Published in Development on August 01, 1996
The many facets of Notch ligands. Oncogene (2008) 2.57
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Spectrum and frequency of jagged1 (JAG1) mutations in Alagille syndrome patients and their families. Am J Hum Genet (1998) 1.57
An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS One (2007) 1.53
Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing. BMC Dermatol (2002) 1.39
Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J (2006) 1.39
Down-regulation of Delta by proteolytic processing. J Cell Biol (2002) 1.37
Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development. Mol Biol Cell (1998) 1.33
Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics (1996) 1.29
The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev Biol (2008) 1.24
Cross talk between notch and growth factor/cytokine signaling pathways in neural stem cells. Mol Cell Biol (2007) 1.21
Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects. Am J Pathol (2002) 1.16
Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans. Mol Biol Cell (1997) 1.15
Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression. Mol Cell Biol (1997) 1.11
The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway. Nucleic Acids Res (2007) 1.11
Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. EMBO J (2002) 1.10
Notch ligand ubiquitylation: what is it good for? Dev Cell (2011) 1.09
Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila. Genetics (2006) 1.09
Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas. BMC Dev Biol (2007) 1.08
Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling. Development (2011) 1.08
The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila. BMC Dev Biol (2004) 1.07
Familial deafness, congenital heart defects, and posterior embryotoxon caused by cysteine substitution in the first epidermal-growth-factor-like domain of jagged 1. Am J Hum Genet (2002) 1.02
Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis. J Cell Biol (2007) 1.01
An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling. Development (2013) 0.92
Drosophila Dystroglycan is a target of O-mannosyltransferase activity of two protein O-mannosyltransferases, Rotated Abdomen and Twisted. Glycobiology (2009) 0.90
A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. PLoS One (2007) 0.90
Beaded of Goldschmidt, an antimorphic allele of Serrate, encodes a protein lacking transmembrane and intracellular domains. Genetics (1997) 0.89
The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptors. Acta Histochem (2010) 0.86
Tools and methods for studying Notch signaling in Drosophila melanogaster. Methods (2014) 0.82
Notch activity opposes Ras-induced differentiation during the Second Mitotic Wave of the developing Drosophila eye. BMC Dev Biol (2006) 0.81
Intracellular trafficking in Drosophila visual system development: a basis for pattern formation through simple mechanisms. Dev Neurobiol (2011) 0.80
Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. PLoS One (2012) 0.80
Regulation of Notch1 signaling by Delta-like ligand 1 intracellular domain through physical interaction. Mol Cells (2011) 0.80
A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases. Mol Cell (2015) 0.77
Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction. Curr Opin Struct Biol (2016) 0.77
Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart. Cardiovasc Res (2015) 0.76
A new mechanism for spatial pattern formation via lateral and protrusion-mediated lateral signalling. J R Soc Interface (2016) 0.75
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell (1985) 6.93
opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster. Cell (1985) 5.71
Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell (1991) 4.37
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell (1990) 4.07
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet (2000) 3.82
The suppressor of hairless protein participates in notch receptor signaling. Cell (1994) 3.81
Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science (1999) 3.74
Genetic and molecular analysis of the 87A7 and 87C1 heat-inducible loci of D. melanogaster. Cell (1979) 3.68
Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell (1997) 3.47
Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell (1993) 3.35
Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci U S A (1995) 3.33
Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol (2000) 3.15
A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development (1994) 2.78
Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat Genet (1992) 2.71
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J Cell Biol (1995) 2.69
An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature (1993) 2.49
Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol (1997) 2.48
Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science (1996) 2.31
slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev (1990) 2.25
Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster. Proc Natl Acad Sci U S A (1983) 2.17
Two hybrid plasmids with D. melanogaster DNA sequences complementary to mRNA coding for the major heat shock protein. Cell (1978) 2.10
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development (1995) 2.09
Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol (1991) 2.05
The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood (1998) 2.05
A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit. Cell (1988) 2.01
Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol (1998) 1.99
Cell proliferation control by Notch signaling in Drosophila development. Development (1998) 1.98
The 5S genes of Drosophila melanogaster. Cell (1977) 1.94
Physical map of two D. melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein. Cell (1979) 1.80
The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins. Proc Natl Acad Sci U S A (1992) 1.76
Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development (1994) 1.73
Molecular genetics of Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol (1985) 1.68
Genes for the 70,000 dalton heat shock protein in two cloned D. melanogaster DNA segments. Cell (1979) 1.66
The involvement of the Notch locus in Drosophila oogenesis. Development (1992) 1.65
The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev (1990) 1.61
Human deltex is a conserved regulator of Notch signalling. Nat Genet (1998) 1.55
Organization of the multiple genes for the 70,000-dalton heat-shock protein in Drosophila melanogaster. Proc Natl Acad Sci U S A (1979) 1.55
The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev (1990) 1.53
The molecular genetics of the Notch locus in Drosophila melanogaster. Dev Biol (1985) 1.49
slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system. Cell (1988) 1.48
The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila. EMBO J (1988) 1.48
Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Genetics (1991) 1.47
Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements. Development (1997) 1.39
Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development (1997) 1.37
Notch: neurogenesis is only part of the picture. Cell (1993) 1.35
Human ligands of the Notch receptor. Am J Pathol (1999) 1.32
The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila. Trends Genet (1988) 1.29
Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics (1996) 1.29
Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos. Development (1993) 1.27
The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development. J Cell Biol (1989) 1.25
Transfer RNA genes of Drosophila melanogaster. Nucleic Acids Res (1980) 1.25
deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster. Genetics (1990) 1.23
The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase. Genetics (1999) 1.20
Primary structure of triosephosphate isomerase from Bacillus stearothermophilus. Eur J Biochem (1980) 1.19
Notch signaling and the determination of appendage identity. Proc Natl Acad Sci U S A (2000) 1.12
The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB. J Mol Biol (1994) 1.12
Comparative aspects of Notch signaling in lower and higher eukaryotes. Perspect Dev Neurobiol (1997) 1.12
Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling. Genetics (1998) 1.12
A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein. Genetics (1994) 1.08
Identification of a divergent actin-related protein in Drosophila. J Mol Biol (1994) 1.06
Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells. Mech Dev (1995) 1.05
Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. Genomics (1996) 1.04
The NOTCH receptor and its ligands. Trends Cell Biol (1997) 1.04
Physical and functional definition of the Drosophila Notch locus by P element transformation. Genetics (1989) 1.03
Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat Genet (1992) 1.01
DNA sequences flanking the starts of the hsp 70 and alpha beta heat shock genes are homologous. Dev Biol (1981) 0.99
Modulation of wingless signaling by Notch in Drosophila. Mech Dev (1994) 0.99
An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin. J Cell Sci (1997) 0.98
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int J Dev Neurosci (2001) 0.96
Modularity of the slit protein. Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions. J Mol Biol (1992) 0.94
Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling. Eur J Cell Biol (1999) 0.90
Purification of a protein from unfertilized eggs of Drosophila with specific affinity for a defined DNA sequence and the cloning of this DNA sequence in bacterial plasmids. Cold Spring Harb Symp Quant Biol (1978) 0.88
The expression of the neurogenic locus Notch during the postembryonic development of Drosophila melanogaster and its relationship to mitotic activity. J Neurogenet (1989) 0.86
Phenotypic and molecular analysis of the facets, a group of intronic mutations at the Notch locus of Drosophila melanogaster which affect postembryonic development. Genetics (1989) 0.85
A genetic screen for novel components of the notch signaling pathway during Drosophila bristle development. Genetics (1998) 0.84
Cloning of a secretory gelsolin from Drosophila melanogaster. J Mol Biol (1993) 0.83
The developmental role of warthog, the notch modifier encoding Drab6. J Cell Biol (1999) 0.82
Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development. C R Acad Sci III (1993) 0.81
Alagille syndrome--a notch up for the Notch receptor. Nat Genet (1997) 0.79
Developmental analysis of the facets, a group of intronic mutations at the Notch locus of Drosophila melanogaster that affect postembryonic development. J Exp Zool (1991) 0.75