The promoter of Alzheimer's disease amyloid A4 precursor gene.

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Published in EMBO J on September 01, 1988

Authors

J M Salbaum1, A Weidemann, H G Lemaire, C L Masters, K Beyreuther

Author Affiliations

1: Centre for Molecular Biology, University of Heidelberg (ZMBH), FRG.

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[Tetrafluorosuccinic anhydride, a new reagent for the specific and reversible masking of amino groups in proteins]. Hoppe Seylers Z Physiol Chem (1968) 1.61

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