Published in J Cell Biol on November 15, 1999
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74
Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol (2002) 5.51
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol (1999) 5.06
Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol (2001) 3.66
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest (2001) 3.28
Physiology and function of the tight junction. Cold Spring Harb Perspect Biol (2009) 3.06
Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J Cell Biol (1999) 3.02
Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Am J Hum Genet (2006) 2.96
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Pores in the wall: claudins constitute tight junction strands containing aqueous pores. J Cell Biol (2000) 2.62
Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex. J Clin Invest (2008) 2.24
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Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Neurobiol Dis (2010) 1.90
Renal salt wasting and chronic dehydration in claudin-7-deficient mice. Am J Physiol Renal Physiol (2009) 1.90
Molecular basis of the core structure of tight junctions. Cold Spring Harb Perspect Biol (2010) 1.87
Claudin association with CD81 defines hepatitis C virus entry. J Biol Chem (2010) 1.67
The neurovascular unit in the setting of stroke. J Intern Med (2010) 1.66
The actin cytoskeleton in endothelial cell phenotypes. Microvasc Res (2008) 1.65
Regulation of vascular permeability by sphingosine 1-phosphate. Microvasc Res (2008) 1.62
Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery. Ther Deliv (2011) 1.57
Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol Biol Cell (2009) 1.46
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. Fluids Barriers CNS (2012) 1.44
Effect of cell polarization on hepatitis C virus entry. J Virol (2007) 1.41
Claudin-14 regulates renal Ca⁺⁺ transport in response to CaSR signalling via a novel microRNA pathway. EMBO J (2012) 1.40
Discovering the molecular components of intercellular junctions--a historical view. Cold Spring Harb Perspect Biol (2009) 1.39
Extensive expansion of the claudin gene family in the teleost fish, Fugu rubripes. Genome Res (2004) 1.38
Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr Neuropharmacol (2008) 1.38
Inflammation and the neurovascular unit in the setting of focal cerebral ischemia. Neuroscience (2008) 1.37
Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci U S A (2010) 1.36
Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16. J Clin Invest (2006) 1.33
Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse. Brain Res (2008) 1.32
A claudin-9-based ion permeability barrier is essential for hearing. PLoS Genet (2009) 1.29
Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5. Mol Cell Biol (2004) 1.29
An occludin-focal adhesion kinase protein complex at the blood-testis barrier: a study using the cadmium model. Endocrinology (2009) 1.28
Regulation and roles for claudin-family tight junction proteins. IUBMB Life (2009) 1.26
Expression and phylogeny of claudins in vertebrate primordia. Proc Natl Acad Sci U S A (2001) 1.21
Architecture of tight junctions and principles of molecular composition. Semin Cell Dev Biol (2014) 1.21
Residues in a highly conserved claudin-1 motif are required for hepatitis C virus entry and mediate the formation of cell-cell contacts. J Virol (2009) 1.19
Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila. J Cell Biol (2003) 1.18
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol (2011) 1.16
claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Mol Cell Biol (2001) 1.14
Tight junction proteins: from barrier to tumorigenesis. Cancer Lett (2013) 1.14
Vulnerability of the developing brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair? Front Physiol (2012) 1.12
Claudins and the kidney. Annu Rev Physiol (2012) 1.11
Claudin-2 forms homodimers and is a component of a high molecular weight protein complex. J Biol Chem (2010) 1.10
Claudin-16 and claudin-19 function in the thick ascending limb. Curr Opin Nephrol Hypertens (2010) 1.09
Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy. Am J Pathol (2010) 1.09
A key claudin extracellular loop domain is critical for epithelial barrier integrity. Am J Pathol (2008) 1.09
Tricellulin deficiency affects tight junction architecture and cochlear hair cells. J Clin Invest (2013) 1.09
Claudin interactions in and out of the tight junction. Tissue Barriers (2013) 1.08
Double gene deletion reveals lack of cooperation between claudin 11 and claudin 14 tight junction proteins. Cell Tissue Res (2008) 1.07
The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control. Genetics (2010) 1.06
Cell adhesion molecules in chemically-induced renal injury. Pharmacol Ther (2007) 1.06
Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability. J Clin Immunol (2008) 1.06
Immunolocalization of tight junction proteins in the adult and developing human brain. Histochem Cell Biol (2004) 1.05
Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2. J Membr Biol (2007) 1.05
Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2. Gastroenterology (2009) 1.04
Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. J Virol (2009) 1.04
Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke. Curr Pharm Des (2012) 1.03
The outer limiting membrane (OLM) revisited: clinical implications. Clin Ophthalmol (2010) 1.02
Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation. Tissue Barriers (2015) 1.02
Claudins: control of barrier function and regulation in response to oxidant stress. Antioxid Redox Signal (2011) 1.00
Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol (2013) 0.99
Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens. Mol Biol Cell (2011) 0.99
Differential pathways of claudin oligomerization and integration into tight junctions. Tissue Barriers (2013) 0.99
Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas. Virchows Arch (2005) 0.99
The alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptor trafficking regulator "stargazin" is related to the claudin family of proteins by Its ability to mediate cell-cell adhesion. J Biol Chem (2005) 0.98
Regulation of the expression of the prostate-specific antigen by claudin-7. J Membr Biol (2003) 0.96
Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier, in vitro. Hum Exp Toxicol (2007) 0.95
Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes. Mol Cell Biol (2012) 0.95
Claudin-2-dependent changes in noncharged solute flux are mediated by the extracellular domains and require attachment to the PDZ-scaffold. Ann N Y Acad Sci (2009) 0.95
Claudins: Gatekeepers of lung epithelial function. Semin Cell Dev Biol (2015) 0.94
Visualization and quantitative analysis of reconstituted tight junctions using localization microscopy. PLoS One (2012) 0.94
Relationship of neurovascular elements to neuron injury during ischemia. Cerebrovasc Dis (2009) 0.94
Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. Histochem Cell Biol (2009) 0.94
Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways. J Exp Clin Cancer Res (2012) 0.94
Tight junctions in salivary epithelium. J Biomed Biotechnol (2010) 0.93
Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5. Cell Mol Neurobiol (2006) 0.93
Function and regulation of claudins in the thick ascending limb of Henle. Pflugers Arch (2008) 0.92
Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands. J Anat (2004) 0.91
Protein kinase C activation has distinct effects on the localization, phosphorylation and detergent solubility of the claudin protein family in tight and leaky epithelial cells. J Membr Biol (2010) 0.91
Comparative tight junction protein expressions in colonic Crohn's disease, ulcerative colitis, and tuberculosis: a new perspective. Virchows Arch (2012) 0.90
Myelin basic protein induces inflammatory mediators from primary human endothelial cells and blood-brain barrier disruption: implications for the pathogenesis of multiple sclerosis. Neuropathol Appl Neurobiol (2013) 0.90
Comparison of six immunohistochemical markers for the histologic diagnosis of neoplasia in Barrett's esophagus. Virchows Arch (2010) 0.89
Enterocytes' tight junctions: From molecules to diseases. World J Gastrointest Pathophysiol (2011) 0.89
ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape. PLoS One (2014) 0.88
Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition. Clin Exp Immunol (2005) 0.88
Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? Curr Pharm Des (2014) 0.88
Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function. Physiol Genomics (2009) 0.88
HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity. Mol Biol Cell (2015) 0.87
Tight junctions: from simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol (2016) 0.87
Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments. J Biol Chem (2014) 0.86
A D-peptide analog of the second extracellular loop of claudin-3 and -4 leads to mislocalized claudin and cellular apoptosis in mammary epithelial cells. Chem Biol Drug Des (2011) 0.86
Scanning ion conductance microscopy measurement of paracellular channel conductance in tight junctions. Anal Chem (2013) 0.86
Remodeling of Tight Junctions and Enhancement of Barrier Integrity of the CACO-2 Intestinal Epithelial Cell Layer by Micronutrients. PLoS One (2015) 0.86
The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation. Proc Natl Acad Sci U S A (2014) 0.85
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