Published in Nature on February 19, 1987
A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. Am J Hum Genet (1988) 1.92
Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment. J Cell Biol (1989) 1.32
Activated ras. Yet another player in melanoma? Am J Pathol (1996) 1.05
Effective testing of gene-disease associations. Am J Hum Genet (1990) 1.05
Close correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human lung cancer to the lymph nodes and other organs. Proc Natl Acad Sci U S A (1988) 1.04
Human hypervariable sequences in risk assessment: rare Ha-ras alleles in cancer patients. Environ Health Perspect (1987) 0.99
Statistical methodology in the analysis of relationships between DNA polymorphisms and disease: putative association of Ha-ras-I hypervariable alleles and cancer. Am J Hum Genet (1988) 0.91
Biochemical and molecular epidemiology of human cancer: indicators of carcinogen exposure, DNA damage, and genetic predisposition. Environ Health Perspect (1987) 0.86
Allele-specific deletion in exon I of the HRAS1 gene. Am J Hum Genet (1989) 0.85
Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes. Am J Pathol (1991) 0.84
Distribution of Ha-ras alleles in patients with colorectal cancer and Crohn's disease. Gut (1991) 0.80
Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer. Gut (1995) 0.75
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell (1993) 12.02
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14
Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy. Nature (1992) 8.85
A genetic map of the mouse suitable for typing intraspecific crosses. Genetics (1992) 8.53
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell (1988) 7.10
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature (2001) 6.76
p53 status and the efficacy of cancer therapy in vivo. Science (1994) 6.72
Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J (1991) 6.13
A family of cAMP-binding proteins that directly activate Rap1. Science (1998) 6.12
Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J Clin Oncol (1999) 5.95
Germline p16 mutations in familial melanoma. Nat Genet (1994) 5.59
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet (1997) 5.34
Physicians clarify their proposal for a National Council for Health Care priorities. BMJ (1996) 5.10
Determinants of retrovirus (HTLV-III) antibody and immunodeficiency conditions in homosexual men. Lancet (1984) 4.68
Bipolar affective disorders linked to DNA markers on chromosome 11. Nature (1987) 4.64
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet (1996) 4.59
Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science (1987) 4.32
Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature (1989) 4.18
Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. N Engl J Med (1995) 4.10
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci U S A (2000) 4.01
Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Lab Invest (1984) 3.86
Isolation and expression of a complementary DNA that confers multidrug resistance. Nature (1986) 3.84
Exon amplification: a strategy to isolate mammalian genes based on RNA splicing. Proc Natl Acad Sci U S A (1991) 3.43
Isolation and chromosomal assignment of 100 highly informative human simple sequence repeat polymorphisms. Genomics (1992) 3.42
Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets. J Exp Med (1982) 3.27
A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol (1984) 3.21
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1986) 3.19
Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts. Proc Natl Acad Sci U S A (1997) 3.18
Individual recognition in mice mediated by major urinary proteins. Nature (2001) 3.09
The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat Genet (1996) 3.05
Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p. N Engl J Med (1989) 3.03
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor. Cell (1990) 3.02
Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet (1998) 3.00
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet (1996) 2.96
Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc Natl Acad Sci U S A (1991) 2.83
Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome. Nat Genet (1993) 2.69
Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nat Genet (1995) 2.62
Direct haplotyping of kilobase-size DNA using carbon nanotube probes. Nat Biotechnol (2000) 2.61
Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivo. J Virol (1988) 2.55
Acquired precursors of cutaneous malignant melanoma. The familial dysplastic nevus syndrome. N Engl J Med (1985) 2.54
Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient. Implications for the study of tumor antigens. J Exp Med (1981) 2.53
The concise handbook of family cancer syndromes. Mayo Familial Cancer Program. J Natl Cancer Inst (1998) 2.53
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A (1998) 2.47
Determinants that contribute to cytoplasmic stability of human c-fos and beta-globin mRNAs are located at several sites in each mRNA. Mol Cell Biol (1988) 2.46
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A (1998) 2.46
The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product. J Exp Med (1990) 2.44
Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature (1984) 2.39
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci U S A (1994) 2.37
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol (1989) 2.35
Human erythroid burst-forming unit: T-cell requirement for proliferation in vitro. J Exp Med (1978) 2.33
Partial physical map of human chromosome 21. Somat Cell Mol Genet (1988) 2.27
Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J Exp Med (2000) 2.25
Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci U S A (1989) 2.25
Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. Blood (1996) 2.21
Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A (1986) 2.19
Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. Cell (1992) 2.15
Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med (1999) 2.15
Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma. Proc Natl Acad Sci U S A (1985) 2.14
Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein. J Exp Med (1995) 2.13
Localization of a unique gene by direct hybridization in situ. Proc Natl Acad Sci U S A (1981) 2.13
Hereditary breast/ovarian and colorectal cancer genetics knowledge in a national sample of US physicians. J Med Genet (2005) 2.13
Insulin control of glucose metabolism in man: a new kinetic analysis. J Clin Invest (1975) 2.09
Insulin-treated diabetes and driving in the UK. Diabet Med (2002) 2.07
Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma. Cancer (1980) 2.04
Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. Proc Natl Acad Sci U S A (1992) 2.04
Tumor immunity and autoimmunity induced by immunization with homologous DNA. J Clin Invest (1998) 2.02
Solid tumors after chronic lymphocytic leukemia. Blood (2001) 2.01
Familial clustering of rheumatoid arthritis with other autoimmune diseases. Hum Genet (1998) 1.99
The complex pathology of trinucleotide repeats. Curr Opin Cell Biol (1997) 1.98
Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA. J Exp Med (1989) 1.98
Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis. Nat Genet (1995) 1.97
Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study. Hum Mol Genet (2000) 1.94
A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. Am J Hum Genet (1988) 1.92
Heteroclitic immunization induces tumor immunity. J Exp Med (1998) 1.92
Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous. Proc Natl Acad Sci U S A (1985) 1.91
Progress in high throughput SNP genotyping methods. Pharmacogenomics J (2002) 1.88
Serological survey of normal humans for natural antibody to cell surface antigens of melanoma. Proc Natl Acad Sci U S A (1980) 1.86
Immune response to a differentiation antigen induced by altered antigen: a study of tumor rejection and autoimmunity. Proc Natl Acad Sci U S A (1996) 1.85
Mutation of a new gene causes a unique form of Hermansky-Pudlak syndrome in a genetic isolate of central Puerto Rico. Nat Genet (2001) 1.83
Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis. Nat Genet (1998) 1.82
Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon. J Exp Med (1984) 1.81
Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol Cell Biol (1993) 1.80
Intracellular sorting and targeting of melanosomal membrane proteins: identification of signals for sorting of the human brown locus protein, gp75. J Cell Biol (1995) 1.76
WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour. Nature (1991) 1.75
Functional defects of Cx26 resulting from a heterozygous missense mutation in a family with dominant deaf-mutism and palmoplantar keratoderma. Hum Genet (1998) 1.75
Precursor lesions in familial melanoma. A new genetic preneoplastic syndrome. JAMA (1978) 1.74
The dynamics of a heroin addiction epidemic. Science (1973) 1.74
Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus. Proc Natl Acad Sci U S A (1983) 1.72
Direct detection of novel expanded trinucleotide repeats in the human genome. Nat Genet (1993) 1.71
Generation of human monoclonal antibodies reactive with cellular antigens. Proc Natl Acad Sci U S A (1983) 1.71
Assignment of the gene coding for the T3-delta subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9. Proc Natl Acad Sci U S A (1985) 1.70
Mutations associated with familial melanoma impair p16INK4 function. Nat Genet (1995) 1.69
Ordering three DNA polymorphisms on human chromosome 3 by sperm typing. Genomics (1991) 1.69
Generation of transforming viruses in cultures of chicken fibroblasts infected with an avian leukosis virus. J Virol (1981) 1.68