Published in Chromosoma on April 22, 2016
Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization. Stem Cell Reports (2017) 0.77
Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases. J Exp Clin Cancer Res (2016) 0.75
Cyclin is degraded by the ubiquitin pathway. Nature (1991) 17.93
A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell (2006) 8.44
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39
Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol (2007) 6.83
Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell (2000) 6.81
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell (2006) 6.46
Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell (2002) 5.91
Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell (2008) 5.87
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell (1995) 5.56
Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev Cell (2002) 5.52
Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol (2001) 5.34
Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell (2009) 5.26
Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J Cell Biol (2001) 4.38
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature (2008) 3.77
AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J (1998) 3.73
Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol (2002) 3.69
INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. Curr Biol (2000) 3.55
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51
Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr Biol (2000) 3.50
The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage. Cell (2006) 3.45
Cell cycle regulation of central spindle assembly. Nature (2004) 3.27
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A (2007) 3.27
The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis. Curr Biol (2000) 3.23
Aurora-A: the maker and breaker of spindle poles. J Cell Sci (2007) 3.20
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Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends Cell Biol (2010) 2.88
The 3Ms of central spindle assembly: microtubules, motors and MAPs. Nat Rev Mol Cell Biol (2009) 2.88
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature (2007) 2.84
Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics (1993) 2.82
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A novel mechanism for activation of the protein kinase Aurora A. Curr Biol (2003) 2.68
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis. J Cell Biol (2005) 2.57
Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation. J Biol Chem (2001) 2.54
Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem (2012) 2.53
Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev (2002) 2.51
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol (2004) 2.44
Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. J Cell Biol (2006) 2.33
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal (2011) 2.33
Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells (2002) 2.28
Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis. Mol Biol Cell (2002) 2.21
Phosphatases: providing safe passage through mitotic exit. Nat Rev Mol Cell Biol (2011) 2.19
APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase. Curr Biol (2008) 2.18
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. Nat Cell Biol (2006) 2.16
AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res (2007) 2.16
A mechanism for chromosome segregation sensing by the NoCut checkpoint. Nat Cell Biol (2009) 2.04
Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. Curr Biol (2005) 2.00
Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase. Nat Cell Biol (2007) 2.00
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev Cell (2007) 1.98
The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A (2009) 1.98
Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis. J Cell Biol (2005) 1.85
The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell (2003) 1.84
Condensin association with histone H2A shapes mitotic chromosomes. Nature (2011) 1.80
Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle. Mol Biol Cell (2003) 1.78
Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression. J Cell Biol (2004) 1.78
Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. J Cell Sci (2007) 1.78
Aurora A kinase and its substrate TACC3 are required for central spindle assembly. EMBO Rep (2013) 1.71
Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property. Mol Cell Biol (2005) 1.67
Feedback control of chromosome separation by a midzone Aurora B gradient. Science (2014) 1.66
PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting. Curr Biol (2011) 1.63
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction. EMBO J (2011) 1.62
Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. J Biol Chem (1999) 1.59
Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res (2009) 1.53
Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex. Curr Biol (2009) 1.52
Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell (2011) 1.43
Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. Dev Biol (2006) 1.43
A chromosome separation checkpoint: A midzone Aurora B gradient mediates a chromosome separation checkpoint that regulates the anaphase-telophase transition. Bioessays (2014) 1.40
Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. Curr Biol (2010) 1.36
Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase. J Cell Biol (2010) 1.32
Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal (2011) 1.31
Spatial Regulation of Kinetochore Microtubule Attachments by Destabilization at Spindle Poles in Meiosis I. Curr Biol (2015) 1.30
Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Cell (2008) 1.30
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J Cell Biol (2009) 1.29
Cooperation between mitotic kinesins controls the late stages of cytokinesis. Curr Biol (2006) 1.28
Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway. Curr Biol (2015) 1.28
Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody. Curr Biol (2009) 1.23
E3 ubiquitin ligases and mitosis: embracing the complexity. Trends Cell Biol (2008) 1.23
The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions. Mol Biol Cell (2007) 1.23
Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient. J Cell Biol (2011) 1.21
A cascade of histone modifications induces chromatin condensation in mitosis. Science (2014) 1.21
A midzone-based ruler adjusts chromosome compaction to anaphase spindle length. Science (2011) 1.19
Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces. Nat Cell Biol (2014) 1.18
Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics (2009) 1.18
Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast. Sci Signal (2011) 1.16
Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development (2011) 1.15
Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J Cell Sci (2009) 1.13
Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics. J Cell Biol (2011) 1.13
Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A. J Cell Biol (2013) 1.13
Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2. J Cell Sci (2011) 1.12
Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase. J Cell Biol (2013) 1.09
Identification of a functional destruction box in the Xenopus laevis aurora-A kinase pEg2. FEBS Lett (2001) 1.09
Aurora A contributes to p150(glued) phosphorylation and function during mitosis. J Cell Biol (2010) 1.08
Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis. Nat Rev Mol Cell Biol (2014) 1.08
A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell (2004) 1.07
A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc Natl Acad Sci U S A (2009) 1.06
Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. J Cell Biol (2012) 1.03
Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued. J Cell Biol (2013) 1.02
Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man. Curr Biol (2013) 1.02