Dynamics of trimethoprim bound to dihydrofolate reductase.

Sequence-specific interaction of Hoechst 33258 with the minor groove of an adenine-tract DNA duplex studied in solution by 1H NMR spectroscopy. Nucleic Acids Res (1990) 1.07

Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate. Protein Sci (1999) 0.83

Effects of fluorine substitution on the structure and dynamics of complexes of dihydrofolate reductase (Escherichia coli). Biophys J (1997) 0.81

The effect of hydration on the dynamics of trimethoprim bound to dihydrofolate reductase. A deuterium NMR study. Biophys J (1993) 0.75

Identification of cellular targets of a series of boron heterocycles using TIPA II-A sensitive target identification platform. Bioorg Med Chem (2016) 0.75

Temperature-dependent X-ray diffraction as a probe of protein structural dynamics. Nature (1979) 9.27

Hydrogen exchange and structural dynamics of proteins and nucleic acids. Q Rev Biophys (1983) 9.14

Dynamics of proteins: elements and function. Annu Rev Biochem (1983) 4.56

Protein normal-mode dynamics: trypsin inhibitor, crambin, ribonuclease and lysozyme. J Mol Biol (1985) 4.56

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. J Biol Chem (1982) 3.84

Dynamics of ligand binding to heme proteins. J Mol Biol (1979) 3.35

Dynamical theory of activated processes in globular proteins. Proc Natl Acad Sci U S A (1982) 2.94

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim. J Biol Chem (1985) 1.62

Characterization of the distribution of internal motions in the basic pancreatic trypsin inhibitor using a large number of internal NMR probes. Q Rev Biophys (1983) 1.61

The crystal and molecular structure of the antifolate drug trimethoprim (2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine). A neutron diffraction study. J Am Chem Soc (1976) 1.58

Binding of flexible ligands to macromolecules. Nature (1975) 1.45

Functional significance of flexibility in proteins. Biopolymers (1983) 1.36

Mobility of polypeptide chain in the pyruvate dehydrogenase complex revealed by proton NMR. Nature (1981) 1.35

NMR investigations of the dynamics of the aromatic amino acid residues in the basic pancreatic trypsin inhibitor. FEBS Lett (1975) 1.30

Large-scale purification and characterization of dihydrofolate reductase from a methotrexate-resistant strain of Lactobacillus casei. Biochem J (1976) 1.24

Large-scale rotational motions of proteins detected by electron paramagnetic resonance and fluorescence. Biophys J (1978) 1.19

Proton magnetic resonance studies of the tyrosine residues of hen lysozyme-assignment and detection of conformational mobility. Proc R Soc Lond B Biol Sci (1975) 1.15

Unusual segmental flexibility in a region of tobacco mosaic virus coat protein. Nature (1978) 1.08

Inhibition of dihydrofolate reductase: effect of reduced nicotinamide adenine dinucleotide phosphate on the selectivity and affinity of diaminobenzylpyrimidines. Biochemistry (1982) 1.06

Binding of coenzyme analogues to Lactobacillus casei dihydrofolate reductase: binary and ternary complexes. Biochemistry (1980) 1.01

Dihydrofolate reductase. 1H resonance assignments and coenzyme-induced conformational changes. J Mol Biol (1986) 0.96

Molecular flexibility in microtubule proteins: proton nuclear magnetic resonance characterization. Biochemistry (1983) 0.91

Protonated state of methotrexate, trimethoprim, and pyrimethamine bound to dihydrofolate reductase. Arch Biochem Biophys (1983) 0.90

1H and 15N NMR studies of protonation and hydrogen-bonding in the binding of trimethoprim to dihydrofolate reductase. Eur Biophys J (1985) 0.88

Nuclear magnetic resonance studies of selectively hindered internal motion of substrate analogs at the active site of pyruvate kinase. Biochemistry (1972) 0.86

19F-n.m.r. studies of 3',5'-difluoromethotrexate binding to Lactobacillus casei dihydrofolate reductase. Molecular motion and coenzyme-induced conformational changes. Biochem J (1984) 0.86

The binding of trimethoprim to bacterial dihydrofolate reductase. FEBS Lett (1981) 0.84

Nuclear magnetic resonance studies of the binding of trimethoprim to dihydrofolate reductase. Biochemistry (1979) 0.81

Effects of coenzyme analogues on the binding of p-aminobenzoyl-L-glutamate and 2,4-diaminopyrimidine to Lactobacillus casei dihydrofolate reductase. Biochemistry (1980) 0.81

Hydrogen-1 nuclear magnetic resonance study of the complexes of two diastereoisomers of folinic acid with dihydrofolate reductase. Biochemistry (1981) 0.80

Trimethoprim binding to Lactobacillus casei dihydrofolate reductase: a 13C NMR study using selectively 13C-enriched trimethoprim. Biochemistry (1986) 0.79

The charge state of trimethoprim bound to Lactobacillus casei dihydrofolate reductase. FEBS Lett (1981) 0.77

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev (1994) 2.96

"Cross-beta" conformation in proteins. J Mol Biol (1968) 2.83

Food production and the energy crisis. Science (1973) 2.55

Effects of adrenaline on human blood platelets. J Physiol (1967) 2.38

N.m.r. and molecular-modelling studies of the solution conformation of heparin. Biochem J (1993) 2.36

Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon. RNA (1998) 2.18

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev (1994) 2.16

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance. J Mol Biol (1997) 2.16

The plurality of long chain isoprenoid alcohols (polyprenols) from natural sources. Biochim Biophys Acta (1967) 2.07

The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation. J Physiol (1968) 1.97

Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91

Nuclear magnetic resonance spectroscopy of amino acids, peptides, and proteins. Adv Protein Chem (1970) 1.89

Conformation and dynamics of heparin and heparan sulfate. Glycobiology (2000) 1.88

Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum. J Mol Biol (2001) 1.87

Intracellular calcium measurements by 19F NMR of fluorine-labeled chelators. Proc Natl Acad Sci U S A (1983) 1.77

Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch Biochem Biophys (1996) 1.70

Nuclear magnetic resonance spectrometry of naturally occurring polyprenols. Anal Biochem (1967) 1.63

Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1. J Mol Biol (1999) 1.61

The mechanism of action of ribonuclease. Proc Natl Acad Sci U S A (1969) 1.51

Mapping the binding site for matrix metalloproteinase on the N-terminal domain of the tissue inhibitor of metalloproteinases-2 by NMR chemical shift perturbation. Biochemistry (1997) 1.50

Binding of flexible ligands to macromolecules. Nature (1975) 1.45

Ischemic sinus node hibernation: resolution following angioplasty. Am Heart J (1991) 1.43

Photolabile precursors of inositol phosphates. Preparation and properties of 1-(2-nitrophenyl)ethyl esters of myo-inositol 1,4,5-trisphosphate. Biochemistry (1989) 1.43

Correction for light absorption in fluorescence studies of protein-ligand interactions. Anal Biochem (1983) 1.40

Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin. Biochemistry (1974) 1.40

Frontal lobe volume in patients with Huntington's disease. Neurology (1998) 1.38

Influences on the ethical beliefs of graduate students concerning research. Sci Eng Ethics (2001) 1.37

Mobility of polypeptide chain in the pyruvate dehydrogenase complex revealed by proton NMR. Nature (1981) 1.35

The catalytic mechanism of cytochrome P450 BM3 involves a 6 A movement of the bound substrate on reduction. Nat Struct Biol (1996) 1.32

Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med (1998) 1.32

The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme. Proc Natl Acad Sci U S A (1996) 1.26

The conformation of acetylcholine and related compounds in aqueous solution as studied by nuclear magnetic resonance spectroscopy. Mol Pharmacol (1972) 1.24

Large-scale purification and characterization of dihydrofolate reductase from a methotrexate-resistant strain of Lactobacillus casei. Biochem J (1976) 1.24

Acromegaly. Clinical and biochemical features in 500 patients. Medicine (Baltimore) (1994) 1.24

Protein-ligand interactions: exchange processes and determination of ligand conformation and protein-ligand contacts. Methods Enzymol (1994) 1.22

Nuclear magnetic resonance studies of the structure and binding sites of enzymes. 8. Inhibitor binding to ribonuclease. J Mol Biol (1969) 1.21

Direct measurement of the pK values of an alkaline Bohr group in human hemoglobin. Proc Natl Acad Sci U S A (1973) 1.21

Structure revision of the antibiotic echinomycin. J Am Chem Soc (1975) 1.21

Ca2+ coordination to backbone carbonyl oxygen atoms in calmodulin and other EF-hand proteins: 15N chemical shifts as probes for monitoring individual-site Ca2+ coordination. Biochemistry (1998) 1.20

Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family. Biochemistry (1994) 1.18

Limited proteolysis and proton n.m.r. spectroscopy of the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli. Biochem J (1981) 1.18

Solution structures of nisin A and its two major degradation products determined by n.m.r. Biochem J (1992) 1.16

The PRINTS database of protein fingerprints: a novel information resource for computational molecular biology. J Chem Inf Comput Sci (1997) 1.16

Effects of coenzyme Q10 and alpha-tocopherol administration on their tissue levels in the mouse: elevation of mitochondrial alpha-tocopherol by coenzyme Q10. Free Radic Biol Med (1999) 1.13

Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains. Biochemistry (2001) 1.13

31P-n.m.r. studies on cerebral energy metabolism under conditions of hypoglycaemia and hypoxia in vitro. Biochem J (1983) 1.13

The solution structure of the bovine S100B protein dimer in the calcium-free state. Structure (1996) 1.12

Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. J Biol Chem (2001) 1.12

Conformational studies of oxytocin and lysine vasopressin in aqueous solution using high resolution NMR spectroscopy. Nat New Biol (1971) 1.11

Role of transmembrane pH gradient and membrane binding in nisin pore formation. J Bacteriol (1997) 1.11

High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3. J Biol Chem (1998) 1.11

Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution. Protein Sci (1999) 1.10

Molecular analysis of the regulation of nisin immunity. Microbiology (1996) 1.10

Adhesion of lymphoid cell lines to fibronectin-coated substratum: biochemical and physiological characterization and the identification of a 140-kDa fibronectin receptor. Exp Cell Res (1987) 1.09

Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin. FEBS Lett (1996) 1.08

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding. Biochemistry (1996) 1.08

Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI. J Mol Biol (2001) 1.08

Imaging of acute pyelonephritis in the adult. Eur Radiol (2006) 1.08

A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei. Biochemistry (1989) 1.06

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. Structure (1997) 1.06

High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein. J Mol Biol (1997) 1.06

Mass-spectrometric determination of the amino acid sequences in peptides isolated from the protein silk fibroin of Bombyx mori. Biochem J (1969) 1.04

1H-NMR studies at 500 MHz of a neutral disaccharide and sulphated di-, tetra-, hexa- and larger oligosaccharides obtained by endo-beta-galactosidase treatment of keratan sulphate. Eur J Biochem (1986) 1.04

Structure-activity relationships in the peptide antibiotic nisin: role of dehydroalanine 5. Appl Environ Microbiol (1996) 1.04

Sequential 1H NMR assignments and secondary structure of an IgG-binding domain from protein G. Biochemistry (1991) 1.03

Anti-HIV-1 activity of chemically modified heparins: correlation between binding to the V3 loop of gp120 and inhibition of cellular HIV-1 infection in vitro. Biochemistry (1994) 1.03

Adhesion of lymphoid cells to the carboxyl-terminal heparin-binding domains of fibronectin. Exp Cell Res (1989) 1.02

Binding of coenzyme analogues to Lactobacillus casei dihydrofolate reductase: binary and ternary complexes. Biochemistry (1980) 1.01

The effect of a respiratory home nurse intervention in patients with chronic obstructive pulmonary disease (COPD). Aust N Z J Med (1999) 1.01

Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents. Psychopharmacology (Berl) (2001) 1.00

Determination of the solution structures of domains II and III of protein G from Streptococcus by 1H nuclear magnetic resonance. J Mol Biol (1992) 1.00

NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam. Biochemistry (1995) 1.00

Proton nuclear magnetic resonance study of the self-complementary hexanucleotide d(pTpA)3 and its interaction with daunomycin. Biochemistry (1980) 1.00

Effect of age and caloric restriction on bleomycin-chelatable and nonheme iron in different tissues of C57BL/6 mice. Free Radic Biol Med (1999) 0.99

Expression of deuterium-isotope-labelled protein in the yeast pichia pastoris for NMR studies. J Biomol NMR (2000) 0.99

Association of Perthes' disease with congenital anomalies of genitourinary tract and inguinal region. Lancet (1971) 0.99

Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. J Med Chem (1996) 0.99

Mechanism of lantibiotic-induced pore-formation. Antonie Van Leeuwenhoek (1996) 0.99

Domain structure and 1H-n.m.r. spectroscopy of the pyruvate dehydrogenase complex of Bacillus stearothermophilus. Biochem J (1984) 0.99

Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. J Med Chem (1992) 0.98

In vivo and in vitro metabolism of gomphoside, a cardiotonic steroid with doubly-linked sugar. J Steroid Biochem (1987) 0.98

The effect of variation of substitution on the solution conformation of heparin: a spectroscopic and molecular modelling study. Carbohydr Res (1994) 0.98

Interaction of the lantibiotic nisin with mixed lipid bilayers: a 31P and 2H NMR study. Biochemistry (2000) 0.97

19 Fnuclear magnetic resonance studies of ligand binding to 3-fluorotyrosine-and 6-fluorotryptophan-containing dihydrofolate reductase from Lactobacillus casei. Biochemistry (1977) 0.97

Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein. Proc Natl Acad Sci U S A (1994) 0.96

A social cognitive approach to burnout in elite athletes. Scand J Med Sci Sports (2007) 0.96

Sexual risk behavior, alcohol use, and social media use among secondary school students in informal settlements in Cape Town and Port Elizabeth, South Africa. AIDS Behav (2014) 0.96

Dihydrofolate reductase. 1H resonance assignments and coenzyme-induced conformational changes. J Mol Biol (1986) 0.96