Published in Nucleic Acids Res on December 01, 1978
The HBV HBX gene expressed in E. coli is recognised by sera from hepatitis patients. EMBO J (1985) 1.45
Point mutations change the thermal denaturation profile of a short DNA fragment containing the lactose control elements. Comparison between experiment and theory. EMBO J (1982) 1.37
Cloning and surface expression in Escherichia coli of a structural gene encoding a surface protein of Haemophilus influenzae type b. Infect Immun (1985) 1.21
Expression of herpes simplex virus type I thymidine kinase gene in Escherichia coli. Proc Natl Acad Sci U S A (1981) 0.97
Chromogenic identification of oligonucleotide-directed mutants. Nucleic Acids Res (1986) 0.83
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Gene (1977) 114.87
A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J Mol Biol (1975) 90.35
Functional expression of cloned yeast DNA in Escherichia coli. Proc Natl Acad Sci U S A (1977) 12.89
A bacterial clone synthesizing proinsulin. Proc Natl Acad Sci U S A (1978) 10.23
An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA. Cell (1977) 9.44
Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Science (1977) 9.28
Functional genetic expression of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A (1976) 8.92
The rabbit beta-globin gene contains a large large insert in the coding sequence. Cell (1977) 6.45
Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences. Proc Natl Acad Sci U S A (1977) 4.64
An improved bacteriophage lambda vector: construction of model recombinants coding for kanamycin resistance. Gene (1977) 3.94
Nucleotide sequence from the coat protein cistron of R17 bacteriophage RNA. Nature (1969) 3.23
Expression in Escherichia coli K-12 of the structural gene for catabolic dehydroquinase of Neurospora crassa. Proc Natl Acad Sci U S A (1977) 3.11
Synthesis of an ovalbumin-like protein by Escherichia coli K12 harbouring a recombinant plasmid. Nature (1978) 1.82
The use of specialised transducing phages in the amplification of enzyme production. Mol Gen Genet (1976) 1.32
Propagation in E. coli of bacteriophage lambda with integrated fragments of adenovirus 2 DNA. Gene (1976) 0.99
Viral messenger structure: some surprising new developments. Science (1977) 0.84
Life with 6000 genes. Science (1996) 41.51
Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature (1979) 15.42
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
The hepatitis B virus. Nature (1985) 8.71
Nucleotide sequence of a cloned duck hepatitis B virus genome: comparison with woodchuck and human hepatitis B virus sequences. J Virol (1984) 8.32
Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses. Nature (1987) 7.96
Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus. Cell (1985) 7.86
Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses. Nature (1979) 6.60
Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. Science (1991) 6.28
The gene for polypeptide IX of adenovirus type 2 and its unspliced messenger RNA. Cell (1980) 5.80
Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature (1990) 5.50
Nucleotide sequence of a cloned woodchuck hepatitis virus genome: comparison with the hepatitis B virus sequence. J Virol (1982) 5.48
Messenger RNA for the Ad2 DNA binding protein: DNA sequences encoding the first leader and heterogenity at the mRNA 5' end. Cell (1979) 5.28
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12
Identification of a second human retinoic acid receptor. Nature (1988) 5.11
Biology of hepatitis B virus. Science (1981) 4.93
Recognition and cleavage site of the intron-encoded omega transposase. Proc Natl Acad Sci U S A (1988) 4.92
Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med (1999) 4.92
Cloning in Escherichia coli and physical structure of hepatitis B virion DNA. Proc Natl Acad Sci U S A (1979) 4.71
Direct determination of DNA nucleotide sequences: structure of a fragment of bacteriophage phiX172 DNA. J Mol Biol (1974) 4.71
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev (2001) 4.68
Widespread long-term gene transfer to mouse skeletal muscles and heart. J Clin Invest (1992) 4.43
Bacteriophage lambda having EcoRI endonuclease sites only in the nonessential region of the genome. Proc Natl Acad Sci U S A (1974) 4.35
Nucleotide sequence of the EcoRI D fragment of adenovirus 2 genome. Nucleic Acids Res (1980) 4.34
Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc Natl Acad Sci U S A (1988) 4.08
Krox-20 controls myelination in the peripheral nervous system. Nature (1994) 4.04
A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J (1988) 3.98
Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA. Proc Natl Acad Sci U S A (1980) 3.97
Determination of the nucleotide sequence of a fragment of bacteriophage phiX 174 DNA. Nat New Biol (1973) 3.74
A spliced Epstein-Barr virus gene expressed in immortalized lymphocytes is created by circularization of the linear viral genome. EMBO J (1988) 3.69
Base sequence discrimination by zinc-finger DNA-binding domains. Nature (1991) 3.61
Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells. J Virol (1987) 3.56
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci (2001) 3.56
Transcription of the hepatitis B surface antigen gene in mouse cells transformed with cloned viral DNA. J Virol (1982) 3.51
Universal code equivalent of a yeast mitochondrial intron reading frame is expressed into E. coli as a specific double strand endonuclease. Cell (1986) 3.48
Nucleotide sequence of adenovirus 2 DNA fragment encoding for the carboxylic region of the fiber protein and the entire E4 region. Nucleic Acids Res (1981) 3.31
Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases. Proc Natl Acad Sci U S A (1984) 3.21
Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature (1980) 3.16
Spliced RNA from the IR1-U2 region of Epstein-Barr virus: presence of an open reading frame for a repetitive polypeptide. EMBO J (1984) 3.12
Detection of hepatitis B virus DNA in serum by a simple spot hybridization technique: comparison with results for other viral markers. Hepatology (1983) 3.11
A promoter for the highly spliced EBNA family of RNAs of Epstein-Barr virus. J Virol (1987) 3.10
Evaluation of the transfer and expression in mice of an enzyme-encoding gene using a human adenovirus vector. Hum Gene Ther (1990) 3.04
Biosynthesis of hepatitis B virus surface antigen in Escherichia coli. Nature (1980) 3.00
Epstein-Barr virus mRNAs produced by alternative splicing. Nucleic Acids Res (1986) 2.94
Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies. Proc Natl Acad Sci U S A (1980) 2.88
New recA mutations that dissociate the various RecA protein activities in Escherichia coli provide evidence for an additional role for RecA protein in UV mutagenesis. J Bacteriol (1989) 2.87
Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021. Proc Natl Acad Sci U S A (2001) 2.83
An Epstein-Barr virus transcription unit is at least 84 kilobases long. Nucleic Acids Res (1986) 2.83
Detection of hepatitis B virus DNA in liver and serum: a direct appraisal of the chronic carrier state. Lancet (1981) 2.80
An adenovirus vector for gene transfer into neurons and glia in the brain. Science (1993) 2.79
Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes. Cell (1982) 2.78
The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell (1983) 2.75
Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice. Nature (1993) 2.73
Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nat Genet (1993) 2.67
The expression of cytokine and cytokine receptor genes in long-term bone marrow culture in congenital and acquired bone marrow hypoplasias. Br J Haematol (1993) 2.66
Nucleotide sequence and expression of the diphtheria tox228 gene in Escherichia coli. Science (1983) 2.65
Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level. Proc Natl Acad Sci U S A (1984) 2.64
Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet (1992) 2.63
Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours. Nature (1990) 2.61
Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid. Proc Natl Acad Sci U S A (2001) 2.59
Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon. EMBO J (1984) 2.55
Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells. Mol Cell Biol (1985) 2.54
Transcription of woodchuck hepatitis virus in the chronically infected liver. EMBO J (1985) 2.49
The cytoplasmic domain of simian immunodeficiency virus transmembrane protein modulates infectivity. J Virol (1989) 2.46
Localization on the viral genome and nucleotide sequence of the gene coding for the two major polypeptides of the hepatitis B surface antigen (HBs Ag). Nucleic Acids Res (1979) 2.42
Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes. EMBO J (1989) 2.41
Structure of two adenovirus type 12 transforming polypeptides and their evolutionary implications. Nature (1980) 2.38
State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases. Proc Natl Acad Sci U S A (1981) 2.37
Molecular cloning of lymphadenopathy-associated virus. Nature (1985) 2.22
Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature (1986) 2.21
In vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses. EMBO J (1985) 2.18
Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen. Science (1985) 2.18
Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse. Nature (1989) 2.18
Nucleotide sequence of the EcoRI-F fragment of adenovirus 2 genome. Gene (1979) 2.17
Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell (1993) 2.17
The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene. EMBO J (1990) 2.12
Recombinational construction in Escherichia coli of infectious adenoviral genomes. Proc Natl Acad Sci U S A (1997) 2.10
Transcriptional regulation of globin gene expression in the human erythroid cell line K562. Science (1983) 2.08
Expression pattern of a Krox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system. Genesis (2000) 2.06
Characterization of a mouse multigene family that encodes zinc finger structures. Mol Cell Biol (1988) 2.05
The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator. Mol Cell Biol (1990) 2.04
The E4 transcriptional unit of Ad2: far upstream sequences are required for its transactivation by E1A. Nucleic Acids Res (1984) 2.02
Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem Biophys Res Commun (1987) 2.01
Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation. Nature (1987) 2.00
Synthesis in animal cells of hepatitis B surface antigen particles carrying a receptor for polymerized human serum albumin. Proc Natl Acad Sci U S A (1984) 2.00
Identification in chickens of an evolutionarily conserved cellular ets-2 gene (c-ets-2) encoding nuclear proteins related to the products of the c-ets proto-oncogene. EMBO J (1988) 1.99
A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature (1988) 1.96
Transmission of hepatitis B from hepatitis-B-seronegative subjects. Lancet (1988) 1.95