Published in EMBO J on June 01, 1985
Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol (1987) 7.05
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24
Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy. J Virol (1994) 5.12
Separation and properties of cellular and scrapie prion proteins. Proc Natl Acad Sci U S A (1986) 4.38
Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol (1986) 1.95
Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent. Proc Natl Acad Sci U S A (1986) 1.92
Two alleles of a neural protein gene linked to scrapie in sheep. Proc Natl Acad Sci U S A (1990) 1.84
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58. EMBO J (1991) 1.74
Evidence suggesting that PrP is not the infectious agent in Creutzfeldt-Jakob disease. EMBO J (1987) 1.64
Molecular mass, biochemical composition, and physicochemical behavior of the infectious form of the scrapie precursor protein monomer. Proc Natl Acad Sci U S A (1990) 1.38
Characterization of major peptides in Creutzfeldt-Jakob disease and scrapie. Proc Natl Acad Sci U S A (1986) 1.15
Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations. Proteomics (2010) 0.99
The search for scrapie agent nucleic acid. Microbiol Rev (1990) 0.97
Evidence that DNA is present in abnormal tubulofilamentous structures found in scrapie. Proc Natl Acad Sci U S A (1988) 0.96
Tubulofilaments in negatively stained scrapie-infected brains: relationship to scrapie-associated fibrils. Proc Natl Acad Sci U S A (1987) 0.87
Ultrastructural studies of glycoconjugates in brain micro-blood vessels and amyloid plaques of scrapie-infected mice. Acta Neuropathol (1988) 0.83
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07
A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem (1984) 19.70
Scrapie prions aggregate to form amyloid-like birefringent rods. Cell (1983) 7.92
Purification and structural studies of a major scrapie prion protein. Cell (1984) 5.98
Abnormal fibrils from scrapie-infected brain. Acta Neuropathol (1981) 5.35
X-ray diffraction studies on amyloid filaments. J Histochem Cytochem (1968) 4.54
Anhydrous hydrogen fluoride deglycosylates glycoproteins. Anal Biochem (1977) 4.08
Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts). N Engl J Med (1980) 3.95
Scrapie infectivity, fibrils and low molecular weight protein. Nature (1984) 3.18
Creation of "amyloid" fibrils from Bence Jones proteins in vitro. Science (1971) 3.14
Characteristics of a short incubation model of scrapie in the golden hamster. J Gen Virol (1977) 2.95
Infection-specific particle from the unconventional slow virus diseases. Science (1984) 2.34
Scrapie-associated fibrils in Creutzfeldt-Jakob disease. Nature (1984) 2.11
A rapid and efficient method to enrich SAF-protein from scrapie brains of hamsters. Biosci Rep (1984) 1.94
Molecular characteristics of the major scrapie prion protein. Biochemistry (1984) 1.64
Sensitive detection of proteins and peptides in polyacrylamide gels after formaldehyde fixation. Methods Enzymol (1983) 1.33
Selective amyloid staining as a function of amyloid composition and structure. Histochemical analysis of the alkaline Congo red, standardized toluidine blue, and iodine methods. Lab Invest (1974) 1.28
Towards purification of the scrapie agent. Eur J Biochem (1983) 1.17
Partial structure of a membrane glycopeptide from virus-transformed hamster cells. Biochemistry (1979) 0.98
Rapid analytical and preparative separation of structural polypeptides of poliovirus by reverse-phase high-performance liquid chromatography. J Virol Methods (1983) 0.89
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol (1999) 7.69
Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol (1987) 7.05
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24
Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Nature (1987) 5.88
Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (1994) 5.34
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell (1989) 4.99
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A (1998) 4.49
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42
The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature (1987) 4.15
How lac repressor binds to DNA. Nature (1972) 3.72
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 3.50
The amino-acid sequence of lac repressor. Proc Natl Acad Sci U S A (1973) 3.36
Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease. J Mol Biol (1991) 3.33
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques. Neurology (1988) 3.28
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med (1989) 3.24
Scrapie infectivity, fibrils and low molecular weight protein. Nature (1984) 3.18
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A (1990) 3.13
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem (1996) 3.10
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (1990) 3.10
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med (1997) 2.95
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep (2001) 2.70
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry (1999) 2.58
[Virus proteins. IV. Constitution of the coat protein of the fd phage]. Hoppe Seylers Z Physiol Chem (1969) 2.56
A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. EMBO J (1996) 2.55
Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person. Neurosci Lett (1990) 2.40
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes. EMBO J (1982) 2.31
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem (1999) 2.30
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) Science (1996) 2.29
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. EMBO J (1988) 2.26
Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes. Nucleic Acids Res (1990) 2.24
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochim Biophys Acta (1988) 2.22
The kinetic mechanism of Ran--nucleotide exchange catalyzed by RCC1. Biochemistry (1995) 2.20
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci (1994) 2.19
In vitro and in vivo products of E. coli lactose permease gene are identical. Nature (1980) 2.18
cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin-S2 in an on-off fashion. FEBS Lett (1999) 2.16
Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes. J Exp Med (1994) 2.13
The cDNA clone for strictosidine synthase from Rauvolfia serpentina. DNA sequence determination and expression in Escherichia coli. FEBS Lett (1988) 2.05
Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm. Biochemistry (1998) 1.97
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem (2001) 1.96
Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol (1986) 1.95
A rapid and efficient method to enrich SAF-protein from scrapie brains of hamsters. Biosci Rep (1984) 1.94
Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1. EMBO J (1986) 1.94
The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J (1988) 1.92
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. J Mol Biol (1992) 1.90
Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen. J Gen Virol (1984) 1.87
Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases) Brain Pathol (1995) 1.86
Two alleles of a neural protein gene linked to scrapie in sheep. Proc Natl Acad Sci U S A (1990) 1.84
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett (2001) 1.82
Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease. Eur J Biochem (1995) 1.80
The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J (2003) 1.75
Biochemical differences among scrapie-associated fibrils support the biological diversity of scrapie agents. J Gen Virol (1985) 1.75
Phosphorylation regulates intracellular trafficking of beta-secretase. J Biol Chem (2001) 1.74
Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves. J Virol (2001) 1.73
The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron (1992) 1.72
Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Neuron (1992) 1.66
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem (1998) 1.66
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. J Biol Chem (2001) 1.64
A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition. J Neuropathol Exp Neurol (1989) 1.62
Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie. Eur J Biochem (1988) 1.62
Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptor. Neuron (1990) 1.61
Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie. J Gen Virol (1996) 1.61
[Tetrafluorosuccinic anhydride, a new reagent for the specific and reversible masking of amino groups in proteins]. Hoppe Seylers Z Physiol Chem (1968) 1.61
Influence of ABO blood groups on primary hemostasis. Transfusion (2001) 1.59
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat Struct Biol (1999) 1.56
Genes contributing to Alzheimer's disease. Mol Psychiatry (1996) 1.55
Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3. J Virol (1990) 1.54
Fibrils from brains of cows with new cattle disease contain scrapie-associated protein. Nature (1988) 1.54
Blood infectivity and the prospects for a diagnostic screening test in Creutzfeldt-Jakob disease. J Lab Clin Med (2001) 1.53
Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. Clin Immunol Immunopathol (1992) 1.51
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. J Biol Chem (1999) 1.48
Changes in phosphatidylinositol metabolism correlated to growth state of normal and Rous sarcoma virus-transformed Japanese quail cells. Cancer Res (1977) 1.48
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem (1996) 1.48
Novel genes coding for lithotrophic sulfur oxidation of Paracoccus pantotrophus GB17. J Bacteriol (2000) 1.47