Published in Sex Dev on July 27, 2017
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature (2004) 7.21
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell (2008) 5.40
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells (2003) 4.11
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett (2004) 4.02
Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97
Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell (2012) 3.85
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A (2008) 3.17
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol (2003) 3.15
Differentiation of embryonic stem cells is induced by GATA factors. Genes Dev (2002) 3.12
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet (2002) 3.06
Hippo pathway regulation by cell morphology and stress fibers. Development (2011) 2.94
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell (2008) 2.89
Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 2.75
alpha-Klotho as a regulator of calcium homeostasis. Science (2007) 2.71
Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study. Int J Epidemiol (2007) 2.67
Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. J Clin Invest (2005) 2.62
Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. Science (2007) 2.55
Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium. Dev Cell (2006) 2.47
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev (2002) 2.41
Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. J Cell Sci (2005) 2.37
Self-formation of functional adenohypophysis in three-dimensional culture. Nature (2011) 2.34
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci (2010) 2.18
Cdc42 and mDia3 regulate microtubule attachment to kinetochores. Nature (2004) 2.15
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab (2009) 2.13
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation (2004) 2.00
Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation. Exp Cell Res (2006) 1.91
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology (2002) 1.90
Phytosiderophore efflux transporters are crucial for iron acquisition in graminaceous plants. J Biol Chem (2010) 1.88
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol (2005) 1.88
Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci U S A (2007) 1.83
Heat flux manipulation with engineered thermal materials. Phys Rev Lett (2012) 1.81
A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns (2007) 1.77
Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development (2008) 1.74
Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex. EMBO J (2003) 1.70
HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J (2004) 1.69
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development (2007) 1.65
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell (2008) 1.63
Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2.6 protein kinase. Biochem J (2009) 1.62
Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med (2005) 1.61
Self-reproduction of supramolecular giant vesicles combined with the amplification of encapsulated DNA. Nat Chem (2011) 1.59
Pulmonary MALT lymphoma with amyloid production in a patient with primary Sjögren's syndrome. Intern Med (2002) 1.58
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem (2003) 1.57
Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging. Genesis (2011) 1.54
Six1 controls patterning of the mouse otic vesicle. Development (2003) 1.53
The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol (2005) 1.53
Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells. Mol Biol Cell (2006) 1.51
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev (2002) 1.46
Need for preoperative computed tomography-guided localization in video-assisted thoracoscopic surgery pulmonary resections of metastatic pulmonary nodules. Ann Thorac Surg (2010) 1.46
Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci (2009) 1.45
Clinical significance of axillary microresiduals after neoadjuvant chemotherapy in breast cancer patients with cytologically proven metastases. Ann Surg Oncol (2009) 1.43
Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev Cell (2005) 1.43
Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice. J Clin Invest (2008) 1.43
E-cadherin is required for gastrulation cell movements in zebrafish. Mech Dev (2005) 1.38
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res (2008) 1.38
Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling [corrected]. Development (2003) 1.38
Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities. J Cell Biol (2003) 1.36
Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells. Biol Reprod (2007) 1.34
Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program. Development (2009) 1.31
NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry. Curr Biol (2013) 1.29
Reduced glutathione enhances fertility of frozen/thawed C57BL/6 mouse sperm after exposure to methyl-beta-cyclodextrin. Biol Reprod (2011) 1.29
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Dev Growth Differ (2005) 1.28
SH2-B is required for both male and female reproduction. Mol Cell Biol (2002) 1.27
LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice. Biol Reprod (2006) 1.27
A rice phenolic efflux transporter is essential for solubilizing precipitated apoplasmic iron in the plant stele. J Biol Chem (2011) 1.26
EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol (2008) 1.24
Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation. Mol Biol Cell (2008) 1.24
Development of new inbred transgenic strains of rats with LacZ or GFP. Biochem Biophys Res Commun (2005) 1.24
A structural model for the catalytic cycle of Ca(2+)-ATPase. J Mol Biol (2002) 1.22
CXorf6 is a causative gene for hypospadias. Nat Genet (2006) 1.21
Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Development (2006) 1.20
Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development (2007) 1.20
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta. Mol Cell Biol (2005) 1.20
Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex. J Cell Biol (2009) 1.19
Health-related quality of life (HRQOL) in Japanese osteoporotic patients and its improvement by elcatonin treatment. J Bone Miner Metab (2005) 1.18
Transcriptomic analysis indicates putative metabolic changes caused by manipulation of phosphorus availability in rice leaves. J Exp Bot (2006) 1.17
Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing. J Biol Chem (2004) 1.17
Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury. J Neurochem (2006) 1.16
Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J Biol Chem (2003) 1.15
Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Proc Natl Acad Sci U S A (2003) 1.15
Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos. Mech Dev (2004) 1.15
DC magnetic cloak. Adv Mater (2011) 1.14
Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter. Development (2012) 1.13
Walking and mortality in Japan: the Miyagi Cohort Study. J Epidemiol (2004) 1.13
Cadherin is required for dendritic morphogenesis and synaptic terminal organization of retinal horizontal cells. Development (2006) 1.13
Retraction: Bidirectional developmental potential in reprogrammed cells with acquired pluripotency. Nature (2014) 1.13
Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. Mol Endocrinol (2009) 1.12
Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells. Blood (2002) 1.12
EphrinB2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation. Proc Natl Acad Sci U S A (2009) 1.11
Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. Biochim Biophys Acta (2002) 1.10
Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis. J Immunol (2012) 1.10
Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Proc Natl Acad Sci U S A (2010) 1.09
Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med (2003) 1.09
Lidocaine for preventing postoperative sore throat. Cochrane Database Syst Rev (2009) 1.08