Published in J Biol Chem on November 15, 1988
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev (1997) 3.33
Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells. J Cell Biol (1994) 2.27
Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J (1990) 2.21
Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis. Am J Pathol (1998) 1.48
Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C. Mol Cell Biol (1990) 1.22
Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase. Am J Pathol (1994) 1.11
Promoter elements in the transcriptional activation of the human stromelysin-1 gene by the inflammatory cytokine, interleukin 1. Biochem J (1994) 0.92
TGF-beta 1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CCl64 cells. EMBO J (1991) 0.90
Aging is associated with increased activities of matrix metalloproteinase-2 and -9 in tenocytes. BMC Musculoskelet Disord (2013) 0.90
Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant. Matrix Biol (1999) 0.89
Loss of NF-kappaB control and repression of Prdx6 gene transcription by reactive oxygen species-driven SMAD3-mediated transforming growth factor beta signaling. J Biol Chem (2009) 0.86
A glimpse of matrix metalloproteinases in diabetic nephropathy. Curr Med Chem (2014) 0.84
Opposite and independent actions of cyclic AMP and transforming growth factor beta in the regulation of type 1 plasminogen activator inhibitor expression. Biochem J (1992) 0.78
Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science (1999) 6.49
Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst (1997) 5.07
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Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol (2000) 4.98
Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci U S A (1997) 3.96
The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene (1999) 3.95
Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMBO J (1985) 3.60
Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J Cell Sci (2001) 3.51
Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells. Mol Cell Biol (1989) 2.78
Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts. Mol Cell Biol (1986) 2.74
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Am J Pathol (1996) 2.50
Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol Med Today (2000) 2.44
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc Natl Acad Sci U S A (1994) 2.43
The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol (2000) 2.42
Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J Clin Invest (2000) 2.39
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors. Proc Natl Acad Sci U S A (1986) 2.28
Structure-function relationships in the collagenase family member transin. J Biol Chem (1988) 2.15
Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin). J Biol Chem (2001) 2.12
Matrilysin: an epithelial matrix metalloproteinase with potentially novel functions. Int J Biochem Cell Biol (1996) 2.12
TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence. Cell (1990) 2.09
Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes. Nucleic Acids Res (1985) 2.08
Growth factors regulate transin gene expression by c-fos-dependent and c-fos-independent pathways. Science (1988) 2.05
Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development. Mol Biol Cell (1995) 1.96
Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas. Mol Carcinog (1991) 1.95
Matrilysin expression and function in airway epithelium. J Clin Invest (1998) 1.94
Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis. Cancer Metastasis Rev (1995) 1.93
Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis. Mol Carcinog (1994) 1.92
Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest (1994) 1.83
Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo. Cancer Res (1994) 1.80
Epidermal growth factor. Ability of tumor promoter to alter its degradation, receptor affinity and receptor number. J Biol Chem (1980) 1.65
Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. J Biol Chem (1990) 1.63
The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis. Cancer Res (1998) 1.60
The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse. Mol Biol Cell (1995) 1.60
Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J Biol Chem (1994) 1.55
Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice. Endocrinology (1997) 1.50
Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption. J Clin Invest (2000) 1.49
The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. Mol Cell Biol (2001) 1.48
Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells. Enzyme Protein (1996) 1.45
Further purification of epidermal growth factor by high-performance liquid chromatography. Anal Biochem (1982) 1.42
Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Mol Biol Cell (2001) 1.40
Matrix metalloproteinases as mediators of reproductive function. Mol Hum Reprod (1997) 1.40
The matrix metalloprotease matrilysin (PUMP) is expressed in developing human mononuclear phagocytes. J Biol Chem (1992) 1.34
Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis. Neoplasia (2002) 1.33
A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate-induced invasion in mouse keratinocytes. Mol Carcinog (1997) 1.27
Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle. Am J Obstet Gynecol (1993) 1.26
TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1. Mol Cell Biol (2000) 1.24
Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. Mol Carcinog (1999) 1.23
Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression. Invasion Metastasis (1995) 1.23
EGF and TGF alpha influence in vitro lung development by the induction of matrix-degrading metalloproteinases. Int J Dev Biol (1991) 1.22
Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C. Mol Cell Biol (1990) 1.22
Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo. Cancer Res (1998) 1.22
Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis. Cancer Res (1995) 1.18
Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J Clin Invest (1997) 1.18
Tumor progression: defining the soil round the tumor seed. Curr Biol (2001) 1.17
Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene. Nucleic Acids Res (1987) 1.17
Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium. Proc Natl Acad Sci U S A (1995) 1.13
Mutational analysis of the transin (rat stromelysin) autoinhibitor region demonstrates a role for residues surrounding the "cysteine switch". J Biol Chem (1991) 1.12
Cytosolic calcium regulates epidermal growth factor endocytosis in rat pancreas and cultured fibroblasts. Proc Natl Acad Sci U S A (1984) 1.10
Stromelysin in tumor progression and metastasis. Cancer Metastasis Rev (1990) 1.07
Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential. Cancer Res (1992) 1.05
Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis. Int J Cancer (1998) 1.05
Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium. Proc Natl Acad Sci U S A (1994) 1.03
Thymidine triphosphate synthesis in senescent WI38 cells. Relationship to loss of replicative capacity. Exp Cell Res (1983) 1.02
Identification of the cellular mechanisms responsible for platelet-derived growth factor induced alterations in cytoplasmic vinculin distribution. J Cell Physiol (1986) 1.02
A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression. Mol Carcinog (1994) 1.01
Matrix metalloproteinases in remodeling of the normal and neoplastic mammary gland. J Mammary Gland Biol Neoplasia (1998) 1.00
Complex roles of matrix metalloproteinases in tumor progression. Curr Top Microbiol Immunol (1996) 1.00
Overexpression of the matrix metalloproteinase matrilysin results in premature mammary gland differentiation and male infertility. Mol Biol Cell (1998) 0.99
Insights from knock-out models concerning postischemic release of TNFalpha from isolated mouse hearts. J Mol Cell Cardiol (2006) 0.98
Activation of p38 mitogen-activated protein kinase is required for tumor necrosis factor-alpha -supported proliferation of leukemia and lymphoma cell lines. J Biol Chem (2000) 0.97
Binding of epidermal growth factor in rat pancreatic acini. Biochem Biophys Res Commun (1983) 0.95
Matrilysin in early stage intestinal tumorigenesis. APMIS (1999) 0.95
Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters. Proc Natl Acad Sci U S A (1986) 0.94
Mechanism of synergistic induction of DNA synthesis by epidermal growth factor and tumor promoters. J Cell Physiol (1981) 0.93
Association of platelet-derived growth factor-induced protein with nuclear material. Nature (1984) 0.93
Effect of epidermal growth factor on clonogenic growth of primary human tumor cells. Int J Cancer (1982) 0.93
Loss of JunB activity enhances stromelysin 1 expression in a model of the epithelial-to-mesenchymal transition of mouse skin tumors. Mol Cell Biol (2001) 0.92
Matrilysin expression in the involuting rat ventral prostate. Prostate (1996) 0.92
Stabilized beta-catenin immortalizes colonic epithelial cells. Cancer Res (2001) 0.92
Intracellular processing of epidermal growth factor. I. Acidification of 125I-epidermal growth factor in intracellular organelles. J Biol Chem (1984) 0.90
A novel nerve growth factor-responsive element in the stromelysin-1 (transin) gene that is necessary and sufficient for gene expression in PC12 cells. J Biol Chem (1995) 0.89
Identification of an epidermal growth factor-related transforming growth factor from rat fetuses. Biochem Biophys Res Commun (1982) 0.89
Differential sensitivity of fibroblasts to epidermal growth factor is related to cyclic AMP concentration. J Cell Physiol (1984) 0.88
Parathyroid hormone-induced resorption in fetal rat limb bones is associated with production of the metalloproteinases collagenase and gelatinase B. J Bone Miner Res (1996) 0.88
Tumor necrosis factor-alpha-induced proliferation of human Mo7e leukemic cells occurs via activation of nuclear factor kappaB transcription factor. J Biol Chem (1999) 0.87
Tumor promoter-induced inhibition of epidermal growth factor binding to cultured mouse primary epidermal cells. Cancer Res (1981) 0.87
Metalloproteinase-7 contributes to joint destruction in Staphylococcus aureus induced arthritis. Microb Pathog (2005) 0.87
Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness. Cancer Res (1997) 0.86
Matrix degrading metalloproteinases. J Neurooncol (1994) 0.86
Tumor promoters induce a transient expression of tumor-associated genes in both basal and differentiated cells of the mouse epidermis. Carcinogenesis (1988) 0.86
Matrix metalloproteinase expression in Macaca mulatta endometrium: evidence for zone-specific regulatory tissue gradients. Biol Reprod (1998) 0.86
Cyclic AMP potentiates down regulation of epidermal growth factor receptors by platelet-derived growth factor. Biochem Biophys Res Commun (1982) 0.85
The role of C-Fos in growth factor regulation of stromelysin/transin gene expression. Matrix Suppl (1992) 0.85
Binding, internalization and intracellular processing of 125I-epidermal growth factor purified by isoelectric focusing. Biochem Biophys Res Commun (1982) 0.84
Altered regulation of protein disulfide isomerase in cells resistant to the growth-inhibitory effects of transforming growth factor beta 1. Cell Growth Differ (1990) 0.82
Expression and regulation of stromelysin and matrilysin by growth factors and oncogenes. Biochem Soc Trans (1994) 0.81
Matrix metalloproteinases as targets for therapy in Kaposi sarcoma. Curr Opin Oncol (2001) 0.81
Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. Br J Cancer (2003) 0.80
Internalization and processing of epidermal growth factor in aging human fibroblasts in culture. Exp Gerontol (1987) 0.80
Targets of extinction: identification of genes whose expression is repressed as a consequence of somatic fusion between cells representing basal and luminal mammary epithelial phenotypes. J Cell Sci (2000) 0.80