Published in Sci Rep on September 13, 2016
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications. Redox Biol (2017) 0.79
Mitochondrial dynamics in neuronal injury, development and plasticity. J Cell Sci (2017) 0.79
Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals. Int J Mol Sci (2017) 0.76
Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis. Exp Neurol (2017) 0.75
Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity. Neurotox Res (2017) 0.75
Polydatin impairs mitochondria fitness and ameliorates podocyte injury by suppressing Drp1 expression. J Cell Physiol (2017) 0.75
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell (2001) 10.33
Mitochondria: dynamic organelles in disease, aging, and development. Cell (2006) 8.30
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A (2008) 5.43
Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A (2010) 5.17
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol (2009) 4.78
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43
Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol (1990) 3.96
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol (2010) 3.91
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet (2010) 3.77
Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann Neurol (1999) 3.63
miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med (2010) 3.50
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol (2009) 3.49
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS One (2010) 3.16
Parkinson's disease. Lancet (2004) 3.08
Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc (2007) 3.00
The mitochondrial p53 pathway. Biochim Biophys Acta (2008) 2.98
Transcription-independent pro-apoptotic functions of p53. Curr Opin Cell Biol (2005) 2.88
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J (2011) 2.71
Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J (2007) 2.62
Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol Dis (2009) 2.49
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis. Cell Death Differ (2007) 2.30
MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO Rep (2011) 2.26
Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1. Ann N Y Acad Sci (2010) 2.20
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J (2010) 2.12
miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genet (2010) 1.97
p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res (2005) 1.88
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death. Curr Biol (2005) 1.87
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. J Clin Invest (2013) 1.83
Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons. Cell Death Differ (2006) 1.77
Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1. J Cell Sci (2005) 1.75
Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo. Nat Commun (2014) 1.61
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Hum Mol Genet (2012) 1.56
Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation. Hum Mol Genet (2013) 1.47
Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons. Hum Mol Genet (2012) 1.42
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci (2012) 1.42
Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis. Cell Death Differ (2007) 1.41
6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells. Free Radic Biol Med (2008) 1.37
The role of glial cells in Parkinson's disease. Curr Opin Neurol (2001) 1.36
Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1. Neurobiol Dis (2006) 1.33
Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann Neurol (2009) 1.31
Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Immunopharmacology (1998) 1.30
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction. J Am Heart Assoc (2013) 1.28
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. Proc Natl Acad Sci U S A (2011) 1.24
MPTP-induced parkinsonism in human and non-human primates--clinical and experimental aspects. Acta Neurol Scand Suppl (1984) 1.20
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci (2014) 1.11
DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell (2011) 1.09
Mitochondrial liaisons of p53. Antioxid Redox Signal (2011) 0.97
Mitochondrial fission and fusion. Essays Biochem (2010) 0.96
Role of glial cells in neurotoxin-induced animal models of Parkinson's disease. Neurol Sci (2010) 0.92
Apoptotic molecules and MPTP-induced cell death. Neurotoxicol Teratol (2002) 0.91
Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo. Biochem J (2014) 0.89
Decreased level of Nurr1 in heterozygous young adult mice leads to exacerbated acute and long-term toxicity after repeated methamphetamine exposure. PLoS One (2010) 0.87
Modafinil abrogates methamphetamine-induced neuroinflammation and apoptotic effects in the mouse striatum. PLoS One (2012) 0.84
Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis. Oncotarget (2015) 0.84
The shh signaling pathway is upregulated in multiple cell types in cortical ischemia and influences the outcome of stroke in an animal model. PLoS One (2015) 0.79
Murine motor and behavior functional evaluations for acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. J Neuroimmune Pharmacol (2011) 0.79
Molecular pathways of programmed cell death in experimental Parkinson's disease. Parkinsonism Relat Disord (2008) 0.78
Drp1 in ischemic neuronal death: an unusual suspect. Curr Med Chem (2014) 0.78
N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins. Brain Res Bull (2015) 0.77
The challenge in translating basic research discoveries to treatment of Huntington disease. Rare Dis (2014) 0.77
Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics. Brain Behav (2016) 0.76
Clinical impact and cost-effectiveness of coronary computed tomography angiography or exercise electrocardiogram in individuals without known cardiovascular disease. Medicine (Baltimore) (2015) 0.76