Published in EMBO J on February 01, 1988
Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol Rev (1993) 4.54
Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol (1997) 3.55
Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity. Mol Cell Biol (1994) 3.18
IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Cell Biol (1989) 3.17
Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae. J Bacteriol (1998) 3.13
SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Mol Cell Biol (1995) 2.97
Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1. Mol Cell Biol (1992) 2.67
Nutrient availability and the RAS/cyclic AMP pathway both induce expression of ribosomal protein genes in Saccharomyces cerevisiae but by different mechanisms. Mol Cell Biol (1995) 2.56
Yeast Hsp70 RNA levels vary in response to the physiological status of the cell. J Bacteriol (1989) 2.51
The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase. Mol Cell Biol (1994) 2.49
IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. Mol Cell Biol (1990) 2.40
CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae. Mol Cell Biol (1988) 2.33
Ubiquitin depletion as a key mediator of toxicity by translational inhibitors. Mol Cell Biol (2003) 2.29
Stress response of yeast. Biochem J (1993) 1.79
Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase. Genes Dev (1998) 1.68
Regulation of a yeast HSP70 gene by a cAMP responsive transcriptional control element. EMBO J (1990) 1.67
RSR1, a ras-like gene homologous to Krev-1 (smg21A/rap1A): role in the development of cell polarity and interactions with the Ras pathway in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.64
Negative regulation of transcription of the Saccharomyces cerevisiae catalase T (CTT1) gene by cAMP is mediated by a positive control element. EMBO J (1991) 1.59
Yeast src homology region 3 domain-binding proteins involved in bud formation. J Cell Biol (1996) 1.44
cAMP-dependent phosphorylation and inactivation of yeast transcription factor ADR1 does not affect DNA binding. Proc Natl Acad Sci U S A (1990) 1.43
Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein. Mol Cell Biol (1997) 1.27
The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor. Mol Cell Biol (1994) 1.26
Control of Saccharomyces cerevisiae catalase T gene (CTT1) expression by nutrient supply via the RAS-cyclic AMP pathway. Mol Cell Biol (1989) 1.26
N alpha acetylation is required for normal growth and mating of Saccharomyces cerevisiae. J Bacteriol (1989) 1.20
Increased ubiquitin-dependent degradation can replace the essential requirement for heat shock protein induction. EMBO J (2003) 1.10
Cyclic AMP-dependent protein kinase inhibits ADH2 expression in part by decreasing expression of the transcription factor gene ADR1. Mol Cell Biol (1997) 1.07
Lub1 participates in ubiquitin homeostasis and stress response via maintenance of cellular ubiquitin contents in fission yeast. Mol Cell Biol (2004) 1.04
Activation of the Ras/cyclic AMP pathway in the yeast Saccharomyces cerevisiae does not prevent G1 arrest in response to nitrogen starvation. J Bacteriol (1995) 0.99
Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans. Mol Microbiol (2011) 0.95
Ubiquitin expression in Neurospora crassa: cloning and sequencing of a polyubiquitin gene. Nucleic Acids Res (1989) 0.90
Polyubiquitin is required for growth, development and pathogenicity in the rice blast fungus Magnaporthe oryzae. PLoS One (2012) 0.84
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem (1983) 206.01
Studies on transformation of Escherichia coli with plasmids. J Mol Biol (1983) 116.81
Transformation of intact yeast cells treated with alkali cations. J Bacteriol (1983) 100.26
One-step gene disruption in yeast. Methods Enzymol (1983) 52.81
Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol (1983) 17.47
In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell (1985) 11.63
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci U S A (1986) 10.41
A yeast gene that is essential for release from glucose repression encodes a protein kinase. Science (1986) 7.73
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Cell (1987) 6.73
Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1982) 5.04
Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22. Cell (1986) 5.00
Regulation of yeast mating-type interconversion: feedback control of HO gene expression by the mating-type locus. Proc Natl Acad Sci U S A (1983) 4.90
Mechanisms of intracellular protein breakdown. Annu Rev Biochem (1982) 4.89
DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell (1985) 4.80
A cyclic AMP- and phorbol ester-inducible DNA element. Nature (1986) 4.60
Interaction of super-repressible and dominant constitutive mutations for the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae. Mol Gen Genet (1977) 4.14
The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein. Nature (1985) 3.52
Ubiquitin is a heat shock protein in chicken embryo fibroblasts. Mol Cell Biol (1985) 3.31
The preferential translation of Drosophila hsp70 mRNA requires sequences in the untranslated leader. Cell (1985) 3.25
The primary structure of a glyceraldehyde-3-phosphate dehydrogenase gene from Saccharomyces cerevisiae. J Biol Chem (1979) 2.96
Initiation of meiosis in yeast mutants defective in adenylate cyclase and cyclic AMP-dependent protein kinase. Cell (1983) 2.91
The nucleotide sequence of the yeast PHO5 gene: a putative precursor of repressible acid phosphatase contains a signal peptide. Nucleic Acids Res (1983) 2.83
Molecular cloning of the actin gene from yeast Saccharomyces cerevisiae. Nucleic Acids Res (1980) 2.81
Genetic analysis of the role of cAMP in yeast. Yeast (1985) 2.78
Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells. Proc Natl Acad Sci U S A (1975) 2.77
Heat shock response of Saccharomyces cerevisiae mutants altered in cyclic AMP-dependent protein phosphorylation. Mol Cell Biol (1987) 2.05
Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes. J Biol Chem (1980) 1.99
Durable synthesis of high molecular weight heat shock proteins in G0 cells of the yeast and other eucaryotes. J Cell Biol (1984) 1.93
Specific early-G1 blocks accompanied with stringent response in Saccharomyces cerevisiae lead to growth arrest in resting state similar to the G0 of higher eucaryotes. J Cell Biol (1984) 1.70
Cloning and sequencing of the PHO80 gene and CEN15 of Saccharomyces cerevisiae. Yeast (1986) 1.63
Isolation, characterization, and amino acid sequence of a ubiquitin-like protein from insect eggs. J Biol Chem (1982) 1.41
Isolation and characterization of a phosphoprotein phosphatase-deficient mutant in yeast. Yeast (1985) 1.07
Mutant regulatory subunit of 3',5'-cAMP-dependent protein kinase of yeast Saccharomyces cerevisiae. Mol Gen Genet (1987) 1.06
Structure and activities of a variant ubiquitin sequence from bakers' yeast. Biochemistry (1986) 0.96
Formation of conjugates by 125I-labelled ubiquitin microinjected into cultured hepatoma cells. FEBS Lett (1982) 0.95
In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell (1985) 11.63
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science (1997) 9.53
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature (1999) 7.31
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science (1995) 6.81
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science (1998) 6.62
Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1982) 5.04
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell (1991) 4.98
GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell (1987) 4.50
Function of positive regulatory gene gal4 in the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae: evidence that the GAL81 region codes for part of the gal4 protein. J Bacteriol (1980) 4.36
Genetic control of galactokinase synthesis in Saccharomyces cerevisiae: evidence for constitutive expression of the positive regulatory gene gal4. J Bacteriol (1978) 4.18
Interaction of super-repressible and dominant constitutive mutations for the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae. Mol Gen Genet (1977) 4.14
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature (1999) 4.01
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell (2000) 3.90
MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol (1993) 3.54
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science (1996) 3.48
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. Mol Cell Biol (1993) 3.47
A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. J Exp Med (1992) 3.37
IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Cell Biol (1989) 3.17
Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J Cell Biol (2000) 3.13
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science (2001) 3.13
S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein. Cell (1990) 3.09
Initiation of meiosis in yeast mutants defective in adenylate cyclase and cyclic AMP-dependent protein kinase. Cell (1983) 2.91
The nucleotide sequence of the yeast PHO5 gene: a putative precursor of repressible acid phosphatase contains a signal peptide. Nucleic Acids Res (1983) 2.83
Isolation and characterization of dominant mutations resistant to carbon catabolite repression of galactokinase synthesis in Saccharomyces cerevisiae. Mol Cell Biol (1981) 2.74
Recessive mutations conferring resistance to carbon catabolite repression of galactokinase synthesis in Saccharomyces cerevisiae. J Bacteriol (1983) 2.73
A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1996) 2.72
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem (1996) 2.64
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J (1999) 2.54
Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc Natl Acad Sci U S A (1988) 2.54
TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J Biol Chem (2000) 2.53
Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med (1999) 2.51
Control of cell division in Saccharomyces cerevisiae mutants defective in adenylate cyclase and cAMP-dependent protein kinase. Exp Cell Res (1983) 2.48
The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates. Cell (2001) 2.43
Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature (1999) 2.42
Combination therapy with fluconazole and flucytosine for cryptococcal meningitis in Ugandan patients with AIDS. Clin Infect Dis (1998) 2.40
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem (1999) 2.40
IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. Mol Cell Biol (1990) 2.40
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J (2001) 2.37
CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae. Mol Cell Biol (1988) 2.33
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature (1999) 2.32
MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae. EMBO J (1994) 2.32
Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. Proc Natl Acad Sci U S A (1991) 2.26
IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell (1992) 2.25
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol (1999) 2.21
Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Science (1994) 2.21
The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3. Nature (1998) 2.18
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J (1998) 2.15
Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol (1995) 2.14
Identification of the structural gene and nonsense alleles for adenylate cyclase in Saccharomyces cerevisiae. J Bacteriol (1984) 2.09
Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol (2001) 2.09
Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol (1997) 2.07
Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions. Cancer Res (1997) 2.06
Heat shock response of Saccharomyces cerevisiae mutants altered in cyclic AMP-dependent protein phosphorylation. Mol Cell Biol (1987) 2.05
Cyclic AMP may not be involved in catabolite repression in Saccharomyes cerevisiae: evidence from mutants capable of utilizing it as an adenine source. J Bacteriol (1982) 2.05
Structural characteristics of the PHO8 gene encoding repressible alkaline phosphatase in Saccharomyces cerevisiae. Gene (1987) 2.04
Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae. FEBS Lett (1998) 2.04
Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology (1999) 2.03
NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease. Neurosci Lett (1997) 2.01
Loss of beta-catenin expression associated with disease progression in malignant melanoma. Br J Dermatol (2001) 2.00
UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans. Neuron (2001) 1.98
Regulation of the yeast pheromone response pathway by G protein subunits. EMBO J (1990) 1.97
Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J Cell Biol (1999) 1.96
Genes coding for the structure of the acid phosphatases in Saccharomyces cerevisiae. Mol Gen Genet (1975) 1.95
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol Cell Biol (2001) 1.93
Post-transcriptional regulation through the HO 3'-UTR by Mpt5, a yeast homolog of Pumilio and FBF. EMBO J (2001) 1.93
Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway. Mol Cell Biol (1999) 1.92
Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone. FEBS Lett (2001) 1.90
Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. J Clin Invest (2000) 1.90
Structure and function of the PHO82-pho4 locus controlling the synthesis of repressible acid phosphatase of Saccharomyces cerevisiae. J Bacteriol (1981) 1.89
Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast. Proc Natl Acad Sci U S A (1996) 1.89
Identification of the genetic locus for the structural gene and a new regulatory gene for the synthesis of repressible alkaline phosphatase in Saccharomyces cerevisiae. Mol Cell Biol (1982) 1.88
Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. J Biol Chem (2001) 1.86
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem (1994) 1.84
A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats. Cardiovasc Res (2001) 1.84
p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis. Mol Cell Biol (1999) 1.83
PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol (1999) 1.83
p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells. Clin Exp Allergy (2000) 1.82
Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Circ Res (1999) 1.80
Applicability of X-ray computerized tomography in endodontics. Endod Dent Traumatol (1990) 1.79
Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. Proc Natl Acad Sci U S A (1995) 1.78
Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway. Mol Cell Biol (1997) 1.77
MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1989) 1.77
Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc Natl Acad Sci U S A (1992) 1.76
Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin. EMBO J (1987) 1.75
SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae. Cell (1991) 1.74
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. EMBO J (1999) 1.74
Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/activator site binding protein 1/translation upstream factor. Proc Natl Acad Sci U S A (1990) 1.74
Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients. Arterioscler Thromb Vasc Biol (2000) 1.73
Evaluation of intraaneurysmal blood velocity by time-density curve analysis and digital subtraction angiography. AJNR Am J Neuroradiol (1998) 1.73
Protection against the mouse-adapted A/FM/1/47 strain of influenza A virus in mice by a monoclonal antibody with cross-neutralizing activity among H1 and H2 strains. J Virol (1994) 1.72
Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates. J Biol Chem (1999) 1.71
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J Biol Chem (1997) 1.70