Synthesis of functional human hemoglobin in transgenic mice.

PubWeight™: 1.53‹?› | Rank: Top 4%

🔗 View Article (PMID 2772649)

Published in Science on September 01, 1989

Authors

R R Behringer1, T M Ryan, M P Reilly, T Asakura, R D Palmiter, R L Brinster, T M Townes

Author Affiliations

1: Laboratory of Reproductive Physiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.

Articles citing this

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. Proc Natl Acad Sci U S A (1993) 3.39

Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice. Proc Natl Acad Sci U S A (1991) 2.06

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster. Mol Cell Biol (1991) 1.97

Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression. Nucleic Acids Res (1994) 1.93

Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions. Proc Natl Acad Sci U S A (1990) 1.89

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells. Proc Natl Acad Sci U S A (1995) 1.61

High expression of human beta S- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences. Proc Natl Acad Sci U S A (1992) 1.42

Production of unmodified human adult hemoglobin in Escherichia coli. Proc Natl Acad Sci U S A (1993) 1.42

High expression of human beta S- and alpha-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia. Proc Natl Acad Sci U S A (1992) 1.37

Retrograde trans-synaptic transfer of green fluorescent protein allows the genetic mapping of neuronal circuits in transgenic mice. Proc Natl Acad Sci U S A (2002) 1.35

Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy. Mol Cell Biol (1994) 1.33

Hypoxia-induced in vivo sickling of transgenic mouse red cells. J Clin Invest (1991) 1.07

Human alpha-globin genes demonstrate autonomous developmental regulation in transgenic mice. Mol Cell Biol (1991) 1.05

Recombinant human hemoglobins designed for gene therapy of sickle cell disease. Proc Natl Acad Sci U S A (1994) 1.02

Development of recombinant hemoglobin-based oxygen carriers. Antioxid Redox Signal (2012) 1.00

Humanized Mouse Model of Cooley's Anemia. J Biol Chem (2008) 0.83

Chimeric hemoglobins--hybrids of human and swine hemoglobin: assembly and stability of interspecies hybrids. Protein Sci (1996) 0.80

Artificial blood. BMJ (1991) 0.78

Animal models of β-hemoglobinopathies: utility and limitations. J Blood Med (2016) 0.75

Sickle Cells Produce Functional Immune Modulators and Cytotoxics. Am J Hematol (2017) 0.75

Articles by these authors

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56

Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undergraded polysomes and messenger ribonucleic acid. Biochemistry (1974) 11.67

Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct. J Biol Chem (1979) 9.48

Germ-line transformation of mice. Annu Rev Genet (1986) 8.67

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci U S A (1985) 7.32

Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature (2001) 6.36

Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med (2001) 5.96

Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J (1985) 5.84

Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A (1988) 5.18

Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature (1982) 5.14

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc Natl Acad Sci U S A (1984) 5.08

Structure of mouse metallothionein-I gene and its mRNA. Nature (1981) 5.06

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat Cell Biol (1999) 4.76

DNA content, kinetic complexity, and the ploidy question in Candida albicans. Mol Cell Biol (1982) 4.64

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. Genes Dev (1989) 4.60

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell (1982) 4.60

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells. Cell (1982) 4.55

An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev (1987) 4.48

Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci U S A (1978) 4.46

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (1982) 4.30

Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost (2009) 4.30

Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell (1981) 4.23

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J Biol Chem (1981) 4.20

Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell (1990) 4.05

Human gamma- to beta-globin gene switching in transgenic mice. Genes Dev (1990) 4.04

Metallothionein-human GH fusion genes stimulate growth of mice. Science (1983) 4.03

Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell (1987) 4.02

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature (1996) 3.99

Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1987) 3.81

The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med (1988) 3.80

DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells. Cell (1981) 3.67

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell (1989) 3.60

Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 3.56

Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44

Building a metal-responsive promoter with synthetic regulatory elements. Mol Cell Biol (1985) 3.39

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet (1999) 3.37

Heterologous introns can enhance expression of transgenes in mice. Proc Natl Acad Sci U S A (1991) 3.34

Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell (1991) 3.31

A practical approach for quantitating specific mRNAs by solution hybridization. Anal Biochem (1983) 3.30

Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science (1996) 3.28

Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science (1990) 3.26

Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol (1984) 3.25

Replacement of diseased mouse liver by hepatic cell transplantation. Science (1994) 3.18

Isolation and characterization of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A (1980) 3.17

The effect of cells transferred into the mouse blastocyst on subsequent development. J Exp Med (1974) 3.17

Ovalbumin messenger ribonucleic acid translation. Comparable rates of polypeptide initiation and elongation on ovalbumin and globin messenger ribonucleic acid in a rabbit reticulocyte lysate. J Biol Chem (1973) 3.13

Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc Natl Acad Sci U S A (1981) 3.11

Transplantation of testis germinal cells into mouse seminiferous tubules. Int J Dev Biol (1997) 3.10

Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. Proc Natl Acad Sci U S A (1997) 3.08

Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes. J Biol Chem (1972) 2.96

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94

beta1- and alpha6-integrin are surface markers on mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (1999) 2.91

Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell (1995) 2.89

Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis. Biochemistry (1978) 2.85

Noradrenaline is essential for mouse fetal development. Nature (1995) 2.84

Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature (1985) 2.77

Regulation of protein synthesis in chick oviduct. I. Independent regulation of ovalbumin, conalbumin, ovomucoid, and lysozyme induction. J Biol Chem (1972) 2.76

Quantitation of parameters that determine the rate of ovalbumin synthesis. Cell (1975) 2.74

Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. J Biol Chem (1971) 2.73

Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell (1984) 2.59

Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature (1985) 2.58

Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids. Nature (1981) 2.58

Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature (1998) 2.57

Role of erythroid Kruppel-like factor in human gamma- to beta-globin gene switching. J Biol Chem (1995) 2.51

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci U S A (1999) 2.50

Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc Natl Acad Sci U S A (2001) 2.48

Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature (1997) 2.47

A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science (1985) 2.47