Published in Cell on February 01, 1983
Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences. Genome Res (2005) 7.09
Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA. Proc Natl Acad Sci U S A (1984) 4.16
Molecular analysis of the human beta-globin locus activation region. Proc Natl Acad Sci U S A (1989) 3.17
Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector. Mol Cell Biol (1987) 2.77
Developmentally regulated expression of chimeric genes containing muscle actin DNA sequences in transfected myogenic cells. EMBO J (1984) 2.60
Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells. Proc Natl Acad Sci U S A (1983) 2.57
The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J (1988) 2.54
Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells. Mol Cell Biol (1985) 2.54
Regulation of transcription by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1989) 2.33
Expression and regulation of chicken actin genes introduced into mouse myogenic and nonmyogenic cells. Proc Natl Acad Sci U S A (1984) 2.26
High-level erythroid expression of human alpha-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1989) 2.26
Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Mol Cell Biol (1992) 2.14
Partial purification of a nuclear protein that binds to the CCAAT box of the mouse alpha 1-globin gene. Mol Cell Biol (1986) 2.04
Tissue restricted and stage specific transcription is maintained within 411 nucleotides flanking the 5' end of the chicken alpha-skeletal actin gene. Nucleic Acids Res (1986) 1.83
Cell-specified expression of a selectable hybrid gene. Proc Natl Acad Sci U S A (1984) 1.74
Regulatory elements involved in Drosophila Adh gene expression are conserved in divergent species and separate elements mediate expression in different tissues. EMBO J (1986) 1.68
Use of a cell cycle mutant to delineate the critical period for the control of histone mRNA levels in the mammalian cell cycle. Mol Cell Biol (1984) 1.57
Developmentally regulated expression of a chicken muscle-specific gene in stably transfected rat myogenic cells. Proc Natl Acad Sci U S A (1985) 1.54
Promoter sequences required for function of the human gamma globin gene in erythroid cells. EMBO J (1986) 1.47
Expression of the human beta-globin gene after retroviral transfer into murine erythroleukemia cells and human BFU-E cells. Mol Cell Biol (1988) 1.45
DNA sequences involved in transcriptional regulation of the mouse beta-globin promoter in murine erythroleukemia cells. Mol Cell Biol (1988) 1.45
An erythroid specific nuclear factor binding to the proximal CACCC box of the beta-globin gene promoter. Nucleic Acids Res (1988) 1.45
Discrimination among potential activators of the beta-globin CACCC element by correlation of binding and transcriptional properties. Mol Cell Biol (1993) 1.43
A negative regulatory sequence near the mouse beta-maj globin gene associated with a region of potential Z-DNA. EMBO J (1984) 1.40
Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells. Mol Cell Biol (1987) 1.35
Identification and characterization of multiple erythroid cell proteins that interact with the promoter of the murine alpha-globin gene. Mol Cell Biol (1988) 1.29
Differential expression of human globin genes introduced in K562 cells. EMBO J (1985) 1.25
Lens-specific promoter activity of a mouse gamma-crystallin gene. Mol Cell Biol (1985) 1.24
Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: analysis of the requirement for upstream factor-binding sites and initiation site sequences. Mol Cell Biol (1991) 1.17
Transfer of genes into hematopoietic cells using recombinant DNA viruses. Proc Natl Acad Sci U S A (1985) 1.12
Definition of the ovalbumin gene promoter by transfer of an ovalglobin fusion gene into cultured cells. Nucleic Acids Res (1983) 1.08
Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers. Mol Cell Biol (1987) 1.04
The proximal element of the beta globin locus control region is not functionally required in vivo. J Clin Invest (1991) 1.03
A naturally occurring gamma globin gene mutation enhances SP1 binding activity. Mol Cell Biol (1990) 1.02
Tissue-specific DNase I hypersensitive sites in a foreign globin gene in transgenic mice. Nucleic Acids Res (1986) 1.01
A directly repeated sequence in the beta-globin promoter regulates transcription in murine erythroleukemia cells. Mol Cell Biol (1990) 1.01
DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11. Proc Natl Acad Sci U S A (1984) 1.01
Genetic variation in rates of antipyrine metabolite formation: a study in uninduced twins. Proc Natl Acad Sci U S A (1981) 0.98
Erythroid differentiation of mouse erythroleukemia cells results in reorganization of protein-DNA complexes in the mouse beta maj globin promoter but not its distal enhancer. Mol Cell Biol (1993) 0.97
Regulated expression of genes inserted at the human chromosomal beta-globin locus by homologous recombination. Proc Natl Acad Sci U S A (1988) 0.96
Transcriptional regulation of a tumor promoter and mitogen-inducible gene in human lymphocytes. Mol Cell Biol (1984) 0.96
Stable transfer and expression of exogenous human globin genes in human erythroleukemia (K562) cells. Proc Natl Acad Sci U S A (1984) 0.95
Gene transfer method for transient gene expression, stable transformation, and cotransformation of suspension cell cultures. Mol Cell Biol (1985) 0.95
Expression of human alpha-globin and mouse/human hybrid beta-globin genes in murine hemopoietic stem cells transduced by recombinant retroviruses. Proc Natl Acad Sci U S A (1990) 0.93
Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice. Mol Cell Biol (1989) 0.93
Human T-cell growth factor (interleukin 2) and gamma-interferon genes: expression in human T-lymphotropic virus type III- and type I-infected cells. Proc Natl Acad Sci U S A (1985) 0.90
Regulated expression of human alpha- and beta-globin genes in transient heterokaryons. Mol Cell Biol (1991) 0.89
Nuclear protein-binding sites in a transcriptional control region of the rabbit alpha-globin gene. Mol Cell Biol (1993) 0.89
Expression of transfected vimentin genes in differentiating murine erythroleukemia cells reveals divergent cis-acting regulation of avian and mammalian vimentin sequences. Mol Cell Biol (1987) 0.89
Subcellular localization of RNAs in transfected cells: role of sequences at the 5' terminus. Nucleic Acids Res (1984) 0.85
Cloned cDNA for rabbit erythrocyte carbonic anhydrase I: A novel erythrocyte-specific probe to study development in erythroid tissues. Proc Natl Acad Sci U S A (1985) 0.84
Changes in minor transcripts from the alpha 1 and beta maj globin and glutathione peroxidase genes during erythropoiesis. Nucleic Acids Res (1987) 0.83
A DNA-bending protein interacts with an essential upstream regulatory element of the human embryonic beta-like globin gene. Mol Cell Biol (1996) 0.82
Gene transfer in lymphoid cells: expression of the Thy-1.2 antigen by Thy-1.1 BW5147 lymphoma cells transfected with unfractionated cellular DNA. Proc Natl Acad Sci U S A (1984) 0.82
Functional expression of a mouse H-2Kb gene isolated from non-expressing teratocarcinoma cells. EMBO J (1984) 0.82
Transformation mapping of the regulatory elements of the ecdysone-inducible P1 gene of Drosophila melanogaster. Mol Cell Biol (1991) 0.81
Trans acting regulation of beta globin gene expression in erythroleukemia (K562) cells. Nucleic Acids Res (1985) 0.80
Adult chicken alpha-globin gene expression in transfected QT6 quail cells: evidence for a negative regulatory element in the alpha D gene region. Nucleic Acids Res (1991) 0.80
Expression of the mouse serum albumin gene introduced into differentiated and dedifferentiated rat hepatoma cells. Proc Natl Acad Sci U S A (1985) 0.78
Transfer of human and murine globin-gene sequences into transgenic mice. Am J Hum Genet (1985) 0.75
Differential expression of mouse beta/goat beta c, mouse beta/goat beta F, and mouse beta/goat epsilon II hybrid globin genes in murine erythroleukemia cells. Mol Cell Biol (1986) 0.75
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56
Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A (1975) 56.75
The isolation of structural genes from libraries of eucaryotic DNA. Cell (1978) 37.13
The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. Cell (1978) 22.88
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell (1986) 22.26
Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis. Biochemistry (1975) 22.00
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell (1991) 18.19
Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Cell (1983) 17.60
Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature (1979) 15.42
Regulation of inducible and tissue-specific gene expression. Science (1987) 15.04
Amplification and characterization of a beta-globin gene synthesized in vitro. Cell (1976) 14.99
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell (1981) 12.73
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell (1994) 11.62
The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell (1977) 11.05
Intragenic DNA spacers interrupt the ovalbumin gene. Proc Natl Acad Sci U S A (1978) 11.03
Detection and localization of single base changes by denaturing gradient gel electrophoresis. Methods Enzymol (1987) 10.90
Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell (1981) 9.81
Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei. Cell (1983) 9.77
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell (1984) 9.13
The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions. Cell (1980) 9.13
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (1990) 8.79
Visualizing an olfactory sensory map. Cell (1996) 8.79
Transcriptional activation: a complex puzzle with few easy pieces. Cell (1994) 8.63
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature (1987) 8.28
The nucleotide sequence of the human beta-globin gene. Cell (1980) 8.11
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell (1993) 8.07
Molecular cloning and characterization of the human beta-like globin gene cluster. Cell (1980) 7.77
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev (1995) 7.36
NF-kappa B: a lesson in family values. Cell (1995) 7.33
Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. Cell (1983) 7.22
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell (1995) 7.17
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell (1985) 7.16
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell (1998) 7.01
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Structure of the lambda operators. Nature (1973) 6.66
Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 6.52
Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature (1983) 6.48
A spatial map of olfactory receptor expression in the Drosophila antenna. Cell (1999) 6.42
A role for exon sequences and splice-site proximity in splice-site selection. Cell (1986) 6.41
A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature (1988) 6.39
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell (1978) 6.38
Fine structure genetic analysis of a beta-globin promoter. Science (1986) 6.36
Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Science (1985) 6.35
Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell (2000) 6.32
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature (2001) 6.26
Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature (1974) 6.22
Detection of single base substitutions in total genomic DNA. Nature (1985) 5.99
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Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell (1996) 5.91
The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene. Cell (1992) 5.85
A novel ras-related gene family. Cell (1985) 5.81
The human beta-interferon gene enhancer is under negative control. Cell (1986) 5.61
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J (1995) 5.59
The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell (1989) 5.50
Enzymatic in vitro synthesis of globin genes. Cell (1976) 5.31
Intron sequences involved in lariat formation during pre-mRNA splicing. Cell (1985) 5.30
An olfactory sensory map in the fly brain. Cell (2000) 5.29
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Biology of hepatitis B virus. Science (1981) 4.93
A novel family of genes encoding putative pheromone receptors in mammals. Cell (1995) 4.88
A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell (1993) 4.82
Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (1990) 4.81
Topographic organization of sensory projections to the olfactory bulb. Cell (1994) 4.74
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Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. Proc Natl Acad Sci U S A (1982) 4.69
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A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell (2001) 4.64
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Activation of the human beta-interferon gene requires an interferon-inducible factor. Mol Cell Biol (1986) 4.38
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Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda. Cell (1975) 4.28
A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell (1999) 4.25
Tuberculosis as a manifestation of the acquired immunodeficiency syndrome (AIDS). JAMA (1986) 4.25
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The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. Cell (1980) 4.15
The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Cell (1982) 4.13
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol (2001) 4.09
Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc Natl Acad Sci U S A (1988) 4.08
Krox-20 controls myelination in the peripheral nervous system. Nature (1994) 4.04