Published in Nature on September 12, 1985
Seroepidemiology of human polyomaviruses. PLoS Pathog (2009) 4.62
Expression of retroviral vectors in transgenic mice obtained by embryo infection. EMBO J (1987) 2.16
The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice. J Virol (1987) 1.75
Introduction of genes into the germ line of animals. Harvey Lect (1988) 1.64
Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO J (1990) 1.54
An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors. Proc Natl Acad Sci U S A (1997) 1.49
Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice. Proc Natl Acad Sci U S A (1992) 1.44
Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc Natl Acad Sci U S A (1986) 1.43
Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice. Mol Cell Biol (1988) 1.40
Viral manipulation of DNA repair and cell cycle checkpoints. DNA Repair (Amst) (2009) 1.37
Heart and bone tumors in transgenic mice. Proc Natl Acad Sci U S A (1988) 1.31
Neuroepithelial carcinomas in mice transgenic with human papillomavirus type 16 E6/E7 ORFs. Am J Pathol (1993) 1.26
Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice. J Virol (1987) 1.24
Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. Mol Cell Biol (1987) 1.23
Construction and characterization of hybrid polyomavirus genomes. J Virol (1986) 1.16
Simian virus 40 in humans. Infect Agent Cancer (2007) 1.09
An endoplasmic reticulum-targeting signal sequence enhances the immunogenicity of an immunorecessive simian virus 40 large T antigen cytotoxic T-lymphocyte epitope. J Virol (1998) 1.09
Identification of cis sequences controlling efficient position-independent tissue-specific expression of human major histocompatibility complex class I genes in transgenic mice. Mol Cell Biol (1991) 1.06
T antigen transgenic mouse models. Semin Cancer Biol (2009) 1.06
Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice. Mol Cell Biol (1989) 1.06
Hepatitis B virus infection and primary hepatocellular carcinoma. Clin Microbiol Rev (1992) 1.04
Multiple endocrine neoplasia induced by the promiscuous expression of a viral oncogene. Proc Natl Acad Sci U S A (1988) 1.02
Lymphotropic papovavirus early region is specifically regulated transgenic mice and efficiently induces neoplasia. J Virol (1989) 1.02
A mouse mammary tumor virus mammary gland enhancer confers tissue-specific but not lactation-dependent expression in transgenic mice. J Virol (1992) 1.01
Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression. Am J Pathol (1998) 1.00
Mice transgenic for a vasopressin-SV40 hybrid oncogene develop tumors of the endocrine pancreas and the anterior pituitary. A possible model for human multiple endocrine neoplasia type 1. Am J Pathol (1987) 0.99
Simian virus 40 transformation, malignant mesothelioma and brain tumors. Expert Rev Respir Med (2011) 0.96
Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice. J Virol (1999) 0.96
Uniform cell-autonomous tumorigenesis of the choroid plexus by papovavirus large T antigens. Mol Cell Biol (1991) 0.95
Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen. J Virol (1989) 0.95
The fodrin-ankyrin cytoskeleton of choroid plexus preferentially colocalizes with apical Na+K(+)-ATPase rather than with basolateral anion exchanger AE2. J Clin Invest (1994) 0.94
Expression of a human immunodeficiency virus type 1 long terminal repeat/simian virus 40 early region fusion gene in transgenic mice. J Virol (1991) 0.93
Simian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen. J Exp Med (1987) 0.92
A foreign dihydrofolate reductase gene in transgenic mice acts as a dominant mutation. Mol Cell Biol (1986) 0.90
Cell models for studying renal physiology. Pflugers Arch (2008) 0.90
Lineage-specific transformation after differentiation of multipotential murine stem cells containing a human oncogene. Mol Cell Biol (1986) 0.88
Regulation of NaCl transport in the renal collecting duct: lessons from cultured cells. Pflugers Arch (2006) 0.87
Functional similarities between human immunodeficiency virus type 1 and simian virus 40 kappa B proto-enhancers. J Virol (1991) 0.87
The folate receptor as a potential therapeutic anticancer target. Invest New Drugs (1999) 0.84
The polyomavirus early region gene in transgenic mice causes vascular and bone tumors. J Virol (1991) 0.84
Metal-inducible pathology in the liver, pancreas, and kidney of transgenic mice expressing SV40 early region genes. Am J Pathol (1989) 0.83
In vivo expansion of the residual tumor antigen-specific CD8+ T lymphocytes that survive negative selection in simian virus 40 T-antigen-transgenic mice. J Virol (2004) 0.82
Neoplastic transformation and angiogenesis in the thymus of transgenic mice expressing SV40 T and t antigen under an L-pyruvate kinase promoter (SV12 mice). Int J Exp Pathol (2005) 0.81
Trilateral retinoblastoma in transgenic mice. Trans Am Ophthalmol Soc (1989) 0.81
Frequency of drug-resistant variants of HIV-1 coexistent with wild-type in treatment-naive patients of India. MedGenMed (2005) 0.81
Rapid accumulation of adoptively transferred CD8+ T cells at the tumor site is associated with long-term control of SV40 T antigen-induced tumors. Cancer Immunol Immunother (2007) 0.79
Combined anti-CD40 conditioning and well-timed immunization prolongs CD8+ T cell accumulation and control of established brain tumors. J Immunother (2008) 0.78
Micrometastasis expressing insulin arise in lung and spleen at advanced stage of rip1-tag2 transgenic mice. Int J Biol Sci (2014) 0.77
Rhabdomyosarcoma arising in transgenic mice harboring the beta-globin locus control region fused with simian virus 40 large T antigen gene. Proc Natl Acad Sci U S A (1993) 0.76
Differential effects of cisplatin in proximal and distal renal tubule epithelial cell lines. Br J Cancer (1999) 0.76
Evaluation of apoptosis in skin biopsies of patients of borderline leprosy and lepra type 1 reaction. Indian J Dermatol (2015) 0.76
Frequency of Drug-Resistant Variants of HIV-1 Coexistent With Wild-Type in Treatment-Naive Patients of India. J Int AIDS Soc (2005) 0.75
Transgene expression and repression in transgenic rats bearing the phosphoenolpyruvate carboxykinase-simian virus 40 T antigen or the phosphoenolpyruvate carboxykinase-transforming growth factor-alpha constructs. Am J Pathol (1999) 0.75
Crystallin genes: lens specificity of the murine alpha A-crystallin gene. Environ Health Perspect (1987) 0.75
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56
Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undergraded polysomes and messenger ribonucleic acid. Biochemistry (1974) 11.67
Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct. J Biol Chem (1979) 9.48
Germ-line transformation of mice. Annu Rev Genet (1986) 8.67
Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci U S A (1985) 7.32
Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature (2001) 6.36
hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis (2001) 6.29
Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J (1985) 5.84
Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci U S A (1988) 5.18
Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature (1982) 5.14
A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc Natl Acad Sci U S A (1984) 5.08
Structure of mouse metallothionein-I gene and its mRNA. Nature (1981) 5.06
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat Cell Biol (1999) 4.76
Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet (2001) 4.63
A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. Genes Dev (1989) 4.60
Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell (1982) 4.60
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet (2000) 4.57
The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells. Cell (1982) 4.55
An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev (1987) 4.48
Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci U S A (1978) 4.46
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (1982) 4.30
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell (1981) 4.23
Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J Biol Chem (1981) 4.20
Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell (1990) 4.05
Human gamma- to beta-globin gene switching in transgenic mice. Genes Dev (1990) 4.04
Metallothionein-human GH fusion genes stimulate growth of mice. Science (1983) 4.03
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell (1987) 4.02
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature (1996) 3.99
Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1987) 3.81
The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med (1988) 3.80
DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells. Cell (1981) 3.67
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell (1989) 3.60
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 3.56
Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. N Engl J Med (1992) 3.41
Building a metal-responsive promoter with synthetic regulatory elements. Mol Cell Biol (1985) 3.39
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet (1999) 3.37
Heterologous introns can enhance expression of transgenes in mice. Proc Natl Acad Sci U S A (1991) 3.34
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell (1995) 3.33
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell (1991) 3.31
A practical approach for quantitating specific mRNAs by solution hybridization. Anal Biochem (1983) 3.30
Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science (1996) 3.28
Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science (1990) 3.26
Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol (1984) 3.25
Replacement of diseased mouse liver by hepatic cell transplantation. Science (1994) 3.18
Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron (1998) 3.18
Isolation and characterization of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A (1980) 3.17
The effect of cells transferred into the mouse blastocyst on subsequent development. J Exp Med (1974) 3.17
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature (1997) 3.14
Ovalbumin messenger ribonucleic acid translation. Comparable rates of polypeptide initiation and elongation on ovalbumin and globin messenger ribonucleic acid in a rabbit reticulocyte lysate. J Biol Chem (1973) 3.13
Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc Natl Acad Sci U S A (1981) 3.11
Transplantation of testis germinal cells into mouse seminiferous tubules. Int J Dev Biol (1997) 3.10
Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes. J Biol Chem (1972) 2.96
Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94
Augmented inverse probability weighted estimator for Cox missing covariate regression. Biometrics (2001) 2.93
beta1- and alpha6-integrin are surface markers on mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (1999) 2.91
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell (1995) 2.89
Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis. Biochemistry (1978) 2.85
Noradrenaline is essential for mouse fetal development. Nature (1995) 2.84
GFAP promoter directs astrocyte-specific expression in transgenic mice. J Neurosci (1994) 2.77
Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature (1985) 2.77
Regulation of protein synthesis in chick oviduct. I. Independent regulation of ovalbumin, conalbumin, ovomucoid, and lysozyme induction. J Biol Chem (1972) 2.76
Quantitation of parameters that determine the rate of ovalbumin synthesis. Cell (1975) 2.74
Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. J Biol Chem (1971) 2.73
Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response. Biochemistry (1997) 2.73
Live astrocytes visualized by green fluorescent protein in transgenic mice. Dev Biol (1997) 2.64
Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell (1984) 2.59
Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature (1985) 2.58
Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids. Nature (1981) 2.58