Published in JAMA on May 07, 2008
Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) (WAFACS) | NCT00000541
CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ (2010) 28.70
Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 4.40
Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 3.48
Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial. Anesthesiology (2013) 2.39
Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA (2008) 2.32
Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. BMJ (2010) 1.89
Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes. Circulation (2011) 1.88
Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study. Arch Intern Med (2009) 1.83
Efficacy of homocysteine-lowering therapy with folic Acid in stroke prevention: a meta-analysis. Stroke (2010) 1.75
Physical activity and cognition in women with vascular conditions. Arch Intern Med (2011) 1.61
Folic acid improves acetylcholine-induced vasoconstriction of coronary vessels isolated from hyperhomocysteinemic mice: an implication to coronary vasospasm. J Cell Physiol (2011) 1.54
Fruits, vegetables and coronary heart disease. Nat Rev Cardiol (2009) 1.47
A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am J Clin Nutr (2008) 1.37
Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J (2008) 1.32
Homocysteine-lowering B vitamin therapy in cardiovascular prevention--wrong again? JAMA (2008) 1.32
Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research. Am J Physiol Heart Circ Physiol (2010) 1.23
Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. PLoS One (2014) 1.23
Limitations of observational evidence: implications for evidence-based dietary recommendations. Adv Nutr (2014) 1.19
Homocysteine lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev (2009) 1.17
Effect of homocysteine-lowering treatment with folic Acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trial. Diabetes (2009) 1.16
The inextricable link between atherosclerosis and prototypical inflammatory diseases rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther (2009) 1.15
Mediterranean diet and cognitive decline in women with cardiovascular disease or risk factors. J Acad Nutr Diet (2012) 1.15
Total mortality risk in relation to use of less-common dietary supplements. Am J Clin Nutr (2010) 1.15
Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. J Biol Chem (2012) 1.10
Vitamin B12 in health and disease. Nutrients (2010) 1.07
Combined methylmalonic acidemia and homocystinuria, cblC type. II. Complications, pathophysiology, and outcomes. J Inherit Metab Dis (2011) 1.06
Quo vadis: whither homocysteine research? Cardiovasc Toxicol (2009) 1.04
Too much folate: a risk factor for cancer and cardiovascular disease? Curr Opin Clin Nutr Metab Care (2009) 1.02
Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials. J Inherit Metab Dis (2010) 0.98
Relationship between lipid profiles and plasma total homocysteine, cysteine and the risk of coronary artery disease in coronary angiographic subjects. Lipids Health Dis (2011) 0.97
Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study. Int J Epidemiol (2011) 0.97
Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovasc Diabetol (2014) 0.97
Effect of L-methionine on hot flashes in postmenopausal women: a randomized controlled trial. Menopause (2009) 0.95
Homocysteine and Hypertension in Diabetes: Does PPARgamma Have a Regulatory Role? PPAR Res (2010) 0.94
Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatr Dis Treat (2010) 0.94
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circ Res (2009) 0.91
Folic acid and human reproduction-ten important issues for clinicians. J Exp Clin Assist Reprod (2011) 0.90
Betaine and secondary events in an acute coronary syndrome cohort. PLoS One (2012) 0.90
Dietary fat intake in relation to cognitive change in high-risk women with cardiovascular disease or vascular factors. Eur J Clin Nutr (2010) 0.89
Micronutrient intake in relation to all-cause mortality in a prospective Danish cohort. Food Nutr Res (2012) 0.89
Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis. PLoS One (2011) 0.89
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. Am J Clin Nutr (2010) 0.88
Effects of folic acid supplementation on serum folate and plasma homocysteine concentrations in older adults: a dose-response trial. Am J Epidemiol (2010) 0.87
Plasma total cysteine and total homocysteine and risk of myocardial infarction in women: a prospective study. Am Heart J (2010) 0.87
Invited commentary: Preventing neural tube defects and more via food fortification? Am J Epidemiol (2008) 0.87
Association between plasma homocysteine and microalbuminuria in persons without hypertension, diabetes mellitus, and cardiovascular disease. Clin Exp Nephrol (2010) 0.86
Effect of long-term supplementation with folic acid and B vitamins on risk of depression in older women. Br J Psychiatry (2015) 0.85
The genetics of vascular complications in diabetes mellitus. Cardiol Clin (2010) 0.85
Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology. Nutrients (2013) 0.83
Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenoma. J Natl Cancer Inst (2012) 0.83
Vegan diet, subnormal vitamin B-12 status and cardiovascular health. Nutrients (2014) 0.83
The randomized Linxian Dysplasia Nutrition Intervention Trial after 26 years of follow-up: no effect of multivitamin supplementation on mortality. JAMA Intern Med (2013) 0.82
Dietary supplements and disease prevention - a global overview. Nat Rev Endocrinol (2016) 0.81
Novel markers of peripheral arterial disease. Vasc Med (2009) 0.81
Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress. J Biol Chem (2016) 0.81
Nutrient supplements and cardiovascular disease: a heartbreaking story. J Lipid Res (2008) 0.80
Folic acid supplementation and cardiac and stroke mortality among hemodialysis patients. J Ren Nutr (2010) 0.80
Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis. Sci Rep (2015) 0.80
MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification. Eur J Nutr (2014) 0.80
Effect of B-vitamin supplementation on stroke: a meta-analysis of randomized controlled trials. PLoS One (2013) 0.80
Autonomic cardiovascular responses in acclimatized lowlanders on prolonged stay at high altitude: a longitudinal follow up study. PLoS One (2014) 0.78
Lycopene dietary intervention: a pilot study in patients with heart failure. J Cardiovasc Nurs (2015) 0.78
Differing Relations to Early Atherosclerosis between Vitamin C from Supplements vs. Food in the Los Angeles Atherosclerosis Study: A Prospective Cohort Study. Open Cardiovasc Med J (2012) 0.77
Folic acid modulates eNOS activity via effects on posttranslational modifications and protein-protein interactions. Eur J Pharmacol (2013) 0.77
Folic Acid, Vitamin B6, and Vitamin B12 in Combination and Age-Related Cataract in a Randomized Trial of Women. Ophthalmic Epidemiol (2016) 0.77
Poststroke hip fracture: prevalence, clinical characteristics, mineral-bone metabolism, outcomes, and gaps in prevention. Stroke Res Treat (2013) 0.77
The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments. PLoS One (2012) 0.77
Herbal, vitamin, and mineral supplement use in patients enrolled in a cardiac rehabilitation program. J Cardiopulm Rehabil Prev (2012) 0.76
Association between B vitamins supplementation and risk of cardiovascular outcomes: a cumulative meta-analysis of randomized controlled trials. PLoS One (2014) 0.76
Hyperhomocysteinemia is an independent predictor of long-term clinical outcomes in Chinese octogenarians with acute coronary syndrome. Clin Interv Aging (2015) 0.76
Effect of folic acid and B vitamins on cardiovascular disease in women. JAMA (2008) 0.76
Update on the NCEP ATP-III emerging cardiometabolic risk factors. BMC Med (2014) 0.76
Efficacy of Supplementation with B Vitamins for Stroke Prevention: A Network Meta-Analysis of Randomized Controlled Trials. PLoS One (2015) 0.76
Antioxidants and coronary artery disease: from pathophysiology to preventive therapy. Coron Artery Dis (2015) 0.76
Daily low-dose folic acid supplementation does not prevent nitroglycerin-induced nitric oxide synthase dysfunction and tolerance: a human in vivo study. Can J Cardiol (2010) 0.76
Can folic acid and vitamin B lower CVD risk in high-risk women? J Fam Pract (2008) 0.75
Effect of folic acid and B vitamins on cardiovascular disease in women. JAMA (2008) 0.75
The association between B vitamins supplementation and adverse cardiovascular events: a meta-analysis. Int J Clin Exp Med (2014) 0.75
Multivitamins : Use or Misuse? Med J Armed Forces India (2011) 0.75
Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. J Chiropr Med (2013) 0.75
Caffeine and cognitive decline in elderly women at high vascular risk. J Alzheimers Dis (2013) 0.75
Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample Mendelian randomization analysis. Eur J Clin Nutr (2016) 0.75
Genetics of redox systems and their relationship with cardiovascular disease. Curr Atheroscler Rep (2011) 0.75
Mendelian randomisation study of the associations of vitamin B12 and folate genetic risk scores with blood pressure and fasting serum lipid levels in three Danish population-based studies. Eur J Clin Nutr (2016) 0.75
Update of secondary stroke prevention. Nephrol Dial Transplant (2009) 0.75
Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Nutrients (2016) 0.75
Effect of folic acid and B vitamins on cardiovascular disease in women. JAMA (2008) 0.75
Prospective study of plasma homocysteine level and risk of age-related macular degeneration in women. Ophthalmic Epidemiol (2015) 0.75
Vitamins, Are They Safe? Adv Pharm Bull (2016) 0.75
Role of folic acid in nitric oxide bioavailability and vascular endothelial function. Nutr Rev (2017) 0.75
Association between adherence to folic acid supplements and serum folate, and plasma homocysteine among hemodialysis patients. J Ren Nutr (2010) 0.75
Allicin improves carotid artery intima-media thickness in coronary artery disease patients with hyperhomocysteinemia. Exp Ther Med (2017) 0.75
Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus. Nutr Res Pract (2017) 0.75
[Inflammation-related cardiovascular morbidity : Pathophysiology and therapy]. Z Rheumatol (2010) 0.75
Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 12.09
Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med (2006) 11.72
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA (1995) 11.45
Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med (2006) 9.53
Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA (2002) 8.11
Homocysteine and atherothrombosis. N Engl J Med (1998) 6.70
The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med (1999) 6.22
Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N Engl J Med (2001) 5.09
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet (2007) 4.74
Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA (2006) 3.39
A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med (2007) 3.37
Issues in comparisons between meta-analyses and large trials. JAMA (1998) 2.77
Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med (2004) 2.75
Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence. BMJ (2006) 1.93
Total homocysteine lowering treatment among coronary artery disease patients in the era of folic acid-fortified cereal grain flour. Arterioscler Thromb Vasc Biol (2002) 1.66
Power Shortage: clinical trials testing the "homocysteine hypothesis" against a background of folic acid-fortified cereal grain flour. Ann Intern Med (2001) 1.63
The Women's Antioxidant Cardiovascular Study: design and baseline characteristics of participants. J Womens Health (Larchmt) (2004) 1.44
Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J (2006) 1.31
Increased plasma homocysteine after menopause. Atherosclerosis (2000) 1.14
Lowering homocysteine for stroke prevention. Lancet (2007) 1.06
Homocysteine in women's health. Menopause (2003) 0.94
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med (2008) 43.36
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med (2005) 17.32
Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med (2002) 16.23
Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA (2007) 15.32
Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology (2010) 14.07
Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2008) 13.35
The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab (2010) 13.29
Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 12.44
Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med (2006) 12.09
Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 12.09
Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA (2004) 11.69
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2011) 11.02
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet (2009) 10.52
Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA (2007) 10.50
Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA (2003) 10.05
Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA (2007) 9.68
Statins: new American guidelines for prevention of cardiovascular disease. Lancet (2013) 9.56
A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med (2003) 9.24
Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 9.03
Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med (2006) 8.73
Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med (2004) 8.63
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 8.32
A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care (2003) 7.40
C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation (2008) 7.33
Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med (2002) 7.32
Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA (2010) 7.12
C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation (2003) 6.99
Calcium/vitamin D supplementation and cardiovascular events. Circulation (2007) 6.63
Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation (2003) 6.62
Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 6.51
Body-mass index and mortality among adults with incident type 2 diabetes. N Engl J Med (2014) 6.51
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med (2010) 6.48
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation (2007) 6.34
Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med (2007) 6.29
Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. Am J Epidemiol (2005) 6.20
Migraine and risk of cardiovascular disease in women. JAMA (2006) 6.16
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16
Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med (2009) 6.00
Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women. Am J Med (2007) 5.95
Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med (2004) 5.86
C-reactive protein and the risk of developing hypertension. JAMA (2003) 5.75
Low-fat dietary pattern and weight change over 7 years: the Women's Health Initiative Dietary Modification Trial. JAMA (2006) 5.75
Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA (2005) 5.74
The effect of including C-reactive protein in cardiovascular risk prediction models for women. Ann Intern Med (2006) 5.69
Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med (2004) 5.67
Laboratory-based versus non-laboratory-based method for assessment of cardiovascular disease risk: the NHANES I Follow-up Study cohort. Lancet (2008) 5.49
Measures of obesity and cardiovascular risk among men and women. J Am Coll Cardiol (2008) 5.28
Physical activity and weight gain prevention. JAMA (2010) 5.27
Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 5.25
Oestrogen plus progestin and lung cancer in postmenopausal women (Women's Health Initiative trial): a post-hoc analysis of a randomised controlled trial. Lancet (2009) 5.22
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 5.13
Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med (2010) 5.05
Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ (2009) 4.98
Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94
Physical activity, including walking, and cognitive function in older women. JAMA (2004) 4.90
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Effects of estrogen plus progestin on health-related quality of life. N Engl J Med (2003) 4.83
Breast cancer after use of estrogen plus progestin in postmenopausal women. N Engl J Med (2009) 4.80
Risk of death and cardiovascular events in initially healthy women with new-onset atrial fibrillation. JAMA (2011) 4.73
Red meat consumption and mortality: results from 2 prospective cohort studies. Arch Intern Med (2012) 4.72
Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes (2004) 4.67
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA (2004) 4.47
Association between a literature-based genetic risk score and cardiovascular events in women. JAMA (2010) 4.46
A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med (2009) 4.46
Prevalence of dry eye syndrome among US women. Am J Ophthalmol (2003) 4.46