Published in Cell on March 01, 1975
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Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei. Proc Natl Acad Sci U S A (1976) 5.27
Upstream open reading frames as regulators of mRNA translation. Mol Cell Biol (2000) 4.99
Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci U S A (1978) 4.46
Molecular cloning of extensive sequences of the in vitro synthesized chicken ovalbumin structural gene. Nucleic Acids Res (1977) 3.32
Development and characterization of a reconstituted yeast translation initiation system. RNA (2002) 2.27
Corrected splicing of a chicken ovalbumin gene transcript in mouse L cells. Proc Natl Acad Sci U S A (1980) 2.19
Genes transcribed at diverse rates have a similar conformation in chromatin. Proc Natl Acad Sci U S A (1977) 2.17
Translational control of protein synthesis after infection by vesicular stomatitis virus. J Virol (1980) 1.65
Termination of the ovalbumin gene transcription. EMBO J (1984) 1.53
Disruption of the typical chromatin structure in a 2500 base-pair region at the 5' end of the actively transcribed ovalbumin gene. EMBO J (1982) 1.51
The ovalbumin gene: structural sequences in native chicken DNA are not contiguous. Proc Natl Acad Sci U S A (1978) 1.42
Isolation of specific messenger RNA by adsorption of polysomes to matrix-bound antibody. Nucleic Acids Res (1977) 1.40
The 5'-leader of tobacco mosaic virus promotes translation through enhanced recruitment of eIF4F. Nucleic Acids Res (2002) 1.40
The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. Mol Cell (2010) 1.35
Kinetic analysis of late steps of eukaryotic translation initiation. J Mol Biol (2008) 1.35
Androgen-dependent synthesis of basic secretory proteins by the rat seminal vesicle. Biochem J (1976) 1.35
Cell-specificity of the chicken ovalbumin and conalbumin promoters. EMBO J (1987) 1.22
The ovalbumin gene: cloning of the natural gene. Proc Natl Acad Sci U S A (1978) 1.19
Estrogen induction of growth factors specific for hormone-responsive mammary, pituitary, and kidney tumor cells. Proc Natl Acad Sci U S A (1978) 1.19
Oviduct-specific expression of two therapeutic proteins in transgenic hens. Proc Natl Acad Sci U S A (2007) 1.16
Molecular cloning of a mouse submaxillary gland renin cDNA fragment. Proc Natl Acad Sci U S A (1981) 1.15
Quantitation of delta-crystallin messenger RNA during lens induction in chick embryos. Proc Natl Acad Sci U S A (1976) 1.12
Effects of testosterone on messenger ribonucleic acid and protein synthesis in rat seminal vesicle. Biochem J (1978) 1.09
Glucocorticoids modulate the in vitro development of the embryonic rat pancreas. J Cell Biol (1977) 1.09
Yeast initiator tRNA identity elements cooperate to influence multiple steps of translation initiation. RNA (2006) 1.06
Steroid hormone dependence of four DNase I-hypersensitive regions located within the 7000-bp 5'-flanking segment of the ovalbumin gene. EMBO J (1986) 1.06
The concept of mRNA abundance classes: a critical reevaluation. Nucleic Acids Res (1978) 1.05
Two processing steps in maturation of vitellogenin polypeptides in Drosophila melanogaster. Proc Natl Acad Sci U S A (1979) 1.05
Evidence for acceleration of the rate of elongation of tyrosine aminotransferase nascent chains by dibutyryl cyclic AMP. Proc Natl Acad Sci U S A (1978) 1.04
Dexamethasone regulates the program of secretory glycoprotein synthesis in hepatoma tissue culture cells. J Cell Biol (1980) 0.95
A detailed comparison of the 5'-end of the ovalbumin gene cloned from chicken oviduct and erythrocyte DNA. Nucleic Acids Res (1980) 0.95
RNA synthesis in myeloma cells synchronized by isoleucine starvation. Nucleic Acids Res (1978) 0.91
Expression in male and genomic organization of the gene(s) coding for a major protein secreted by the rat seminal vesicle epithelium. Nucleic Acids Res (1982) 0.90
Transient expression of the chicken lysozyme gene after transfer into human cells. EMBO J (1982) 0.90
Herpesvirus infection modifies adenovirus RNA metabolism in adenovirus type 5-transformed cells. J Virol (1978) 0.89
Developmental regulation of secretory protein synthesis in rat seminal vesicle. Proc Natl Acad Sci U S A (1981) 0.85
Characterization of a cycloheximide-resistant Tetrahymena thermophila mutant which also displays altered growth properties. Mol Cell Biol (1983) 0.84
Multiple Parallel Pathways of Translation Initiation on the CrPV IRES. Mol Cell (2016) 0.79
Chicken globin gene number. Nucleic Acids Res (1976) 0.78
The time course of the effect of hypophysectomy and oestrogen treatment on the hepatic metabolism of androst-4-ene-3,17-dione in male and female rats. Biochem J (1978) 0.77
Membrane-bound ribosomes of myeloma cells. V. Subcellular distribution of immunoglobulin mRNA molecules. J Cell Biol (1981) 0.76
Change in message sequences during erythrodifferentiation. Nucleic Acids Res (1980) 0.75
Oviduct-specific expression of tissue plasminogen activator in laying hens. Genet Mol Biol (2011) 0.75
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56
Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undergraded polysomes and messenger ribonucleic acid. Biochemistry (1974) 11.67
Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct. J Biol Chem (1979) 9.48
Germ-line transformation of mice. Annu Rev Genet (1986) 8.67
Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci U S A (1985) 7.32
Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature (2001) 6.36
Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J (1985) 5.84
Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A (1988) 5.18
Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature (1982) 5.14
A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc Natl Acad Sci U S A (1984) 5.08
Structure of mouse metallothionein-I gene and its mRNA. Nature (1981) 5.06
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat Cell Biol (1999) 4.76
A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. Genes Dev (1989) 4.60
Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell (1982) 4.60
The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells. Cell (1982) 4.55
An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev (1987) 4.48
Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci U S A (1978) 4.46
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (1982) 4.30
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell (1981) 4.23
Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J Biol Chem (1981) 4.20
Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell (1990) 4.05
Human gamma- to beta-globin gene switching in transgenic mice. Genes Dev (1990) 4.04
Metallothionein-human GH fusion genes stimulate growth of mice. Science (1983) 4.03
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell (1987) 4.02
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature (1996) 3.99
Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1987) 3.81
DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells. Cell (1981) 3.67
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell (1989) 3.60
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 3.56
Building a metal-responsive promoter with synthetic regulatory elements. Mol Cell Biol (1985) 3.39
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet (1999) 3.37
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell (1991) 3.31
A practical approach for quantitating specific mRNAs by solution hybridization. Anal Biochem (1983) 3.30
Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science (1996) 3.28
Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science (1990) 3.26
Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol (1984) 3.25
Replacement of diseased mouse liver by hepatic cell transplantation. Science (1994) 3.18
Isolation and characterization of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A (1980) 3.17
Ovalbumin messenger ribonucleic acid translation. Comparable rates of polypeptide initiation and elongation on ovalbumin and globin messenger ribonucleic acid in a rabbit reticulocyte lysate. J Biol Chem (1973) 3.13
Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc Natl Acad Sci U S A (1981) 3.11
Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes. J Biol Chem (1972) 2.96
Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell (1995) 2.89
Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis. Biochemistry (1978) 2.85
Noradrenaline is essential for mouse fetal development. Nature (1995) 2.84
Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature (1985) 2.77
Regulation of protein synthesis in chick oviduct. I. Independent regulation of ovalbumin, conalbumin, ovomucoid, and lysozyme induction. J Biol Chem (1972) 2.76
Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. J Biol Chem (1971) 2.73
Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature (1985) 2.58
Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids. Nature (1981) 2.58
Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature (1998) 2.57
Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci U S A (1999) 2.50
Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature (1997) 2.47
A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science (1985) 2.47
Genetically haploid spermatids are phenotypically diploid. Nature (1989) 2.45
Prevention of NH2-terminal acetylation of proteins synthesized in cell-free systems. J Biol Chem (1977) 2.38
Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature (1995) 2.37
The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron (1991) 2.37
Spermatid-specific expression of protamine 1 in transgenic mice. Proc Natl Acad Sci U S A (1987) 2.36
Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell (1988) 2.36
Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science (1987) 2.35
Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc Natl Acad Sci U S A (1994) 2.34
Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell (1987) 2.32
Transgenic mice. Cell (1985) 2.30
Production of transgenic rabbits, sheep and pigs by microinjection. Nature (1985) 2.26
High-level erythroid expression of human alpha-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1989) 2.26
Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron (2001) 2.24
Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice. Proc Natl Acad Sci U S A (1987) 2.24
Abnormal sexual development in transgenic mice chronically expressing müllerian inhibiting substance. Nature (1990) 2.20
Oncogene-induced liver neoplasia in transgenic mice. Oncogene (1989) 2.20
Organization of polysomes from pre-existing ribosomes in chick oviduct by a secondary administration of either estradiol or progesterone. J Biol Chem (1970) 2.12
The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice. Mol Cell Biol (1987) 2.12
Glucocorticoid regulation of metallothionein-I mRNA synthesis in cultured mouse cells. J Biol Chem (1981) 2.12
SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice. Nature (1985) 2.10
Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice. Proc Natl Acad Sci U S A (1991) 2.06
Protamine 3'-untranslated sequences regulate temporal translational control and subcellular localization of growth hormone in spermatids of transgenic mice. Genes Dev (1989) 2.06
Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase. J Neurochem (1998) 2.03
Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones. Proc Natl Acad Sci U S A (1984) 2.03
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci U S A (2000) 2.02
The action of estrogen and progesterone on the expression of the transferrin gene. A comparison of the response in chick liver and oviduct. J Biol Chem (1978) 2.01
Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A (1995) 1.94
Precursor of egg white lysozyme. Amino acid sequence of an NH2-terminal extension. J Biol Chem (1977) 1.93
Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry (1994) 1.91
The NH2-terminal sequence of the avian oncovirus gag precursor polyprotein (Pr76gag). Virology (1978) 1.90
Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey. Proc Natl Acad Sci U S A (1997) 1.89
A significant lag in the induction of ovalbumin messenger RNA by steroid hormones: a receptor translocation hypothesis. Cell (1976) 1.89
Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells. Eur J Immunol (1992) 1.83
Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell (1990) 1.83
Climate change and the integrity of science. Science (2010) 1.80
Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci U S A (1996) 1.80
Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs. Proc Natl Acad Sci U S A (1989) 1.77
Dwarf mice produced by genetic ablation of growth hormone-expressing cells. Genes Dev (1988) 1.74
Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: an in vivo approach to investigate Ia gene function. Cell (1987) 1.74
Growth enhancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology (1988) 1.72
Pancreatic tumor pathogenesis reflects the causative genetic lesion. Proc Natl Acad Sci U S A (1991) 1.72
Transmission distortion and mosaicism in an unusual transgenic mouse pedigree. Cell (1984) 1.71
Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med (1998) 1.70
Relationship of nuclear estrogen receptor levels to induction of ovalbumin and conalbumin mRNA in chick oviduct. J Biol Chem (1977) 1.70
Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells. J Exp Med (1989) 1.67
Complete reconstitution of mouse liver with xenogeneic hepatocytes. Proc Natl Acad Sci U S A (1995) 1.65