Published in Proc Natl Acad Sci U S A on June 01, 1987
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A (1993) 3.73
Probing the biology of Alzheimer's disease in mice. Neuron (2010) 2.96
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci U S A (1988) 2.95
Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron (2006) 2.76
Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease. Am J Pathol (1989) 2.61
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A (1989) 2.48
Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci U S A (1990) 2.41
Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc Natl Acad Sci U S A (1992) 2.31
Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease. EMBO J (1987) 2.16
The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J (1988) 1.92
Cerebral amyloid angiopathy: a systematic review. J Clin Neurol (2011) 1.77
The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proc Natl Acad Sci U S A (1989) 1.73
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc Natl Acad Sci U S A (1993) 1.73
Beta-amyloid modulation of synaptic transmission and plasticity. J Neurosci (2007) 1.68
Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. Proc Natl Acad Sci U S A (1992) 1.67
Epigenetics, oxidative stress, and Alzheimer disease. Free Radic Biol Med (2009) 1.56
Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol (1989) 1.54
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A (1992) 1.52
A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor. Proc Natl Acad Sci U S A (1989) 1.48
Senile plaques do not progressively accumulate with normal aging. Acta Neuropathol (1994) 1.45
Senile plaques in temporal lobe epilepsy. Acta Neuropathol (1994) 1.44
Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease. Proc Natl Acad Sci U S A (1988) 1.43
Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders. Am J Hum Genet (1991) 1.43
Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. Am J Pathol (1991) 1.43
Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide. Proc Natl Acad Sci U S A (1992) 1.41
Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. Proc Natl Acad Sci U S A (1992) 1.40
Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathol (1992) 1.39
Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am J Hum Genet (1992) 1.37
Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein. Am J Pathol (1987) 1.36
Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway. Am J Pathol (2009) 1.30
Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. Am J Pathol (1998) 1.29
Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles. Proc Natl Acad Sci U S A (1991) 1.26
Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J (1994) 1.25
Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system. Am J Pathol (1989) 1.24
Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth. J Cell Biol (1993) 1.23
Molecular mechanism in the formation of a human ring chromosome 21. Proc Natl Acad Sci U S A (1989) 1.19
Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc Natl Acad Sci U S A (1994) 1.17
Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques. Proc Natl Acad Sci U S A (1988) 1.17
Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits. Am J Pathol (1990) 1.17
Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein. EMBO J (1994) 1.13
Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity. Proc Natl Acad Sci U S A (2009) 1.12
The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells. Mol Med (1997) 1.11
Amyloid in the brains of aged squirrel monkeys. Acta Neuropathol (1990) 1.08
Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease. Am J Pathol (1993) 1.07
Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. Proc Natl Acad Sci U S A (1992) 1.07
Immunoreactive A4 and gamma-trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease. Am J Pathol (1990) 1.06
Differential brain expression of the Alzheimer's amyloid precursor protein. EMBO J (1989) 1.06
Targets for AD treatment: conflicting messages from γ-secretase inhibitors. J Neurochem (2011) 1.05
Identification of cellular and extracellular sites of amyloid precursor protein extracytoplasmic domain in normal and Alzheimer disease brains. Proc Natl Acad Sci U S A (1989) 1.04
Widespread expression of amyloid beta-protein precursor gene in rat brain. Am J Pathol (1989) 1.03
Disease-modifying treatments for Alzheimer's disease. Ther Adv Neurol Disord (2011) 1.03
Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives. Neurobiol Aging (2010) 1.00
Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex. Proc Natl Acad Sci U S A (1988) 1.00
Immunohistochemical study of cerebral amyloid angiopathy. II. Enhancement of immunostaining using formic acid pretreatment of tissue sections. Am J Pathol (1988) 0.98
Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21. Proc Natl Acad Sci U S A (1988) 0.98
Are Abeta and its derivatives causative agents or innocent bystanders in AD? Neurodegener Dis (2010) 0.98
Beta-amyloid formation by myocytes of leptomeningeal vessels. Acta Neuropathol (1994) 0.98
Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease. Biochem J (1992) 0.98
Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA. Am J Pathol (1989) 0.96
From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc Natl Acad Sci U S A (1998) 0.95
On the subject of rigor in the study of amyloid β-protein assembly. Alzheimers Res Ther (2013) 0.94
Beta-secretase: structure, function, and evolution. CNS Neurol Disord Drug Targets (2008) 0.92
Expression of active secreted forms of human amyloid beta-protein precursor by recombinant baculovirus-infected insect cells. Proc Natl Acad Sci U S A (1991) 0.92
The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease. Curr Neurol Neurosci Rep (2008) 0.92
Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro. Biochemistry (2009) 0.91
Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice. Proc Natl Acad Sci U S A (1988) 0.91
Progress in Alzheimer's disease. J Neurol (2011) 0.90
High glucose promotes Aβ production by inhibiting APP degradation. PLoS One (2013) 0.89
N-terminal domain of myelin basic protein inhibits amyloid beta-protein fibril assembly. J Biol Chem (2010) 0.88
An update on the amyloid hypothesis. Neurol Clin (2007) 0.87
Kynurenines, neurodegeneration and Alzheimer's disease. J Cell Mol Med (2010) 0.87
Expression of the amyloid precursor protein gene in mouse oocytes and embryos. Proc Natl Acad Sci U S A (1991) 0.87
Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration. Proc Natl Acad Sci U S A (1993) 0.86
The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2. Proc Natl Acad Sci U S A (1991) 0.85
Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques. Am J Pathol (1991) 0.85
Two-hybrid system as a model to study the interaction of beta-amyloid peptide monomers. Proc Natl Acad Sci U S A (1996) 0.85
Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease. Neurotherapeutics (2015) 0.84
The genesis of the senile plaque. Further evidence in support of its neuronal origin. Am J Pathol (1992) 0.84
Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats. Proc Natl Acad Sci U S A (1990) 0.84
The role of APP and BACE1 trafficking in APP processing and amyloid-β generation. Alzheimers Res Ther (2013) 0.83
Overexpression of amyloid precursor protein A4 (beta-amyloid) immunoreactivity in genetically transformed cells: implications for a cellular model of Alzheimer amyloidosis. Proc Natl Acad Sci U S A (1989) 0.83
Transcriptional Regulation of TMP21 by NFAT. Mol Neurodegener (2011) 0.82
Alzheimer's amyloid precursor protein-positive degenerative neurites exist even within kuru plaques not specific to Alzheimer's disease. Am J Pathol (1991) 0.81
Advances in our Understanding of the Pathophysiology, Detection and Management of Cerebral Amyloid Angiopathy. Eur Neurol Rev (2012) 0.81
Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease. Curr Neuropharmacol (2010) 0.81
Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E. Biophys J (2000) 0.81
Biological function of Presenilin and its role in AD pathogenesis. Transl Neurodegener (2013) 0.81
Membrane cholesterol modulates {beta}-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of N-methyl-D-aspartic acid receptors. J Biol Chem (2010) 0.81
Alzheimer's disease and the Blood-Brain Barrier: Past, Present and Future. Aging health (2008) 0.80
Responses of Cultured Astrocytes, C6 Glioma and 1321NI Astrocytoma Cells to Amyloid beta-Peptide Fragments. Nonlinearity Biol Toxicol Med (2004) 0.80
Gene mutations in inherited amyloidopathies of the nervous system. Am J Hum Genet (1991) 0.80
Fine mapping of the amyloid β-protein binding site on myelin basic protein. Biochemistry (2013) 0.80
Characterization of cDNA encoding a human sperm membrane protein related to A4 amyloid protein. Proc Natl Acad Sci U S A (1990) 0.79
Analysis of amyloid precursor protein function in Drosophila melanogaster. Exp Brain Res (2011) 0.79
Cell signaling abnormalities may drive neurodegeneration in familial Alzheimer disease. Neurochem Res (2013) 0.78
Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity. Front Mol Neurosci (2017) 0.77
Frontiers in the pathogenesis of Alzheimer's disease. Indian J Psychiatry (2009) 0.77
Analysis of Amyloid Precursor Protein Function in Drosophila melanogaster. Front Mol Neurosci (2016) 0.77
Alzheimer disease: the new agenda. Am J Hum Genet (1992) 0.77
cDNA isolation of Alzheimer's amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray. Biochem J (1998) 0.76
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A (1980) 109.70
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci U S A (1972) 83.88
A system for shotgun DNA sequencing. Nucleic Acids Res (1981) 52.99
Codon catalog usage is a genome strategy modulated for gene expressivity. Nucleic Acids Res (1981) 32.85
The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. Cell (1978) 22.88
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10
Intracellular protein topogenesis. Proc Natl Acad Sci U S A (1980) 13.40
Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). N Engl J Med (1980) 9.38
DNA methylation and the frequency of CpG in animal DNA. Nucleic Acids Res (1980) 9.34
A cellular gene encodes scrapie PrP 27-30 protein. Cell (1985) 8.86
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science (1987) 8.29
Scrapie prions aggregate to form amyloid-like birefringent rods. Cell (1983) 7.92
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem (1986) 6.91
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science (1987) 6.89
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24
Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell (1984) 5.39
Isolation of the human insulin-like growth factor I gene using a single synthetic DNA probe. EMBO J (1984) 3.74
Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Proc Natl Acad Sci U S A (1985) 3.54
Membrane proteins: the amino acid composition of membrane-penetrating segments. Eur J Biochem (1981) 2.52
Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids. Am J Hum Genet (1986) 2.45
Infection-specific particle from the unconventional slow virus diseases. Science (1984) 2.34
A general method for detection and characterization of an mRNA using an oligonucleotide probe. J Biol Chem (1981) 2.18
Alzheimer's disease in Down's syndrome: clinicopathologic studies. Neurology (1985) 1.75
Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues. Proc Natl Acad Sci U S A (1986) 1.75
Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent. Ann Neurol (1981) 1.56
Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain. Biochem Biophys Res Commun (1986) 1.09
Recent developments in scrapie and Creutzfeldt-Jakob disease. Prog Med Virol (1986) 1.07
Pedigrees of 30 families with Alzheimer disease: associations with defective organization of microfilaments and microtubules. Behav Genet (1978) 0.99
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A (1986) 10.13
Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol (1987) 7.05
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem (1986) 6.91
Abnormal fibrils from scrapie-infected brain. Acta Neuropathol (1981) 5.35
Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell (2001) 4.25
Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol (1985) 3.83
The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience (2000) 3.40
Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res (1989) 3.10
Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition. Acta Neuropathol (1984) 2.97
Alzheimer paired helical filaments: immunochemical identification of polypeptides. Acta Neuropathol (1984) 2.70
Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiol Aging (1997) 2.68
Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease. Arch Neurol (2000) 2.66
Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigen(s). Acta Neuropathol (1984) 2.58
Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia. Ann Neurol (1979) 2.50
Infection-specific particle from the unconventional slow virus diseases. Science (1984) 2.34
Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques. Acta Neuropathol (1983) 2.23
Evidence that Alzheimer neurofibrillary tangles originate from neurotubules. Lancet (1979) 2.22
Bacillus subtilis spo0H gene. J Bacteriol (1984) 2.18
Scrapie-associated fibrils in Creutzfeldt-Jakob disease. Nature (1984) 2.11
Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease. Ann Neurol (1999) 1.96
Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol (1986) 1.95
Defective brain microtubule assembly in Alzheimer's disease. Lancet (1986) 1.89
MRI of entorhinal cortex in mild Alzheimer's disease. Lancet (1999) 1.86
Ultrastructure of paired helical filaments of Alzheimer's neurofibrillary tangle. J Neuropathol Exp Neurol (1984) 1.86
Adult fragile X syndrome. Clinico-neuropathologic findings. Acta Neuropathol (1985) 1.80
The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis. Acta Neuropathol (1986) 1.77
Alzheimer's disease in Down's syndrome: clinicopathologic studies. Neurology (1985) 1.75
Biochemical differences among scrapie-associated fibrils support the biological diversity of scrapie agents. J Gen Virol (1985) 1.75
Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues. Proc Natl Acad Sci U S A (1986) 1.75
Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol Cell (1999) 1.74
Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol (1992) 1.71
Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease. J Neuropathol Exp Neurol (1997) 1.67
Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations. J Gen Virol (1986) 1.67
Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc Natl Acad Sci U S A (2001) 1.67
Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon. Acta Neuropathol (1984) 1.60
Primary demyelination as a nonspecific consequence of a cell-mediated immune reaction. J Exp Med (1975) 1.57
Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent. Ann Neurol (1981) 1.56
Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments. Brain Res (1988) 1.51
An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination. J Neuropathol Exp Neurol (1989) 1.51
Induction of kidney epithelial morphogenesis by cells expressing Wnt-1. Dev Biol (1994) 1.49
A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathol (1992) 1.49
Substructures of paired helical filaments from Alzheimer's disease neurofibrillary tangles. Acta Neuropathol (1985) 1.48
Cloning of an early sporulation gene in Bacillus subtilis. J Bacteriol (1981) 1.44
Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease. Proc Natl Acad Sci U S A (1989) 1.40
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol (1995) 1.40
Alzheimer disease (AD): aspirin prophylaxis and therapy. Alzheimer Dis Assoc Disord (1992) 1.39
Alzheimer neurofibrillary tangles: antiserum and immunohistological staining. Ann Neurol (1979) 1.39
Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation. Genes Brain Behav (2005) 1.36
Alzheimer paired helical filaments: cross-reacting polypeptide/s normally present in brain. Acta Neuropathol (1985) 1.36
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles. Acta Neuropathol (1987) 1.35
Antisera to scrapie-associated fibril protein and prion protein decorate scrapie-associated fibrils. J Virol (1987) 1.35
Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. Am J Pathol (1992) 1.34
Substructures of neurofilaments. Acta Neuropathol (1984) 1.34
The complex of microglial cells and amyloid star in three-dimensional reconstruction. Acta Neuropathol (1990) 1.31
Neurofibrillary pathology--correlation with hippocampal formation atrophy in Alzheimer disease. Neurobiol Aging (1997) 1.30
The complete DNA sequence and regulatory regions of the Bacillus licheniformis spoOH gene. Nucleic Acids Res (1984) 1.30
Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies. Acta Neuropathol (1985) 1.27
Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends Neurosci (1998) 1.27
Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci Lett (1991) 1.26
Basal ganglia calcification (BGC) in Down's syndrome (DS)--another manifestation of premature aging. Ann N Y Acad Sci (1982) 1.26
Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors. Neuroscience (1999) 1.23
Chronic relapsing experimental allergic encephalomyelitis: clinicopathological comparison with multiple sclerosis. Arch Neurol (1979) 1.22
Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules. Brain Res (1978) 1.21
Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains. J Neurosci Res (1996) 1.20
Aluminum-induced neurofibrillary changes in axons and dendrites. Acta Neuropathol (1984) 1.18
Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains. Biochem Biophys Res Commun (1992) 1.18
Studies on demyelination by activated lymphocytes in the rabbit eye. II. Antibody-dependent cell-mediated demyelination. J Immunol (1977) 1.18
About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation. Acta Neuropathol (1989) 1.18
Ultrastructural observations on the transvascular route of protein removal in vasogenic brain edema. Acta Neuropathol (1985) 1.17
Peripheral nerve ischemia: Part 2. Accumulation of organelles. Ann Neurol (1978) 1.17
Chronic relapsing EAE. Time course of neurological symptoms and pathology. Acta Neuropathol (1978) 1.17
The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences. Brain Res Mol Brain Res (1991) 1.16
Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease. Brain Res (1991) 1.13
A PvuII RFLP detected in the human prion protein (PrP) gene. Nucleic Acids Res (1987) 1.13
Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease. Brain Res (1998) 1.12
Chronic relapsing experimental allergic encephalomyelitis. Immunohistochemical studies. Arch Neurol (1980) 1.12
Nature of the scrapie agent: current status of facts and hypotheses. J Gen Virol (1985) 1.12
Inhibition of Alzheimer beta-fibrillogenesis by melatonin. J Biol Chem (1998) 1.12
Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. J Neurosci Res (1992) 1.11
Mites as vectors for scrapie. Lancet (1996) 1.11
Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J Neurosci (1997) 1.10
Cerebellar atrophy in Alzheimer's disease-clinicopathological correlations. Brain Res (1999) 1.09
Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain. Biochem Biophys Res Commun (1986) 1.09
Increased plasma amyloid beta protein 1-42 levels in Down syndrome. Neurosci Lett (1998) 1.09
Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience (2002) 1.08
In vivo demyelinating activity of sera from animals with chronic experimental allergic encephalomyelitis. Antibody nature of the demyelinating factor and the role of complement. J Neurol Sci (1983) 1.07
The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid. J Biol Chem (1996) 1.07
Chemical pathology of neurofibrils. Neurofibrillary tangles of Alzheimer's presenile-senile dementia. J Histochem Cytochem (1975) 1.06
Differential brain expression of the Alzheimer's amyloid precursor protein. EMBO J (1989) 1.06
The effects of 4-nonylphenol in rats: a multigeneration reproduction study. Toxicol Sci (1999) 1.05
Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. J Biol Chem (1994) 1.05
Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice. Brain Res Mol Brain Res (1999) 1.05
Ultracytochemical studies of the blood-meningeal barrier (BMB) in rat spinal cord. Acta Neuropathol (1981) 1.05