Published in J Exp Med on October 01, 1979
Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med (1982) 9.49
Continuous proliferation of murine antigen-specific helper T lymphocytes in culture. J Exp Med (1979) 7.20
Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line. J Exp Med (1980) 4.32
Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. Proc Natl Acad Sci U S A (1985) 3.95
Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc Natl Acad Sci U S A (1982) 3.74
B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor. J Exp Med (1981) 3.40
Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen. Proc Natl Acad Sci U S A (1981) 3.28
Enhanced production of murine interferon gamma by T cells generated in response to bacterial infection. J Exp Med (1982) 3.27
Concanavalin A-inducible, interleukin-2-producing T cell hybridoma. J Exp Med (1980) 3.02
Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines. J Exp Med (1980) 3.00
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function. Proc Natl Acad Sci U S A (1981) 2.95
Multiple biologic activities of a cloned inducer T-cell population. Proc Natl Acad Sci U S A (1981) 2.95
Activated B cells express receptors for, and proliferate in response to, pure interleukin 2. J Exp Med (1984) 2.74
B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors. J Exp Med (1988) 2.64
Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays. J Exp Med (1983) 2.56
T-Cell lymphoma model for the analysis of interleukin 1-mediated T-cell activation. Proc Natl Acad Sci U S A (1981) 2.51
Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene. J Exp Med (1981) 2.46
Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor. J Exp Med (1982) 2.22
Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis. Clin Exp Immunol (1984) 2.17
Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype. J Exp Med (1983) 2.15
Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J Clin Invest (1981) 2.04
B cell-stimulatory factor 1 (BSF-1) promotes growth of helper T cell lines. J Exp Med (1986) 1.82
Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2. J Exp Med (1982) 1.76
Interleukin 2 induces antigen-reactive T cell lines to secrete BCGF-I. J Exp Med (1983) 1.71
Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo. J Exp Med (1981) 1.59
Purification of murine T cell growth factor. A lymphocyte mitogen with helper activity. J Exp Med (1981) 1.57
Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor. Proc Natl Acad Sci U S A (1982) 1.53
Purification of human interleukin 2 to apparent homogeneity and its molecular heterogeneity. J Exp Med (1982) 1.50
Purification to homogeneity and partial characterization of interleukin 2 from a human T-cell leukemia. Proc Natl Acad Sci U S A (1984) 1.47
Deficit of interleukin 2 production associated with impaired T-cell proliferative responses in Mycobacterium lepraemurium infection. Infect Immun (1983) 1.42
Helper and killer T cells do not express B cell immunoglobulin joining and constant region gene segments. J Exp Med (1980) 1.42
Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens. Proc Natl Acad Sci U S A (1981) 1.35
Murine Peyer's patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses. J Exp Med (1982) 1.30
Stimulation of the proliferation of human bone cells in vitro by human monocyte products with interleukin-1 activity. J Clin Invest (1985) 1.30
Antigen-specific, H-2-restricted helper T cell hybridomas. J Exp Med (1982) 1.29
Increased thymocyte-activating factor in human gingival fluid during gingival inflammation. Infect Immun (1982) 1.27
Generation of an interleukin-I-like lymphocyte-stimulating factor at inflammatory sites: correlation with the infiltration of polymorphonuclear leucocytes. Br J Exp Pathol (1984) 1.24
Antibody production by single, hapten-specific B lymphocytes: an antigen-driven cloning system free of filler or accessory cells. Proc Natl Acad Sci U S A (1981) 1.10
Direct evidence for granuloma-inducing activity of interleukin-1. Induction of experimental pulmonary granuloma formation in mice by interleukin-1-coupled beads. Am J Pathol (1988) 1.10
Strain variation of bacillus Calmette-Guerin-induced pulmonary granuloma formation is correlated with anergy and the local production of migration inhibition factor and interleukin 1. Am J Pathol (1985) 1.07
Monoclonal antibody directed against interleukin 2. I. Inhibition of T lymphocyte mitogenesis and the in vitro differentiation of alloreactive cytolytic T cells. J Exp Med (1981) 1.06
Human interleukin 2 can promote the growth and differentiation of single hapten-specific B cells in the presence of specific antigen. Proc Natl Acad Sci U S A (1984) 1.00
Mitogen-initiated synthesis and secretion of T cell growth factor(s) by a T-lymphoma cell line. J Exp Med (1980) 0.95
Antibodies to interleukin 2. Effects on immune responses in vitro and in vivo. J Exp Med (1984) 0.92
Production and characterization of bovine interleukin-2. Immunology (1984) 0.92
Cloned measles virus-specific T lymphocytes from a twin with multiple sclerosis. Proc Natl Acad Sci U S A (1983) 0.90
A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion. J Exp Med (1982) 0.89
Resistance of cultures of normal T cells to infection with murine type C viruses. J Virol (1981) 0.85
Interleukin-2 allows in vivo induction of anti-erythrocyte autoantibody production in nude mice associated with the injection of rat erythrocytes. Clin Exp Immunol (1981) 0.85
Interleukin 2 activity in chronic liver disease and the effect of in vitro alpha-interferon. Clin Exp Immunol (1986) 0.84
Purification and initial characterization of rat interleukin 2. Proc Natl Acad Sci U S A (1982) 0.82
Development of fetal thymocytes in organ cultures. Effect of interleukin 2. J Exp Med (1987) 0.82
Expression of structurally diverse Qa-2-encoded molecules on the surface of cloned cytotoxic T lymphocytes. J Exp Med (1984) 0.80
Studies of the pathogenesis of angioimmunoblastic lymphadenopathy. J Clin Invest (1985) 0.80
Paradoxical presence of T cell anergy during successful T cell-dependent tumour immunotherapy: characterization of a state of T cell 'amnaesia' following systemic administration of C. parvum. Clin Exp Immunol (1984) 0.80
Effect of macrophages on the go-gl and gl-S transition of thymocytes. Immunology (1982) 0.79
Lymphokine-induced suppressor B cells. Immunology (1982) 0.79
Cultured T lymphocytes cytotoxic for a syngeneic lymphoma: derivation in Con A-conditioned medium and in vivo activity. Clin Exp Immunol (1981) 0.77
Lethal effect of the intravenous injection of H-2 alloantigen activated T cells. Clin Exp Immunol (1982) 0.77
Correlated expression of T cell growth factor dependence, sensitivity to Vicia villosa lectin, and cytolytic activity in hybrids between cytolytic T cells and T lymphomas. J Exp Med (1982) 0.77
Requirement of dual stimulation by homologous recombinant IL-2 and recombinant IL-12 for the in vitro production of interferon gamma by canine peripheral blood mononuclear cells. BMC Res Notes (2014) 0.76
The history of fever, leukocytic pyrogen and interleukin-1. Temperature (Austin) (2015) 0.75
Effect of T-cell factors on the induction of anti-ssDNA antibodies by bacterial lipopolysaccharide. Immunology (1982) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol (1978) 28.92
Long term culture of tumour-specific cytotoxic T cells. Nature (1977) 14.15
Two genes in the major histocompatibility complex control immune response. Nature (1975) 4.08
Long-term culture of human antigen-specific cytotoxic T-cell lines. J Exp Med (1978) 3.80
Absolute macrophage dependency of T lymphocyte activation by mitogens. J Immunol (1976) 3.61
Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes. J Exp Med (1974) 3.54
In vitro generation of tumor-specific cytotoxic lymphocytes. Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells. J Exp Med (1977) 3.11
Molecular and quantitative analysis of helper T cell-replacing factors on the induction of antigen-sensitive B and T lymphocytes. J Immunol (1979) 2.79
Biochemical relationship of thymocyte mitogenic factor and factors enhancing humoral and cell-mediated immune responses. J Immunol (1978) 2.28
A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors. J Exp Med (1977) 2.18
Effects of costimulator on immune responses in vitro. J Immunol (1978) 2.06
The purification and quantitation of helper T cell-replacing factors secreted by murine spleen cells activated by concanavalin A. J Immunol (1979) 1.95
Letter: T cell-dependent mediator in the immune response. Nature (1973) 1.94
The effect of T cell growth factor on the generation of cytolytic T cells. J Immunol (1978) 1.92
Proliferation of murine thymic lymphocytes in vitro is mediated by the concanavalin A-induced release of a lymphokine (costimulator). J Immunol (1976) 1.92
Characterization of lymphocyte-activating factor (LAF) produced by a macrophage cell line, P388D1. II. Biochemical characterization of LAF induced by activated T cells and LPS. J Immunol (1978) 1.92
Reconstitution of the antibody response in vitro of T cell-deprived spleen cells by supernatants from spleen cell cultures. J Immunol (1972) 1.73
Further studies on the thymocyte stimulating factor. Cell Immunol (1976) 1.71
Antigen-specific and nonspecific mediators of T cell/B cell cooperation. III. Characterization of the nonspecific mediator(s) from different sources. J Immunol (1976) 1.69
T cell-dependent mediator in the immune response. II. Physical and biological properties. Immunology (1974) 1.65
Helper T cell-replacing factors secreted by thymus-derived cells and macrophages: cellular requirements for B cell activation and synergistic properties. J Immunol (1979) 1.59
In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L. Eur J Immunol (1977) 1.56
Biochemical relationship between murine immune interferon and a killer cell helper factor. J Immunol (1979) 1.29
In vitro analysis of allogeneic lymphocyte interaction. I. Characterization and cellular origin of an Ia-positive helper factor-allogeneic effect factor. J Exp Med (1977) 1.26
Partial characterization and purification of murine T cell-replacing factor, TRF. II. Biochemical characteristics. Immunochemistry (1978) 1.20
Evidence for the identification of lymphocyte activating factor as the adherent cell-derived mediator responsible for enhanced antibody synthesis by nude mouse spleen cells. Cell Immunol (1978) 1.16
Activation of T and B lymphocytes in vitro. VI. Biochemical and physicochemical characterization of the allogeneic effect factor. J Immunol (1977) 1.09
Basis for the probit analysis of an interferon plaque reduction assay. J Gen Virol (1972) 0.99
Generation of T helper cells in vitro. III. Helper cell culture-derived factors are related to alloantigens coded for the I region of the H-2 major histocompatibility complex. J Immunol (1977) 0.99
Helper T cells are required for the polyclonal stimulation of cytotoxic T cells by concanavalin A. J Exp Med (1977) 0.98
T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol (1978) 28.92
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T cell growth factor receptors. Quantitation, specificity, and biological relevance. J Exp Med (1981) 10.66
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature (1985) 9.94
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature (1982) 9.42
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Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2. J Immunol (1984) 5.51
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Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver--conditioned medium. Cell (1990) 3.66
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ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes Dev (1999) 3.45
Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. J Immunol (1979) 3.32
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Cloning, sequence and expression of human interleukin-2 receptor. Nature (1985) 3.02
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Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE). J Immunol (1983) 2.95
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