Published in Antioxid Redox Signal on March 30, 2016
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol (2017) 0.77
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases. Redox Biol (2017) 0.76
A Novel Way of Amelioration of Amyloid Beta Induced Toxicity in Caenorhabditis elegans. Ann Neurosci (2016) 0.75
Proteostasis, oxidative stress and aging. Redox Biol (2017) 0.75
Redox regulation of proteasome function. Redox Biol (2017) 0.75
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature (2000) 15.98
The hallmarks of aging. Cell (2013) 14.29
The plasticity of aging: insights from long-lived mutants. Cell (2005) 9.88
Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature (2007) 5.94
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell (2008) 5.60
Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci U S A (1995) 3.36
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature (2011) 3.20
Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics (1995) 3.07
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev (2005) 2.81
Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem (1995) 2.68
Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast. FEBS Lett (1999) 2.54
Impaired proteasome function in Alzheimer's disease. J Neurochem (2000) 2.44
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell (2009) 2.32
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem (2005) 2.31
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol (2003) 2.19
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.14
RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature (2012) 2.11
Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model. Neurobiol Aging (2003) 1.78
Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal (2010) 1.77
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation. Nat Rev Mol Cell Biol (2011) 1.73
Ageing as a risk factor for disease. Curr Biol (2012) 1.71
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol (2008) 1.69
Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Biochem J (2008) 1.67
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS Genet (2011) 1.52
Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem (2003) 1.51
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A (2008) 1.44
Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival rates. J Biol Chem (2005) 1.43
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta (2011) 1.40
Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet (2011) 1.35
Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line. Int Immunopharmacol (2004) 1.26
Role of the ubiquitin proteasome system in Alzheimer's disease. BMC Biochem (2007) 1.25
Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches. Bioessays (2008) 1.17
Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem (2010) 1.16
Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free Radic Biol Med (2007) 1.15
Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome? Free Radic Biol Med (2005) 1.10
Fibroblast cultures from healthy centenarians have an active proteasome. Exp Gerontol (2000) 1.07
Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nat Med (2015) 1.07
Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans. J Gerontol A Biol Sci Med Sci (1998) 1.04
Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. PLoS One (2012) 1.02
The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts. Rejuvenation Res (2007) 1.01
20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans. FASEB J (2014) 0.93
Proteasome activation delays aging in vitro and in vivo. Free Radic Biol Med (2014) 0.92
Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Cell Rep (2013) 0.91
Anti-ageing and rejuvenating effects of quercetin. Exp Gerontol (2010) 0.91
Macromolecular and small-molecule modulation of intracellular Aβ42 aggregation and associated toxicity. Biochem J (2012) 0.90
Oleuropein aglycone protects transgenic C. elegans strains expressing Aβ42 by reducing plaque load and motor deficit. PLoS One (2013) 0.88
Proteasome activation as a novel antiaging strategy. IUBMB Life (2008) 0.86
Selectivity of action of glycyrrhizin derivatives on the growth of MCF-7 and HEP-2 cells. Anticancer Res (2003) 0.86
The ubiquitin proteasome system in Caenorhabditis elegans and its regulation. Redox Biol (2014) 0.84
Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases. Ageing Res Rev (2014) 0.84
Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status. Aging Cell (2008) 0.83
Glycyrrhizin and some analogues induce growth of primary cultured adult rat hepatocytes via epidermal growth factor receptors. Eur J Pharmacol (2001) 0.83
A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis. Free Radic Biol Med (2011) 0.81
Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals. BMC Biol (2014) 0.80
Employing Alzheimer disease animal models for translational research: focus on dietary components. Neurodegener Dis (2013) 0.79
Resveratrol reduces amyloid-beta (Aβ1-42)-induced paralysis through targeting proteostasis in an Alzheimer model of Caenorhabditis elegans. Eur J Nutr (2015) 0.78
18α-glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line. J Dig Dis (2013) 0.78
Effects of plant extracts on the reversal of glucose-induced impairment of stress-resistance in Caenorhabditis elegans. Plant Foods Hum Nutr (2014) 0.78
Amyloid-beta (Aβ1-42)-induced paralysis in Caenorhabditis elegans is reduced by restricted cholesterol supply. Neurosci Lett (2014) 0.77
The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity. Mol Nutr Food Res (2014) 0.77
A catechin-enriched green tea extract prevents glucose-induced survival reduction in Caenorhabditis elegans through sir-2.1 and uba-1 dependent hormesis. Fitoterapia (2015) 0.76