Alzheimer paired helical filaments: immunochemical identification of polypeptides.

PubWeight™: 2.70‹?› | Rank: Top 1%

🔗 View Article (PMID 6428153)

Published in Acta Neuropathol on January 01, 1984

Authors

I Grundke-Iqbal, K Iqbal, Y C Tung, H M Wisniewski

Articles citing this

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A (1986) 10.13

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau) Proc Natl Acad Sci U S A (1986) 4.26

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci U S A (2001) 2.97

Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition. Acta Neuropathol (1984) 2.97

Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigen(s). Acta Neuropathol (1984) 2.58

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.39

Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol (1986) 1.95

Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides. Am J Pathol (1985) 1.84

Alzheimer's paired helical filaments share epitopes with neurofilament side arms. EMBO J (1986) 1.81

Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy. Am J Pathol (1985) 1.77

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci U S A (1997) 1.73

Substructures of paired helical filaments from Alzheimer's disease neurofibrillary tangles. Acta Neuropathol (1985) 1.48

Alzheimer paired helical filaments: cross-reacting polypeptide/s normally present in brain. Acta Neuropathol (1985) 1.36

Antisera to scrapie-associated fibril protein and prion protein decorate scrapie-associated fibrils. J Virol (1987) 1.35

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proc Natl Acad Sci U S A (1989) 1.29

Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies. Acta Neuropathol (1985) 1.27

Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes. J Neurol Neurosurg Psychiatry (1986) 1.27

The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS One (2009) 1.15

Tau and neurodegenerative disease: the story so far. Nat Rev Neurol (2015) 1.10

Quantitative assessment of the density of neurofibrillary tangles and senile plaques in senile dementia of the Alzheimer type. Comparison of immunocytochemistry with a specific antibody and Bodian's protargol method. Acta Neuropathol (1987) 1.10

Relationship of aluminum to Alzheimer's disease. Environ Health Perspect (1985) 1.07

Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs. FASEB J (2011) 1.02

Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein-tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex. Acta Neuropathol (1989) 0.99

Ultrastructural study of enriched fractions of "tangles" from human patients with senile dementia of the Alzheimer type. Acta Neuropathol (1984) 0.87

The comparative immunoreactivities of brain amyloids in Alzheimer's disease and scrapie. Acta Neuropathol (1987) 0.84

Expression in cultured human neuroblastoma cells of epitopes associated with affected neurons in Alzheimer's disease. Am J Pathol (1990) 0.76

Immune electron microscopic characterization of monoclonal antibodies to Alzheimer neurofibrillary tangles. Am J Pathol (1992) 0.75

Paired twisted filaments: a new ultrastructural marker of human pinealomas? Acta Neuropathol (1984) 0.75

Articles cited by this

Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71

A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem (1973) 31.32

The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem (1970) 20.22

Microtubule assembly in the absence of added nucleotides. Proc Natl Acad Sci U S A (1973) 18.46

Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants. Nature (1982) 4.93

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature (1983) 3.67

Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition. Acta Neuropathol (1984) 2.97

Isolation of filaments from brain. Science (1971) 2.03

Immunocytochemical studies of neurofibrillary tangles. Am J Pathol (1981) 2.01

Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum. J Neurosci (1982) 1.88

Neurofibrillary changes in human brain. An immunocytochemical study with a neurofilament antiserum. J Neuropathol Exp Neurol (1983) 1.72

Protein changes in senile dementia. Brain Res (1974) 1.65

Presence of neurofilament protein in Alzheimer's neurofibrillary tangles (ANT). An immunofluorescent study. Acta Neuropathol (1979) 1.54

Alzheimer neurofibrillary tangles: antiserum and immunohistological staining. Ann Neurol (1979) 1.39

Immunohistochemical demonstration of S-100 protein and GFA protein in interstitial cells of rat pineal gland. Brain Res (1978) 1.19

Steady-state kinetics of smooth muscle myosin. Biochemistry (1978) 0.92

Articles by these authors

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A (1986) 10.13

Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol (1987) 7.05

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem (1986) 6.91

Abnormal fibrils from scrapie-infected brain. Acta Neuropathol (1981) 5.35

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc Natl Acad Sci U S A (1987) 3.97

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol (1985) 3.83

The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience (2000) 3.40

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett (1986) 3.36

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res (1989) 3.10

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci U S A (2001) 2.97

Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition. Acta Neuropathol (1984) 2.97

Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF. Neurology (1999) 2.74

Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiol Aging (1997) 2.68

Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease. Arch Neurol (2000) 2.66

Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigen(s). Acta Neuropathol (1984) 2.58

Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia. Ann Neurol (1979) 2.50

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med (1996) 2.46

Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. Lancet (1987) 2.44

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.39

Infection-specific particle from the unconventional slow virus diseases. Science (1984) 2.34

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem (1993) 2.30

Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques. Acta Neuropathol (1983) 2.23

Evidence that Alzheimer neurofibrillary tangles originate from neurotubules. Lancet (1979) 2.22

Scrapie-associated fibrils in Creutzfeldt-Jakob disease. Nature (1984) 2.11

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. J Neuropathol Exp Neurol (1999) 2.08

Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res (2010) 2.07

Phosphoprotein phosphatase activities in Alzheimer disease brain. J Neurochem (1993) 2.05

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem (1992) 2.04

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J Biol Chem (2000) 2.00

Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease. Ann Neurol (1999) 1.96

Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol (1986) 1.95

Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. Arch Biochem Biophys (1993) 1.90

Defective brain microtubule assembly in Alzheimer's disease. Lancet (1986) 1.89

MRI of entorhinal cortex in mild Alzheimer's disease. Lancet (1999) 1.86

Ultrastructure of paired helical filaments of Alzheimer's neurofibrillary tangle. J Neuropathol Exp Neurol (1984) 1.86

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain. J Neurochem (1995) 1.86

Adult fragile X syndrome. Clinico-neuropathologic findings. Acta Neuropathol (1985) 1.80

Post-translational modifications of tau protein in Alzheimer's disease. J Neural Transm (Vienna) (2004) 1.78

The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis. Acta Neuropathol (1986) 1.77

Alzheimer's disease in Down's syndrome: clinicopathologic studies. Neurology (1985) 1.75

Biochemical differences among scrapie-associated fibrils support the biological diversity of scrapie agents. J Gen Virol (1985) 1.75

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci U S A (1997) 1.73

Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol (1992) 1.71

Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease. J Neuropathol Exp Neurol (1997) 1.67

Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations. J Gen Virol (1986) 1.67

Protein changes in senile dementia. Brain Res (1974) 1.65

Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. Curr Med Chem (2008) 1.64

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain. J Neuropathol Exp Neurol (1997) 1.63

Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon. Acta Neuropathol (1984) 1.60

Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease. Nat Med (1996) 1.57

Primary demyelination as a nonspecific consequence of a cell-mediated immune reaction. J Exp Med (1975) 1.57

Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent. Ann Neurol (1981) 1.56

Role of feedforward control of movement stability in reducing slip-related balance loss and falls among older adults. J Neurophysiol (2003) 1.52

Simulated movement termination for balance recovery: can movement strategies be sought to maintain stability in the presence of slipping or forced sliding? J Biomech (1999) 1.52

Outcomes in African Americans and Hispanics with lupus nephritis. Kidney Int (2006) 1.52

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments. Brain Res (1988) 1.51

An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination. J Neuropathol Exp Neurol (1989) 1.51

Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. Arch Biochem Biophys (1998) 1.51

Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles. J Neuropathol Exp Neurol (1988) 1.49