High-level production, chemical modification and site-directed mutagenesis of a cephalosporin C acylase from Pseudomonas strain N176.

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Published in Eur J Biochem on June 01, 1995

Authors

Y Ishii1, Y Saito, T Fujimura, H Sasaki, Y Noguchi, H Yamada, M Niwa, K Shimomura

Author Affiliations

1: Pharmacological Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.

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The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. Int Psychogeriatr (1994) 5.47

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The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J (1996) 5.09

Mechanism of double ventricular response to a single atrial extrastimulus in patients with Wolff-Parkinson-White syndrome. Pacing Clin Electrophysiol (1990) 5.03

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J (1997) 5.03

Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science (2000) 4.94

Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell (2000) 4.69

Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med (1998) 4.65

A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol (1998) 4.64

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37

p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett (1997) 4.31

Trends in healthy life expectancy in the United States, 1970-1990: gender, racial, and educational differences. Soc Sci Med (2001) 4.30

Endoscopic papillary balloon dilation for the management of common bile duct stones: experience of 226 cases. Endoscopy (1998) 4.11

Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci U S A (1997) 4.10

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Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest (1991) 3.70

Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol (2001) 3.66

Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol (1999) 3.57

A new endoscopic mucosal resection procedure using an insulation-tipped electrosurgical knife for rectal flat lesions: report of two cases. Gastrointest Endosc (1999) 3.55

Routine coagulation of visible vessels may prevent delayed bleeding after endoscopic submucosal dissection--an analysis of risk factors. Endoscopy (2008) 3.50

Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells. J Exp Med (2000) 3.50

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Magnifying endoscopy combined with narrow band imaging system for early gastric cancer: correlation of vascular pattern with histopathology (including video). Endoscopy (2004) 3.36

Regulation of imprinted X-chromosome inactivation in mice by Tsix. Development (2001) 3.12

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Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell (1995) 2.81

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Interactions of outer membrane proteins O-8 and O-9 with peptidoglycan sacculus of Escherichia coli K-12. J Biochem (1976) 2.61

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ACE inhibitors and pneumonia. Lancet (1998) 2.38

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Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases. Nucleic Acids Res (2001) 2.36

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Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci (1999) 2.23

Analysis of a drosophila tRNA gene cluster. Cell (1980) 2.22

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Experimental models of congenital hydrocephalus and comparable clinical problems in the fetal and neonatal periods. Childs Nerv Syst (1996) 2.15

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Giant negative thermal expansion in magnetic nanocrystals. Nat Nanotechnol (2008) 2.14

Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem Biophys Res Commun (2000) 2.14

Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res (1994) 2.13

Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest (1992) 2.13

Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol (1999) 2.12

Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry. Cell Microbiol (2001) 2.12

mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanylytransferase subunit from Saccharomyces cerevisiae. J Biol Chem (1992) 2.12

Identification of a T3-associated gamma delta T cell receptor on Thy-1+ dendritic epidermal Cell lines. Science (1987) 2.12

Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure. J Biol Chem (1988) 2.09

The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine. Anesthesiology (1997) 2.06

Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology (1992) 2.06

Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol (2001) 2.06

Analgesic effect of morphine glucuronides. Tohoku J Exp Med (1971) 2.02

The relationships of proteinuria, serum creatinine, glomerular filtration rate with cardiovascular disease mortality in Japanese general population. Kidney Int (2006) 2.02

Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Science (1998) 2.02

Function of the Escherichia coli nucleoid protein, H-NS: molecular analysis of a subset of proteins whose expression is enhanced in a hns deletion mutant. Mol Gen Genet (1993) 2.01

Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. J Appl Physiol (1985) (1992) 2.01

A cross-validation of the European Organization for Research and Treatment of Cancer QLQ-C30 (EORTC QLQ-C30) for Japanese with lung cancer. Eur J Cancer (1998) 2.01

Pneumatic displacement of subretinal hemorrhage without tissue plasminogen activator. Arch Ophthalmol (1998) 2.01

Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine. J Biochem (1996) 2.00