Published in J Mol Biol on May 05, 1984
The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions. Proc Natl Acad Sci U S A (2001) 2.97
Polar residues drive association of polyleucine transmembrane helices. Proc Natl Acad Sci U S A (2001) 2.47
Epstein-Barr virus genome may encode a protein showing significant amino acid and predicted secondary structure homology with glycoprotein B of herpes simplex virus 1. J Virol (1985) 2.25
Internal packing of helical membrane proteins. Proc Natl Acad Sci U S A (2000) 2.12
NMR study of the tetrameric KcsA potassium channel in detergent micelles. Protein Sci (2006) 2.07
Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption. Blood (2010) 1.83
The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions. Biophys J (1999) 1.82
Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci U S A (1992) 1.79
Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure (2008) 1.64
Serine and threonine residues bend alpha-helices in the chi(1) = g(-) conformation. Biophys J (2000) 1.57
Structure of the integrin alphaIIb transmembrane segment. J Biol Chem (2008) 1.57
Helical structure of the COOH terminus of S3 and its contribution to the gating modifier toxin receptor in voltage-gated ion channels. J Gen Physiol (2001) 1.47
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Pharmacol Rev (2010) 1.45
G protein-coupled receptors: in silico drug discovery in 3D. Proc Natl Acad Sci U S A (2004) 1.43
Parallel helix bundles and ion channels: molecular modeling via simulated annealing and restrained molecular dynamics. Biophys J (1994) 1.41
Implications of threonine hydrogen bonding in the glycophorin A transmembrane helix dimer. Biophys J (2002) 1.34
Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors. Biophys J (1999) 1.32
SCAMP 37, a new marker within the general cell surface recycling system. EMBO J (1993) 1.21
Non-pore lining amino acid side chains influence anion selectivity of the human CFTR Cl- channel expressed in mammalian cell lines. J Physiol (1998) 1.19
The activated state of a sodium channel voltage sensor in a membrane environment. Proc Natl Acad Sci U S A (2010) 1.18
Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors. Biophys J (2011) 1.15
Gauging a hydrocarbon ruler by an intrinsic exciton probe. Biochemistry (2007) 1.14
Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices. Biophys J (2004) 1.14
Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism. Proc Natl Acad Sci U S A (2014) 1.12
Molecular dynamics of individual alpha-helices of bacteriorhodopsin in dimyristol phosphatidylocholine. I. Structure and dynamics. Biophys J (1997) 1.10
Defining the transmembrane helix of M2 protein from influenza A by molecular dynamics simulations in a lipid bilayer. Biophys J (1999) 1.10
Membrane driven spatial organization of GPCRs. Sci Rep (2013) 1.03
Molecular dynamics simulations of individual alpha-helices of bacteriorhodopsin in dimyristoylphosphatidylcholine. II. Interaction energy analysis. Biophys J (1998) 1.02
Glycines: role in α-helical membrane protein structures and a potential indicator of native conformation. Biochemistry (2012) 1.01
Assignment of groups responsible for the "opsin shift" and light absorptions of rhodopsin and red, green, and blue iodopsins (cone pigments). Proc Natl Acad Sci U S A (1988) 0.99
Role of the coronavirus E viroporin protein transmembrane domain in virus assembly. J Virol (2007) 0.96
Strength of a bifurcated H bond. Proc Natl Acad Sci U S A (2014) 0.88
Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins. Biophys J (2014) 0.82
Ser/Thr motifs in transmembrane proteins: conservation patterns and effects on local protein structure and dynamics. J Membr Biol (2012) 0.82
The power of hard-sphere models: explaining side-chain dihedral angle distributions of Thr and Val. Biophys J (2012) 0.82
Conformations of islet amyloid polypeptide monomers in a membrane environment: implications for fibril formation. PLoS One (2012) 0.82
A single residue in transmembrane domain 11 defines the different affinity for thiazides between the mammalian and flounder NaCl transporters. Am J Physiol Renal Physiol (2010) 0.81
The transmembrane prolines of the mitochondrial ADP/ATP carrier are involved in nucleotide binding and transport and its biogenesis. J Biol Chem (2012) 0.81
Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia. Am J Hum Genet (2016) 0.80
Replacements in a conserved leucine cluster in the hydrophobic heme pocket of cytochrome c. Protein Sci (1995) 0.80
Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix. Biophys J (2014) 0.79
Re-introduction of transmembrane serine residues reduce the minimum pore diameter of channelrhodopsin-2. PLoS One (2012) 0.79
Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin. J Comput Aided Mol Des (2001) 0.78
NMR structure determination of the tetramerization domain of the Mnt repressor: An asymmetric alpha-helical assembly in slow exchange. J Biomol NMR (1999) 0.78
Characterizing the Murine Leukemia Virus Envelope Glycoprotein Membrane-Spanning Domain for Its Roles in Interface Alignment and Fusogenicity. J Virol (2015) 0.76
Anatomy of a conformational transition of beta-strand 6 in soybean beta-amylase caused by substrate (or inhibitor) binding to the catalytical site. Protein Sci (1997) 0.76
Energetics of side-chain snorkeling in transmembrane helices probed by nonproteinogenic amino acids. Proc Natl Acad Sci U S A (2016) 0.76
Structural Basis of the Disorder in the Tandem Zinc Finger Domain of the RNA-Binding Protein Tristetraprolin. J Chem Theory Comput (2016) 0.75
Adjacent channelrhodopsin-2 residues within transmembranes 2 and 7 regulate cation selectivity and distribution of the two open states. J Biol Chem (2017) 0.75
Can proteins be intrinsically disordered inside a membrane? Intrinsically Disord Proteins (2015) 0.75
Computational prediction of kink properties of helices in membrane proteins. J Comput Aided Mol Des (2014) 0.75
Solvent content of protein crystals. J Mol Biol (1968) 106.07
Comparison of the predicted and observed secondary structure of T4 phage lysozyme. Biochim Biophys Acta (1975) 17.03
The helix-turn-helix DNA binding motif. J Biol Chem (1989) 6.87
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. Science (1992) 6.51
Structure of the cro repressor from bacteriophage lambda and its interaction with DNA. Nature (1981) 5.24
Structural basis of amino acid alpha helix propensity. Science (1993) 4.36
Enhancement of the method of molecular replacement by incorporation of known structural information. Acta Crystallogr D Biol Crystallogr (1994) 4.26
Structural basis of DNA-protein recognition. Trends Biochem Sci (1989) 3.95
Three-dimensional structure of tosyl-alpha-chymotrypsin. Nature (1967) 3.57
DNA-binding proteins. Science (1983) 3.56
The molecular basis of DNA-protein recognition inferred from the structure of cro repressor. Nature (1982) 3.56
Three-dimensional structure of beta-galactosidase from E. coli. Nature (1994) 3.46
A relationship between protein stability and protein function. Proc Natl Acad Sci U S A (1995) 3.44
A mutant T4 lysozyme displays five different crystal conformations. Nature (1990) 3.07
Structure of bacteriophage T4 lysozyme refined at 1.7 A resolution. J Mol Biol (1987) 3.02
Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. Proc Natl Acad Sci U S A (1992) 2.89
Structural similarity in the DNA-binding domains of catabolite gene activator and cro repressor proteins. Proc Natl Acad Sci U S A (1982) 2.84
Structure of thermolysin refined at 1.6 A resolution. J Mol Biol (1982) 2.84
Structure of crystalline -chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism. J Mol Biol (1968) 2.72
Accurate calculation of the density of proteins. Acta Crystallogr D Biol Crystallogr (2000) 2.70
Control of enzyme activity by an engineered disulfide bond. Science (1989) 2.70
Protein flexibility and adaptability seen in 25 crystal forms of T4 lysozyme. J Mol Biol (1995) 2.55
Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J Mol Biol (1993) 2.50
Structure and X-ray amino acid sequence of a bacteriochlorophyll A protein from Prosthecochloris aestuarii refined at 1.9 A resolution. J Mol Biol (1986) 2.45
Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3. Nature (1988) 2.32
Protein-DNA interaction. No code for recognition. Nature (1988) 2.31
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme. Biochemistry (1991) 2.31
Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme. Proc Natl Acad Sci U S A (2000) 2.25
The conformation of thermolysin. J Biol Chem (1974) 2.25
Structural analysis of zinc substitutions in the active site of thermolysin. Protein Sci (1995) 2.24
Stabilization of phage T4 lysozyme by engineered disulfide bonds. Proc Natl Acad Sci U S A (1989) 2.17
Covalent structure of a group-specific protease from rat small intestine. Appendix: crystallographic data for a group specific protease from rat intestine. Biochemistry (1978) 2.17
Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing. Nature (1990) 2.14
Toroidal structure of lambda-exonuclease. Science (1997) 2.14
Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein. Biochemistry (1987) 2.12
Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: linkage of dynamics and structural plasticity. Biochemistry (1995) 2.10
A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene. Nature (1992) 2.10
Structure of the DNA-binding region of lac repressor inferred from its homology with cro repressor. Proc Natl Acad Sci U S A (1982) 2.09
Structure and function of the methionine aminopeptidases. Biochim Biophys Acta (2000) 2.09
Substantial increase of protein stability by multiple disulphide bonds. Nature (1989) 2.08
Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft. Biochemistry (1991) 2.03
The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect. Protein Sci (1998) 2.02
Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature (1987) 2.01
Structural studies of protein-nucleic acid interactions. Annu Rev Biophys Bioeng (1983) 1.95
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J Mol Biol (1994) 1.95
Three-dimensional structure of human basic fibroblast growth factor. Proc Natl Acad Sci U S A (1991) 1.94
Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles. Nature (1988) 1.89
Kinetic studies on Cro repressor-operator DNA interaction. J Mol Biol (1987) 1.85
A structural basis for processivity. Protein Sci (2001) 1.85
Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme. Biochemistry (1993) 1.80
Many gene-regulatory proteins appear to have a similar alpha-helical fold that binds DNA and evolved from a common precursor. J Mol Evol (1983) 1.80
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry (1991) 1.79
Type II restriction endonucleases: structural, functional and evolutionary relationships. Curr Opin Chem Biol (1999) 1.79
The structure of thermolysin: an electron density map at 2-3 A resolution. J Mol Biol (1972) 1.77
Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase. Proc Natl Acad Sci U S A (2000) 1.76
Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. Proc Natl Acad Sci U S A (1995) 1.76
Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis. Biochemistry (1991) 1.76
Energetic origins of specificity of ligand binding in an interior nonpolar cavity of T4 lysozyme. Biochemistry (1995) 1.75
Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. J Mol Biol (1992) 1.73
Structure-based design of a lysozyme with altered catalytic activity. Nat Struct Biol (1995) 1.73
Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme. Biochemistry (2000) 1.72
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive. Protein Eng (1995) 1.68
Atomic co-ordinates for tosyl-alpha-chymotrypsin. Biochem Biophys Res Commun (1969) 1.67
Molecular basis of thermostability in the lysozyme from bacteriophage T4. Nature (1979) 1.66
A crystallographic study of the complex of phosphoramidon with thermolysin. A model for the presumed catalytic transition state and for the binding of extended substances. J Mol Biol (1977) 1.65
Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. Proc Natl Acad Sci U S A (1990) 1.63
Reversible lattice repacking illustrates the temperature dependence of macromolecular interactions. J Mol Biol (2001) 1.60
An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides. Biochemistry (1984) 1.59
Comparison of the crystal structure of bacteriophage T4 lysozyme at low, medium, and high ionic strengths. Proteins (1991) 1.57
A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme. Proc Natl Acad Sci U S A (1996) 1.56
Structure of Escherichia coli exonuclease I suggests how processivity is achieved. Nat Struct Biol (2000) 1.55
Structure of a bacteriochlorophyll a-protein from the green photosynthetic bacterium Prosthecochloris aestuarii. J Mol Biol (1979) 1.54
The three dimensional structure of the lysozyme from bacteriophage T4. Proc Natl Acad Sci U S A (1974) 1.52
A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme. Science (1993) 1.50
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants. Proc Natl Acad Sci U S A (1989) 1.50
Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. Proc Natl Acad Sci U S A (1992) 1.49
Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator. Proc Natl Acad Sci U S A (2001) 1.49
Comparison of the structures of cro and lambda repressor proteins from bacteriophage lambda. J Mol Biol (1983) 1.48
Relation between hen egg white lysozyme and bacteriophage T4 lysozyme: evolutionary implications. J Mol Biol (1981) 1.46
Comparison of the structures of carboxypeptidase A and thermolysin. J Biol Chem (1977) 1.46
Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis. Biochemistry (1981) 1.46
A systematic approach to the comparison of protein structures. J Mol Biol (1980) 1.45
Alanine scanning mutagenesis of the alpha-helix 115-123 of phage T4 lysozyme: effects on structure, stability and the binding of solvent. J Mol Biol (1995) 1.43
Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme. J Mol Biol (2000) 1.43
Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. Biochemistry (1992) 1.42
Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme. Biochemistry (1991) 1.42
Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues. Biochemistry (1987) 1.42
Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by X-ray crystallography: a novel class of transition-state analogues for zinc peptidases. Biochemistry (1984) 1.40
Determination of molecular weight from protein crystals. J Mol Biol (1974) 1.40
The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme. Science (1993) 1.39
Crystallographic study of the binding of dipeptide inhibitors to thermolysin: implications for the mechanism of catalysis. Biochemistry (1977) 1.37
Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability. Science (1988) 1.37
Sequence and structure comparison suggest that methionine aminopeptidase, prolidase, aminopeptidase P, and creatinase share a common fold. Proc Natl Acad Sci U S A (1994) 1.37
Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis. Biochemistry (1992) 1.36
High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for alpha-complementation. Protein Sci (2000) 1.36
Structural, functional, and evolutionary relationships between lambda-exonuclease and the type II restriction endonucleases. Proc Natl Acad Sci U S A (1998) 1.35
Comparison of protein structures. Methods Enzymol (1985) 1.35
A structural view of the action of Escherichia coli (lacZ) beta-galactosidase. Biochemistry (2001) 1.35
How amino-acid insertions are allowed in an alpha-helix of T4 lysozyme. Nature (1993) 1.33
Crystal structure of the regulatory subunit H of the V-type ATPase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2001) 1.31