Published in Am J Pathol on February 01, 1984
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. J Immunol (1975) 47.77
Junctional complexes in various epithelia. J Cell Biol (1963) 31.83
The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell (1982) 19.91
Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci U S A (1978) 18.32
Different intermediate-sized filaments distinguished by immunofluorescence microscopy. Proc Natl Acad Sci U S A (1978) 6.28
Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell (1980) 5.83
Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med (1976) 5.37
Immunofluorescent staining of keratin fibers in cultured cells. Cell (1978) 4.25
The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell (1982) 4.17
Antibody to prekeratin. Decoration of tonofilament like arrays in various cells of epithelial character. Exp Cell Res (1978) 4.01
Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology. Lab Invest (1983) 3.91
Keratin filaments of cultured human epidermal cells. Formation of intermolecular disulfide bonds during terminal differentiation. J Biol Chem (1978) 3.82
Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell (1981) 3.61
Keratin cytoskeletons in epithelial cells of internal organs. Proc Natl Acad Sci U S A (1979) 3.45
Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. J Mol Biol (1981) 3.37
HeLa cells contain intermediate-sized filaments of the prekeratin type. Exp Cell Res (1979) 2.98
Immunochemical identification of intermediate-sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologist. Am J Pathol (1981) 2.94
A new small (40 kd) keratin filament protein made by some cultured human squamous cell carcinomas. Cell (1981) 2.87
Complex cytokeratin polypeptide patterns observed in certain human carcinomas. Differentiation (1983) 2.35
Immunohistochemical localization of keratin in normal human tissues. Lab Invest (1980) 2.28
Experimental production of antibodies against stratum corneum keratin polypeptides. Arch Dermatol Res (1980) 1.87
Immunoperoxidase localization of keratin in human neoplasms: a preliminary survey. Am J Pathol (1980) 1.76
Mesothelioma: profile of keratin proteins and carcinoembryonic antigen: an immunoperoxidase study of 20 cases and comparison with pulmonary adenocarcinomas. Am J Pathol (1982) 1.74
Fibrous protein of human epidermis. J Invest Dermatol (1978) 1.69
Optimized conditions for the growth of human epidermal cells in culture. J Invest Dermatol (1980) 1.57
Differences of expression of cytoskeletal proteins in cultured rat hepatocytes and hepatoma cells. Exp Cell Res (1981) 1.51
The use of antikeratin antiserum as a diagnostic tool: thymoma versus lymphoma. Hum Pathol (1980) 1.48
Characterization of an immune complex kinase in immunoprecipitates of avian sarcoma virus-transformed fibroblasts. J Virol (1979) 1.48
Differentiation of human epidermal cells transformed by SV40. J Cell Biol (1983) 1.45
The respiratory epithelium. V. Histogenesis of lung carcinomas in the human. J Natl Cancer Inst (1978) 1.35
Keratin alterations during embryonic epidermal differentiation: a presage of adult epidermal maturation. J Cell Biol (1982) 1.28
Keratin proteins and carcinoembryonic antigen in lung carcinoma: an immunoperoxidase study of fifty-four cases, with ultrastructural correlations. Hum Pathol (1983) 1.26
Liver tumors distinguished by immunofluorescence microscopy with antibodies to proteins of intermediate-sized filaments. Proc Natl Acad Sci U S A (1980) 1.19
Keratin polypeptides distribution in normal and diseased human epidermis and oral mucosa. Immunohistochemical study on unaltered epithelium and inflammatory, premalignant and malignant lesions. Virchows Arch A Pathol Anat Histol (1980) 1.18
Expression of a neural type of intermediate filament as a distinguishing feature between oat cell carcinoma and other lung cancers. Am J Pathol (1983) 1.16
Tissue-specific expression of keratin proteins in human esophageal and epidermal epithelium and their cultured keratinocytes. Exp Cell Res (1983) 1.10
Identification of prekeratin by immunofluorescence staining in the differential diagnosis of tumors. Hum Pathol (1981) 1.08
Antibodies to intermediate filaments as diagnostic tools: human gastrointestinal carcinomas express prekeratin. Lab Invest (1982) 1.08
Keratins as markers of malignancy in mouse epidermal tumors. Carcinogenesis (1980) 1.05
Filamentous protein of basal cell epithelioma: characteristics in vivo and in vitro. J Natl Cancer Inst (1980) 1.04
Immunohistochemical localisation of keratin in human lung tumours. Virchows Arch A Pathol Anat Histol (1982) 1.04
Demonstration of keratin in human adenocarcinomas. Am J Pathol (1983) 0.98
Immunohistochemical localization of prekeratin filaments in benign and malignant cells in effusions. Comparison with intermediate filament distribution by electron microscopy. Am J Pathol (1982) 0.96
Bovine epidermal keratin filament assembly in vitro. Biochem Biophys Res Commun (1976) 0.95
Histogenetic classification of pulmonary carcinomas. Peripheral adenocarcinomas studied by light microscopy, histochemistry, and electron microscopy. Pathol Annu (1982) 0.88
Immunohistochemical localization of keratin-type proteins in epithelial neoplasms. Correlation with electron microscopic findings. Am J Clin Pathol (1982) 0.86
A comparison of World Health Organization (WHO) classification of lung tumors by light and electron microscopy. Cancer (1982) 0.79
p53 mutations in human cancers. Science (1991) 31.96
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res (1994) 11.29
Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature (1991) 6.16
Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res (1994) 5.64
Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med (1976) 5.37
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell (1999) 5.28
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci U S A (1994) 3.76
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet (2001) 3.76
IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools. Nucleic Acids Res (1998) 3.74
The nomenclature of cell death: recommendations of an ad hoc Committee of the Society of Toxicologic Pathologists. Toxicol Pathol (1999) 3.73
The effects of HIV/AIDS intervention groups for high-risk women in urban clinics. Am J Public Health (1994) 3.37
Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration. Am J Pathol (1968) 3.13
Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc Natl Acad Sci U S A (1986) 2.93
Distribution and modulation of the cellular receptor for transforming growth factor-beta. J Cell Biol (1987) 2.87
Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women. J Natl Cancer Inst (1999) 2.83
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet (2001) 2.82
GADD45 induction of a G2/M cell cycle checkpoint. Proc Natl Acad Sci U S A (1999) 2.80
TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene (2007) 2.71
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucleic Acids Res (1996) 2.65
New ultrastructural characteristics of cells fixed in a glutaraldehyde-osmium tetroxide mixture. Lab Invest (1966) 2.51
Mouse liver cell culture. I. Hepatocyte isolation. In Vitro (1981) 2.50
p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer. Mutat Res (1999) 2.36
Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res (2000) 2.31
Renal tubular lesions caused by mercuric chloride. Electron microscopic observations: degeneration of the pars recta. Am J Pathol (1968) 2.29
Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features. Oncogene (1999) 2.19
Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucleic Acids Res (1997) 2.17
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res (1998) 2.15
The ultrastructure of the functioning kidney. Lab Invest (1967) 2.14
Improved SPECT quantification using compensation for scattered photons. J Nucl Med (1984) 2.14
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene (1999) 2.12
Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J Natl Cancer Inst (1999) 2.10
Frequent mutation of the p53 gene in human esophageal cancer. Proc Natl Acad Sci U S A (1990) 2.07
DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc Natl Acad Sci U S A (2001) 2.00
Outbreak of Legionnaires' disease in Glasgow Royal Infirmary: microbiological aspects. J Hyg (Lond) (1986) 1.99
Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. Exp Cell Res (1974) 1.94
Poliomyelitis: A gap in immunity? Lancet (1973) 1.93
Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. Science (1985) 1.88
Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells. Cancer Res (1991) 1.88
The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J Biol Chem (1999) 1.84
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci U S A (1993) 1.84
p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis (1993) 1.84
Childhood- versus adult-onset asthma. Am J Respir Crit Care Med (1995) 1.83
Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. Clin Cancer Res (2000) 1.81
Observations on the application to electron microscopy on the lead phosphate technique for the demonstration of acid phosphatase. Histochemie (1965) 1.81
"Thanatosomes": a unifying morphogenetic concept for tumor hyaline globules related to apoptosis. Hum Pathol (2000) 1.77
Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung. Proc Natl Acad Sci U S A (1989) 1.73
Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. Proc Natl Acad Sci U S A (1993) 1.71
Erythromycin-resistant thermophilic Campylobacter species isolated from pigs. Vet Rec (1996) 1.70
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci U S A (1996) 1.68
High-frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells. Science (1983) 1.67
Intermediate filament and cross-linked envelope expression in human lung tumor cell lines. Cancer Res (1985) 1.66
Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model. Cancer Res (1996) 1.65
Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res (1995) 1.64
Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation. Differentiation (1988) 1.64
Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Res (1998) 1.64
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes Dev (1996) 1.63
Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer. J Pathol (1999) 1.62
Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci U S A (1997) 1.60
Asbestos-associated chromosomal changes in human mesothelial cells. Proc Natl Acad Sci U S A (1985) 1.60
Ultrasensitive enzymatic radioimmunoassay: application to detection of cholera toxin and rotavirus. Proc Natl Acad Sci U S A (1979) 1.58
Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines. Int J Cancer (1994) 1.57
p53 mutations in lung cancers from non-smoking atomic-bomb survivors. Lancet (1994) 1.56
Cancer risk and low-penetrance susceptibility genes in gene-environment interactions. J Clin Oncol (2000) 1.56
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells. Nat Med (1998) 1.55
Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sci U S A (1985) 1.54
Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet (1992) 1.53
Geographic variation of p53 mutational profile in nonmalignant human liver. Science (1994) 1.51
Value of ampicillin in the hospital treatment of exacerbations of chronic bronchitis. Br Med J (1965) 1.51
Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma. Am J Pathol (1989) 1.51
Explant culture of human colon. Gastroenterology (1978) 1.50
Conformation-dependent phosphorylation of p53. Proc Natl Acad Sci U S A (1997) 1.49
Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum. Cell (2001) 1.47
Disorders of cell volume regulation. I. Effects of inhibition of plasma membrane adenosine triphosphatase with ouabain. Am J Pathol (1968) 1.45
Differentiation of human epidermal cells transformed by SV40. J Cell Biol (1983) 1.45
Human renal ultrastructure. I. Proximal tubule of healthy individuals. Lab Invest (1966) 1.45
Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. Proc Natl Acad Sci U S A (2000) 1.44
Interaction of p53 with the human Rad51 protein. Nucleic Acids Res (1997) 1.43
Gentamicin resistant Staphylococcus aureus associated with the use of topical gentamicin. J Antimicrob Chemother (1977) 1.40
Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer. Oncogene (1991) 1.40
Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells. Exp Cell Res (1984) 1.40
p53-mediated apoptosis is attenuated in Werner syndrome cells. Genes Dev (1999) 1.39
Strontium phosphate transfection of human cells in primary culture: stable expression of the simian virus 40 large-T-antigen gene in primary human bronchial epithelial cells. Mol Cell Biol (1987) 1.39
Functional interaction of p53 and BLM DNA helicase in apoptosis. J Biol Chem (2001) 1.37
Inflammation and oxidative stress in carcinogenesis. Cancer Cells (1991) 1.37
Interlaboratory comparison of antisera and immunoassays for benzo[a]pyrene-diol-epoxide-I-modified DNA. Carcinogenesis (1988) 1.37
Studies on cellular autophagocytosis. Relationship between heterophagy and autophagy in HeLa cells. Lab Invest (1971) 1.35
The respiratory epithelium. V. Histogenesis of lung carcinomas in the human. J Natl Cancer Inst (1978) 1.35
Genetic polymorphisms in DNA repair genes and risk of lung cancer. Carcinogenesis (2001) 1.35
Clonal growth of epithelial cells from normal adult human bronchus. Cancer Res (1981) 1.33
The glomerular capillary wall in human kidney disease: acute glomerulonephritis, systemic lupus erythematosus, and preeclampsia-eclampsia. Comparative electron microscopic observations and a review. Lab Invest (1966) 1.33
Studies of mouse liver necrosis in vitro. Ultrastructural and cytochemical alterations in hepatic parenchymal cell nuclei. Lab Invest (1965) 1.33