Published in Cell on September 12, 1986
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An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm (2009) 4.99
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An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly. EMBO J (1987) 4.52
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The yeast homologue of U3 snRNA. EMBO J (1987) 3.74
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Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Mol Cell Biol (1987) 3.00
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U1 small nuclear RNA plays a direct role in the formation of a rev-regulated human immunodeficiency virus env mRNA that remains unspliced. Proc Natl Acad Sci U S A (1990) 2.90
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A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. Genes Dev (1998) 2.64
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Plant intron sequences: evidence for distinct groups of introns. Nucleic Acids Res (1988) 2.42
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Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA. Mol Cell Biol (1999) 2.32
Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for binding. EMBO J (1988) 2.32
Direct, sequence-specific binding of the human U1-70K ribonucleoprotein antigen protein to loop I of U1 small nuclear RNA. Mol Cell Biol (1989) 2.29
Evidence for a base-pairing interaction between U6 small nuclear RNA and 5' splice site during the splicing reaction in yeast. Proc Natl Acad Sci U S A (1992) 2.28
Regulation of alternative polyadenylation by U1 snRNPs and SRp20. Mol Cell Biol (1998) 2.26
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements. Proc Natl Acad Sci U S A (1999) 2.26
The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA-pre-mRNA complex and is recognized in the absence of U2 snRNA. EMBO J (1991) 2.26
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Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Mol Cell Biol (2000) 2.22
UACUAAC is the preferred branch site for mammalian mRNA splicing. Proc Natl Acad Sci U S A (1989) 2.22
Nucleotide sequence determination and secondary structure of Xenopus U3 snRNA. Nucleic Acids Res (1988) 2.20
The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites. Proc Natl Acad Sci U S A (1994) 2.14
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Unusual branch point selection in processing of human growth hormone pre-mRNA. Mol Cell Biol (1988) 2.12
Heterogeneous nuclear ribonucleoprotein A1 catalyzes RNA.RNA annealing. Proc Natl Acad Sci U S A (1992) 2.05
Direct interactions between pre-mRNA and six U2 small nuclear ribonucleoproteins during spliceosome assembly. Mol Cell Biol (1994) 2.03
The spliceosomal snRNAs of Caenorhabditis elegans. Nucleic Acids Res (1990) 2.03
Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals. Nucleic Acids Res (1988) 2.02
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Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol (1992) 2.01
Both conserved signals on mammalian histone pre-mRNAs associate with small nuclear ribonucleoproteins during 3' end formation in vitro. Mol Cell Biol (1987) 1.98
The Mr 70,000 protein of the U1 small nuclear ribonucleoprotein particle binds to the 5' stem-loop of U1 RNA and interacts with Sm domain proteins. Proc Natl Acad Sci U S A (1988) 1.98
Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast. EMBO J (1991) 1.97
Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes. EMBO J (1990) 1.96
PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle. Mol Cell Biol (1989) 1.95
An abundant U6 snRNP found in germ cells and embryos of Xenopus laevis. EMBO J (1989) 1.94
Reconstitution of the U1 small nuclear ribonucleoprotein particle. Mol Cell Biol (1987) 1.94
Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91
Comparative analysis detects dependencies among the 5' splice-site positions. RNA (2004) 1.91
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Structure and expression of the Drosophila melanogaster gene for the U1 small nuclear ribonucleoprotein particle 70K protein. Mol Cell Biol (1990) 1.85
U1 small nuclear ribonucleoproteins are required early during spliceosome assembly. Mol Cell Biol (1987) 1.83
The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome. RNA (1996) 1.81
Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing. Nucleic Acids Res (1989) 1.81
Tissue-specific expression and cDNA cloning of small nuclear ribonucleoprotein-associated polypeptide N. Proc Natl Acad Sci U S A (1988) 1.78
Loop I of U1 small nuclear RNA is the only essential RNA sequence for binding of specific U1 small nuclear ribonucleoprotein particle proteins. Mol Cell Biol (1988) 1.77
The yeast PRP19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome. Mol Cell Biol (1993) 1.77
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. Nucleic Acids Res (1995) 1.77
An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5' splice sites. Mol Cell Biol (2000) 1.75
Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. Genes Dev (1999) 1.71
Cooperation of pre-mRNA sequence elements in splice site selection. Mol Cell Biol (1992) 1.70
Determinants of the inherent strength of human 5' splice sites. RNA (2005) 1.69
The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA. Mol Cell Biol (1987) 1.68
A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component. Mol Cell Biol (1989) 1.68
The determinants for Sm protein binding to Xenopus U1 and U5 snRNAs are complex and non-identical. EMBO J (1993) 1.67
An intron enhancer containing a 5' splice site sequence in the human calcitonin/calcitonin gene-related peptide gene. Mol Cell Biol (1995) 1.67
Intrinsic differences between authentic and cryptic 5' splice sites. Nucleic Acids Res (2003) 1.66
Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP family. Proc Natl Acad Sci U S A (1990) 1.65
Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K). EMBO J (1988) 1.62
The simian virus 40 small-t intron, present in many common expression vectors, leads to aberrant splicing. Mol Cell Biol (1990) 1.62
In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes. Nucleic Acids Res (1996) 1.62
The sequence of U3 from Schizosaccharomyces pombe suggests structural divergence of this snRNA between metazoans and unicellular eukaryotes. Nucleic Acids Res (1988) 1.61
Mechanism for cryptic splice site activation during pre-mRNA splicing. Proc Natl Acad Sci U S A (1990) 1.60
Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing. EMBO J (1990) 1.60
In vivo recognition of a vertebrate mini-exon as an exon-intron-exon unit. Mol Cell Biol (1993) 1.60
Cotranscriptional recruitment of the U1 snRNP to intron-containing genes in yeast. Mol Cell Biol (2003) 1.60
Evidence for nuclear factors involved in recognition of 5' splice sites. Nucleic Acids Res (1989) 1.58
Direct selection for mutations affecting specific splice sites in a hamster dihydrofolate reductase minigene. Mol Cell Biol (1993) 1.57
A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Nucleic Acids Res (1996) 1.57
Inhibiting expression of specific genes in mammalian cells with 5' end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA. Proc Natl Acad Sci U S A (2003) 1.55
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A compensatory base change in human U2 snRNA can suppress a branch site mutation. Genes Dev (1989) 3.79
Formation of the 3' end of U1 snRNA requires compatible snRNA promoter elements. Cell (1986) 3.69
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Orientation-dependent transcriptional activator upstream of a human U2 snRNA gene. Mol Cell Biol (1985) 2.87
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Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes. Mol Cell (2000) 1.46
Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus. EMBO J (1995) 1.45
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