wilmer Eye Institute, Johns Hopkins University Hospital, Baltimore, Maryland, USA.
56: Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, San Diego, California, USA.
57: Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia, USA.
58: Department of Ophthalmology, King's College London, London, UK.
59: James and Jean Culver Vision Discovery Institute, Georgia Regents University, Augusta, Georgia, USA.
60: Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia.