Published in Cancer Lett on September 01, 1987
Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene (2003) 1.64
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol (2012) 1.17
Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes. Oncotarget (2016) 0.81
Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies. Curr Pathobiol Rep (2014) 0.76
Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes. PLoS One (2017) 0.75
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol (1977) 2.45
The sequential analysis of cancer development. Adv Cancer Res (1980) 2.28
Cell proliferation is not a major risk factor for cancer. Mod Pathol (1996) 2.05
The multistep nature of cancer development. Cancer Res (1984) 1.93
Hepatocarcinogenesis: a dynamic cellular perspective. Lab Invest (1987) 1.82
An invasive cleavage assay for direct quantitation of specific RNAs. Nat Biotechnol (2001) 1.79
Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture. Cancer Res (1984) 1.70
The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens. Cancer Res (1976) 1.58
Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy. Am J Pathol (1984) 1.48
Genetic association between sensitivity to warfarin and expression of CYP2C9*3. Pharmacogenetics (1997) 1.47
The sequential analysis of liver cancer induction. Biochim Biophys Acta (1980) 1.46
Studies on DNA repair in human lymphocytes treated with proximate carcinogens and alkylating agents. Cancer Res (1971) 1.44
Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. J Biol Chem (1994) 1.42
Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens. Cancer Res (1980) 1.42
Chemical carcinogenesis. N Engl J Med (1981) 1.41
Carcinogenesis--cellular evolution as a unifying thread: Presidential address. Cancer Res (1973) 1.30
The inhibition of liver ribonucleic acid synthesis by ethionine. J Biol Chem (1966) 1.30
Patterns of transfer RNA in normal rat liver and during hepatic carcinogenesis. Proc Natl Acad Sci U S A (1967) 1.27
Chemical carcinogenesis: a biologic perspective. Am J Pathol (1982) 1.26
A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. Cancer Res (1976) 1.26
Ethionine fatty liver. Adv Lipid Res (1967) 1.26
Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem (1994) 1.25
Initiation of chemical carcinogenesis requires cell proliferation. Nature (1978) 1.25
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis. Cancer Res (1978) 1.24
The rapid acceleration of hepatic nuclear ribonucleic acid breakdown by actinomycin but not by ethionine. J Biol Chem (1968) 1.21
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc Natl Acad Sci U S A (1987) 1.21
Differences in growth of transplants of liver, liver hyperplastic nodules, and hepatocellular carcinomas in the mammary fat pad. Am J Pathol (1977) 1.20
Reversal by adenine of the ethionine-induced lipid accumulation in the endoplasmic reticulum of the rat liver. A preliminary report. J Cell Biol (1965) 1.19
On the mechanism of induction of hepatic adenosine triphosphate deficiency by ethionine. J Biol Chem (1966) 1.19
On the molecular pathology of ischemic renal cell death. Reversible and irreversible cellular and mitochondrial metabolic alterations. Am J Pathol (1968) 1.19
Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. Cancer Res (1981) 1.17
Cycloheximide, an inhibitor of peptide chain termination or release in liver in vivo and in vitro. Biochem Biophys Res Commun (1971) 1.17
Pre-cancerous steps in carcinogenesis. Their physiological adaptive nature. Biochim Biophys Acta (1984) 1.16
Biochemistry of carcinogenesis. Cancer Res (1968) 1.15
Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene. Lab Invest (1985) 1.10
Cloning and expression of a cDNA for the human prostanoid IP receptor. J Biol Chem (1994) 1.09
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis (1984) 1.08
Phenotypic diversity as an early property of putative preneoplastic hepatocyte populations in liver carcinogenesis. Cancer Res (1980) 1.08
ATP and cell integrity. Fed Proc (1973) 1.07
Chemicals, evolution, and cancer development: Rous-Whipple Award Lecture. Am J Pathol (1982) 1.07
Nonrandom nature of in vivo methylation of dimethylnitrosamine and the subsequent removal of methylated products from rat liver chromatin DNA. Cancer Res (1976) 1.06
The biochemistry of preneoplastic liver: a common metabolic pattern in hepatocyte nodules. Can J Biochem Cell Biol (1984) 1.06
Effect of cycloheximide on the cell cycle of the crypts of the small intestine of the rat. J Cell Biol (1967) 1.06
Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism. Cancer Res (1967) 1.04
Newer insights into the pathogenesis of liver cancer. Am J Pathol (1977) 1.04
Hyperplastic areas, hyperplastic nodules, and hyperbasophilic areas as putative precursor lesions. Cancer Res (1976) 1.03
A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4. J Biol Chem (2000) 1.02
Molecular pathology of in-vivo inhibition of protein synthesis. Electron microscopy of rat pancreatic acinar cells in puromycin-induced necrosis. Am J Pathol (1968) 1.02
A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat. Cancer Res (1985) 1.02
In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics. Pharmacogenetics (2001) 1.01
Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites. Drug Metab Dispos (1999) 1.01
Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos (2001) 0.98
Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine. Biochem J (1971) 0.98
The cancer-initiating potential of the fumonisin B mycotoxins. Carcinogenesis (1992) 0.97
Biochemical pathology. Annu Rev Pharmacol (1971) 0.97
Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor. J Pharmacol Exp Ther (2000) 0.97
The biochemical pathology of inhibition of protein synthesis in vivo. The effects of cycloheximide on hepatic parenchymal cell ultrastructure. Lab Invest (1969) 0.97
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride. Cancer Res (1983) 0.97
Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: a new perspective. Lab Invest (1993) 0.96
Cloning and expression of three isoforms of the human EP3 prostanoid receptor. FEBS Lett (1994) 0.96
Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome. Xenobiotica (2006) 0.96
The disorganization of hepatic cell nucleoli induced by ethionine and its reversal by adenine. J Cell Biol (1968) 0.96
Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis. Cancer Res (1982) 0.96
In vitro measurement of carcinogen-resistant liver cells during hepatocarcinogenesis. Int J Cancer (1978) 0.95
The effect of cycloheximide on the interaction between mitochondrial respiration and gluconeogenesis in guinea pig and rat liver. J Biol Chem (1973) 0.95
Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver. Cancer Res (1983) 0.95
Acute pancreatic necrosis induced by puromycin. Lab Invest (1967) 0.95
Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene. Int J Cancer (1987) 0.95
Sequential analysis of hepatic carcinogenesis: a comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal, and regenerating liver. Lab Invest (1979) 0.94
Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis. Environ Health Perspect (1983) 0.94
Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis. Cancer Res (1984) 0.94
Inhibition of protein synthesis in rat liver by D-galactosamine. Res Commun Chem Pathol Pharmacol (1973) 0.94
Nature of early appearing, carcinogen-induced liver lesions to iron accumulation. J Natl Cancer Inst (1976) 0.93
Sequential alterations in growth control and cell dynamics of rat hepatocytes in early precancerous steps in hepatocarcinogenesis. Cancer Res (1986) 0.93
Deoxyribonucleoside incorporation and the role of hydroxyurea in a model lymphocyte system for studying DNA repair in carcinogenesis. Cancer Res (1971) 0.93
A probable role for protein synthesis in intestinal epithelial cell damage induced in vivo by cytosine arabinoside, nitrogen mustard, or X-irradiation. Cancer Res (1970) 0.93
The biochemical pathology of ethionine-induced pancreatic damage: ethionine incorporation into proteins, and ATP levels in pancreas of rats. Arch Biochem Biophys (1968) 0.92
The binding of 2-acetylaminofluorene to rat liver ribonucleic acid in vivo. Cancer Res (1965) 0.92
Halothane-induced liver injury in outbred guinea pigs: role of trifluoroacetylated protein adducts in animal susceptibility. Chem Res Toxicol (2001) 0.91
Effects of ethionine on adenosine triphosphate levels and ionic composition of liver cell nuclei. J Biol Chem (1968) 0.91
Chordoma: a case report. Surg Neurol (1997) 0.91
Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine. Cancer Lett (1984) 0.91
Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver. Cancer Res (1977) 0.90
Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine. Cancer Res (1985) 0.90
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics. Biochem J (1979) 0.90
Sequential analysis of hepatic carcinogenesis: the comparative architecture of preneoplastic, malignant, prenatal, postnatal and regenerating liver. Br J Cancer (1979) 0.90
Highly selective in vivo ethylation of rat liver nuclear protein by ethionine. Biochem Biophys Res Commun (1969) 0.90
The effects of cycloheximide on energy transfer in rat and guinea pig liver mitochondria. J Biol Chem (1973) 0.90
Morphologic and metabolic alterations in hepatic cell nucleoli induced by varying doses of actinomycin D. Cancer Res (1969) 0.89
Chemical carcinogenesis: persistence of bound forms of 2-fluorenylacetamide. Science (1968) 0.89
Putative precursor lesions: summary and some analytical considerations. Cancer Res (1976) 0.89
Enzyme kinetics of cytochrome P450-mediated reactions. Curr Drug Metab (2001) 0.89
A characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules generated during liver carcinogenesis in several models. Biochem Biophys Res Commun (1983) 0.88
Interaction between ethionine and rat liver ribonucleic acid and protein in vivo. Cancer Res (1967) 0.88
Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem J (1999) 0.88
The effects of inosine and aminoimidazole carboxamide upon the ethionine fatty liver. Biochem Pharmacol (1965) 0.88
Allogeneic hepatocyte transplantation in the rat spleen under cyclosporine immunosuppression. Transplantation (1986) 0.88
A new common marker for premalignant and malignant hepatocytes induced in the rat by chemical carcinogens. J Natl Cancer Inst (1975) 0.88