Published in Lancet on August 22, 1981
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Ethics of a predictive test for Huntington's chorea. Br Med J (Clin Res Ed) (1982) 1.58
A genetic register for Huntington's chorea in South Wales. J Med Genet (1982) 1.56
Genetic prediction and family structure in Huntington's chorea. Br Med J (Clin Res Ed) (1985) 1.38
Effect of genetic counselling on the prevalence of Huntington's chorea. Br Med J (Clin Res Ed) (1983) 0.86
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A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy. Nature (1982) 11.57
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Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome. Nucleic Acids Res (1983) 8.92
Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy. Nature (1992) 8.85
Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nat Genet (1993) 5.70
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The autism genetic resource exchange: a resource for the study of autism and related neuropsychiatric conditions. Am J Hum Genet (2001) 5.23
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Von Recklinghausen neurofibromatosis. A clinical and population study in south-east Wales. Brain (1988) 4.69
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The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol (2000) 4.08
Prediction of colorectal cancer by a patient consultation questionnaire and scoring system: a prospective study. Lancet (2002) 3.95
Systematic implementation of an advance directive program in nursing homes: a randomized controlled trial. JAMA (2000) 3.87
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities. Clin Genet (1975) 3.81
Identification of p53 gene mutations in bladder cancers and urine samples. Science (1991) 3.68
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Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc Natl Acad Sci U S A (2007) 3.60
A number of different nuclear genes for the small subunit of RuBPCase are transcribed in petunia. Nucleic Acids Res (1983) 3.56
Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature (1991) 3.43
Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia. BMJ (1989) 3.34
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med (1996) 3.10
The preterm prediction study: maternal stress is associated with spontaneous preterm birth at less than thirty-five weeks' gestation. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol (1996) 3.09
The next ten years of health spending: what does the future hold? The Health Expenditures Projection Team. Health Aff (Millwood) (1998) 3.04
Stigmatization of AIDS patients by physicians. Am J Public Health (1987) 3.03
Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol (1993) 3.01
p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res (1993) 2.99
Clinical aspects of X-linked hypohidrotic ectodermal dysplasia. Arch Dis Child (1987) 2.95
Transdermal nicotine for active ulcerative colitis. N Engl J Med (1994) 2.90
Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats. Am J Hum Genet (1996) 2.88
Double-blind trials. Br J Psychiatry (1990) 2.88
Respiratory epithelial cell invasion by group B streptococci. Infect Immun (1992) 2.86
A randomised controlled trial of stress reduction for hypertension in older African Americans. Hypertension (1995) 2.85
Frame-shift deletions in patients with Duchenne and Becker muscular dystrophy. Science (1988) 2.82
Heatstroke in well-wrapped infants. Lancet (1979) 2.81
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Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: systematic review. Lancet (2005) 2.78
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Two-step glutamate dehydrogenase antigen real-time polymerase chain reaction assay for detection of toxigenic Clostridium difficile. J Hosp Infect (2009) 2.76
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet (2001) 2.76
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The prevention of Huntington's chorea. The Milroy lecture 1985. J R Coll Physicians Lond (1986) 2.74
Comparison of CT scan muscle measurements and isokinetic trunk strength in postoperative patients. Spine (Phila Pa 1976) (1989) 2.70
The action of substances allied to 4:4'-diaminodiphenylsulphone in streptococcal and other infections in mice. Biochem J (1938) 2.69
Determining the common medical presenting problems to an accident and emergency department. Arch Dis Child (2001) 2.67
DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element. Nucleic Acids Res (1981) 2.67
Genetic risks for children of women with myotonic dystrophy. Am J Hum Genet (1991) 2.65
TRF1 is a dimer and bends telomeric DNA. EMBO J (1997) 2.64
Validation of the Edinburgh Postnatal Depression Scale (EPDS) in non-postnatal women. J Affect Disord (1996) 2.62
Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Science (2001) 2.61
Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. Curr Biol (2000) 2.58
Breakfast and dietary aspects of Crohn's disease. Br Med J (1978) 2.57
AIDS and haemophilia: morbidity and morality in a well defined population. Br Med J (Clin Res Ed) (1985) 2.54
The use of linked DNA polymorphisms for genotype prediction in families with Duchenne muscular dystrophy. J Med Genet (1983) 2.45
Randomized clinical trial of laparoscopic Nissen fundoplication compared with proton-pump inhibitors for treatment of chronic gastro-oesophageal reflux. Br J Surg (2005) 2.42
Size of the unstable CTG repeat sequence in relation to phenotype and parental transmission in myotonic dystrophy. Am J Hum Genet (1993) 2.42
Cloning and characterization of an ftsZ homologue from a bacterial symbiont of Drosophila melanogaster. Mol Gen Genet (1993) 2.40
Early-onset dystrophia myotonica. Evidence supporting a maternal environmental factor. Lancet (1972) 2.40
Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg (2003) 2.40
Glycosyltransferases in plant natural product synthesis: characterization of a supergene family. Trends Plant Sci (2000) 2.37
Unstable DNA sequence in myotonic dystrophy. Lancet (1992) 2.36
Four country healthcare associated infection prevalence survey 2006: overview of the results. J Hosp Infect (2008) 2.35
The care of HIV-infected adults in rural areas of the United States. J Acquir Immune Defic Syndr (2001) 2.34
Huntington's Chorea in South Wales. A genetic and epidemiological study. Clin Genet (1981) 2.31
Diagnostic accuracy of faecal occult blood tests used in screening for colorectal cancer: a systematic review. J Med Screen (2007) 2.30
Cytoplasmic DNA in the unfertilized sea urchin egg: physical properties of circular mitochondrial DNA and the occurrence of catenated forms. Proc Natl Acad Sci U S A (1968) 2.30
Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE). Circulation (2001) 2.30
Evaluation of the medical diagnostic imaging support system based on 2 years of clinical experience. J Digit Imaging (1995) 2.29
Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis. Gut (1994) 2.28
Premorbid social functioning in schizophrenia and bipolar disorder: similarities and differences. Am J Psychiatry (1997) 2.26
Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology (2005) 2.24
Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet (1986) 2.24
Efficacy of progesterone and progestogens in management of premenstrual syndrome: systematic review. BMJ (2001) 2.23
Controlled randomised crossover trial of the effects of physiotherapy on mobility in chronic multiple sclerosis. J Neurol Neurosurg Psychiatry (2001) 2.23
Psychosis with good prognosis in Afro-Caribbean people now living in the United Kingdom. BMJ (1995) 2.22
Seizures and status epilepticus in childhood cerebral malaria. QJM (1996) 2.22
Assessing operative skill. Needs to become more objective. BMJ (1999) 2.19
Studies of a DNA marker (G8) genetically linked to Huntington disease in British families. Hum Genet (1986) 2.18
Genetic linkage between Becker muscular dystrophy and a polymorphic DNA sequence on the short arm of the X chromosome. J Med Genet (1983) 2.16
Aggregation of ferrihaems. Dimerization and protolytic equilibria of protoferrihaem and deuteroferrihaem in aqueous solution. Biochem J (1970) 2.16
Molecular analysis and clinical correlations of the Huntington's disease mutation. Lancet (1993) 2.15
A quantitative assessment of residual protein levels on dental instruments reprocessed by manual, ultrasonic and automated cleaning methods. Br Dent J (2011) 2.13
Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc Natl Acad Sci U S A (1987) 2.12
Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. J Biol Chem (1998) 2.12
Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Neuroimage (2006) 2.09
Exclusion testing for Huntington's disease in pregnancy with a closely linked DNA marker. Lancet (1987) 2.09
Adoption and genetic prediction for Huntington's disease. Lancet (1988) 2.09
Mouse in vitro fertilization, embryo development and viability, and human sperm motility in substances used for human sperm preparation for assisted reproduction. Fertil Steril (1997) 2.09
Changes in motoneurone firing rates during sustained maximal voluntary contractions. J Physiol (1983) 2.08
Effective strategy for prenatal prediction of Duchenne and Becker muscular dystrophy. Lancet (1987) 2.08