D Beach

Author PubWeight™ 419.77‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997 29.13
2 An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 2000 23.17
3 p21 is a universal inhibitor of cyclin kinases. Nature 1993 15.55
4 A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993 13.68
5 Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996 11.41
6 p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 1994 10.95
7 RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 1999 8.55
8 Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 1995 8.53
9 The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 1994 8.22
10 Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 1995 7.25
11 Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 1988 6.88
12 Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J 1994 6.83
13 The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell 1988 6.45
14 mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 1991 6.25
15 Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 1993 5.70
16 p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 1995 5.63
17 D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 1992 5.51
18 Human D-type cyclin. Cell 1991 5.47
19 A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 1995 5.46
20 Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 1989 5.35
21 Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev 1993 5.32
22 Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol Gen Genet 1982 5.17
23 Four mating-type genes control sexual differentiation in the fission yeast. EMBO J 1988 5.00
24 Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell 1989 4.68
25 The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. EMBO J 1987 4.45
26 The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 1989 4.43
27 Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A 1996 4.33
28 Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 1996 4.23
29 cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell 1988 4.12
30 p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 1994 4.08
31 p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 1995 4.08
32 p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J 1987 3.91
33 Functionally homologous cell cycle control genes in budding and fission yeast. Nature 1982 3.78
34 Myc activates telomerase. Genes Dev 1998 3.74
35 Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev 1993 3.70
36 Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev 1996 3.61
37 Construction of an improved host strain for two hybrid screening. Nucleic Acids Res 1994 3.43
38 Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase. Cell 1991 3.37
39 Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell 1991 3.34
40 Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules. EMBO J 1988 3.27
41 Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 1994 3.21
42 Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell 1987 3.12
43 A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell 1989 3.08
44 Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature 1989 3.07
45 CDC25 phosphatases as potential human oncogenes. Science 1995 2.84
46 Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc Natl Acad Sci U S A 1990 2.77
47 Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. EMBO J 1989 2.75
48 Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication. Nature 1989 2.67
49 Repression of cyclin D1: a novel function of MYC. Mol Cell Biol 1994 2.67
50 Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe. Mol Cell Biol 1986 2.66
51 cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J 1994 2.64
52 Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae. Plasmid 1986 2.58
53 Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell 1993 2.57
54 The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Mol Gen Genet 1986 2.46
55 Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. Nature 1990 2.46
56 Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. Proc Natl Acad Sci U S A 1992 2.43
57 Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science 1995 2.42
58 Involvement of ras in sexual differentiation but not in growth control in fission yeast. EMBO J 1986 2.31
59 Deletion of the p16 and p15 genes in human bladder tumors. J Natl Cancer Inst 1995 2.25
60 Isolation of chromosomal origins of replication in yeast. Nature 1980 2.20
61 Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation. Cell 1993 2.19
62 Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control. Cell 1989 2.16
63 Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe. Mol Cell Biol 1987 2.13
64 Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase. EMBO J 1987 2.10
65 Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin. Cell 1990 2.08
66 Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene 1995 2.05
67 A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe. Nature 1988 1.87
68 Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. Genes Dev 1990 1.86
69 Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit. Proc Natl Acad Sci U S A 1989 1.80
70 Homology between the ran1+ gene of fission yeast and protein kinases. EMBO J 1986 1.76
71 Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. EMBO J 1991 1.72
72 Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics 1992 1.70
73 Mutations associated with familial melanoma impair p16INK4 function. Nat Genet 1995 1.69
74 Phosphorylation of gamma-tubulin regulates microtubule organization in budding yeast. Dev Cell 2001 1.60
75 MaRX: an approach to genetics in mammalian cells. Science 1999 1.58
76 Two new multi-purpose multicopy Schizosaccharomyces pombe shuttle vectors, pSP1 and pSP2. Curr Genet 1993 1.58
77 Identification of seven new cut genes involved in Schizosaccharomyces pombe mitosis. J Cell Sci 1993 1.58
78 A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase. Mol Biol Cell 1996 1.55
79 Physical interaction of mammalian CDC37 with CDK4. J Biol Chem 1996 1.53
80 Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle. Mol Cell Biol 1994 1.50
81 p53-independent role of MDM2 in TGF-beta1 resistance. Science 1998 1.48
82 Population explosion in the cyclin family. Curr Biol 1991 1.46
83 KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. Proc Natl Acad Sci U S A 1994 1.45
84 14-3-3 proteins associate with cdc25 phosphatases. Proc Natl Acad Sci U S A 1995 1.44
85 Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B. Cell 1992 1.44
86 Prospective evaluation of three smoking interventions in 205 recovering alcoholics: one-year results of Project SCRAP-Tobacco. J Consult Clin Psychol 1997 1.42
87 Fission yeast cdc25 is a cell-cycle regulated protein. Biochem Biophys Res Commun 1990 1.41
88 Molecular rearrangement of mating-type genes in fission yeast. Nature 1982 1.41
89 Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Curr Biol 1996 1.41
90 Human p53 inhibits growth in Schizosaccharomyces pombe. Mol Cell Biol 1992 1.38
91 Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25. EMBO J 1996 1.37
92 Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev 1995 1.33
93 cdc2 and the regulation of mitosis: six interacting mcs genes. Genetics 1989 1.32
94 An alternative eukaryotic DNA excision repair pathway. Mol Cell Biol 1995 1.31
95 Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. EMBO J 1993 1.31
96 A role for the p34cdc2 kinase and phosphatases in the regulation of phosphorylation and disassembly of lamin B2 during the cell cycle. EMBO J 1991 1.30
97 A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene 1999 1.29
98 A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro. J Cell Biol 1991 1.24
99 Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. Science 1991 1.19
100 Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation. J Virol 1996 1.18
101 Synthesis of p34, the mammalian homolog of the yeast cdc2+/CDC28 protein kinase, is stimulated during adenovirus-induced proliferation of primary baby rat kidney cells. Oncogene 1988 1.12
102 Imaging of kinked configurations of DNA molecules undergoing orthogonal field alternating gel electrophoresis by fluorescence microscopy. Biochemistry 1990 1.12
103 Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase. Mol Biol Cell 1993 1.10
104 An integrated approach for increasing the survival of autologous fat grafts in the treatment of contour defects. Plast Reconstr Surg 1999 1.09
105 p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol 1996 1.08
106 p21 is a component of active cell cycle kinases. Cold Spring Harb Symp Quant Biol 1994 1.01
107 Comparison of several lizard Leishmania species and strains in terms of kinetoplast minicircle and maxicircle DNA sequences, nuclear chromosomes, and membrane lipids. Mol Biochem Parasitol 1988 1.01
108 Fission yeast cyclin: subcellular localisation and cell cycle regulation. J Cell Sci Suppl 1989 0.97
109 Enhancing the survival of aspirated human fat injected into nude mice. Plast Reconstr Surg 1998 0.96
110 Direct activation of cdc2 with phosphatase: identification of p13suc1-sensitive and insensitive steps. FEBS Lett 1990 0.96
111 The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle. J Cell Sci Suppl 1989 0.95
112 The pharyngeal effect of partial nasal obstruction. Pediatrics 1979 0.95
113 Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines. Mol Carcinog 1996 0.93
114 A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet 1996 0.92
115 A cdc2-like kinase phosphorylates histone H1 in the amitotic macronucleus of Tetrahymena. EMBO J 1991 0.89
116 The Cdc2 protein kinase controls Cdc10/Sct1 complex formation. Mol Biol Cell 1997 0.88
117 Direct observation of microtubule-f-actin interaction in cell free lysates. J Cell Sci 1999 0.87
118 Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase. Anticancer Res 1992 0.86
119 Sexual differentiation is controlled by a protein kinase encoded by the ran1+ gene in fission yeast. Cold Spring Harb Symp Quant Biol 1985 0.85
120 Cell cycle regulation of p34cdc2 kinase activity in Physarum polycephalum. J Cell Sci 1990 0.85
121 A versatile microtiter assay for the universal cdc2 cell cycle regulator. Anal Biochem 1990 0.83
122 Isolation of newly-initiated DNA from the early S phase of the synchronous eukaryote, Physarum polycephalum. Exp Cell Res 1980 0.83
123 Novel hyperactive mitogen to endothelial cells: human decidual NKG5. Am J Reprod Immunol 1999 0.83
124 Ran1 functions to control the Cdc10/Sct1 complex through Puc1. Mol Biol Cell 1997 0.83
125 Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4. Mol Carcinog 1996 0.82
126 The spil GTPase interacts with RCCl in cell cycle dependency. Cold Spring Harb Symp Quant Biol 1991 0.82
127 High linoleic acid diets ameliorate diabetic nephropathy in rats. Am J Kidney Dis 1990 0.80
128 Effect of dietary cholesterol on unsaturated fatty acid biosynthesis in a ciliated protozoan. Biochim Biophys Acta 1966 0.78
129 Stimulated healing of recalcitrant wounds by topical application of enriched cell culture medium: a clinical report. Plast Reconstr Surg 2001 0.78
130 RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation. Mol Biol Cell 1995 0.78
131 Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors. Cancer Res 1995 0.77
132 Pilot study of a novel treatment for androgenetic alopecia using enriched cell culture medium: clinical trials. Dermatol Online J 2003 0.77
133 [Genome mapping of Schizosaccharomyces pombe]. Tanpakushitsu Kakusan Koso 1993 0.76
134 Regulation of the vertebrate cell cycle by the cdc2 protein kinase. Cold Spring Harb Symp Quant Biol 1988 0.76
135 Menstrual-cycle-dependent and -independent features of the human Fallopian tube fimbrial epithelium: an ultrastructural and cytochemical study. Gynecol Obstet Invest 1983 0.75
136 Uterine angiogenic factor induces vascularization of collagen sponges in guinea-pigs. Burns 1989 0.75
137 Spi1 GTPase interacts with RCC1 to maintain interdependency of cell cycle events. Princess Takamatsu Symp 1991 0.75
138 Zero (0) concept for health and health care. Rev Odontol P R 1990 0.75
139 Improved vitality of experimental random dorsal skin flaps in rats treated with enriched cell culture medium. Plast Reconstr Surg 1999 0.75
140 Ultrastructural localization of calcium in human uterine tube epithelial cells. Acta Anat (Basel) 1982 0.75
141 Serum-free cell culture medium induces acceleration of wound healing in guinea-pigs. Burns 1995 0.75
142 A five-year follow-up of physically disabled clients. Rehabil Lit 1975 0.75
143 Isolation and culture of human decidual capillary endothelial cells in serum-free medium supplemented with human uterine angiogenic factor. Acta Anat (Basel) 1991 0.75
144 Juxtanuclear globule of the human fimbrial epithelium ciliary cell: a histo- and cytochemical study. Acta Anat (Basel) 1982 0.75
145 Human fallopian tube epithelium cytochemistry in the first and third trimesters of pregnancy. Eur J Obstet Gynecol Reprod Biol 1981 0.75
146 Ultrastructural localization of alkaline and acid phosphatases in the human fallopian tube epithelium during the menstrual cycle. Anat Rec 1982 0.75
147 Steroidal binding sites in the ampulla of the human fallopian tube--autoradiographic and biochemical study. Eur J Obstet Gynecol Reprod Biol 1987 0.75
148 Ovarian hyperstimulation in rats. Eur J Obstet Gynecol Reprod Biol 1980 0.75
149 Follow-up of clients placed into regular employment. Rehabil Lit 1974 0.75
150 A five-year follow-up of mentally retarded clients. Rehabil Lit 1974 0.75
151 p34, a protein kinase involved in cell cycle regulation in eukaryotic cells. Adv Exp Med Biol 1988 0.75
152 Effect of decidua angiogenic factors on experimental dermis allografts. Burns 1989 0.75
153 Ectopic pregnancy effects on the ipsilateral fallopian tube epithelium--an ultrastructural study. Eur J Obstet Gynecol Reprod Biol 1984 0.75
154 Zimbabwe: pre-colonial history, demographic disaster and the university. Zambezia 1999 0.75