Published in J Biol Chem on April 05, 1987
The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II. EMBO J (1990) 2.38
S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment. Proc Natl Acad Sci U S A (1988) 1.88
Phosphorylation of the catalytic subunit of Na+,K(+)-ATPase inhibits the activity of the enzyme. Proc Natl Acad Sci U S A (1991) 1.66
Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals. Proc Natl Acad Sci U S A (1989) 1.40
p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. Mol Cell Biol (1990) 1.28
Protein kinase C and cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain. Biochem J (1994) 1.24
Studies on the phosphorylation of protein kinase C-alpha. Biochem J (1992) 1.22
Specificity of protein kinase inhibitor peptides and induction of long-term potentiation. Proc Natl Acad Sci U S A (1994) 1.18
The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells. Mol Med (1997) 1.11
Isolation and characterization of protein kinase C from Y-1 adrenal cell cytoskeleton. J Cell Biol (1989) 1.04
Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites. Proc Natl Acad Sci U S A (1989) 1.00
Protein kinase C and cAMP-dependent protein kinase phosphorylate the beta subunit of the purified gamma-aminobutyric acid A receptor. Proc Natl Acad Sci U S A (1990) 0.99
Phosphorylation of the RAS2 gene product by protein kinase A inhibits the activation of yeast adenylyl cyclase. Proc Natl Acad Sci U S A (1988) 0.97
Occurrence of immunoreactive 80 kDa and non-immunoreactive diacylglycerol kinases in different pig tissues. Biochem J (1988) 0.96
Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system. Proc Natl Acad Sci U S A (1996) 0.95
Phosphorylation of diacylglycerol kinase in vitro by protein kinase C. Biochem J (1989) 0.92
Phosphorylation of synthetic random polypeptides by protein kinase P and other protein-serine (threonine) kinases and stimulation or inhibition of kinase activities by microbial toxins. Proc Natl Acad Sci U S A (1988) 0.91
Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C. J Biol Chem (2006) 0.91
Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K(+)-ATPase affects its conformational equilibrium. Proc Natl Acad Sci U S A (1996) 0.90
Specific dephosphorylation of phosphoproteins by protein-serine and -tyrosine kinases. Proc Natl Acad Sci U S A (1988) 0.89
Brain protein kinase C phosphorylating poly(arginine,serine) or lamin B is stimulated by anions and by an activator purified from bovine serum albumin preparations. Proc Natl Acad Sci U S A (1989) 0.86
The major phosphorylation site of the NADPH oxidase component p67phox is Thr233. Biochem J (1999) 0.86
Decreased susceptibility of a 70-kDa protein to cathepsin L after phosphorylation by protein kinase C. Proc Natl Acad Sci U S A (1989) 0.84
Purification and characterization of calponin phosphatase from smooth muscle. Effect of dephosphorylation on calponin function. Biochem J (1992) 0.84
Activation of the plasma membrane chloride channel by protein kinase C in isolated guinea-pig hepatocytes. J Physiol (1995) 0.83
Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. Eur J Pharmacol (2008) 0.83
Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A. PLoS One (2011) 0.83
Dihydropyridine-sensitive skeletal muscle Ca channels in polarized planar bilayers. 3. Effects of phosphorylation by protein kinase C. Biophys J (1992) 0.82
Purification and characterization of protein kinase C from the nematode Caenorhabditis elegans. Biochem J (1992) 0.82
Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells. Cell Growth Differ (1995) 0.79
Circular dichroism analysis of ligand-induced conformational changes in protein kinase C. Mechanism of translocation of the enzyme from the cytosol to the membranes and its implications. Biochem J (1993) 0.77
Characterization of 6-phosphofructo-2-kinase from foetal-rat liver. Biochem J (1992) 0.75
Mitogen-induced phosphorylation of human B-lymphocyte proteins. Relationship to protein kinase C activation. Biochem J (1989) 0.75
Purification and characterization of protein kinase C from rabbit iris smooth muscle. Myosin light-chain phosphorylation in vitro and in intact muscle. Biochem J (1988) 0.75
In vitro polyoma DNA synthesis: inhibition by 1-beta-d-arabinofuranosyl CTP. J Virol (1975) 57.17
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
The protein kinase complement of the human genome. Science (2002) 35.36
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A (1980) 22.30
Oncogenic kinase signalling. Nature (2001) 16.30
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol (1991) 15.04
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Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J (1995) 14.45
Detection and quantification of phosphotyrosine in proteins. Methods Enzymol (1983) 11.89
The stress-activated protein kinase subfamily of c-Jun kinases. Nature (1994) 11.45
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell (1994) 8.90
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature (2000) 8.37
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature (1985) 8.36
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (1995) 8.25
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell (1989) 8.19
Phosphorylation of c-jun mediated by MAP kinases. Nature (1991) 8.07
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A (1999) 7.70
A thousand and one protein kinases. Cell (1987) 7.61
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science (1999) 7.60
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature (1988) 7.45
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature (1990) 7.34
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol (1991) 7.18
An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Cell (1979) 7.02
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol (1996) 6.88
Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell (1989) 6.88
Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus. Cell (1980) 6.76
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell (1988) 6.75
Characterization of Rous sarcoma virus src gene products synthesized in vitro. J Virol (1978) 6.39
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J (1998) 6.28
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature (1995) 6.20
Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. Cell (1981) 5.74
Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells. Mol Cell Biol (1981) 5.67
Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo. J Virol (1978) 5.30
Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol (1994) 5.24
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell (1981) 5.08
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature (1995) 5.00
Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science (1986) 4.99
A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature (1996) 4.65
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol (1996) 4.61
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J (1997) 4.39
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. Nature (1984) 4.27
Structural basis for phosphoserine-proline recognition by group IV WW domains. Nat Struct Biol (2000) 4.25
Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell (1997) 4.24
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem (1984) 4.20
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature (1995) 4.14
Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell (1991) 3.98
C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem (1984) 3.88
Characterization of T antigens in polyoma-infected and transformed cells. Cell (1978) 3.76
Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant Physiol (2000) 3.73
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell (1992) 3.64
Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. Biochem J (1994) 3.62
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol (1995) 3.61
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A (2000) 3.61
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J (1993) 3.51
Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. Eur J Biochem (1986) 3.37
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proc Natl Acad Sci U S A (1982) 3.28
A tail of two src's: mutatis mutandis. Cell (1987) 3.28
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Temperature-sensitive transformation by Rous sarcoma virus and temperature-sensitive protein kinase activity. J Virol (1980) 3.25
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc Natl Acad Sci U S A (2001) 3.24
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol Cell Biol (1996) 3.21
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem (1991) 3.17
PKB/AKT: functional insights from genetic models. Nat Rev Mol Cell Biol (2001) 3.15
cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. EMBO J (1989) 3.10
Glycogen synthase kinase-3: functions in oncogenesis and development. Biochim Biophys Acta (1992) 3.02
Role of methionine in the initiation of haemoglobin synthesis. Nature (1970) 3.02
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J (1995) 2.96
Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. EMBO J (1996) 2.93
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins. Cell (1982) 2.92
Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol (1999) 2.91
Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins. Mol Cell Biol (1981) 2.88
Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J (1991) 2.86
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ (2001) 2.85
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci Lett (1992) 2.85
Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat Struct Biol (2000) 2.85
The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates. J Biol Chem (1975) 2.84
Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol (1998) 2.83
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol (1997) 2.83
PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell (1998) 2.83
Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science (1997) 2.74
The stress-activated protein kinase pathways. Cell Mol Life Sci (1999) 2.72
NeW wrinkles for an old domain. Cell (2000) 2.72
Product of in vitro translation of the Rous sarcoma virus src gene has protein kinase activity. J Virol (1979) 2.72
Transcription. A growing coactivator network. Nature (1996) 2.71
c-rel activates but v-rel suppresses transcription from kappa B sites. Proc Natl Acad Sci U S A (1991) 2.65
Protein kinase C phosphorylates pp60src at a novel site. Cell (1985) 2.63
The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein. J Cell Biol (1986) 2.63
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell (1992) 2.62
Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes. J Biol Chem (1992) 2.57
In vitro polyoma DNA synthesis: characterization of a system from infected 3T3 cells. J Virol (1974) 2.52
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol (1998) 2.52
Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med (2000) 2.51
The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms. Proc Natl Acad Sci U S A (1999) 2.51
trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol Cell Biol (1991) 2.48