Published in EMBO J on October 01, 1984
Predicting the orientation of eukaryotic membrane-spanning proteins. Proc Natl Acad Sci U S A (1989) 5.15
Infection-derived Enterococcus faecalis strains are enriched in esp, a gene encoding a novel surface protein. Infect Immun (1999) 3.34
Transit peptides of nuclear-encoded chloroplast proteins share a common amino acid framework. EMBO J (1986) 2.89
The complete amino acid sequence of human complement factor H. Biochem J (1988) 2.63
The legumin gene family: structure of a B type gene of Vicia faba and a possible legumin gene specific regulatory element. Nucleic Acids Res (1986) 2.63
Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins. EMBO J (1987) 2.53
Primary structure of an archaebacterial transducer, a methyl-accepting protein associated with sensory rhodopsin I. Proc Natl Acad Sci U S A (1992) 2.51
Nucleotide sequence of the hygromycin B phosphotransferase gene from Streptomyces hygroscopicus. Nucleic Acids Res (1986) 2.39
Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases. J Exp Med (1988) 2.38
Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of ADP/ATP carrier. EMBO J (1985) 2.19
Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis. Am J Hum Genet (2005) 2.17
Tomato Ve disease resistance genes encode cell surface-like receptors. Proc Natl Acad Sci U S A (2001) 2.03
Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci (2004) 1.80
Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections. PLoS Pathog (2011) 1.57
Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infect Immun (1997) 1.57
Molecular cloning and protein structure of a human blood group Rh polypeptide. Proc Natl Acad Sci U S A (1990) 1.52
A charged amino acid substitution within the transmembrane anchor of the Rous sarcoma virus envelope glycoprotein affects surface expression but not intracellular transport. J Cell Biol (1987) 1.50
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum. PLoS Biol (2011) 1.48
Positive charges at the NH2 terminus convert the membrane-anchor signal peptide of cytochrome P-450 to a secretory signal peptide. Proc Natl Acad Sci U S A (1988) 1.47
The COOH-terminal ends of internal signal and signal-anchor sequences are positioned differently in the ER translocase. J Cell Biol (1994) 1.39
Identification of protein products encoded by the proto-oncogene int-1. Mol Cell Biol (1987) 1.38
Molecular characterization of the pathogen-specific, 34-kilodalton membrane immunogen of Treponema pallidum. Infect Immun (1989) 1.37
The cytoplasmic domain of Escherichia coli leader peptidase is a "translocation poison" sequence. Proc Natl Acad Sci U S A (1988) 1.34
Signal peptide amino acid sequences in Escherichia coli contain information related to final protein localization. A multivariate data analysis. EMBO J (1987) 1.34
Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. J Clin Invest (1992) 1.30
Subcellular localization of two porphyrin-synthesis enzymes in Pisum sativum (pea) and Arum (cuckoo-pint) species. Biochem J (1988) 1.22
The structure of cytochrome b561, a secretory vesicle-specific electron transport protein. EMBO J (1988) 1.21
The amino-terminal structures that determine topological orientation of cytochrome P-450 in microsomal membrane. EMBO J (1990) 1.19
Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis. J Clin Invest (1989) 1.17
Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention. Diabetes (2009) 1.14
Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions. Structure (2012) 1.10
In vivo kinetics of protein targeting to the endoplasmic reticulum determined by site-specific phosphorylation. EMBO J (2000) 1.09
Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions. Biol Direct (2014) 1.08
Amino-terminal precursor sequence modulates canine distemper virus fusion protein function. J Virol (2002) 0.97
Functional tolerance of the human immunodeficiency virus type 1 envelope signal peptide to mutations in the amino-terminal and hydrophobic regions. J Virol (1992) 0.96
Association of the halobacterial 7S RNA to the polysome correlates with expression of the membrane protein bacterioopsin. Proc Natl Acad Sci U S A (1992) 0.90
Secretory signal peptide modification for optimized antibody-fragment expression-secretion in Leishmania tarentolae. Microb Cell Fact (2012) 0.89
Control of competence for DNA transformation in streptococcus suis by genetically transferable pherotypes. PLoS One (2014) 0.88
Selection for efficient translation initiation biases codon usage at second amino acid position in secretory proteins. Nucleic Acids Res (2007) 0.87
In vivo evidence for posttranslational translocation and signal cleavage of the killer preprotoxin of Saccharomyces cerevisiae. Mol Cell Biol (1986) 0.86
Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex. Nat Struct Mol Biol (2014) 0.83
E. coli selection of human genes encoding secreted and membrane proteins based on cDNA fusions to a leaderless beta-lactamase reporter. Genome Res (2003) 0.78
In vitro processing of tomato proteinase inhibitor I by barley microsomal membranes: a system for analysis of cotranslational processing of plant endomembrane proteins. Plant Physiol (1992) 0.78
New user-friendly approach to obtain an Eisenberg plot and its use as a practical tool in protein sequence analysis. Int J Mol Sci (2011) 0.77
Intragenic revertants of yeast invertase variants with secretion-defective leader sequences. Mol Cell Biol (1989) 0.77
Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide. Elife (2017) 0.75
A conserved cationic motif enhances membrane binding and insertion of the chloride intracellular channel protein 1 transmembrane domain. Eur Biophys J (2014) 0.75
Patterns of amino acids near signal-sequence cleavage sites. Eur J Biochem (1983) 26.68
A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides. J Mol Biol (1983) 16.07
Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development. Nature (1984) 12.10
How signal sequences maintain cleavage specificity. J Mol Biol (1984) 11.03
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature (1984) 10.02
Mechanism of incorporation of cell envelope proteins in Escherichia coli. Annu Rev Microbiol (1982) 8.18
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Structure and expression of a cloned cDNA for human interleukin-2. Nature (1983) 7.04
Mechanisms of protein localization. Microbiol Rev (1983) 6.12
Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature (1984) 6.08
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature (1983) 5.27
Detailed analysis of the portion of the herpes simplex virus type 1 genome encoding glycoprotein C. J Virol (1983) 4.56
Molecular Basis of Herbicide Resistance in Amaranthus hybridus. Science (1983) 4.46
Herpes simplex virus type-1 glycoprotein D gene: nucleotide sequence and expression in Escherichia coli. Science (1982) 4.28
Structure of the human immune interferon gene. Nature (1982) 4.25
Complete nucleotide sequence of a French bean storage protein gene: Phaseolin. Proc Natl Acad Sci U S A (1983) 4.10
Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld. Proc Natl Acad Sci U S A (1982) 3.73
Human leukocyte and fibroblast interferons are structurally related. Nature (1980) 3.57
Molecular cloning of cDNA for murine interleukin-3. Nature (1984) 3.50
Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor. Nature (1983) 3.43
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature (1984) 3.33
Gene sequence of the lambda receptor, an outer membrane protein of E. coli K12. Cell (1981) 3.28
Complete primary structures of the E beta chain and gene of the mouse major histocompatibility complex. Proc Natl Acad Sci U S A (1983) 3.09
Membrane-bound penicillinases in Gram-positive bacteria. J Biol Chem (1982) 2.69
Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature (1984) 2.69
Effects of the complete removal of basic amino acid residues from the signal peptide on secretion of lipoprotein in Escherichia coli. J Biol Chem (1983) 2.66
Nucleotide sequence and expression of the diphtheria tox228 gene in Escherichia coli. Science (1983) 2.65
Isolation and characterization of the human apolipoprotein A-I gene. Proc Natl Acad Sci U S A (1983) 2.42
Homology between the primary structure of alpha-fetoprotein, deduced from a complete cDNA sequence, and serum albumin. Nature (1981) 2.37
Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation. Cell (1983) 2.37
Isolation and sequence analysis of a barley alpha-amylase cDNA clone. J Biol Chem (1983) 2.23
Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains. EMBO J (1984) 2.18
Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d. Science (1983) 2.12
Rat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNA. J Biol Chem (1983) 2.12
Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish. Nature (1980) 2.11
The biosynthesis and primary structure of pea seed lectin. J Biol Chem (1983) 2.06
Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor. Nature (1983) 1.98
Complete nucleotide sequence of the gene for the specific glycoprotein (gp55) of Friend spleen focus-forming virus. Proc Natl Acad Sci U S A (1983) 1.86
Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene. Proc Natl Acad Sci U S A (1983) 1.85
Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes. Biochemistry (1978) 1.82
A single gene encodes multiple neuropeptides mediating a stereotyped behavior. Cell (1983) 1.75
The complete nucleotide sequence of the I-E alpha d immune response gene. Nucleic Acids Res (1983) 1.75
Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature (1983) 1.71
Cloning and sequence analysis of a cDNA encoding rat preprocholecystokinin. Proc Natl Acad Sci U S A (1984) 1.70
Molecular components of the signal sequence that function in the initiation of protein export. J Cell Biol (1982) 1.65
Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin. Proc Natl Acad Sci U S A (1983) 1.57
Evidence for a coupling of synthesis and export of an outer membrane protein in Escherichia coli. EMBO J (1983) 1.50
Signal sequence mutations disrupt feedback between secretion of an exported protein and its synthesis in E. coli. Nature (1984) 1.44
Complete amino acid sequence of mouse pro-opiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA. J Biol Chem (1983) 1.42
Gene and protein structure of a beta-crystallin polypeptide in murine lens: relationship of exons and structural motifs. Nature (1983) 1.37
Cloning and sequence analysis of cDNA for ovine corticotropin-releasing factor precursor. Nature (1983) 1.36
The heavy chain of human B-cell alloantigen HLA-DS has a variable N-terminal region and a constant immunoglobulin-like region. Nature (1983) 1.31
Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family. Science (1983) 1.30
Isolation and analysis of genomic DNA clones encoding the third component of mouse complement. Proc Natl Acad Sci U S A (1982) 1.30
Cloning and sequencing of the preprotoxin-coding region of the yeast M1 double-stranded RNA. EMBO J (1984) 1.28
Comparison of the lipoprotein gene among the Enterobacteriaceae. DNA sequence of Erwinia amylovora lipoprotein gene. J Biol Chem (1981) 1.27
Kinetics of maturation of the amino termini of the cell proteins of Escherichia coli. Biochim Biophys Acta (1969) 1.21
Nucleotide sequence of a cloned structural gene coding for a precursor of pancreatic somatostatin. Proc Natl Acad Sci U S A (1980) 1.19
A cDNA sequence encoding a rabbit heavy chain variable region of the VHa2 allotype showing homologies with human heavy chain sequences. Nature (1982) 1.12
Somatic mutation in genes for the variable portion of the immunoglobulin heavy chain. Science (1982) 1.11
Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin. Proc Natl Acad Sci U S A (1983) 1.11
Sequence of a cDNA encoding pancreatic preprosomatostatin-22. Proc Natl Acad Sci U S A (1982) 1.10
Removal of formyl-methionine residue from nascent bacteriophage f2 protein. J Mol Biol (1972) 1.08
Primary structures of bovine liver low molecular weight kininogen precursors and their two mRNAs. Proc Natl Acad Sci U S A (1983) 1.02
Seminal vesicle secretion IV gene: allelic difference due to a series of 20-base-pair direct tandem repeats within an intron. Proc Natl Acad Sci U S A (1983) 0.93
Nucleotide and amino acid sequence comparisons of preprosomatostatins. J Biol Chem (1983) 0.90
DNA sequence coding for an antifreeze protein precursor from winter flounder. Proc Natl Acad Sci U S A (1982) 0.89
The nucleotide sequences defining the signal peptides of the galactose-binding protein and the arabinose-binding protein. J Biol Chem (1983) 0.87
Isolation of two genomic sequences encoding the Mr = 14,000 subunit of rat prostatein. J Biol Chem (1983) 0.84
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol (2001) 66.87
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng (1997) 38.38
A new method for predicting signal sequence cleavage sites. Nucleic Acids Res (1986) 37.19
Patterns of amino acids near signal-sequence cleavage sites. Eur J Biochem (1983) 26.68
Predicting subcellular localization of proteins based on their N-terminal amino acid sequence. J Mol Biol (2000) 22.77
Signal sequences. The limits of variation. J Mol Biol (1985) 21.24
A hidden Markov model for predicting transmembrane helices in protein sequences. Proc Int Conf Intell Syst Mol Biol (1998) 14.18
How signal sequences maintain cleavage specificity. J Mol Biol (1984) 11.03
TopPred II: an improved software for membrane protein structure predictions. Comput Appl Biosci (1994) 10.03
ChloroP, a neural network-based method for predicting chloroplast transit peptides and their cleavage sites. Protein Sci (1999) 9.82
Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method. Protein Eng (1997) 8.25
Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms. Protein Sci (1998) 7.88
A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Int J Neural Syst (1999) 7.40
Mitochondrial targeting sequences may form amphiphilic helices. EMBO J (1986) 7.11
Machine learning approaches for the prediction of signal peptides and other protein sorting signals. Protein Eng (1999) 6.72
Sequence determinants of cytosolic N-terminal protein processing. Eur J Biochem (1986) 5.59
A conserved cleavage-site motif in chloroplast transit peptides. FEBS Lett (1990) 4.25
Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineering. Protein Eng (1990) 4.17
How proteins adapt to a membrane-water interface. Trends Biochem Sci (2000) 3.76
Trans-membrane translocation of proteins. The direct transfer model. Eur J Biochem (1979) 3.13
Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membrane. J Biol Chem (1993) 3.02
Predicting the topology of eukaryotic membrane proteins. Eur J Biochem (1993) 2.73
YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase. EMBO J (2000) 2.70
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Cleavage-site motifs in mitochondrial targeting peptides. Protein Eng (1990) 2.38
The Escherichia coli SRP and SecB targeting pathways converge at the translocon. EMBO J (1998) 2.35
A receptor component of the chloroplast protein translocation machinery. Science (1994) 2.34
Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli. FEBS Lett (2001) 2.28
Fine-tuning the topology of a polytopic membrane protein: role of positively and negatively charged amino acids. Cell (1990) 2.24
On the hydrophobic nature of signal sequences. Eur J Biochem (1981) 2.01
Competition between Sec- and TAT-dependent protein translocation in Escherichia coli. EMBO J (1999) 1.95
Prediction of organellar targeting signals. Biochim Biophys Acta (2001) 1.93
Structures of N-terminally acetylated proteins. Eur J Biochem (1985) 1.92
Assembly of a cytoplasmic membrane protein in Escherichia coli is dependent on the signal recognition particle. FEBS Lett (1996) 1.89
Topology, subcellular localization, and sequence diversity of the Mlo family in plants. J Biol Chem (1999) 1.88
Nascent membrane and presecretory proteins synthesized in Escherichia coli associate with signal recognition particle and trigger factor. Mol Microbiol (1997) 1.85
Net N-C charge imbalance may be important for signal sequence function in bacteria. J Mol Biol (1986) 1.85
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Amino acid distributions around O-linked glycosylation sites. Biochem J (1991) 1.82
Anionic phospholipids are determinants of membrane protein topology. EMBO J (1997) 1.77
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Membrane protein topology: effects of delta mu H+ on the translocation of charged residues explain the 'positive inside' rule. EMBO J (1994) 1.53
Translation rate modification by preferential codon usage: intragenic position effects. J Theor Biol (1987) 1.51
A nascent secretory protein may traverse the ribosome/endoplasmic reticulum translocase complex as an extended chain. J Biol Chem (1996) 1.51
The aromatic residues Trp and Phe have different effects on the positioning of a transmembrane helix in the microsomal membrane. Biochemistry (1999) 1.49
Towards a comparative anatomy of N-terminal topogenic protein sequences. J Mol Biol (1986) 1.46
Chloroplast transit peptides from the green alga Chlamydomonas reinhardtii share features with both mitochondrial and higher plant chloroplast presequences. FEBS Lett (1990) 1.45
A 30-residue-long "export initiation domain" adjacent to the signal sequence is critical for protein translocation across the inner membrane of Escherichia coli. Proc Natl Acad Sci U S A (1991) 1.43
The distribution of charged amino acids in mitochondrial inner-membrane proteins suggests different modes of membrane integration for nuclearly and mitochondrially encoded proteins. Eur J Biochem (1992) 1.42
Sec dependent and sec independent assembly of E. coli inner membrane proteins: the topological rules depend on chain length. EMBO J (1993) 1.41
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The 'positive-inside rule' applies to thylakoid membrane proteins. FEBS Lett (1991) 1.40
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Architecture of helix bundle membrane proteins: an analysis of cytochrome c oxidase from bovine mitochondria. Protein Sci (1997) 1.38
Determination of the border between the transmembrane and cytoplasmic domains of human integrin subunits. J Biol Chem (1999) 1.37
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Defining a similarity threshold for a functional protein sequence pattern: the signal peptide cleavage site. Proteins (1996) 1.31
Positively and negatively charged residues have different effects on the position in the membrane of a model transmembrane helix. J Mol Biol (1998) 1.27
Proline-induced disruption of a transmembrane alpha-helix in its natural environment. J Mol Biol (1998) 1.26
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A 12-residue-long polyleucine tail is sufficient to anchor synaptobrevin to the endoplasmic reticulum membrane. J Biol Chem (1996) 1.25
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Positively charged amino acids placed next to a signal sequence block protein translocation more efficiently in Escherichia coli than in mammalian microsomes. Mol Gen Genet (1993) 1.13
Different positively charged amino acids have similar effects on the topology of a polytopic transmembrane protein in Escherichia coli. J Biol Chem (1992) 1.10
Mapping of catalytically important domains in Escherichia coli leader peptidase. EMBO J (1990) 1.08
Homology to region X from staphylococcal protein A is not unique to cell surface proteins. J Theor Biol (1987) 1.07
Phosphatidylethanolamine mediates insertion of the catalytic domain of leader peptidase in membranes. FEBS Lett (1998) 1.04
Analysis and prediction of mitochondrial targeting peptides. Methods Cell Biol (2001) 1.02
Three-dimensional model for the membrane domain of Escherichia coli leader peptidase based on disulfide mapping. Biochemistry (1993) 1.02
Do protein-lipid interactions determine the recognition of transmembrane helices at the ER translocon? Biochem Soc Trans (2005) 1.01
Distant downstream sequence determinants can control N-tail translocation during protein insertion into the endoplasmic reticulum membrane. J Biol Chem (2000) 1.01
Architecture of beta-barrel membrane proteins: analysis of trimeric porins. Protein Sci (1998) 1.00
A signal peptide with a proline next to the cleavage site inhibits leader peptidase when present in a sec-independent protein. FEBS Lett (1992) 1.00
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De novo design of integral membrane proteins. Nat Struct Biol (1994) 0.99
Directionality in protein translocation across membranes: the N-tail phenomenon. Trends Cell Biol (1995) 0.98
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Membrane topology of Kch, a putative K+ channel from Escherichia coli. J Biol Chem (1996) 0.94
Breaking the camel's back: proline-induced turns in a model transmembrane helix. J Mol Biol (1998) 0.93
The internal repeats in the Na+/Ca2+ exchanger-related Escherichia coli protein YrbG have opposite membrane topologies. J Biol Chem (2001) 0.93
Alanine insertion scanning mutagenesis of lactose permease transmembrane helices. J Biol Chem (1997) 0.92
In vitro membrane integration of leader peptidase depends on the Sec machinery and anionic phospholipids and can occur post-translationally. FEBS Lett (1997) 0.91
Helical sidedness and the distribution of polar residues in trans-membrane helices. J Mol Biol (1983) 0.91
N-tail translocation in a eukaryotic polytopic membrane protein: synergy between neighboring transmembrane segments. Eur J Biochem (1999) 0.91
A de novo designed signal peptide cleavage cassette functions in vivo. J Biol Chem (1991) 0.91