Published in Proc Natl Acad Sci U S A on November 01, 1982
Phylogenetic group-specific oligodeoxynucleotide probes for identification of single microbial cells. J Bacteriol (1988) 21.38
The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family. Biochem J (1988) 7.51
Identification and classification of bacterial plasmids. Microbiol Rev (1988) 4.16
Specific amino acid substitutions in bacterioopsin: Replacement of a restriction fragment in the structural gene by synthetic DNA fragments containing altered codons. Proc Natl Acad Sci U S A (1984) 3.67
Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine. Proc Natl Acad Sci U S A (1985) 3.01
Primary structure of the M subunit of the reaction center from Rhodopseudomonas sphaeroides. Proc Natl Acad Sci U S A (1983) 2.87
Biochemical and genetic evidence for a pseudoknot structure at the 3' terminus of the poliovirus RNA genome and its role in viral RNA amplification. J Virol (1993) 2.65
Role of flagella in adherence, internalization, and translocation of Campylobacter jejuni in nonpolarized and polarized epithelial cell cultures. Infect Immun (1993) 2.63
Role of 3'-end sequences in infectivity of poliovirus transcripts made in vitro. J Virol (1989) 2.52
Two-codon insertion mutagenesis of plasmid genes by using single-stranded hexameric oligonucleotides. Proc Natl Acad Sci U S A (1985) 2.50
beta-lactamase I from Bacillus cereus. Structure and site-directed mutagenesis. Biochem J (1987) 2.45
Enzymatic and nucleotide sequence studies of a kanamycin-inactivating enzyme encoded by a plasmid from thermophilic bacilli in comparison with that encoded by plasmid pUB110. J Bacteriol (1984) 2.40
Role of the conserved amino acids of the 'SDN' loop (Ser130, Asp131 and Asn132) in a class A beta-lactamase studied by site-directed mutagenesis. Biochem J (1990) 2.27
Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease. J Virol (1990) 2.11
Further improvements on the phosphotriester synthesis of deoxyribooligonucleotides and the oligonucleotide directed site-specific mutagenesis of E. coli lipoprotein gene. Nucleic Acids Res (1983) 2.05
Alterations in PBP 1A essential-for high-level penicillin resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother (1998) 1.98
Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity. J Virol (1988) 1.85
Three poliovirus 2B mutants exhibit noncomplementable defects in viral RNA amplification and display dosage-dependent dominance over wild-type poliovirus. J Virol (1991) 1.84
Thiol-beta-lactamase: replacement of the active-site serine of RTEM beta-lactamase by a cysteine residue. Proc Natl Acad Sci U S A (1982) 1.74
Site-saturation studies of beta-lactamase: production and characterization of mutant beta-lactamases with all possible amino acid substitutions at residue 71. Proc Natl Acad Sci U S A (1986) 1.74
Site-directed mutagenesis of beta-lactamase I. Single and double mutants of Glu-166 and Lys-73. Biochem J (1990) 1.73
Detection of genes for heat-stable enterotoxin I in Escherichia coli strains isolated in Brazil. Infect Immun (1985) 1.52
Multiple pathways of reversion in viroids for conservation of structural elements. EMBO J (1993) 1.44
Active site of triosephosphate isomerase: in vitro mutagenesis and characterization of an altered enzyme. Proc Natl Acad Sci U S A (1985) 1.44
Formation of a thermodynamically metastable structure containing hairpin II is critical for infectivity of potato spindle tuber viroid RNA. EMBO J (1991) 1.38
Site-directed mutagenesis. Biochem J (1986) 1.38
Escherichia coli K-12 mutation that inactivates biodegradative threonine dehydratase by transposon Tn5 insertion. J Bacteriol (1984) 1.33
Lymphotoxin activation by human T-cell leukemia virus type I-infected cell lines: role for NF-kappa B. J Virol (1990) 1.30
Isolation and sequence analysis of the gene (cpdB) encoding periplasmic 2',3'-cyclic phosphodiesterase. J Bacteriol (1986) 1.28
Colony probing as an alternative to standard sequencing as a means of direct analysis of chromosomal DNA to determine the spectrum of single-base changes in regions of known sequence. Proc Natl Acad Sci U S A (1986) 1.21
Use of oligonucleotide probes to study the relatedness of delta-endotoxin genes among Bacillus thuringiensis subspecies and strains. Appl Environ Microbiol (1987) 1.15
Gene synthesis, expression, and mutagenesis of the blue copper proteins azurin and plastocyanin. Proc Natl Acad Sci U S A (1991) 1.13
A site-specific mutation within the active site of ribulose-1,5-bisphosphate carboxylase of Rhodospirillum rubrum. EMBO J (1984) 1.13
Single-turnover and steady-state kinetics of hydrolysis of cephalosporins by beta-lactamase I from Bacillus cereus. Biochem J (1985) 1.13
Site-directed mutagenesis of proposed active-site residues of penicillin-binding protein 5 from Escherichia coli. Biochem J (1994) 1.11
Cloning of the flagellin gene from Bacillus subtilis and complementation studies of an in vitro-derived deletion mutation. J Bacteriol (1989) 1.09
Extension of the substrate spectrum by an amino acid substitution at residue 219 in the Citrobacter freundii cephalosporinase. J Bacteriol (1990) 1.09
Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation. J Exp Med (1995) 1.06
High-efficiency oligonucleotide-directed plasmid mutagenesis. Proc Natl Acad Sci U S A (1990) 1.05
Toward computer-aided site-directed mutagenesis of enzymes. Proc Natl Acad Sci U S A (1986) 1.03
Creation of a test plasmid for detecting G-C-to-T-A transversions by changing serine to arginine in the active site of beta-lactamase. J Bacteriol (1987) 1.03
Coding sequences for vasoactive intestinal peptide and PHM-27 peptide are located on two adjacent exons in the human genome. Proc Natl Acad Sci U S A (1985) 0.98
Protein engineering. The design, synthesis and characterization of factitious proteins. Biochem J (1987) 0.96
Activation of Ha-ras p21 by substitution, deletion, and insertion mutations. Mol Cell Biol (1985) 0.95
Regulation of three beta-tubulin mRNAs during rat brain development. EMBO J (1985) 0.91
Active-site serine mutants of the Streptomyces albus G beta-lactamase. Biochem J (1991) 0.90
Directed evolution of a bacterial alpha-amylase: toward enhanced pH-performance and higher specific activity. Protein Sci (2003) 0.89
cDNAs for the postsynaptic 43-kDa protein of Torpedo electric organ encode two proteins with different carboxyl termini. Proc Natl Acad Sci U S A (1987) 0.88
The complete pattern of mutagenesis arising from the repair of site-specific psoralen crosslinks: analysis by oligonucleotide hybridization. Nucleic Acids Res (1984) 0.87
Trapping the acyl-enzyme intermediate in beta-lactamase I catalysis. Biochem J (1989) 0.87
Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase. Proc Natl Acad Sci U S A (1986) 0.86
Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J (1992) 0.85
Introduction of restriction enzyme sites in protein-coding DNA sequences by site-specific mutagenesis not affecting the amino acid sequence: a computer program. Nucleic Acids Res (1984) 0.84
Epidemiological study of Salmonella enteritidis strains of animal origin in Belgium. Epidemiol Infect (1991) 0.84
Point mutations in the middle of 16S ribosomal RNA of E. coli produced by deletion loop mutagenesis. Nucleic Acids Res (1984) 0.83
Deletions in the tL structure upstream to the rRNA genes in the E. coli rrnB operon cause transcription polarity. Nucleic Acids Res (1987) 0.82
Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity. Front Mol Biosci (2016) 0.81
The isolation of a peptide from the catalytic domain of Bacillus stearothermophilus tryptophyl-tRNA synthetase. The interaction of Brown MX-5BR with tyrosyl-tRNA synthetase. Biochem J (1987) 0.80
The tL structure within the leader region of Escherichia coli ribosomal RNA operons has post-transcriptional functions. Nucleic Acids Res (1990) 0.79
Rational Protein Engineering Guided by Deep Mutational Scanning. Int J Mol Sci (2015) 0.78
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res (1979) 214.95
Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Gene (1977) 114.87
A complementation analysis of the restriction and modification of DNA in Escherichia coli. J Mol Biol (1969) 71.21
Rapid and efficient cosmid cloning. Nucleic Acids Res (1981) 40.13
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A (1978) 19.34
The structure of beta-lactamases. Philos Trans R Soc Lond B Biol Sci (1980) 17.57
Local mutagenesis: a method for generating viral mutants with base substitutions in preselected regions of the viral genome. Proc Natl Acad Sci U S A (1978) 8.36
Filter replicas and permanent collections of recombinant DNA plasmids. Nucleic Acids Res (1979) 8.00
Mutagenesis at a specific position in a DNA sequence. J Biol Chem (1978) 7.56
Directed deletion of a yeast transfer RNA intervening sequence. Science (1980) 6.67
Solid phase synthesis of polynucleotides. VI. Further studies on polystyrene copolymers for the solid support. Nucleic Acids Res (1982) 6.38
Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site. Nature (1982) 5.61
Secretion of beta-lactamase requires the carboxy end of the protein. Cell (1980) 5.03
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: II. In vitro selection of mutant DNA. Gene (1979) 4.99
Efficient correction of a mutation by use of chemically synthesized DNA. Proc Natl Acad Sci U S A (1978) 4.13
beta-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin. Biochemistry (1980) 3.94
Directed selective pressure on a beta-lactamase to analyse molecular changes involved in development of enzyme function. Nature (1977) 2.93
Gap misrepair mutagenesis: efficient site-directed induction of transition, transversion, and frameshift mutations in vitro. Proc Natl Acad Sci U S A (1982) 2.78
Rapid and simple removal of contaminating RNA from plasmid DNA without the use of RNase. Anal Biochem (1981) 2.51
Penicillinase active sites: labelling of serine-44 in beta-lactamase I by 6beta-bromopenicillanic acid. FEBS Lett (1979) 2.45
Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopencillanic acid: mechanism. Biochemistry (1980) 2.19
Site-directed mutagenesis in DNA: generation of point mutations in cloned beta globin complementary dna at the positions corresponding to amino acids 121 to 123. J Mol Biol (1978) 2.17
Segment-directed mutagenesis: construction in vitro of point mutations limited to a small predetermined region of a circular DNA molecule. Proc Natl Acad Sci U S A (1980) 2.10
Site-specific mutagenesis on cloned DNAs: generation of a mutant of Escherichia coli tyrosine suppressor tRNA in which the sequence G-T-T-C corresponding to the universal G-T-pseudouracil-C sequence of tRNAs is changed to G-A-T-C. Proc Natl Acad Sci U S A (1981) 2.09
Defined transversion mutations at a specific position in DNA using synthetic oligodeoxyribonucleotides as mutagens. Nucleic Acids Res (1979) 1.99
6-beta-bromopenicillanic acid, a potent beta-lactamase inhibitor. Proc Natl Acad Sci U S A (1978) 1.60
6 beta-Bromopenicillanic acid inactivates beta-lactamase I. Biochem J (1979) 1.30
Oligonucleotide-directed mutagenesis of gene IX of bacteriophage M13. Nucleic Acids Res (1982) 1.29
Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopenicillanic acid: kinetics. Biochemistry (1980) 1.22
Rapid preparation of covalently closed circular DNA by acridine yellow affinity chromatography. Anal Biochem (1981) 0.95
Hybridization of synthetic oligodeoxyribonucleotides to phi chi 174 DNA: the effect of single base pair mismatch. Nucleic Acids Res (1979) 14.12
DNA methylation and gene function. Science (1980) 14.01
Lac repressor-operator interaction. I. Equilibrium studies. J Mol Biol (1970) 13.32
The lac repressor-operator interaction. 3. Kinetic studies. J Mol Biol (1970) 10.07
The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit beta-globin DNA. Nucleic Acids Res (1981) 9.56
Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Science (1977) 9.28
X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet (1975) 8.74
On the mechanism of DNA replication in mammalian chromosomes. J Mol Biol (1968) 8.34
Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides. Proc Natl Acad Sci U S A (1983) 7.52
Genomic sequencing and methylation analysis by ligation mediated PCR. Science (1989) 7.38
Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. Proc Natl Acad Sci U S A (1981) 7.24
Crystal structure analysis of a complete turn of B-DNA. Nature (1980) 7.18
Determination of intracellular pH by 31P magnetic resonance. J Biol Chem (1973) 6.71
Directed deletion of a yeast transfer RNA intervening sequence. Science (1980) 6.67
Solid phase synthesis of polynucleotides. VI. Further studies on polystyrene copolymers for the solid support. Nucleic Acids Res (1982) 6.38
Structure of a B-DNA dodecamer: conformation and dynamics. Proc Natl Acad Sci U S A (1981) 6.38
Chemical synthesis of genes for human insulin. Proc Natl Acad Sci U S A (1978) 6.09
Lac repressor binding to non-operator DNA: detailed studies and a comparison of eequilibrium and rate competition methods. J Mol Biol (1972) 5.62
High-salt d(CpGpCpG), a left-handed Z' DNA double helix. Nature (1980) 5.46
Synthetic lac operator DNA is functional in vivo. Nature (1976) 5.36
A set of synthetic oligodeoxyribonucleotide primers for DNA sequencing in the plasmid vector pBR322. Gene (1981) 5.06
DNA binding of the lac repressor. J Mol Biol (1968) 5.02
Mammalian X-chromosome inactivation. Annu Rev Genet (1983) 4.89
Chemical synthesis of restriction enzyme recognition sites useful for cloning. Science (1977) 4.81
Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci U S A (1979) 4.72
Solid-phase synthesis of polynucleotides. III. Synthesis of polynucleotides with defined sequences by the block coupling phosphotriester method. Nucleic Acids Res (1980) 4.69
Simplications in the synthesis of short oligonucleotide blocks. Nucleic Acids Res (1980) 4.64
Synthesis and use of synthetic oligonucleotides. Annu Rev Biochem (1984) 4.53
Purification and DNA-binding properties of the catabolite gene activator protein. Proc Natl Acad Sci U S A (1971) 4.43
alpha 1-antitrypsin deficiency detection by direct analysis of the mutation in the gene. Nature (1983) 4.38
Clonal analysis using recombinant DNA probes from the X-chromosome. Cancer Res (1987) 4.25
Efficient correction of a mutation by use of chemically synthesized DNA. Proc Natl Acad Sci U S A (1978) 4.13
Improved triester approach for the synthesis of pentadecathymidylic acid. J Am Chem Soc (1975) 4.08
Methylation of mouse liver DNA studied by means of the restriction enzymes msp I and hpa II. Science (1979) 4.06
Oligonucleotide directed mutagenesis of the human beta-globin gene: a general method for producing specific point mutations in cloned DNA. Nucleic Acids Res (1981) 3.87
Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Nature (1979) 3.80
Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation. Mol Cell Biol (1990) 3.78
Structure, dynamics, and energetics of deoxyguanosine . thymidine wobble base pair formation in the self-complementary d(CGTGAATTCGCG) duplex in solution. Biochemistry (1982) 3.76
The general affinity of lac repressor for E. coli DNA: implications for gene regulation in procaryotes and eucaryotes. Cell (1975) 3.73
Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase. Gene (1984) 3.67
Solid-phase synthesis of polynucleotides. IV. Usage of polystyrene resins for the synthesis of polydeoxyribonucleotides by the phosphostriester method. Nucleic Acids Res (1980) 3.59
Ancestral, mammalian-wide subfamilies of LINE-1 repetitive sequences. J Mol Biol (1995) 3.50
Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane. Proc Natl Acad Sci U S A (1982) 3.44
Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes. Transplantation (1971) 3.42
Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse. Transplantation (1972) 3.34
Premelting and melting transitions in the d(CGCGAATTCGCG) self-complementary duplex in solution. Biochemistry (1982) 3.30
5-methylcytosine, gene regulation, and cancer. Adv Cancer Res (1983) 3.27
Solid-phase synthesis of polynucleotides. II. Synthesis of polythymidylic acids by the block coupling phosphotriester method. Nucleic Acids Res (1980) 3.20
The use of arylsulfonyltriazoles for the synthesis of oligonucleotides by the triester approach. J Am Chem Soc (1975) 3.16
Dissociation kinetics of 19 base paired oligonucleotide-DNA duplexes containing different single mismatched base pairs. Nucleic Acids Res (1987) 3.05
Extra adenosine stacks into the self-complementary d(CGCAGAATTCGCG) duplex in solution. Biochemistry (1982) 3.02
Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci (2002) 3.02
On the assay, isolation and characterization of the lac repressor. J Mol Biol (1968) 2.94
A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers. EMBO J (1986) 2.91
Pain expression and stimulus localisation in individuals with Down's syndrome. Lancet (2000) 2.90
Tiggers and DNA transposon fossils in the human genome. Proc Natl Acad Sci U S A (1996) 2.89
A quantitative HpaII-PCR assay to measure methylation of DNA from a small number of cells. Nucleic Acids Res (1990) 2.81
Chemical synthesis and sequence studies of deoxyribooligonucleotides which constitute the duplex sequence of the lactose operator of Escherichia coli. J Biol Chem (1975) 2.79
Soluble transition metals mediate residual oil fly ash induced acute lung injury. J Toxicol Environ Health (1997) 2.76
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Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability. Proc Natl Acad Sci U S A (1990) 2.51
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Assessing changes in presynaptic inhibition of I a fibres: a study in man and the cat. J Physiol (1987) 2.43
lac repressor--operator interaction. II. Effect of galactosides and other ligands. J Mol Biol (1970) 2.42
Interaction of effecting ligands with lac repressor and repressor-operator complex. Biochemistry (1975) 2.41
Lac operator analogues: bromodeoxyuridine substitution in the lac operator affects the rate of dissociation of the lac repressor. Proc Natl Acad Sci U S A (1972) 2.36
Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase. Mol Cell Biol (1986) 2.35
A comparison of lac repressor binding to operator and to nonoperator DNA. Biochem Biophys Res Commun (1975) 2.32
5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine. J Biol Chem (1977) 2.32
Pattern of group I fibre projections from ankle flexor and extensor muscles in man. Exp Brain Res (1981) 2.30
DNA conformation, dynamics, and interactions in solution. Science (1982) 2.30
Solid phase synthesis of polynucleotides. VIII. Synthesis of mixed oligodeoxyribonucleotides by the phosphotriester solid phase method. Nucleic Acids Res (1983) 2.20
Solid-phase synthesis of polynucleotides: V. Synthesis of oligodeoxyribonucleotides by the phosphomonotriazolide method. Nucleic Acids Symp Ser (1980) 2.20
Isolation of a cDNA clone for the murine transplantation antigen H-2Kb. Proc Natl Acad Sci U S A (1982) 2.20
Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR. Genes Dev (1991) 2.20
Photochemical attachment of lac repressor to bromodeoxyuridine-substituted lac operator by ultraviolet radiation. Proc Natl Acad Sci U S A (1974) 2.20
Human papillomavirus infection of the uterine cervix. Int J Gynecol Pathol (1982) 2.18
Cloning and sequencing of papain-encoding cDNA. Gene (1986) 2.15
Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern. Proc Natl Acad Sci U S A (1997) 2.04
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The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r. Gene (1982) 1.98
Amphiphilicity is essential for mitochondrial presequence function. EMBO J (1988) 1.93
ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature (2000) 1.89
Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis. Nucleic Acids Res (1990) 1.86
MIRs are classic, tRNA-derived SINEs that amplified before the mammalian radiation. Nucleic Acids Res (1995) 1.86
The Saccharomyces cerevisiae Prp5 protein has RNA-dependent ATPase activity with specificity for U2 small nuclear RNA. J Biol Chem (1996) 1.84
A sensitive, quantitative assay for measurement of allele-specific transcripts differing by a single nucleotide. PCR Methods Appl (1992) 1.84
Purification of insulin receptor with full binding activity. J Biol Chem (1983) 1.82
Electron tunneling in proteins: coupling through a beta strand. Science (1995) 1.79
Carbon nuclear magnetic resonance studies of the histidine residue in alpha-lytic protease. Implications for the catalytic mechanism of serine proteases. Biochemistry (1973) 1.77