Published in Cell on June 01, 1984
Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol (1987) 5.67
Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes. Proc Natl Acad Sci U S A (1986) 3.19
Nucleotide sequence of cDNA clones of the murine myb proto-oncogene. EMBO J (1985) 2.73
Two modes of c-myb activation in virus-induced mouse myeloid tumors. Mol Cell Biol (1986) 2.57
Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus. Proc Natl Acad Sci U S A (1986) 2.47
The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain. EMBO J (1987) 2.35
Isolation of human cDNA clones of myb-related genes, A-myb and B-myb. Nucleic Acids Res (1988) 2.26
Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest (1995) 2.26
Human proto-oncogene N-myc encodes nuclear proteins that bind DNA. Mol Cell Biol (1986) 2.15
v-rel oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells. J Virol (1988) 2.08
Characterization of the sequence-specific interaction of mouse c-myb protein with DNA. EMBO J (1990) 2.05
Murine myb protooncogene mRNA: cDNA sequence and evidence for 5' heterogeneity. Proc Natl Acad Sci U S A (1986) 2.05
Changes in gene expression associated with induced differentiation of erythroleukemia: protooncogenes, globin genes, and cell division. Proc Natl Acad Sci U S A (1986) 1.99
An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines. Proc Natl Acad Sci U S A (1989) 1.98
Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein. Proc Natl Acad Sci U S A (1986) 1.89
Subnuclear localization of proteins encoded by the oncogene v-myb and its cellular homolog c-myb. Mol Cell Biol (1986) 1.81
Identification and characterization of the protein encoded by the human c-myb proto-oncogene. EMBO J (1986) 1.80
Structure of the protein encoded by the chicken proto-oncogene c-myb. Mol Cell Biol (1986) 1.69
Expression patterns of myb genes from Antirrhinum flowers. Plant Cell (1991) 1.62
Antibodies to the evolutionarily conserved amino-terminal region of the v-myb-encoded protein detect the c-myb protein in widely divergent metazoan species. Proc Natl Acad Sci U S A (1986) 1.59
Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene. Mol Cell Biol (1991) 1.58
trans activation of gene expression by v-myb. Mol Cell Biol (1990) 1.48
Drosophila and vertebrate myb proteins share two conserved regions, one of which functions as a DNA-binding domain. EMBO J (1987) 1.48
Nuclear compartmentalization of the v-myb oncogene product. Mol Cell Biol (1985) 1.48
Regulation of c-myc mRNA levels in normal human lymphocytes by modulators of cell proliferation. Proc Natl Acad Sci U S A (1985) 1.38
Extension of the DNA binding consensus of the chicken c-Myb and v-Myb proteins. Nucleic Acids Res (1992) 1.32
D-type cyclins repress transcriptional activation by the v-Myb but not the c-Myb DNA-binding domain. EMBO J (1998) 1.26
Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging. Proc Natl Acad Sci U S A (1991) 1.25
Transformation by v-myb correlates with trans-activation of gene expression. Mol Cell Biol (1990) 1.23
Structural and functional domains of the myb oncogene: requirements for nuclear transport, myeloid transformation, and colony formation. J Virol (1988) 1.23
A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C. Mol Cell Biol (1988) 1.23
Identification in chicken macrophages of a set of proteins related to, but distinct from, the chicken cellular c-ets-encoded protein p54c-ets. EMBO J (1986) 1.22
Requirement of protein co-factor for the DNA-binding function of the human ski proto-oncogene product. Nucleic Acids Res (1990) 1.20
Multiple domains for the chicken cellular sequences homologous to the v-ets oncogene of the E26 retrovirus. Mol Cell Biol (1987) 1.20
Alternative splicing within the chicken c-ets-1 locus: implications for transduction within the E26 retrovirus of the c-ets proto-oncogene. J Virol (1988) 1.17
c-myb protein expression is a late event during T-lymphocyte activation. Mol Cell Biol (1987) 1.16
Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation. Mol Cell Biol (1988) 1.11
Characterization of the v-myb DNA binding domain. Nucleic Acids Res (1990) 1.11
Phosphorylation of Ga14p at a single C-terminal residue is necessary for galactose-inducible transcription. Mol Cell Biol (1996) 1.10
Expression of molecular clones of v-myb in avian and mammalian cells independently of transformation. J Virol (1986) 1.10
Induced differentiation of avian myeloblastosis virus-transformed myeloblasts: phenotypic alteration without altered expression of the viral oncogene. Mol Cell Biol (1984) 1.06
Properties of a murine retroviral recombinant of avian acute leukemia virus E26: a murine fibroblast assay for v-ets function. J Virol (1989) 1.04
Murine myeloid cell lines derived by in vitro infection with recombinant c-myb retroviruses express myb from rearranged vector proviruses. EMBO J (1989) 1.02
v-myb blocks granulocyte colony-stimulating factor-induced myeloid cell differentiation but not proliferation. Mol Cell Biol (1993) 1.01
Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo. Mol Cell Biol (1993) 1.00
A second c-myb protein is translated from an alternatively spliced mRNA expressed from normal and 5'-disrupted myb loci. Mol Cell Biol (1989) 0.98
Two nuclear oncogenic proteins, P135gag-myb-ets and p61/63myc, cooperate to induce transformation of chicken neuroretina cells. J Virol (1989) 0.91
Transforming and mitogenic effects of avian leukemia virus E26 on chicken hematopoietic cells and fibroblasts, respectively, correlate with level of expression of the provirus. J Virol (1987) 0.91
Neoplastic transformation and tumorigenesis by the human protooncogene MYC. Proc Natl Acad Sci U S A (1990) 0.90
DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation. J Virol (1988) 0.89
Transcription of the chicken myb proto-oncogene starts within a CpG island. Nucleic Acids Res (1989) 0.89
The myc proteins are not associated with chromatin in mitotic cells. EMBO J (1984) 0.87
Transformation of Brown Leghorn chicken embryo fibroblasts by avian myeloblastosis virus proviral DNA. J Virol (1985) 0.87
Functional analysis of carboxy-terminal deletion mutants of c-Myb. J Virol (1999) 0.86
Coordinate regulation of myelomonocytic phenotype by v-myb and v-myc. Mol Cell Biol (1986) 0.85
Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex. Proc Natl Acad Sci U S A (2011) 0.85
Structural organization of upstream exons and distribution of transcription start sites in the chicken c-myb gene. Mol Cell Biol (1989) 0.84
Myb-Ets fusion oncoprotein inhibits thyroid hormone receptor/c-ErbA and retinoic acid receptor functions: a novel mechanism of action for leukemogenic transformation by E26 avian retrovirus. Mol Cell Biol (1996) 0.84
v-myb and v-ets cooperate for the mitogenic stimulation of primary fibroblasts by avian E26 retrovirus. J Virol (1991) 0.84
v-myb does not prevent the expression of c-myb in avian erythroblasts. J Virol (1987) 0.84
Subnuclear associations of the v-myb oncogene product and actin are dependent on ionic strength during nuclear isolation. Mol Cell Biol (1987) 0.83
Alternative splicing of RNAs transcribed from the human c-myb gene. Mol Cell Biol (1990) 0.82
Transcription and cancer. Br J Cancer (1991) 0.81
Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor. J Virol (1992) 0.81
Protein truncation is not required for c-myb proto-oncogene activity in neuroretina cells. J Virol (1992) 0.81
Nucleotide sequence of chicken myb proto-oncogene promoter region: detection of an evolutionarily conserved element. Nucleic Acids Res (1988) 0.80
The carboxyterminus of human c-myb protein stimulates activated transcription in trans. Nucleic Acids Res (1994) 0.78
Predicted common structural features of DNA-binding domains from Ets, Myb and HMG transcription factors. Nucleic Acids Res (1993) 0.78
Transformation-defective mutant of avian myeloblastosis virus that is temperature sensitive for production of transforming protein p45v-myb. Mol Cell Biol (1985) 0.78
Individual repeats of Drosophila Myb can function in transformation by v-Myb. J Virol (1993) 0.77
Interferon gamma abrogates the differentiation block in v-myc-expressing U-937 monoblasts. Proc Natl Acad Sci U S A (1991) 0.76
Expression of viral p21ras during acquisition of a transformed phenotype by rat adrenal cortex cells infected with Kirsten murine sarcoma virus. Mol Cell Biol (1986) 0.76
DNA segment containing C beta 1, a gene for the constant region of the beta chain of the T-cell antigen receptor, was inserted into chromosome 6 in cells from one patient with human T-cell leukemia. Proc Natl Acad Sci U S A (1987) 0.75
In vivo cooperation of two nuclear oncogenic proteins, P135gag-myb-ets and p61/63myc, leads to transformation and immortalization of chicken myelomonocytic cells. J Virol (1994) 0.75
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell (1978) 13.33
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein. Cell (1978) 11.17
Correct integration of retroviral DNA in vitro. Cell (1987) 10.73
Cellular oncogenes and retroviruses. Annu Rev Biochem (1983) 10.65
The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat Cell Biol (2000) 9.87
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature (1976) 9.81
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (1984) 9.64
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature (1982) 9.12
A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev (1989) 8.80
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature (1983) 8.18
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc Natl Acad Sci U S A (1989) 8.13
Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell (1999) 8.03
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res (1995) 7.95
The molecular genetics of cancer. Science (1987) 7.64
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Natl Acad Sci U S A (1979) 7.55
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell (1978) 7.46
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci U S A (1983) 7.01
Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state. Cell (1981) 6.98
Virus-specific ribonucleic acid in cells producing rous sarcoma virus: detection and characterization. J Virol (1972) 6.38
Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31
Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell (1982) 6.19
Viral myb oncogene encodes a sequence-specific DNA-binding activity. Nature (1988) 5.72
Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues. Mol Cell Biol (1982) 5.70
Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol (1987) 5.67
Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (1992) 5.50
Retroviruses. Annu Rev Biochem (1978) 5.41
The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses. Cell (1977) 5.23
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22
Viral oncogenes. Cell (1985) 5.20
Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev (1998) 5.14
Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses. J Mol Biol (1976) 5.07
The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane. Proc Natl Acad Sci U S A (1980) 4.99
Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J (1997) 4.99
The MYC protein activates transcription of the alpha-prothymosin gene. EMBO J (1991) 4.96
Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src). Proc Natl Acad Sci U S A (1981) 4.69
Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature (1989) 4.65
The low molecular weight RNAs of Rous sarcoma virus. I. The 4 S RNA. Virology (1970) 4.64
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature (2006) 4.57
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell (1983) 4.53
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates. Proc Natl Acad Sci U S A (1978) 4.47
c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature (2001) 4.46
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature (1985) 4.31
Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts. Proc Natl Acad Sci U S A (1973) 4.19
A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase. Cell (1977) 4.18
Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell (1993) 4.10
Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA. Cell (1977) 4.06
Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src). Proc Natl Acad Sci U S A (1981) 4.04
Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells. J Mol Biol (1978) 4.04
The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine. J Biol Chem (1980) 3.95
Transcription of DNA from the 70S RNA of Rous sarcoma virus. I. Identification of a specific 4S RNA which serves as primer. J Virol (1974) 3.90
A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle. Cell (1990) 3.87
Identification of nuclear proteins encoded by viral and cellular myc oncogenes. Nature (1984) 3.86
Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements. Proc Natl Acad Sci U S A (1981) 3.82
Computer-based screening system for patients at risk of hypothyroidism. Lancet (1969) 3.70
DNA and RNA from uninfected vertebrate cells contain nucleotide sequences related to the putative transforming gene of avian myelocytomatosis virus. J Virol (1979) 3.68
Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus. Nature (1975) 3.63
c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J (1994) 3.58
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature (1983) 3.56
Induction of apoptosis by the Bcl-2 homologue Bak. Nature (1995) 3.56
Purification and characterization of the deoxyribonucleic acid polymerase associated with Rous sarcoma virus. Biochemistry (1972) 3.53
Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus. Cell (1982) 3.53
Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell (1996) 3.45
Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature (1992) 3.43
Daily requirement of oxygen to reverse pulmonary hypertension in patients with chronic bronchitis. Br Med J (1972) 3.43
Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus. Nature (1983) 3.42
Transduction of a cellular oncogene: the genesis of Rous sarcoma virus. Proc Natl Acad Sci U S A (1983) 3.41
Production of mouse mammary tumor virus by cultured cells in the absence and presence of hormones: assay by molecular hybridization. Virology (1975) 3.40
A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein. Proc Natl Acad Sci U S A (1981) 3.32
RNA-directed DNA polymerase of Rous sarcoma virus: initiation of synthesis with 70 S viral RNA as template. J Mol Biol (1973) 3.32
The protein encoded by the human proto-oncogene c-myc. Proc Natl Acad Sci U S A (1984) 3.31
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA. Proc Natl Acad Sci U S A (1977) 3.31
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells). Proc Natl Acad Sci U S A (1972) 3.28
Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci U S A (1999) 3.24
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant. Mol Cell Biol (1988) 3.24
New method for oxygen therapy in the home using an oxygen concentrator. Br Med J (1973) 3.22
Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus. J Mol Biol (1973) 3.21
Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Cell (1989) 3.21
The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb. Cell (1983) 3.21
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A (1997) 3.20
Characterization of the low-molecular-weight RNAs associated with the 70S RNA of Rous sarcoma virus. J Virol (1973) 3.19
Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol (1981) 3.18
The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome. Nucleic Acids Res (1980) 3.16
Medical audits. J R Coll Physicians Lond (1980) 3.15
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol (1993) 3.13
Restricted expression of EBV latent genes and T-lymphocyte-detected membrane antigen in Burkitt's lymphoma cells. EMBO J (1986) 3.07
Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell (1997) 3.06
Reversal of pulmonary hypertension by prolonged oxygen administration to patients with chronic bronchitis. Circ Res (1968) 3.06
Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src. Cell (1984) 3.06
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Molecular cloning of the avian erythroblastosis virus genome and recovery of oncogenic virus by transfection of chicken cells. J Virol (1980) 3.01
RNA-directed DNA synthesis by virions of Rous sarcoma virus: further characterization of the templates and the extent of their transcription. Virology (1973) 3.00
Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertants. Virology (1977) 2.99
Nucleotide sequence of the human N-myc gene. Proc Natl Acad Sci U S A (1986) 2.99