Published in Nature on June 30, 1983
Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci. Proc Natl Acad Sci U S A (1985) 2.19
Six HLA-D region alpha-chain genes on human chromosome 6: polymorphisms and associations of DC alpha-related sequences with DR types. Proc Natl Acad Sci U S A (1984) 1.90
A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles. J Clin Invest (1989) 1.72
A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1985) 1.69
Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis. J Exp Med (1986) 1.69
Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus. J Clin Invest (1992) 1.63
Characterization of an HLA DR beta pseudogene. Proc Natl Acad Sci U S A (1985) 1.62
Extended major histocompatibility complex haplotypes in type I diabetes mellitus. J Clin Invest (1984) 1.58
HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus. Am J Hum Genet (1984) 1.54
Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis. Proc Natl Acad Sci U S A (1984) 1.52
Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene. Proc Natl Acad Sci U S A (1985) 1.26
An extended HLA-D region haplotype associated with celiac disease. Proc Natl Acad Sci U S A (1988) 1.21
Molecular cloning of a polymorphic DNA endonuclease fragment associates insulin-dependent diabetes mellitus with HLA-DQ. J Clin Invest (1987) 1.17
Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies. Am J Hum Genet (1995) 1.09
The genetics of diabetes: from nightmare to headache. Br Med J (Clin Res Ed) (1987) 1.02
HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism. J Exp Med (1986) 0.96
Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs. Am J Hum Genet (1994) 0.94
HLA class II alpha chain gene polymorphisms in patients with insulin-dependent diabetes mellitus, dermatitis herpetiformis, and celiac disease. J Clin Invest (1987) 0.86
TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility. Proc Natl Acad Sci U S A (1993) 0.83
Unusual clustering of diseases in a Canadian Old Colony (Chortitza) Mennonite kindred and community. CMAJ (1988) 0.80
Use of synthetic oligonucleotides for genomic DNA dot hybridization to split the DQw3 haplotype. Proc Natl Acad Sci U S A (1988) 0.79
Novel HLA class II-associated structural patterns in coeliac disease and type I diabetes. Clin Exp Immunol (1988) 0.78
Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11. Clin Exp Immunol (1991) 0.78
HLA-DR antigens and HLA-DQ beta chain polymorphism in susceptibility to rheumatoid arthritis. Ann Rheum Dis (1990) 0.78
Molecular biology of IDDM. Diabetologia (1994) 0.77
The role of immunotherapy in type I diabetes mellitus. West J Med (1987) 0.77
Pathophysiology of diabetes. A review of selected recent developments and their impact on treatment. Drugs (1992) 0.76
Lack of association of T cell receptor beta-chain constant region polymorphism with insulin-dependent diabetes mellitus in Finland. Clin Exp Immunol (1990) 0.76
Rapid HLA typing by multiplex amplification refractory mutation system. J Clin Pathol (1993) 0.75
RFLP analysis of HLA-DR beta and -DQ beta genes in the Korean patients with insulin-dependent diabetes mellitus. Korean J Intern Med (1989) 0.75
Immunological aspects on IDDM in children. Indian J Pediatr (1990) 0.75
Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum. EMBO J (1990) 7.03
Molecular cloning of the a1 locus of Zea mays using the transposable elements En and Mu1. EMBO J (1985) 6.97
The regulatory c1 locus of Zea mays encodes a protein with homology to myb proto-oncogene products and with structural similarities to transcriptional activators. EMBO J (1987) 5.98
An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science (1996) 5.93
Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Science (1992) 4.74
Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum. Cell (1989) 4.47
HL-A antigens and diabetes mellitus. Lancet (1974) 4.42
The Spm (En) transposable element controls the excision of a 2-kb DNA insert at the wx allele of Zea mays. EMBO J (1984) 4.41
Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove. Science (1997) 4.27
A viral inhibitor of peptide transporters for antigen presentation. Nature (1995) 4.26
Influence of transposable elements on the structure and function of the A1 gene of Zea mays. EMBO J (1987) 4.23
Plant transposable elements generate the DNA sequence diversity needed in evolution. EMBO J (1985) 4.12
HLA and disease 1982--a survey. Immunol Rev (1983) 3.87
2 -Microglobulin--a free immunoglobulin domain. Proc Natl Acad Sci U S A (1972) 3.74
Retrieval of transmembrane proteins to the endoplasmic reticulum. J Cell Biol (1993) 3.67
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science (1998) 3.64
Emerging principles for the recognition of peptide antigens by MHC class I molecules. Science (1992) 3.64
Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance. Cell (1985) 3.59
Epidermal Langerhans cells express Ia antigens. Nature (1977) 3.51
Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens. Cell (1982) 3.36
Intracellular transport of class II MHC molecules directed by invariant chain. Nature (1990) 3.35
Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J Immunol (1995) 3.30
Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens. Proc Natl Acad Sci U S A (1982) 3.30
Genetic and molecular analysis of the Enhancer (En) transposable element system of Zea mays. EMBO J (1985) 3.28
Molecular cloning of the c locus of Zea mays: a locus regulating the anthocyanin pathway. EMBO J (1986) 3.18
Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proc Natl Acad Sci U S A (1996) 3.16
CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature (1996) 3.08
A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science (2000) 3.06
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J Biol Chem (2000) 2.96
The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity (1997) 2.93
Use of anti-idiotypic antibodies as cell-surface receptor probes. Proc Natl Acad Sci U S A (1978) 2.92
A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum. Cell (1987) 2.88
HL-A and disease associations--a survey. Transplant Rev (1975) 2.87
The three-dimensional structure of retinol-binding protein. EMBO J (1984) 2.82
Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age. Diabetologia (1999) 2.81
DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression. J Virol (1999) 2.80
TCR-Mediated internalization of peptide-MHC complexes acquired by T cells. Science (1999) 2.70
The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia (1974) 2.69
Highly purified papain-solubilized HL-A antigens contain beta2-microglobulin. Proc Natl Acad Sci U S A (1974) 2.66
cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. Proc Natl Acad Sci U S A (1983) 2.66
An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum. EMBO J (1994) 2.65
Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. EMBO J (1996) 2.64
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature (1982) 2.58
The complete amino acid sequence of beta 2-microglobulin. Biochemistry (1973) 2.55
Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon. Cell (1983) 2.42
Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. Immunity (1994) 2.39
Peptide binding and presentation by mouse CD1. Science (1995) 2.38
Autoimmune type 1 diabetes: resolved and unresolved issues. J Clin Invest (2001) 2.35
Mutations and selection in the generation of class II histocompatibility antigen polymorphism. EMBO J (1984) 2.34
The molecular chaperone calnexin binds Glc1Man9GlcNAc2 oligosaccharide as an initial step in recognizing unfolded glycoproteins. J Biol Chem (1995) 2.31
A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics (1994) 2.31
Four secretory proteins synthesized by hepatocytes are transported from endoplasmic reticulum to Golgi complex at different rates. EMBO J (1984) 2.27
HLA and disease associations: detecting the strongest association. Tissue Antigens (1994) 2.22
Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains. EMBO J (1984) 2.18
Maize transposable elements. Annu Rev Genet (1989) 2.14
Structure of a gene encoding the 1.7 S storage protein, napin, from Brassica napus. J Biol Chem (1987) 2.13
Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins. Cell (1982) 2.13
Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways. Nature (1990) 2.11
A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet (1995) 2.10
High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc Natl Acad Sci U S A (1994) 2.09
Antigen presentation and T cell development in H2-M-deficient mice. Science (1996) 2.07
Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease. Histopathology (2001) 2.07
The cell attachment domain of fibronectin. Determination of the primary structure. J Biol Chem (1982) 2.03
The insulin gene is located on chromosome 11 in humans. Nature (1980) 2.03
A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia (1994) 2.03
The insulin gene is located on the short arm of chromosome 11 in humans. Diabetes (1981) 2.00
The En/Spm transposable element of Zea mays contains splice sites at the termini generating a novel intron from a dSpm element in the A2 gene. EMBO J (1990) 2.00
Leukocyte and fibroblast interferon genes are located on human chromosome 9. Proc Natl Acad Sci U S A (1981) 1.98
Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of beta-2-macroglobulin, albumin, and total protein. J Clin Invest (1969) 1.97
MLC typing in juvenile diabetes mellitus and idiopathic Addison's disease. Transplant Rev (1975) 1.97
Role of beta2-microglobulin in the intracellular processing of HLA antigens. Biochemistry (1981) 1.96
Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line. Proc Natl Acad Sci U S A (1978) 1.94
Structure of C-terminal half of two H-2 antigens from cloned mRNA. Nature (1981) 1.90
Hormonal regulation of the expression of Ia antigens on mammary gland epithelium. Eur J Immunol (1980) 1.90
The glucosinolate-degrading enzyme myrosinase in Brassicaceae is encoded by a gene family. Plant Mol Biol (1992) 1.90
cDNA clone coding for part of a mouse H-2d major histocompatibility antigen. Proc Natl Acad Sci U S A (1981) 1.90
T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells. J Exp Med (2000) 1.88
EEG abnormalities with and without relation to severe hypoglycaemia in adolescents with type 1 diabetes. Diabetologia (2005) 1.87
Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet (1992) 1.87
Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans. Science (1980) 1.85
Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene. Proc Natl Acad Sci U S A (1983) 1.85
Regulation of MHC class I transport by the molecular chaperone, calnexin (p88, IP90). Science (1994) 1.79
Empty and peptide-containing conformers of class I major histocompatibility complex molecules expressed in Drosophila melanogaster cells. Proc Natl Acad Sci U S A (1992) 1.79