Published in Neurology on November 01, 1988
Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (1991) 49.03
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement (2012) 5.10
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol (2012) 3.77
Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol (2007) 2.65
Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease. J Neurol Neurosurg Psychiatry (1994) 2.24
The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease. Acta Neuropathol (1990) 2.23
Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia. Acta Neuropathol (1990) 2.05
Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques. Acta Neuropathol (1990) 2.03
Cerebrospinal fluid protein biomarkers for Alzheimer's disease. NeuroRx (2004) 2.02
Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol (1989) 1.95
Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiol Genomics (2006) 1.88
Dementia of frontal lobe type: neuropathology and immunohistochemistry. J Neurol Neurosurg Psychiatry (1993) 1.62
Prevalence of Alzheimer plaques in AIDS. J Neurol Neurosurg Psychiatry (1998) 1.62
YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry (2010) 1.59
Senile plaques do not progressively accumulate with normal aging. Acta Neuropathol (1994) 1.45
Senile plaques in temporal lobe epilepsy. Acta Neuropathol (1994) 1.44
Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease. Proc Natl Acad Sci U S A (1990) 1.42
The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. Am J Pathol (1990) 1.40
Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins. Acta Neuropathol (1990) 1.31
Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging. J Alzheimers Dis (2010) 1.28
Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease. Proc Natl Acad Sci U S A (1990) 1.22
Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease. Am J Pathol (1998) 1.21
Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease. Am J Pathol (1992) 1.20
Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study. Acta Neuropathol (2012) 1.16
Increased tau accumulation in senile plaques as a hallmark in Alzheimer's disease. Am J Pathol (1989) 1.16
Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease. Proc Natl Acad Sci U S A (1991) 1.12
Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer's disease: relationship with the intellectual status of 26 cases. Acta Neuropathol (1991) 1.08
Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain. Acta Neuropathol (1995) 1.08
Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers. PLoS One (2011) 1.07
Ultrastructure of diffuse plaques in senile dementia of the Alzheimer type: comparison with primitive plaques. Acta Neuropathol (1991) 1.05
Striatal amyloid plaque density predicts Braak neurofibrillary stage and clinicopathological Alzheimer's disease: implications for amyloid imaging. J Alzheimers Dis (2012) 1.04
Microglia in cerebellar plaques in Alzheimer's disease. Acta Neuropathol (1990) 1.02
Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease. Biochim Biophys Acta (2008) 1.01
Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system. Brain Struct Funct (2009) 0.97
TDP-43 deposition in prospectively followed, cognitively normal elderly individuals: correlation with argyrophilic grains but not other concomitant pathologies. Acta Neuropathol (2013) 0.95
A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ. J Neurochem (2011) 0.95
Pre- and post-synaptic cortical cholinergic deficits are proportional to amyloid plaque presence and density at preclinical stages of Alzheimer's disease. Acta Neuropathol (2011) 0.94
Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective? Int J Exp Pathol (2005) 0.94
Deposition of amyloid beta protein in non-Alzheimer dementias: evidence for a neuronal origin of parenchymal deposits of beta protein in neurodegenerative disease. Acta Neuropathol (1992) 0.91
Identification and characterization of C-terminal fragments of the beta-amyloid precursor produced in cell culture. EMBO J (1990) 0.90
Therapeutic application of melatonin in mild cognitive impairment. Am J Neurodegener Dis (2012) 0.90
A yeast model for amyloid-β aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity. Dis Model Mech (2012) 0.89
Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology. EMBO J (1991) 0.86
Cerebral beta amyloid deposition in patients with malignant neoplasms: its prevalence with aging and effects of radiation therapy on vascular amyloid. Acta Neuropathol (1995) 0.86
FDG- and amyloid-PET in Alzheimer's disease: is the whole greater than the sum of the parts? Q J Nucl Med Mol Imaging (2011) 0.86
Ultrastructural localization of the putative precursors of the A4 amyloid protein associated with Alzheimer's disease. Am J Pathol (1990) 0.85
Theoretical impact of Florbetapir (18F) amyloid imaging on diagnosis of alzheimer dementia and detection of preclinical cortical amyloid. J Neuropathol Exp Neurol (2014) 0.84
cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases. Int J Alzheimers Dis (2010) 0.84
Brain stem serotonin-synthesizing neurons in Alzheimer's disease: a clinicopathological correlation. Acta Neuropathol (1992) 0.84
A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer's disease. Eur J Nucl Med Mol Imaging (2008) 0.84
Presence of Striatal Amyloid Plaques in Parkinson's Disease Dementia Predicts Concomitant Alzheimer's Disease: Usefulness for Amyloid Imaging. J Parkinsons Dis (2012) 0.82
Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs. Biochem J (1996) 0.82
Immunohistochemical colocalization of amyloid precursor protein with cerebrovascular amyloid of Alzheimer's disease. Am J Pathol (1991) 0.82
Establishment of a monoclonal antibody against senile plaques and its application for immunohistological and immunoelectron microscopical studies in the brain of the elderly. Acta Neuropathol (1989) 0.81
CSF tau and β-amyloid as biomarkers for mild cognitive impairment. Dialogues Clin Neurosci (2004) 0.79
Analysis of staining methods for different cortical plaques in Alzheimer's disease. Acta Neuropathol (1994) 0.79
Gerstmann-Sträussler-Scheinker disease showing beta-protein type cerebellar and cerebral amyloid angiopathy. Acta Neuropathol (1994) 0.79
Design of metastable β-sheet oligomers from natively unstructured peptide. ACS Chem Neurosci (2013) 0.78
FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer's Disease. Adv J Mol Imaging (2014) 0.78
AAV2/1 CD74 Gene Transfer Reduces β-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer's Disease. Mol Ther (2015) 0.77
Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease. Discov Med (2014) 0.77
Can education rescue genetic liability for cognitive decline? Soc Sci Med (2014) 0.77
Histological staining of amyloid and pre-amyloid peptides and proteins in mouse tissue. Methods Mol Biol (2012) 0.77
Melatonin Therapy in Patients with Alzheimer's Disease. Antioxidants (Basel) (2014) 0.76
Harnessing Cerebrospinal Fluid Biomarkers in Clinical Trials for Treating Alzheimer's and Parkinson's Diseases: Potential and Challenges. J Clin Neurol (2016) 0.76
A betaPP peptide carboxyl-terminal to Abeta is neurotoxic. Am J Pathol (1999) 0.75
Curcumin: a natural substance with potential efficacy in Alzheimer's disease. J Exp Pharmacol (2013) 0.75
Preventing Alzheimer's disease by means of natural selection. J R Soc Interface (2015) 0.75
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10
Imaging beta-amyloid burden in aging and dementia. Neurology (2007) 7.70
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol (1999) 7.69
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24
Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Nature (1987) 5.88
Creutzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering. Ann Neurol (1979) 5.53
Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (1994) 5.34
Oxide semiconductor thin-film transistors: a review of recent advances. Adv Mater (2012) 5.18
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell (1989) 4.99
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A (1998) 4.49
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42
The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature (1987) 4.15
How lac repressor binds to DNA. Nature (1972) 3.72
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 3.50
The amino-acid sequence of lac repressor. Proc Natl Acad Sci U S A (1973) 3.36
Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease. J Mol Biol (1991) 3.33
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med (1989) 3.24
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A (1990) 3.13
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem (1996) 3.10
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (1990) 3.10
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med (1997) 2.95
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep (2001) 2.70
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry (1999) 2.58
Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia (2008) 2.58
[Virus proteins. IV. Constitution of the coat protein of the fd phage]. Hoppe Seylers Z Physiol Chem (1969) 2.56
A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. EMBO J (1996) 2.55
Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease. Brain (2006) 2.54
Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). The nature and progression of spongiform change. Brain (1978) 2.49
Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person. Neurosci Lett (1990) 2.40
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes. EMBO J (1982) 2.31
Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol (2007) 2.31
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem (1999) 2.30
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) Science (1996) 2.29
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. EMBO J (1988) 2.26
Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes. Nucleic Acids Res (1990) 2.24
Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques. Acta Neuropathol (1983) 2.23
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci (1994) 2.19
In vitro and in vivo products of E. coli lactose permease gene are identical. Nature (1980) 2.18
Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes. J Exp Med (1994) 2.13
Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry (2008) 2.12
Amyloid, aluminium and the aetiology of Alzheimer's disease. Med J Aust (1995) 2.09
The cDNA clone for strictosidine synthase from Rauvolfia serpentina. DNA sequence determination and expression in Escherichia coli. FEBS Lett (1988) 2.05
Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology (2010) 1.99
Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates. J Infect Dis (1980) 1.96
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem (2001) 1.96
Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1. EMBO J (1986) 1.94
The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J (1988) 1.92
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. J Mol Biol (1992) 1.90
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease. Neuroscience (2007) 1.86
Two alleles of a neural protein gene linked to scrapie in sheep. Proc Natl Acad Sci U S A (1990) 1.84
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett (2001) 1.82
The familial occurrence of Creutzfeldt-Jakob disease and Alzheimer's disease. Brain (1981) 1.80
Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease. Eur J Biochem (1995) 1.80
The protein component of scrapie-associated fibrils is a glycosylated low molecular weight protein. EMBO J (1985) 1.76
The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J (2003) 1.75