PubRank

R Cortese

Author PubWeight™ 247.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 pEMBL: a new family of single stranded plasmids. Nucleic Acids Res 1983 19.19
2 A fast and simple method for sequencing DNA cloned in the single-stranded bacteriophage M13. J Mol Biol 1979 7.73
3 A novel method for site-directed mutagenesis: its application to an eukaryotic tRNAPro gene promoter. EMBO J 1982 4.67
4 IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 1990 4.58
5 A general method to select for M13 clones carrying base pair substitution mutants constructed in vitro. Nucleic Acids Res 1983 4.14
6 [Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications]. Nat New Biol 1972 3.57
7 The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell 1989 3.51
8 Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter. EMBO J 1988 3.14
9 Order and intracellular location of the events involved in the maturation of a spliced tRNA. Nature 1980 3.07
10 Cell-specific expression of a transfected human alpha 1-antitrypsin gene. Cell 1985 2.99
11 Common and interchangeable elements in the promoters of genes transcribed by RNA polymerase iii. Cell 1983 2.94
12 Cloning of nematode tRNA genes and their expression in the frog oocyte. Nucleic Acids Res 1978 2.91
13 Promoter of a eukaryotic tRNAPro gene is composed of three noncontiguous regions. Proc Natl Acad Sci U S A 1982 2.91
14 Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates. Proc Natl Acad Sci U S A 1980 2.73
15 Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene. EMBO J 1987 2.69
16 Transcription by RNA polymerase III. Curr Top Dev Biol 1983 2.63
17 Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA. EMBO J 1988 2.60
18 Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. Nucleic Acids Res 1985 2.59
19 Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J Biol Chem 1988 2.40
20 Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO J 1988 2.36
21 Biosynthesis of pseudouridine in transfer ribonucleic acid. J Biol Chem 1974 2.36
22 Cloning of several cDNA segments coding for human liver proteins. EMBO J 1983 2.32
23 Cloning of the gene coding for human L apoferritin. Nucleic Acids Res 1986 2.31
24 Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. Proc Natl Acad Sci U S A 1974 2.31
25 Relationship between the two components of the split promoter of eukaryotic tRNA genes. Proc Natl Acad Sci U S A 1982 2.13
26 Structure and expression of the human haptoglobin locus. EMBO J 1985 2.09
27 A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1. Cell 1990 2.09
28 Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells. EMBO J 1987 2.08
29 Transcription signals in embryonic Xenopus laevis U1 RNA genes. EMBO J 1985 2.07
30 Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals. EMBO J 1985 2.05
31 The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. EMBO J 1989 2.04
32 Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J 1990 1.95
33 Structure of gene and pseudogenes of human apoferritin H. Nucleic Acids Res 1986 1.91
34 Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor. Cell 1979 1.91
35 A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. EMBO J 1994 1.90
36 Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. Proc Natl Acad Sci U S A 1989 1.89
37 The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes. EMBO J 1987 1.85
38 Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J 1987 1.85
39 The human haptoglobin gene: transcriptional regulation during development and acute phase induction. EMBO J 1987 1.82
40 Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants. J Bacteriol 1977 1.69
41 Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants. EMBO J 1998 1.61
42 LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J 1991 1.60
43 Nucleotide sequence of rat liver HMG1 cDNA. Nucleic Acids Res 1987 1.59
44 Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J 1990 1.51
45 The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res 1993 1.49
46 The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc Natl Acad Sci U S A 1991 1.48
47 Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nat Biotechnol 1997 1.47
48 Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides. Gene 1993 1.47
49 The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism. J Mol Biol 1999 1.44
50 Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance. Gut 2004 1.42
51 Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family. EMBO J 1984 1.42
52 Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc Natl Acad Sci U S A 1999 1.38
53 Site-directed mutagenesis of a tRNA gene: base alterations in the coding region affect transcription. Proc Natl Acad Sci U S A 1982 1.38
54 Cloning and sequencing of a full length cDNA coding for human retinol-binding protein. Nucleic Acids Res 1983 1.36
55 LFB1 and LFB3 homeoproteins are sequentially expressed during kidney development. Development 1992 1.33
56 The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding. EMBO J 1993 1.32
57 Derivation of vaccines from mimotopes. Immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage. J Immunol 1995 1.32
58 Product inhibition of the hepatitis C virus NS3 protease. Biochemistry 1998 1.32
59 Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector. Proc Natl Acad Sci U S A 1999 1.32
60 Mutations in Box B of the promoter of a eucaryotic tRNAPro gene affect rate of transcription, processing, and stability of the transcripts. Cell 1984 1.30
61 Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA. Nucleic Acids Res 1983 1.29
62 Site-specific integration in mammalian cells mediated by a new hybrid baculovirus-adeno-associated virus vector. J Virol 1998 1.28
63 Mimicking of discontinuous epitopes by phage-displayed peptides, II. Selection of clones recognized by a protective monoclonal antibody against the Bordetella pertussis toxin from phage peptide libraries. Gene 1993 1.26
64 Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein. Biochem Biophys Res Commun 1985 1.25
65 A POU-A related region dictates DNA binding specificity of LFB1/HNF1 by orienting the two XL-homeodomains in the dimer. EMBO J 1992 1.19
66 Early impairment of hepatitis C virus specific T cell proliferation during acute infection leads to failure of viral clearance. Gut 2006 1.19
67 Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci U S A 1997 1.15
68 Transcriptional regulation of liver-specific gene expression. Curr Opin Cell Biol 1991 1.15
69 Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice. Genes Dev 1988 1.15
70 Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer. J Virol 2000 1.13
71 Identification of peptides specific for cerebrospinal fluid antibodies in multiple sclerosis by using phage libraries. Proc Natl Acad Sci U S A 1996 1.12
72 Gene therapy progress and prospects: transcription regulatory systems. Gene Ther 2004 1.10
73 Molecular cloning of human LDL apolipoprotein B cDNA. Evidence for more than one gene per haploid genome. Atherosclerosis 1985 1.10
74 Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression. Eur J Neurol 2012 1.09
75 Recognition by human sera and immunogenicity of HBsAg mimotopes selected from an M13 phage display library. Gene 1994 1.08
76 pEMBL: a new family of single-stranded plasmids for sequencing DNA. Methods Enzymol 1987 1.08
77 Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products. Biochemistry 1998 1.07
78 Sequences of four tRNA genes from Caenorhabditis elegans and the expression of C. elegans tRNALeu (anticodon IAG) in Xenopus oocytes. Nucleic Acids Res 1982 1.07
79 Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease. Protein Eng 1997 1.06
80 Targeted integration of adeno-associated virus-derived plasmids in transfected human cells. Virology 1998 1.06
81 Properties of a genetically engineered G domain of elongation factor Tu. Proc Natl Acad Sci U S A 1987 1.05
82 Development of animal models for adeno-associated virus site-specific integration. J Virol 1999 1.04
83 The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology. Nucleic Acids Res 1985 1.03
84 Mapping epitopes on protein surfaces. Biopolymers 1995 1.03
85 Post-transcriptional control of negative acute phase genes by transforming growth factor beta. EMBO J 1989 1.02
86 Characterization of an imidazolepyruvicacid reducing system from Escherichia coli B +. Biochem Biophys Res Commun 1968 1.01
87 Biosynthesis of pseudouridine in the in vitro transcribed tRNATyr precursor. FEBS Lett 1977 1.01
88 Circular dichroism study on the conformational stability of the dimerization domain of transcription factor LFB1. Biochemistry 1991 1.01
89 Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library. J Biol Chem 1999 1.00
90 Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies. J Mol Biol 1999 0.99
91 Selection of antigenic and immunogenic mimics of hepatitis C virus using sera from patients. J Immunol 1996 0.99
92 The transcription factor LF-A1 interacts with a bipartite recognition sequence in the promoter regions of several liver-specific genes. Nucleic Acids Res 1991 0.98
93 Characterization of a Salmonella typhimurium hisU mutant defective in tRNA precursor processing. J Bacteriol 1978 0.98
94 Transcription factors and liver-specific genes. Biochim Biophys Acta 1992 0.97
95 Biosynthesis of tRNA in histidine regulatory mutants of Salmonella typhimurium. Nucleic Acids Res 1977 0.97
96 The transcriptional regulation of liver-specific gene expression. Oxf Surv Eukaryot Genes 1988 0.97
97 Purification of pseudouridylate synthetase I from Salmonella typhimurium. Nucleic Acids Res 1978 0.96
98 Immunogenicity of filamentous phage displaying peptide mimotopes after oral administration. Vaccine 1997 0.96
99 The human alpha-1-antitrypsin gene is efficiently expressed from two tissue-specific promotors in transgenic mice. Nucleic Acids Res 1987 0.96
100 The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a nonclassical homeodomain. EMBO J 1993 0.96
101 Characterization of human ferritin H chain synthetized in Escherichia coli. Gene 1987 0.95
102 The affinity-selection of a minibody polypeptide inhibitor of human interleukin-6. EMBO J 1994 0.95
103 Extinction of alpha 1-antitrypsin gene expression in somatic cell hybrids: evidence for multiple controls. Genes Dev 1992 0.94
104 Frameshift mutations induced by an Escherichia coli strain carrying a mutator gene, mutD5. Mol Gen Genet 1983 0.93
105 Characterization of the promoter elements required for hepatic and intestinal transcription of the human apoB gene: definition of the DNA-binding site of a tissue-specific transcriptional factor. Mol Cell Biol 1990 0.93
106 The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts. Cell Death Differ 2008 0.92
107 Prolonged expression and effective readministration of erythropoietin delivered with a fully deleted adenoviral vector. Hum Gene Ther 2000 0.92
108 Coupling protein design and in vitro selection strategies: improving specificity and affinity of a designed beta-protein IL-6 antagonist. J Mol Biol 1996 0.92
109 Transcription of the promoter of the rat NF-1 gene depends on the integrity of an Sp1 recognition site. Mol Cell Biol 1990 0.92
110 Processing of eukaryotic tRNA precursors: secondary structure of the precursor specific sequences affects the rate but not the accuracy of processing reactions. Nucleic Acids Res 1982 0.92
111 Efficient display of an HCV cDNA expression library as C-terminal fusion to the capsid protein D of bacteriophage lambda. J Mol Biol 1998 0.92
112 Induction of anti-carbohydrate antibodies by phage library-selected peptide mimics. Eur J Immunol 1997 0.92
113 Myocardial mechanical, biochemical, and structural alterations induced by chronic ethanol ingestion in rats. Circ Res 1992 0.92
114 Isolation of two cDNAs encoding zinc finger proteins which bind to the alpha 1-antitrypsin promoter and to the major histocompatibility complex class I enhancer. Nucleic Acids Res 1991 0.92
115 The dimerization domain of LFB1/HNF1 related transcription factors: a hidden four helix bundle? Protein Eng 1992 0.91
116 Disruption of the LF-A1 and LF-B1 binding sites in the human alpha-1-antitrypsin gene has a differential effect during development in transgenic mice. EMBO J 1991 0.91
117 Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes. Gene Ther 2006 0.90
118 Mimotopes of the hepatitis C virus hypervariable region 1, but not the natural sequences, induce cross-reactive antibody response by genetic immunization. Hepatology 2001 0.90
119 1H resonance assignment and secondary structure determination of the dimerization domain of transcription factor LFB1. Biochemistry 1991 0.90
120 Codon-based mutagenesis using dimer-phosphoramidites. Nucleic Acids Res 1998 0.90
121 Engineering, characterization and phage display of hepatitis C virus NS3 protease and NS4A cofactor peptide as a single-chain protein. Protein Eng 1998 0.89
122 Cerebrospinal fluid neurofilament light chain levels: marker of progression to generalized amyotrophic lateral sclerosis. Eur J Neurol 2014 0.88
123 CSF-enriched antibodies do not share specificities among MS patients. Mult Scler 1998 0.88
124 Identification of peptides binding to IgG in the CSF of multiple sclerosis patients. Mult Scler 1998 0.87
125 Identification of a novel type 1 diabetes-specific epitope by screening phage libraries with sera from pre-diabetic patients. J Mol Biol 1997 0.87
126 Selective 32P-labelling of individual species in a total tRNA population. Nucleic Acids Res 1980 0.86
127 Mimotopes of the hyper variable region 1 of the hepatitis C virus induce cross-reactive antibodies directed against discontinuous epitopes. Mol Immunol 2001 0.86
128 Selection of phage-displayed peptides mimicking type 1 diabetes-specific epitopes. J Autoimmun 1996 0.85
129 Immunization with phage-displayed mimotopes. Methods Enzymol 1996 0.85
130 The analysis of the human hemopexin promoter defines a new class of liver-specific genes. Nucleic Acids Res 1989 0.85
131 A conformationally homogeneous combinatorial peptide library. J Mol Biol 1995 0.84
132 Regulated and prolonged expression of mIFN(alpha) in immunocompetent mice mediated by a helper-dependent adenovirus vector. Gene Ther 2001 0.84
133 Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires. J Virol 1997 0.84
134 Cross-reactive phage-displayed mimotopes lead to the discovery of mimicry between HSV-1 and a brain-specific protein. J Neuroimmunol 2001 0.83
135 Mapping of the gene TCF2 coding for the transcription factor LFB3 to human chromosome 17 by polymerase chain reaction. Genomics 1990 0.82
136 Generation of small mutation in large genomic fragments by homologous recombination: description of the technique and examples of its use. Nucleic Acids Res 1990 0.82
137 ADAM-HCV, a new-concept diagnostic assay for antibodies to hepatitis C virus in serum. Eur J Biochem 2001 0.82
138 A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody. Protein Eng 1999 0.82
139 Osteopontin is an autoantigen of the somatostatin cells in human islets: identification by screening random peptide libraries with sera of patients with insulin-dependent diabetes mellitus. Vaccine 1999 0.81
140 Studies on the deamination of L-amino acids in mammalian tissues. Enzymologia 1966 0.81
141 Transcription of multimeric tRNA genes. Nucleic Acids Res 1984 0.80
142 Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin). Nucleic Acids Res 1986 0.80
143 Fractionation of Escherichia coli isoaccepting tRNA species by sepharose 4B column chromatography. Anal Biochem 1979 0.80
144 Nonrheumatoid IgM in human hepatitis C virus-associated type II cryoglobulinemia recognize mimotopes of the CD4-like LAG-3 protein. J Immunol 1996 0.80
145 LFB1/HNF1 acts as a repressor of its own transcription. Nucleic Acids Res 1994 0.80
146 Induction of cross-reactive humoral immune response by immunization with mimotopes of the hypervariable region 1 of the hepatitis C virus. Int Rev Immunol 2001 0.80
147 A negative regulatory element in the promoter of the human alpha 1-antitrypsin gene. Nucleic Acids Res 1989 0.80
148 Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). Genomics 1992 0.80
149 Phage-displayed peptides as tools for characterization of human sera. Methods Enzymol 1996 0.79
150 Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity. EMBO J 1996 0.79
151 The Interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4. Genomics 1991 0.79
152 DNA-based selection and screening of peptide ligands. Nat Biotechnol 1998 0.78
153 A prokaryotic tRNATyr gene, inactive in Xenopus laevis oocytes, is activated by recombination with an eukaryotic tRNAPro gene. EMBO J 1982 0.78
154 cDNA sequence coding for human coagulation factor XII (Hageman). Nucleic Acids Res 1986 0.78
155 Gene injection into amphibian oocytes. Results Probl Cell Differ 1980 0.78
156 A bipartite activation domain is responsible for the activity of transcription factor HNF1/LFB1 in cells of hepatic and nonhepatic origin. DNA Cell Biol 1993 0.77
157 Characterization of an IL-6-responsive element (IL6RE) present on liver-specific genes and identification of the cognate IL-6-dependent DNA-binding protein (IL6DBP). Ann N Y Acad Sci 1989 0.77
158 Selective destruction of the outer hair cells in the chinchilla. Clin Otolaryngol Allied Sci 1982 0.77
159 A recombinant apoA-1--protein A hybrid reproduces the binding parameters of HDL to its receptor. EMBO J 1987 0.77
160 Functional assay of tRNA molecules transcribed from a purified gene. Nucleic Acids Res 1982 0.77
161 Selection of potent inhibitors of farnesyl-protein transferase from a synthetic tetrapeptide combinatorial library. J Biol Chem 1996 0.76
162 Identification of HCV core mimotopes: improved methods for the selection and use of disease-related phage-displayed peptides. Biol Chem 1997 0.76
163 Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation. Int J Obes (Lond) 2015 0.76
164 Identification of disease-specific epitopes. Methods Mol Biol 1998 0.76
165 Relationship between juxtaglomerular apparatus and plasma renin activity in human reno-vascular hypertension. Nephron 1977 0.75
166 A database system for handling phage library-derived sequences. Gene 1993 0.75
167 Mutagenicity of pesticides containing 1,3-dichloropropene. Cancer Res 1977 0.75
168 Expression of human alpha-1-acid glycoprotein in human cell lines. Prog Clin Biol Res 1989 0.75
169 Mutagenicity of diallate, sulfallate, and triallate and relationship between structure and mutagenic effects of carbamates used widely in agriculture. Cancer Res 1978 0.75
170 Pharmacological aspects and neurological speech therapy: target of dysphony, dysarthria and dysphagia. Int J Immunopathol Pharmacol 2012 0.75
171 [Identification and purification of an alpha-ketoacid aromatic reductase of Escherichia coli B]. C R Seances Soc Biol Fil 1968 0.75
172 Multicentre comparison of the antihypertensive effect of acebutolol and hydrochlorothiazide in uncomplicated mild-moderate hypertension in the elderly. Eur J Clin Pharmacol 1985 0.75
173 [Radiographic view of asbestosis and respiratory functional correlations]. Arch Monaldi 1984 0.75
174 DNA polymorphisms as potential genetic risk markers for cardiovascular diseases. Boll Soc Ital Biol Sper 1987 0.75
175 Biologically active recombinant prothrombin and antithrombin III expressed in a human hepatoma/vaccinia virus system. Biotechnol Appl Biochem 1991 0.75
176 New developments in combinatorial libraries. Biol Chem 1997 0.75