Published in Nucleic Acids Res on January 25, 1984
Transcription of two classes of rat growth hormone gene-associated repetitive DNA: differences in activity and effects of tandem repeat structure. Nucleic Acids Res (1984) 1.11
A yeast tRNA(Arg) gene can act as promoter for a 5' flank deficient, non-transcribable tRNA(SUP)6 gene to produce biologically active suppressor tRNA. Nucleic Acids Res (1988) 0.98
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. Gene (1982) 59.01
Selective and accurate initiation of transcription at the Ad2 major late promotor in a soluble system dependent on purified RNA polymerase II and DNA. Cell (1979) 19.98
Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro. Proc Natl Acad Sci U S A (1977) 18.85
A control region in the center of the 5S RNA gene directs specific initiation of transcription: I. The 5' border of the region. Cell (1980) 13.19
A novel method for site-directed mutagenesis: its application to an eukaryotic tRNAPro gene promoter. EMBO J (1982) 4.67
A split promoter for a eucaryotic tRNA gene. Cell (1981) 4.18
A general method to select for M13 clones carrying base pair substitution mutants constructed in vitro. Nucleic Acids Res (1983) 4.14
Common and interchangeable elements in the promoters of genes transcribed by RNA polymerase iii. Cell (1983) 2.94
Cloning of nematode tRNA genes and their expression in the frog oocyte. Nucleic Acids Res (1978) 2.91
Promoter of a eukaryotic tRNAPro gene is composed of three noncontiguous regions. Proc Natl Acad Sci U S A (1982) 2.91
Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates. Proc Natl Acad Sci U S A (1980) 2.73
Transcription by RNA polymerase III. Curr Top Dev Biol (1983) 2.63
Transcription initiation of eucaryotic transfer RNA genes. Cell (1982) 2.18
Relationship between the two components of the split promoter of eukaryotic tRNA genes. Proc Natl Acad Sci U S A (1982) 2.13
Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor. Cell (1979) 1.91
Dimeric tRNA precursors in yeast. Nature (1980) 1.85
Kilo-sequencing: an ordered strategy for rapid DNA sequence data acquisition. Nucleic Acids Res (1983) 1.82
Dimeric transfer RNA precursors in S. pombe. Cell (1980) 1.48
Processing of eukaryotic tRNA precursors: secondary structure of the precursor specific sequences affects the rate but not the accuracy of processing reactions. Nucleic Acids Res (1982) 0.92
pEMBL: a new family of single stranded plasmids. Nucleic Acids Res (1983) 19.19
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity (1999) 7.78
A fast and simple method for sequencing DNA cloned in the single-stranded bacteriophage M13. J Mol Biol (1979) 7.73
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science (1996) 6.70
A novel method for site-directed mutagenesis: its application to an eukaryotic tRNAPro gene promoter. EMBO J (1982) 4.67
IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell (1990) 4.58
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity (1997) 4.19
A general method to select for M13 clones carrying base pair substitution mutants constructed in vitro. Nucleic Acids Res (1983) 4.14
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J (1994) 3.60
[Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications]. Nat New Biol (1972) 3.57
The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell (1989) 3.51
Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med (1998) 3.20
Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter. EMBO J (1988) 3.14
Order and intracellular location of the events involved in the maturation of a spliced tRNA. Nature (1980) 3.07
Cell-specific expression of a transfected human alpha 1-antitrypsin gene. Cell (1985) 2.99
Common and interchangeable elements in the promoters of genes transcribed by RNA polymerase iii. Cell (1983) 2.94
Cloning of nematode tRNA genes and their expression in the frog oocyte. Nucleic Acids Res (1978) 2.91
Promoter of a eukaryotic tRNAPro gene is composed of three noncontiguous regions. Proc Natl Acad Sci U S A (1982) 2.91
CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. J Clin Invest (1998) 2.74
Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates. Proc Natl Acad Sci U S A (1980) 2.73
Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene. EMBO J (1987) 2.69
Elevated levels of interleukin-6 in unstable angina. Circulation (1996) 2.66
Transcription by RNA polymerase III. Curr Top Dev Biol (1983) 2.63
Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA. EMBO J (1988) 2.60
Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. Nucleic Acids Res (1985) 2.59
Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J Biol Chem (1988) 2.40
Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO J (1988) 2.36
Biosynthesis of pseudouridine in transfer ribonucleic acid. J Biol Chem (1974) 2.36
Cloning of several cDNA segments coding for human liver proteins. EMBO J (1983) 2.32
Cloning of the gene coding for human L apoferritin. Nucleic Acids Res (1986) 2.31
Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. Proc Natl Acad Sci U S A (1974) 2.31
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology (2000) 2.24
Relationship between the two components of the split promoter of eukaryotic tRNA genes. Proc Natl Acad Sci U S A (1982) 2.13
Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. J Clin Invest (1997) 2.11
Structure and expression of the human haptoglobin locus. EMBO J (1985) 2.09
Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J Biol Chem (2001) 2.09
A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1. Cell (1990) 2.09
Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells. EMBO J (1987) 2.08
Transcription signals in embryonic Xenopus laevis U1 RNA genes. EMBO J (1985) 2.07
Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals. EMBO J (1985) 2.05
The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. EMBO J (1989) 2.04
Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J (1989) 1.98
Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J (1990) 1.95
Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. Blood (1998) 1.93
Structure of gene and pseudogenes of human apoferritin H. Nucleic Acids Res (1986) 1.91
Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor. Cell (1979) 1.91
A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. EMBO J (1994) 1.90
Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. Proc Natl Acad Sci U S A (1989) 1.89
The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes. EMBO J (1987) 1.85
Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J (1987) 1.85
The human haptoglobin gene: transcriptional regulation during development and acute phase induction. EMBO J (1987) 1.82
Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. J Virol (2000) 1.70
Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants. J Bacteriol (1977) 1.69
Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites. EMBO J (1990) 1.63
Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K). EMBO J (1988) 1.62
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J (1991) 1.60
Nucleotide sequence of rat liver HMG1 cDNA. Nucleic Acids Res (1987) 1.59
Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J (1990) 1.53
Formation of the 3' end on U snRNAs requires at least three sequence elements. EMBO J (1986) 1.52
Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J (1990) 1.51
Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J (1998) 1.50
Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation. Gene Ther (2004) 1.50
The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res (1993) 1.49
The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc Natl Acad Sci U S A (1991) 1.48
Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nat Biotechnol (1997) 1.47
Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides. Gene (1993) 1.47
CD4+CD25+ regulatory T-cell-inactivation in combination with adenovirus vaccines enhances T-cell responses and protects mice from tumor challenge. Cancer Gene Ther (2006) 1.45
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice. Blood (1994) 1.45
Identification of sequences responsible for acute-phase induction of human C-reactive protein. Nucleic Acids Res (1988) 1.44
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism. J Mol Biol (1999) 1.44
Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance. Gut (2004) 1.42
Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family. EMBO J (1984) 1.42
Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling. EMBO J (1995) 1.39
Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc Natl Acad Sci U S A (1999) 1.38
Site-directed mutagenesis of a tRNA gene: base alterations in the coding region affect transcription. Proc Natl Acad Sci U S A (1982) 1.38
Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Mol Cell Biol (2001) 1.37
Cloning and sequencing of a full length cDNA coding for human retinol-binding protein. Nucleic Acids Res (1983) 1.36
Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina. Circulation (1998) 1.36
LFB1 and LFB3 homeoproteins are sequentially expressed during kidney development. Development (1992) 1.33
The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding. EMBO J (1993) 1.32
Derivation of vaccines from mimotopes. Immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage. J Immunol (1995) 1.32