Published in J Biol Chem on April 25, 1983
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J (1986) 6.62
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor. Biochem J (1986) 1.87
Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1985) 1.66
Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta. Proc Natl Acad Sci U S A (1984) 1.49
The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens. Proc Natl Acad Sci U S A (1986) 1.44
Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem J (1993) 1.37
Protein kinase activity of the insulin receptor. Biochem J (1986) 1.31
Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors. EMBO J (1989) 1.17
Two systems in vitro that show insulin-stimulated serine kinase activity towards the insulin receptor. Biochem J (1988) 1.10
Class I histocompatibility antigens and insulin receptors: evidence for interactions. Proc Natl Acad Sci U S A (1986) 1.05
Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor molecules. EMBO J (1987) 1.03
The monomeric alpha beta form of the insulin receptor exhibits much higher insulin-dependent tyrosine-specific protein kinase activity than the intact alpha 2 beta 2 form of the receptor. Proc Natl Acad Sci U S A (1985) 1.03
An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors. Proc Natl Acad Sci U S A (1986) 0.93
Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor. Proc Natl Acad Sci U S A (1992) 0.92
A monoclonal anti-peptide antibody reacting with the insulin receptor beta-subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptors. Biochem J (1992) 0.91
Differential sensitivity of two functions of the insulin receptor to the associated proteolysis: kinase action and hormone binding. Proc Natl Acad Sci U S A (1986) 0.90
Tyrosine-specific phosphorylation of calmodulin by the insulin receptor kinase purified from human placenta. Biochem J (1989) 0.90
In vitro tyrosine phosphorylation studies on RAS proteins and calmodulin suggest that polylysine-like basic peptides or domains may be involved in interactions between insulin receptor kinase and its substrate. Proc Natl Acad Sci U S A (1989) 0.90
Effect of basic polycations and proteins on purified insulin receptor. Insulin-independent activation of the receptor tyrosine-specific protein kinase by poly(L-lysine). Biochem J (1989) 0.87
Avidin-biotin affinity chromatography: application to the isolation of human placental insulin receptor. Proc Natl Acad Sci U S A (1984) 0.86
ATP sensitizes the insulin receptor to insulin. Proc Natl Acad Sci U S A (1988) 0.85
A model for the quaternary structure of human placental insulin receptor deduced from electron microscopy. Proc Natl Acad Sci U S A (1991) 0.85
Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor. Proc Natl Acad Sci U S A (1988) 0.84
Phospholipid environment alters hormone-sensitivity of the purified insulin receptor kinase. Biochem J (1987) 0.84
Surface proteins and glycoproteins of human leucocytes. Biochem J (1988) 0.83
Insulin-stimulated glucose uptake in rat diaphragm during postnatal development: lack of correlation with the number of insulin receptors and of intracellular glucose transporters. Proc Natl Acad Sci U S A (1985) 0.82
The endogenous functional turkey erythrocyte and rat liver insulin receptor is an alpha 2 beta 2 heterotetrameric complex. Biochem J (1990) 0.80
Epidermal growth factor, but not insulin, stimulates tyrosine phosphorylation of an endogenous protein of Mr 95,000 in triton extracts of human placental syncytiotrophoblast membranes. Biochem J (1987) 0.79
The alpha beta monomer of the insulin receptor has hormone-responsive tyrosine kinase activity. Biochem J (1991) 0.78
Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues. PLoS One (2012) 0.78
Chloroquine augments the binding of insulin to its receptor. Biochem J (1995) 0.78
An insulin receptor peptide (1135-1156) stimulates guanosine 5'-[gamma-thio]triphosphate binding to the 67 kDa G-protein associated with the insulin receptor. Biochem J (1993) 0.78
Association of the insulin receptor and phosphatidylinositol 3-kinase requires a third component. Biochem J (1994) 0.76
Nonbinding inhibitory antiinsulin receptor antibodies. A new type of autoantibodies in human diabetes. J Clin Invest (1988) 0.75
Structure of covalent insulin-receptor complexes (I-S-S-R) in isolated rat adipocytes and human placental membranes. Biochem J (1985) 0.75
Development of affinity resins for isolation of angiotensin receptors. Yale J Biol Med (1986) 0.75
Alkylation, reduction, solubilization and enrichment of binding activity do not impair the ability of insulin receptors to convert from a rapid- into a slow-dissociating state. Biochem J (1989) 0.75
Insertion of isolated insulin receptors into placental membrane vesicles. Biochem J (1992) 0.75
Affinity Chromatography of Native and Recombinant Proteins from Receptors for Insulin and IGF-I to Recombinant Single Chain Antibodies. Front Endocrinol (Lausanne) (2015) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Hybridization of synthetic oligodeoxyribonucleotides to phi chi 174 DNA: the effect of single base pair mismatch. Nucleic Acids Res (1979) 14.12
The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit beta-globin DNA. Nucleic Acids Res (1981) 9.56
Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Science (1977) 9.28
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science (1995) 8.58
Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides. Proc Natl Acad Sci U S A (1983) 7.52
Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. Proc Natl Acad Sci U S A (1981) 7.24
Crystal structure analysis of a complete turn of B-DNA. Nature (1980) 7.18
Directed deletion of a yeast transfer RNA intervening sequence. Science (1980) 6.67
Solid phase synthesis of polynucleotides. VI. Further studies on polystyrene copolymers for the solid support. Nucleic Acids Res (1982) 6.38
Structure of a B-DNA dodecamer: conformation and dynamics. Proc Natl Acad Sci U S A (1981) 6.38
Chemical synthesis of genes for human insulin. Proc Natl Acad Sci U S A (1978) 6.09
High-salt d(CpGpCpG), a left-handed Z' DNA double helix. Nature (1980) 5.46
Synthetic lac operator DNA is functional in vivo. Nature (1976) 5.36
Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr (2000) 5.29
A set of synthetic oligodeoxyribonucleotide primers for DNA sequencing in the plasmid vector pBR322. Gene (1981) 5.06
Chemical synthesis of restriction enzyme recognition sites useful for cloning. Science (1977) 4.81
Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci U S A (1979) 4.72
Solid-phase synthesis of polynucleotides. III. Synthesis of polynucleotides with defined sequences by the block coupling phosphotriester method. Nucleic Acids Res (1980) 4.69
Simplications in the synthesis of short oligonucleotide blocks. Nucleic Acids Res (1980) 4.64
Oligonucleotide-directed mutagenesis as a general and powerful method for studies of protein function. Proc Natl Acad Sci U S A (1982) 4.64
Synthesis and use of synthetic oligonucleotides. Annu Rev Biochem (1984) 4.53
alpha 1-antitrypsin deficiency detection by direct analysis of the mutation in the gene. Nature (1983) 4.38
Efficient correction of a mutation by use of chemically synthesized DNA. Proc Natl Acad Sci U S A (1978) 4.13
Improved triester approach for the synthesis of pentadecathymidylic acid. J Am Chem Soc (1975) 4.08
Nutritional Regulation of Lignin Degradation by Phanerochaete chrysosporium. Appl Environ Microbiol (1981) 4.03
Oligonucleotide directed mutagenesis of the human beta-globin gene: a general method for producing specific point mutations in cloned DNA. Nucleic Acids Res (1981) 3.87
Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Nature (1979) 3.80
Structure, dynamics, and energetics of deoxyguanosine . thymidine wobble base pair formation in the self-complementary d(CGTGAATTCGCG) duplex in solution. Biochemistry (1982) 3.76
Solid-phase synthesis of polynucleotides. IV. Usage of polystyrene resins for the synthesis of polydeoxyribonucleotides by the phosphostriester method. Nucleic Acids Res (1980) 3.59
Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane. Proc Natl Acad Sci U S A (1982) 3.44
Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes. Transplantation (1971) 3.42
Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse. Transplantation (1972) 3.34
Premelting and melting transitions in the d(CGCGAATTCGCG) self-complementary duplex in solution. Biochemistry (1982) 3.30
Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron (1999) 3.29
Solid-phase synthesis of polynucleotides. II. Synthesis of polythymidylic acids by the block coupling phosphotriester method. Nucleic Acids Res (1980) 3.20
The use of arylsulfonyltriazoles for the synthesis of oligonucleotides by the triester approach. J Am Chem Soc (1975) 3.16
Dissociation kinetics of 19 base paired oligonucleotide-DNA duplexes containing different single mismatched base pairs. Nucleic Acids Res (1987) 3.05
Extra adenosine stacks into the self-complementary d(CGCAGAATTCGCG) duplex in solution. Biochemistry (1982) 3.02
Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83
Chemical synthesis and sequence studies of deoxyribooligonucleotides which constitute the duplex sequence of the lactose operator of Escherichia coli. J Biol Chem (1975) 2.79
Effects of the complete removal of basic amino acid residues from the signal peptide on secretion of lipoprotein in Escherichia coli. J Biol Chem (1983) 2.66
Neuro-QOL: brief measures of health-related quality of life for clinical research in neurology. Neurology (2012) 2.50
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach. Arch Surg (1999) 2.47
Deoxyguanosine-deoxyadenosine pairing in the d(C-G-A-G-A-A-T-T-C-G-C-G) duplex: conformation and dynamics at and adjacent to the dG X dA mismatch site. Biochemistry (1984) 2.44
Brain stem blood flow, pupillary response, and outcome in patients with severe head injuries. Neurosurgery (1999) 2.35
DNA conformation, dynamics, and interactions in solution. Science (1982) 2.30
The slow wave in the circular muscle of the guinea-pig stomach. J Physiol (1975) 2.29
Solid phase synthesis of polynucleotides. VIII. Synthesis of mixed oligodeoxyribonucleotides by the phosphotriester solid phase method. Nucleic Acids Res (1983) 2.20
Solid-phase synthesis of polynucleotides: V. Synthesis of oligodeoxyribonucleotides by the phosphomonotriazolide method. Nucleic Acids Symp Ser (1980) 2.20
Isolation of a cDNA clone for the murine transplantation antigen H-2Kb. Proc Natl Acad Sci U S A (1982) 2.20
Ventriculostomy infections: the effect of monitoring duration and catheter exchange in 584 patients. J Neurosurg (1996) 2.07
Does anaesthetic technique really matter for total knee arthroplasty? Br J Anaesth (2013) 2.04
Deoxyadenosine-deoxycytidine pairing in the d(C-G-C-G-A-A-T-T-C-A-C-G) duplex: conformation and dynamics at and adjacent to the dA X dC mismatch site. Biochemistry (1984) 1.98
The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r. Gene (1982) 1.98
Electrical characteristics of pancreatic islet cells. J Physiol (1975) 1.96
Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol (1994) 1.95
Effects of tetraethylammonium chloride on the membrane activity of guinea-pig stomach smooth muscle. J Physiol (1970) 1.95
Arylamine N-acetyltransferase from chicken liver II. Cloning of cDNA and expression in Chinese hamster ovary cells. J Biol Chem (1988) 1.94
ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature (2000) 1.89
A precision measurement of the mass of the top quark. Nature (2004) 1.87
A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes. J Biol Chem (1984) 1.79
Letter: HL-A5 and Behçet's disease. Lancet (1973) 1.76
Isolation of a cDNA clone for human X-linked 3-phosphoglycerate kinase by use of a mixture of synthetic oligodeoxyribonucleotides as a detection probe. Proc Natl Acad Sci U S A (1983) 1.71
Cytokine mRNA expression in postischemic/reperfused myocardium. Am J Pathol (1995) 1.71
Dynamics of DNA duplexes containing internal G.T, G.A, A.C, and T.C pairs: hydrogen exchange at and adjacent to mismatch sites. Fed Proc (1984) 1.70
Solid-phase synthesis of polynucleotides. VIII: A simplified synthesis of oligodeoxyribonucleotides. Cold Spring Harb Symp Quant Biol (1983) 1.70
Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. J Immunol (1991) 1.69
The molecular structure of d(ICpCpGpG), a fragment of right-handed double helical A-DNA. Nature (1982) 1.68
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67
Cloning of Drosophila choline acetyltransferase cDNA. Proc Natl Acad Sci U S A (1986) 1.65
Letter: Hereditary ataxia and HL-A. N Engl J Med (1974) 1.65
Pancreatic islet cells: effects of monosaccharides, glycolytic intermediates and metabolic inhibitors on membrane potential and electrical activity. J Physiol (1975) 1.64
Obesity is associated with reduced self-rated general health status: evidence from a representative sample of white, black, and Hispanic Americans. Prev Med (2001) 1.63
An alternate method for synthesis of double-stranded DNA segments. J Biol Chem (1982) 1.63
Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res (1999) 1.63
Specific histocompatibility antigens associated with Behçet's disease. Am J Ophthalmol (1975) 1.63
Preoperative NT-proBNP and CRP predict perioperative major cardiovascular events in non-cardiac surgery. Heart (2009) 1.62
Translocation of autophosphorylated calcium/calmodulin-dependent protein kinase II to the postsynaptic density. J Biol Chem (1997) 1.60
Synthesis and properties of oligonucleotides containing 2'-deoxynebularine and 2'-deoxyxanthosine. Nucleic Acids Res (1986) 1.60
A salt-induced conformational change in crystals of the synthetic DNA tetramer d(CpGpCpG). J Mol Biol (1978) 1.58
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
High level of extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure. J Neurosurg (2000) 1.54
Measurement of the forward-backward charge asymmetry in top-quark pair production. Phys Rev Lett (2008) 1.53
Structure and energetics of a hexanucleotide duplex with stacked trinucleotide ends formed by the sequence d(GAATTCGCG). Biochemistry (1982) 1.53
Bovine leukemia virus matrix-associated protein MA(p15): further processing and formation of a specific complex with the dimer of the 5'-terminal genomic RNA fragment. J Virol (1991) 1.52
Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer. Cancer Res (1993) 1.51
Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription. J Biol Chem (1982) 1.50
Transcription and processing of a yeast tRNA gene containing a modified intervening sequence. Proc Natl Acad Sci U S A (1980) 1.50
Chemical and enzymatic synthesis of lactose operator of Escherichia coli and its binding to lactose repressor. Proc Natl Acad Sci U S A (1976) 1.48
Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. J Biol Chem (2001) 1.48
Measurement of the W boson mass with the D0 detector. Phys Rev Lett (2012) 1.46
Characterization of the insulin receptor kinase purified from human placental membranes. J Biol Chem (1983) 1.45
Exercise-induced systolic dysfunction in patients with non-obstructive hypertrophic cardiomyopathy and mutations in the cardiac troponin genes. Heart (2008) 1.43
Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest (1999) 1.42
Chronic cervical cord compression: clinical significance of increased signal intensity on MR images. Radiology (1989) 1.41
Chemical DNA synthesis and recombinant DNA studies. Science (1980) 1.41
Identification of an H-2Kb-related molecule by molecular cloning. Immunogenetics (1981) 1.41
Structurally abnormal insulin in a diabetic patient. Characterization of the mutant insulin A3 (Val----Leu) isolated from the pancreas. J Clin Invest (1986) 1.39