Systematic identification of trans eQTLs as putative drivers of known disease associations.

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Published in Nat Genet on September 08, 2013

Authors

Harm-Jan Westra1, Marjolein J Peters2,3, Tõnu Esko4, Hanieh Yaghootkar5, Claudia Schurmann6, Johannes Kettunen7,8, Mark W Christiansen9, Benjamin P Fairfax10,11, Katharina Schramm12,13, Joseph E Powell14,15, Alexandra Zhernakova1, Daria V Zhernakova1, Jan H Veldink16, Leonard H Van den Berg16, Juha Karjalainen1, Sebo Withoff1, André G Uitterlinden2,3,17, Albert Hofman3,17, Fernando Rivadeneira2,3,17, Peter A C 't Hoen18, Eva Reinmaa4, Krista Fischer4, Mari Nelis4, Lili Milani4, David Melzer19, Luigi Ferrucci20, Andrew B Singleton21, Dena G Hernandez21,22, Michael A Nalls21, Georg Homuth6, Matthias Nauck23, Dörte Radke24, Uwe Völker6, Markus Perola4,8, Veikko Salomaa8, Jennifer Brody9, Astrid Suchy-Dicey25, Sina A Gharib26, Daniel A Enquobahrie25, Thomas Lumley27, Grant W Montgomery28, Seiko Makino10, Holger Prokisch12,13, Christian Herder29, Michael Roden29,30, Harald Grallert31, Thomas Meitinger12,13,32, Konstantin Strauch33,34, Yang Li35, Ritsert C Jansen35, Peter M Visscher14,15, Julian C Knight10, Bruce M Psaty9,36, Samuli Ripatti7,8,37, Alexander Teumer6, Timothy M Frayling5, Andres Metspalu4, Joyce B J van Meurs2,3, Lude Franke1

Author Affiliations

1: Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.
2: Department of Internal Medicine, Erasmus Medical Centre Rotterdam, the Netherlands.
3: The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/Rotterdam, the Netherlands.
4: Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
5: Genetics of Complex Traits, University of Exeter Medical School, Exeter, EX1 2LU, UK.
6: Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany.
7: Institute for Molecular Medicine Finland FIMM, FI-00014 University of Helsinki, Helsinki, Finland.
8: Department of Chronic Disease Prevention, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
9: Cardiovascular Health Research Unit, University of Washington, Seattle, WA.
10: Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
11: Department of Oncology, Cancer and Haematology Centre, Churchill Hospital, Oxford, OX3 7LJ.
12: Institute of Human Genetics, Helmholz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
13: Institute of Human Genetics, Technical University Munich, Munich, Germany.
14: University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
15: The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
16: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, the Netherlands.
17: Department of Epidemiology, Erasmus Medical Center Rotterdam, the Netherlands.
18: Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
19: Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK.
20: Clinical Research Branch, National Institute on Aging NIA-ASTRA Unit, Harbor Hospital, MD, USA.
21: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD, USA.
22: Department of Molecular Neuroscience and Reta Lila Laboratories, Institute of Neurology, UCL, Queen Square House, Queen Square, London WC1N 3BG, UK.
23: Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
24: Institute for Community Medicine, University Medicine Greifswald, D-17487 Greifswald, Germany.
25: Department of Epidemiology, University of Washington, Seattle, WA, USA.
26: Computational Medicine Core, Center for Lung Biology, Division of Pulmonary & Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
27: Department of Statistics, University of Auckland, Auckland, New Zealand.
28: Queensland Institute of Medical Research, Herston, Brisbane, Australia.
29: Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, University Düsseldorf, Düsseldorf, Germany.
30: Departments of Endocrinology & Diabetology & Metabolic Diseases, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
31: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
32: German Center for Cardiovascular Research (DZHK), Germany; Munich Heart Allience, Munich, Germany.
33: Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Neuherberg, Germany.
34: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
35: Groningen Bioinformatics Centre, University of Groningen, Groningen, the Netherlands.
36: Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
37: Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus,CB10 1SA, Hinxton, UK.

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