Published in J Bacteriol on March 01, 1994
Characterization of outer membranes isolated from Borrelia burgdorferi, the Lyme disease spirochete. Infect Immun (1995) 1.66
Characterization of outer membranes isolated from Treponema pallidum, the syphilis spirochete. Infect Immun (1995) 1.48
Tromp1, a putative rare outer membrane protein, is anchored by an uncleaved signal sequence to the Treponema pallidum cytoplasmic membrane. J Bacteriol (1997) 1.29
Membrane topology of Borrelia burgdorferi and Treponema pallidum lipoproteins. Infect Immun (1995) 1.24
Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete. J Bacteriol (2009) 1.18
Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete. Infect Immun (1997) 1.13
Molecular characterization and cellular localization of TpLRR, a processed leucine-rich repeat protein of Treponema pallidum, the syphilis spirochete. J Bacteriol (1997) 1.13
Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments. PLoS Negl Trop Dis (2012) 1.05
The 47-kDa major lipoprotein immunogen of Treponema pallidum is a penicillin-binding protein with carboxypeptidase activity. Proc Natl Acad Sci U S A (1994) 1.02
The Treponema denticola major sheath protein is predominantly periplasmic and has only limited surface exposure. Infect Immun (1999) 1.01
Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN. J Biol Chem (2015) 0.85
A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326. J Bacteriol (2015) 0.77
Treponema pallidum Lipoprotein TP0435 Expressed in Borrelia burgdorferi Produces Multiple Surface/Periplasmic Isoforms and mediates Adherence. Sci Rep (2016) 0.77
MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis. PLoS One (2013) 0.75
Studies on treponemal immobilizing antibodies in syphilis. I. Techniques of measurement and factors influencing immobilization. J Immunol (1951) 11.01
Inoculation syphilis in human volunteers. Medicine (Baltimore) (1956) 6.18
Membrane splitting in freeze-ethching. Covalently bound ferritin as a membrane marker. J Cell Biol (1970) 5.62
Treponema pallidum (Nichols strain) in tissue cultures: cellular attachment, entry, and survival. Infect Immun (1975) 4.41
Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by -irradiation. J Immunol (1973) 3.45
Identification and localization of integral membrane proteins of virulent Treponema pallidum subsp. pallidum by phase partitioning with the nonionic detergent triton X-114. Infect Immun (1988) 3.42
Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum. Proc Natl Acad Sci U S A (1989) 3.17
Humoral immune response in human syphilis to polypeptides of Treponema pallidum. J Immunol (1982) 2.99
Characterization of the attachment of Treponema pallidum (Nichols strain) to cultured mammalian cells and the potential relationship of attachment to pathogenicity. Infect Immun (1977) 2.95
The structure of erythrocyte membranes studied by freeze-etching. II. Localization of receptors for phytohemagglutinin and influenza virus to the intramembranous particles. J Exp Med (1972) 2.78
Demonstration of rare protein in the outer membrane of Treponema pallidum subsp. pallidum by freeze-fracture analysis. J Bacteriol (1989) 2.46
Demonstration of the in vitro phagocytosis of Treponema pallidum by rabbit peritoneal macrophages. J Immunol (1978) 2.42
Relationship between treponemal immobilizing antibodies and acquired immunity in experimental syphilis. J Immunol (1951) 2.42
Antigens of Treponema pallidum recognized by IgG and IgM antibodies during syphilis in humans. J Infect Dis (1985) 2.29
Major integral membrane protein immunogens of Treponema pallidum are proteolipids. Infect Immun (1989) 2.15
Monoclonal antibody with hemagglutination, immobilization, and neutralization activities defines an immunodominant, 47,000 mol wt, surface-exposed immunogen of Treponema pallidum (Nichols). J Exp Med (1984) 2.11
Humoral immune response in experimental syphilis to polypeptides of Treponema pallidum. J Immunol (1983) 1.97
The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum. Infect Immun (1992) 1.86
Production of immobilizing antibodies unaccompanied by active immunity to Treponema pallidum as shown by injecting rabbits and mice with the killed organisms. Am J Syph Gonorrhea Vener Dis (1953) 1.82
Phase transitions of phospholipid bilayers and membranes of Acholeplasma laidlawii B visualized by freeze fracturing electron microscopy. Biochim Biophys Acta (1972) 1.81
Lateral phase separations in Escherichia coli membranes. Biochim Biophys Acta (1974) 1.78
Lipids of the Spirochaetales: comparison of the lipids of several members of the genera Spirochaeta, Treponema, and Leptospira. J Bacteriol (1974) 1.77
Complement activation limits the rate of in vitro treponemicidal activity and correlates with antibody-mediated aggregation of Treponema pallidum rare outer membrane protein. J Immunol (1990) 1.76
Changes in the cell surface properties of Treponema pallidum that occur during in vitro incubation of freshly extracted organisms. Infect Immun (1987) 1.67
Macrophage-mediated killing of opsonized Treponema pallidum. J Infect Dis (1992) 1.55
Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity. Infect Immun (1993) 1.47
Monoclonal antibody selection and analysis of a recombinant DNA-derived surface immunogen of Treponema pallidum expressed in Escherichia coli. Infect Immun (1986) 1.47
Lipid phase transitions in cytoplasmic and outer membranes of Escherichia coli. Biochim Biophys Acta (1975) 1.42
The 34-kilodalton membrane immunogen of Treponema pallidum is a lipoprotein. Infect Immun (1990) 1.42
Characterization of lipid-modified immunogenic proteins of Treponema pallidum expressed in Escherichia coli. Microb Pathog (1989) 1.39
Lipid modification of the 15 kiloDalton major membrane immunogen of Treponema pallidum. Mol Microbiol (1990) 1.19
Phagocytosis of opsonized Treponema pallidum subsp. pallidum proceeds slowly. Infect Immun (1990) 1.13
Lipid composition of treponemal strains. Acta Microbiol Acad Sci Hung (1966) 1.11
Immunochemical characterization and purification of Treponema pallidum antigen TpD expressed by Escherichia coli K12. Sex Transm Dis (1987) 1.06
Lipid phase separations and protein distribution in membranes. J Supramol Struct (1974) 1.02
Organization of glycosphingolipids in phosphatidylcholine bilayers: use of antibody molecules and Fab fragments as morphologic markers. Biochemistry (1990) 1.01
Effects of lipid phase transition of the freeze-cleaved envelope of Escherichia coli. J Bacteriol (1977) 0.87
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science (1999) 8.63
A critical appraisal of "chronic Lyme disease". N Engl J Med (2007) 7.84
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science (1999) 7.75
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem (1999) 5.81
Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36
Factors affecting the transformation of Escherichia coli strain chi1776 by pBR322 plasmid DNA. Gene (1978) 5.15
A phenylalanine ammonia-lyase gene from parsley: structure, regulation and identification of elicitor and light responsive cis-acting elements. EMBO J (1989) 5.03
Inducible in vivo DNA footprints define sequences necessary for UV light activation of the parsley chalcone synthase gene. EMBO J (1989) 4.79
Induction of direct antimicrobial activity through mammalian toll-like receptors. Science (2001) 4.46
A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. N Engl J Med (1997) 4.11
Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins. Infect Immun (1990) 4.10
Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway. Proc Natl Acad Sci U S A (2001) 3.65
Structure and elicitor or u.v.-light-stimulated expression of two 4-coumarate:CoA ligase genes in parsley. EMBO J (1987) 3.59
Identification and localization of integral membrane proteins of virulent Treponema pallidum subsp. pallidum by phase partitioning with the nonionic detergent triton X-114. Infect Immun (1988) 3.42
A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state. J Clin Invest (1998) 3.41
Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum. Proc Natl Acad Sci U S A (1989) 3.17
Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis. J Immunol (2001) 3.06
Primary structures and catalytic properties of isoenzymes encoded by the two 4-coumarate: CoA ligase genes in parsley. Eur J Biochem (1988) 3.05
Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi. Mol Microbiol (2000) 3.00
Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol Microbiol (1995) 2.92
A diffusible cytotoxin of Haemophilus ducreyi. Proc Natl Acad Sci U S A (1997) 2.89
Bacterial nutrients in drinking water. Appl Environ Microbiol (1991) 2.62
Increased amplification of pBR322 plasmid deoxyribonucleic acid in Escherichia coli K-12 strains RR1 and chi1776 grown in the presence of high concentrations of nucleoside. J Bacteriol (1979) 2.55
Sensitive detection of Treponema pallidum by using the polymerase chain reaction. J Clin Microbiol (1991) 2.51
Rapid and simple removal of contaminating RNA from plasmid DNA without the use of RNase. Anal Biochem (1981) 2.51
Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J Immunol (2001) 2.24
Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect Immun (1998) 2.23
Use of polymerase chain reaction and rabbit infectivity testing to detect Treponema pallidum in amniotic fluid, fetal and neonatal sera, and cerebrospinal fluid. J Clin Microbiol (1991) 2.20
Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family. Infect Immun (1999) 2.18
Major integral membrane protein immunogens of Treponema pallidum are proteolipids. Infect Immun (1989) 2.15
Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames and a lipoprotein gene family. J Bacteriol (1996) 2.14
Monoclonal antibody with hemagglutination, immobilization, and neutralization activities defines an immunodominant, 47,000 mol wt, surface-exposed immunogen of Treponema pallidum (Nichols). J Exp Med (1984) 2.11
Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct. J Immunol (1991) 2.09
Murine monoclonal antibodies specific for virulent Treponema pallidum (Nichols). Infect Immun (1982) 2.08
Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks. Infect Immun (2000) 2.00
Functional architecture of the light-responsive chalcone synthase promoter from parsley. Plant Cell (1989) 2.00
Cardiovascular syphilis. Am J Med (1989) 1.99
Two alleles of the single-copy chalcone synthase gene in parsley differ by a transposon-like element. Mol Gen Genet (1988) 1.97
Cloning and expression of Treponema pallidum (Nichols) antigen genes in Escherichia coli. Infect Immun (1983) 1.94
Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infect Immun (1997) 1.93
Limited surface exposure of Borrelia burgdorferi outer surface lipoproteins. Proc Natl Acad Sci U S A (1996) 1.90
On the cloning of eukaryotic total poly(A)-RNA populations in Escherichia coli. J Biol Chem (1980) 1.89
The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum. Infect Immun (1992) 1.86
Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages. J Immunol (1995) 1.86
Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides. Infect Immun (1999) 1.84
Clinical manifestations of early syphilis by HIV status and gender: results of the syphilis and HIV study. Sex Transm Dis (2001) 1.82
Purification and characterization of a cloned protease-resistant Treponema pallidum-specific antigen. Infect Immun (1984) 1.80
A temperature-dependent rabbit model for production of dermal lesions by Haemophilus ducreyi. J Infect Dis (1991) 1.77
Monoclonal antibody analysis of specific antigenic similarities among pathogenic Treponema pallidum subspecies. Infect Immun (1984) 1.77
Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol (2000) 1.77
Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals. Infect Immun (2001) 1.73
Isolation of integral membrane proteins by phase partitioning with Triton X-114. Methods Enzymol (1994) 1.70
Putative promoter elements for the ribosomal RNA genes of the thermoacidophilic archaebacterium Sulfolobus sp. strain B12. Nucleic Acids Res (1987) 1.68
Plasmid DNA in Treponema pallidum (Nichols): potential for antibiotic resistance by syphilis bacteria. Science (1981) 1.67
Characterization of outer membranes isolated from Borrelia burgdorferi, the Lyme disease spirochete. Infect Immun (1995) 1.66
Analysis of Borrelia burgdorferi membrane architecture by freeze-fracture electron microscopy. J Bacteriol (1994) 1.61
Use of electroporation to construct isogenic mutants of Haemophilus ducreyi. J Bacteriol (1992) 1.61
The surface of virulent Treponema pallidum: resistance to antibody binding in the absence of complement and surface association of recombinant antigen 4D. Infect Immun (1986) 1.61
A hemoglobin-binding outer membrane protein is involved in virulence expression by Haemophilus ducreyi in an animal model. Infect Immun (1996) 1.60
Evaluation of molecular methodologies and rabbit infectivity testing for the diagnosis of congenital syphilis and neonatal central nervous system invasion by Treponema pallidum. J Infect Dis (1993) 1.60
Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone. Nat Struct Biol (1999) 1.60
Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infect Immun (1997) 1.57
The TprK protein of Treponema pallidum is periplasmic and is not a target of opsonic antibody or protective immunity. J Exp Med (2001) 1.57
Treponema pallidum in gel microdroplets: a novel strategy for investigation of treponemal molecular architecture. Mol Microbiol (1995) 1.54
Acylation of the 47-kilodalton major membrane immunogen of Treponema pallidum determines its hydrophobicity. Infect Immun (1989) 1.53
Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy. Kidney Int (2000) 1.52
The distribution of metastases in the liver. A quantitative postmortem study. Virchows Arch A Pathol Anat Histol (1981) 1.50
Cloning and expression of the major 47-kilodalton surface immunogen of Treponema pallidum in Escherichia coli. Infect Immun (1986) 1.50
Characterization of outer membranes isolated from Treponema pallidum, the syphilis spirochete. Infect Immun (1995) 1.48
Fatty acids of Treponema pallidum and Borrelia burgdorferi lipoproteins. J Bacteriol (1994) 1.48
Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity. Infect Immun (1993) 1.47
Monoclonal antibody selection and analysis of a recombinant DNA-derived surface immunogen of Treponema pallidum expressed in Escherichia coli. Infect Immun (1986) 1.47
Localization of outer surface proteins A and B in both the outer membrane and intracellular compartments of Borrelia burgdorferi. J Bacteriol (1991) 1.46
Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide. J Immunol (1998) 1.45
The 34-kilodalton membrane immunogen of Treponema pallidum is a lipoprotein. Infect Immun (1990) 1.42