Published in Biochim Biophys Acta on June 16, 1978
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Alteration of cell-surface proteins by viral transformation and by proteolysis. Proc Natl Acad Sci U S A (1973) 6.98
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development (1993) 6.56
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature (1999) 6.50
Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell (1998) 6.44
Three different fibronectin mRNAs arise by alternative splicing within the coding region. Cell (1983) 6.27
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell (1993) 6.05
Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul (1991) 5.80
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Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell (1986) 5.29
The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem (1999) 4.92
10 nm filaments in normal and transformed cells. Cell (1978) 4.77
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest (2000) 4.54
Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell (1996) 4.52
Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development (1995) 4.44
Cell surface proteins and malignant transformation. Biochim Biophys Acta (1976) 4.33
Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development (1993) 4.22
Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell (1998) 4.20
The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol (1986) 4.16
Relationships between fibronectin (LETS protein) and actin. Cell (1978) 4.12
Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell (1986) 4.01
Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest (1998) 4.00
A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci U S A (1998) 3.54
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell (1990) 3.46
Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol (1998) 3.46
Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat. J Cell Biol (1989) 3.44
Developmental defects in mouse embryos lacking N-cadherin. Dev Biol (1997) 3.39
Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein. Cell (1977) 3.36
Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi. J Cell Biol (1988) 3.35
Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med (1998) 3.26
Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes Dev (1994) 3.20
Changes in integrin receptors on oncogenically transformed cells. Cell (1989) 3.09
Sequence and domain structure of talin. Nature (1990) 2.98
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci U S A (2001) 2.82
Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. J Cell Biol (1988) 2.72
Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest (2000) 2.68
The combined role of P- and E-selectins in atherosclerosis. J Clin Invest (1998) 2.53
Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers. Proc Natl Acad Sci U S A (1999) 2.47
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol (1997) 2.46
Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest (1993) 2.42
Surface distribution of LETS protein in relation to the cytoskeleton of normal and transformed cells. J Cell Biol (1977) 2.40
Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials (1995) 2.40
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc Natl Acad Sci U S A (1995) 2.37
Extensive disulfide bonding at the mammalian cell surface. Proc Natl Acad Sci U S A (1977) 2.32
Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells. Science (1983) 2.31
Cross-linking of fibronectin to sulfated proteoglycans at the cell surface. Cell (1979) 2.28
Plasma fibronectin is synthesized and secreted by hepatocytes. J Biol Chem (1983) 2.25
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res (1992) 2.17
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol (2001) 2.16
Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. Blood (1997) 2.15
Density and cell cycle dependence of cell surface proteins in hamster fibroblasts. Cell (1974) 2.13
Hemostasis in the mouse (Mus musculus): a review. Thromb Haemost (1999) 2.13
A large glycoprotein lost from the surfaces of transformed cells. Ann N Y Acad Sci (1978) 2.11
Precocious mammary gland development in P-cadherin-deficient mice. J Cell Biol (1997) 2.10
Cell-type-specific fibronectin subunits generated by alternative splicing. J Biol Chem (1986) 2.09
Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins. Blood (2000) 2.05
An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin. Blood (1989) 2.05
Multiple sites of alternative splicing of the rat fibronectin gene transcript. EMBO J (1987) 2.03
Expression of normal and mutant avian integrin subunits in rodent cells. J Cell Biol (1989) 2.03
Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Cell (1996) 2.01
A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Proc Natl Acad Sci U S A (1984) 2.00
Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell (1982) 1.96
Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. J Cell Sci (1996) 1.95
Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. Cell Regul (1990) 1.94
Interaction of fibronectin with its receptor on platelets. Cell (1985) 1.92
alpha 3A beta 1 integrin localizes to focal contacts in response to diverse extracellular matrix proteins. J Cell Sci (1995) 1.88
The location of proteins labeled by the 125I-lactoperoxidase system in the NIL 8 hamster fibroblast. Cell (1975) 1.84
Control of alternative pre-mRNA splicing by distributed pentameric repeats. Proc Natl Acad Sci U S A (1997) 1.82
Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J Clin Invest (1996) 1.81
Fibronectin localization in the rat glomerulus. J Cell Biol (1980) 1.80
Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development (1997) 1.75
Effects of LETS glycoprotein on cell motility. Cell (1978) 1.69
Novel roles for alpha3beta1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes. J Cell Biol (1998) 1.69
Alternative splicing of fibronectin is temporally and spatially regulated in the chicken embryo. Development (1989) 1.69
Biosynthesis and processing of fibronectin in NIL.8 hamster cells. J Biol Chem (1979) 1.66
Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13. Mol Biol Cell (1999) 1.64
Defects in hemostasis in P-selectin-deficient mice. Blood (1996) 1.64
Absence of P-selectin delays fatty streak formation in mice. J Clin Invest (1997) 1.63
Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J Biol Chem (1996) 1.62
A difference between plasma and cellular fibronectins located with monoclonal antibodies. Cell (1981) 1.62
Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell (1979) 1.62
Effects of cytochalasin B and colchicine on attachment of a major surface protein of fibroblasts. Biochim Biophys Acta (1977) 1.61
Fibronectins. Sci Am (1986) 1.61
A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. Development (1997) 1.60
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Nat Med (2005) 1.58
Xenopus laevis integrins. Structural conservation and evolutionary divergence of integrin beta subunits. J Biol Chem (1988) 1.57
Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance. J Exp Med (1999) 1.55
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Proc Natl Acad Sci U S A (1999) 1.55
Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn (1996) 1.55
Elements regulating an alternatively spliced exon of the rat fibronectin gene. Mol Cell Biol (1993) 1.54
Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity (1999) 1.51
Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development. Dev Biol (1999) 1.51