Published in Nature on November 18, 1982
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Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen. J Exp Med (1984) 6.45
Transient expression of interleukin 2 receptors. Consequences for T cell growth. J Exp Med (1983) 5.82
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med (1994) 5.20
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci U S A (1984) 4.90
Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex. Proc Natl Acad Sci U S A (1983) 4.83
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A (1984) 4.78
Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex. Proc Natl Acad Sci U S A (1986) 4.61
Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med (1987) 4.53
Interleukin 2 regulates its own receptors. Proc Natl Acad Sci U S A (1985) 4.19
Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2. Proc Natl Acad Sci U S A (1983) 4.01
Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. Proc Natl Acad Sci U S A (1985) 3.74
The interleukin 2 receptor. Functional consequences of its bimolecular structure. J Exp Med (1987) 3.66
Molecular cloning of human interleukin 2 cDNA and its expression in E. coli. Nucleic Acids Res (1983) 3.44
Expression of interleukin 2 receptors on activated human B cells. J Exp Med (1984) 3.27
Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus. Proc Natl Acad Sci U S A (1983) 3.01
Simultaneous flow cytometric analysis of human T cell activation antigen expression and DNA content. J Exp Med (1983) 2.94
Direct demonstration of the identity of T cell growth factor binding protein and the Tac antigen. J Exp Med (1983) 2.82
Expression of Tac antigen on activated normal human B cells. J Exp Med (1984) 2.76
Characterization of the human receptor for T-cell growth factor. Proc Natl Acad Sci U S A (1983) 2.76
Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. Proc Natl Acad Sci U S A (1983) 2.73
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Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors. Proc Natl Acad Sci U S A (1987) 2.65
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Voltage-gated potassium channels are required for human T lymphocyte activation. J Exp Med (1984) 2.54
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol (2011) 2.47
Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies. Proc Natl Acad Sci U S A (1989) 2.43
High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells. J Exp Med (1986) 2.37
Interleukin 2 regulates the expression of Tac antigen on peripheral blood T lymphocytes. J Exp Med (1984) 2.26
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CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci Transl Med (2012) 2.22
Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes. Proc Natl Acad Sci U S A (1984) 2.17
Phenotypic expression of Hodgkin's and Reed-Sternberg cells in Hodgkin's disease. Am J Pathol (1985) 2.17
Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function. J Exp Med (1985) 2.14
Only high-affinity receptors for interleukin 2 mediate internalization of ligand. Proc Natl Acad Sci U S A (1986) 2.12
Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. J Exp Med (1988) 2.08
Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells. J Exp Med (1985) 1.99
Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells. J Exp Med (1983) 1.99
Role of the Bp35 cell surface polypeptide in human B-cell activation. Proc Natl Acad Sci U S A (1985) 1.89
Detection and functional studies of p60-65 (Tac antigen) on activated human B cells. J Exp Med (1984) 1.84
Interleukin 2 receptor gene expression in normal human T lymphocytes. Proc Natl Acad Sci U S A (1985) 1.80
Regulation of interleukin 2 receptor alpha subunit (Tac or CD25 antigen) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation. Proc Natl Acad Sci U S A (1988) 1.74
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Phenotypic changes associated with activation of CD45RA+ and CD45RO+ T cells. Immunology (1990) 1.66
Infection of human endothelial cells by human T-cell leukemia virus type I. Proc Natl Acad Sci U S A (1984) 1.61
Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells. J Clin Invest (1985) 1.58
Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells. J Clin Invest (1988) 1.56
Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis. J Exp Med (1984) 1.51
Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells. Proc Natl Acad Sci U S A (1984) 1.51
Functional properties of a unique subset of cytotoxic CD3+ T lymphocytes that express Fc receptors for IgG (CD16/Leu-11 antigen). J Exp Med (1985) 1.51
Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. Immunology (1988) 1.48
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A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562. J Exp Med (1985) 1.41
Purification and chemical characterization of the receptor for interleukin 2 from activated human T lymphocytes and from a human T-cell lymphoma cell line. Proc Natl Acad Sci U S A (1984) 1.37
Spontaneous release of interleukin 2 by lung T lymphocytes in active pulmonary sarcoidosis is primarily from the Leu3+DR+ T cell subset. J Clin Invest (1986) 1.35
Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses. J Exp Med (1990) 1.33
Many cytokines are very useful therapeutic targets in disease. J Clin Invest (2008) 1.33
Autocrine growth stimulation of a human T-cell lymphoma line by interleukin 2. Proc Natl Acad Sci U S A (1985) 1.32
The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells. J Exp Med (1988) 1.28
Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli. Proc Natl Acad Sci U S A (1988) 1.24
Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signaling. J Exp Med (1992) 1.24
Function and phenotype of immature CD4+ lymphocytes in healthy infants and early lymphocyte activation in uninfected infants of human immunodeficiency virus-infected mothers. Clin Diagn Lab Immunol (1997) 1.23
Preferential activation of helper/inducer T lymphocytes in autoimmune chronic active hepatitis. Clin Exp Immunol (1987) 1.23
Possible involvement of the T4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of CTL-target cell binding. J Exp Med (1984) 1.21
Immunopathology of cutaneous T-cell lymphomas. Am J Pathol (1985) 1.20
Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel. Clin Exp Immunol (1987) 1.19
Selection of BoCD25 monoclonal antibodies by screening mouse L cells transfected with the bovine p55-interleukin-2 (IL-2) receptor gene. Immunology (1992) 1.18
Correction of interleukin-2 production in patients with systemic lupus erythematosus by removal of spontaneously activated suppressor cells. J Clin Invest (1985) 1.18
Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study. Proc Natl Acad Sci U S A (1997) 1.17
Phenotypic expression of T lymphocytes in thymus and peripheral lymphoid tissues. Am J Pathol (1985) 1.16
Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor. J Clin Invest (1984) 1.13
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Modulation of IL-2Rα with daclizumab for treatment of multiple sclerosis. Nat Rev Neurol (2013) 1.13
The T-lymphocyte population in first-trimester human decidua does not express the interleukin-2 receptor. Immunology (1986) 1.12
TLiSA1, a human T lineage-specific activation antigen involved in the differentiation of cytotoxic T lymphocytes and anomalous killer cells from their precursors. J Exp Med (1985) 1.11
Interleukin 2-diphtheria toxin fusion protein can abolish cell-mediated immunity in vivo. Proc Natl Acad Sci U S A (1988) 1.10
Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen. J Exp Med (1983) 1.10
Medical immunology: a new journal for a new subspecialty. Med Immunol (2002) 1.10
Activated T lymphocytes in uveitis. Br J Ophthalmol (1988) 1.10
Evidence for an interleukin-independent pathway for human lymphocyte activation. Proc Natl Acad Sci U S A (1983) 1.10
Selective blockade of the antigen-receptor-mediated pathway of T cell activation in patients with impaired primary immune responses. J Clin Invest (1987) 1.09
Bismuth-212-labeled anti-Tac monoclonal antibody: alpha-particle-emitting radionuclides as modalities for radioimmunotherapy. Proc Natl Acad Sci U S A (1986) 1.08
Sera from patients with the acquired immunodeficiency syndrome inhibit production of interleukin-2 by normal lymphocytes. J Clin Invest (1985) 1.04
Evidence of cells bearing interleukin-2 receptor at sites of disease activity in sarcoid patients. Clin Exp Immunol (1984) 1.03
Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens. J Exp Med (1983) 1.03
Cloning of cDNA for the bovine IL-2 receptor (bovine Tac antigen). Immunology (1988) 1.02
Localization of interferons and interleukin 2 in polymyositis and muscular dystrophy. Clin Exp Immunol (1986) 1.01
Immunohistological analysis of Tac antigen expression in tissues involved by Hodgkin's disease. Br J Cancer (1984) 1.00
Selective inhibition of growth factor-dependent human B cell proliferation by monoclonal antibody AB1 to an antigen expressed by activated B cells. J Exp Med (1984) 1.00
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