Published in Nature on June 26, 1997
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2003) 4.89
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell (2008) 3.09
Mammalian glycosylation in immunity. Nat Rev Immunol (2008) 2.74
Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J Cell Biol (1999) 2.39
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. Nat Struct Mol Biol (2008) 2.22
Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Dev Cell (2009) 2.03
Glycosylation in cancer: mechanisms and clinical implications. Nat Rev Cancer (2015) 2.00
Signaling mechanisms controlling cell fate and embryonic patterning. Cold Spring Harb Perspect Biol (2012) 1.89
A Notch updated. J Cell Biol (2009) 1.86
Notch signaling at a glance. J Cell Sci (2013) 1.76
Roles of Pofut1 and O-fucose in mammalian Notch signaling. J Biol Chem (2008) 1.71
The molecular logic of Notch signaling--a structural and biochemical perspective. J Cell Sci (2008) 1.65
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol (2000) 1.54
Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1. Proc Natl Acad Sci U S A (2001) 1.51
Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell (2012) 1.44
Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science (2015) 1.41
Drosophila follicle cells: morphogenesis in an eggshell. Semin Cell Dev Biol (2008) 1.36
Highly conserved O-fucose sites have distinct effects on Notch1 function. J Biol Chem (2005) 1.35
Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity. EMBO Rep (2006) 1.31
Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling. BMC Biol (2008) 1.26
The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev Biol (2008) 1.24
Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem (2013) 1.19
O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1. J Biol Chem (2011) 1.17
Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage. Genes Dev (1998) 1.15
Notch ligand endocytosis: mechanistic basis of signaling activity. Semin Cell Dev Biol (2012) 1.14
Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation. Endocrinology (2008) 1.14
Notch and wingless regulate expression of cuticle patterning genes. Mol Cell Biol (1999) 1.13
Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling. Genetics (1998) 1.12
Role of glycosylation of Notch in development. Semin Cell Dev Biol (2010) 1.10
Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development. Dev Biol (2006) 1.09
Significance of glycosylation in Notch signaling. Biochem Biophys Res Commun (2014) 1.09
Role of unusual O-glycans in intercellular signaling. Int J Biochem Cell Biol (2008) 1.08
Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway. Dev Dyn (2009) 1.06
The segmentation clock mechanism moves up a notch. Trends Cell Biol (2010) 1.01
Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development (2011) 1.00
Notch signalling in context. Nat Rev Mol Cell Biol (2016) 0.99
Notch signaling in cardiac development and disease. Pediatr Cardiol (2009) 0.98
Role of glycans and glycosyltransferases in the regulation of Notch signaling. Glycobiology (2010) 0.97
Notch signaling during cell fate determination in the inner ear. Semin Cell Dev Biol (2013) 0.97
Glycobiology on the fly: developmental and mechanistic insights from Drosophila. Glycobiology (2008) 0.96
Proteolytic cleavage of Notch: "HIT and RUN". Curr Mol Med (2011) 0.95
O-fucosylation of DLL3 is required for its function during somitogenesis. PLoS One (2015) 0.93
The twisted gene encodes Drosophila protein O-mannosyltransferase 2 and genetically interacts with the rotated abdomen gene encoding Drosophila protein O-mannosyltransferase 1. Genetics (2005) 0.93
The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. Mol Genet Genomics (2006) 0.93
The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis. BMC Dev Biol (2008) 0.93
Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor. J Biol Chem (2013) 0.92
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. J Biol Chem (2011) 0.92
Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. Elife (2014) 0.92
Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling. J Biol Chem (2011) 0.91
Dynamical analysis of the regulatory network defining the dorsal-ventral boundary of the Drosophila wing imaginal disc. Genetics (2006) 0.91
Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse. Cell Cycle (2014) 0.91
Notch signal strength controls cell fate in the haemogenic endothelium. Nat Commun (2015) 0.90
Drosophila Dystroglycan is a target of O-mannosyltransferase activity of two protein O-mannosyltransferases, Rotated Abdomen and Twisted. Glycobiology (2009) 0.90
Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium. J Mol Histol (2007) 0.90
MFng is dispensable for mouse pancreas development and function. Mol Cell Biol (2009) 0.89
Positional cloning of a Bombyx wingless locus flugellos (fl) reveals a crucial role for fringe that is specific for wing morphogenesis. Genetics (2008) 0.89
Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development. BMC Dev Biol (2009) 0.89
Essential roles for lines in mediating leg and antennal proximodistal patterning and generating a stable Notch signaling interface at segment borders. Dev Biol (2009) 0.89
Lunatic fringe promotes the lateral inhibition of neurogenesis. Development (2009) 0.88
Oscillations and patterns in spatially discrete models for developmental intercellular signalling. J Math Biol (2003) 0.88
Competition in notch signaling with cis enriches cell fate decisions. PLoS One (2014) 0.88
Neural and synaptic defects in slytherin, a zebrafish model for human congenital disorders of glycosylation. PLoS One (2010) 0.88
CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. J Cell Sci (2012) 0.87
A 380-kb Duplication in 7p22.3 Encompassing the LFNG Gene in a Boy with Asperger Syndrome. Mol Syndromol (2012) 0.87
Fringe controls naïve CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models. PLoS One (2012) 0.87
Two Notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord. PLoS One (2010) 0.87
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Dev Dyn (2011) 0.86
The role of Adams in Notch signaling. Adv Exp Med Biol (2012) 0.86
LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo. Development (2008) 0.85
Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors. Cancers (Basel) (2012) 0.85
Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. Dev Cell (2016) 0.85
Pattern selection by dynamical biochemical signals. Biophys J (2015) 0.85
Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila. Proc Natl Acad Sci U S A (2012) 0.85
Sequential Notch activation regulates ventricular chamber development. Nat Cell Biol (2015) 0.85
Comparative analysis of Wingless patterning in the embryonic grasshopper eye. Dev Genes Evol (2005) 0.84
A murine homologue of the Drosophila brainiac gene shows homology to glycosyltransferases and is required for preimplantation development of the mouse. Mol Cell Biol (2001) 0.84
Regulation of EGFR and Notch signaling by distinct isoforms of D-cbl during Drosophila development. Dev Biol (2010) 0.84
Reciprocal roles for bowl and lines in specifying the peripodial epithelium and the disc proper of the Drosophila wing primordium. Development (2008) 0.84
A genetic screen for novel components of the notch signaling pathway during Drosophila bristle development. Genetics (1998) 0.84
Robustness and stability of the gene regulatory network involved in DV boundary formation in the Drosophila wing. PLoS One (2007) 0.84
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function. PLoS One (2014) 0.84
NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer. Nat Rev Urol (2014) 0.83
Hedgehog signaling in the Drosophila eye and head: an analysis of the effects of different patched trans-heterozygotes. Genetics (2003) 0.83
Notch signalling stabilises boundary formation at the midbrain-hindbrain organiser. Development (2011) 0.82
Lunatic fringe causes expansion and increased neurogenesis of trunk neural tube and neural crest populations. Neuron Glia Biol (2007) 0.82
Tools and methods for studying Notch signaling in Drosophila melanogaster. Methods (2014) 0.82
Expression of active Notch1 in avian coronary development. Dev Dyn (2009) 0.82
An expanded Notch-Delta model exhibiting long-range patterning and incorporating MicroRNA regulation. PLoS Comput Biol (2014) 0.81
Soluble forms of the Notch ligands Delta1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distinct phenotypes. Am J Pathol (2008) 0.81
Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet (2015) 0.81
O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. J Biol Chem (2014) 0.81
Initial neurogenesis in Drosophila. Wiley Interdiscip Rev Dev Biol (2013) 0.80
Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. J Biol Chem (2016) 0.79
S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B cell development. Mol Cell Biol (2014) 0.79
How Drosophila melanogaster Forms its Mechanoreceptors. Curr Genomics (2008) 0.79
Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Genes Cells (2015) 0.79
Notch Signaling in Neuroendocrine Tumors. Front Oncol (2016) 0.78
Medical and dental staffing prospects in the NHS in England and Wales 1993. Health Trends (1994) 13.22
Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med (2001) 9.08
Generation and analysis of 280,000 human expressed sequence tags. Genome Res (1996) 8.27
Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X. Neurology (2001) 6.55
New approach to primary medical care. Nine-point plan for a family practice service. Can Fam Physician (1994) 5.42
The C. elegans genome sequencing project: a beginning. Nature (1992) 5.36
Failed intubation revisited: 17-yr experience in a teaching maternity unit. Br J Anaesth (1996) 4.18
Rural background and clinical rural rotations during medical training: effect on practice location. CMAJ (1999) 4.12
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Non-O group 1 Vibrio cholerae gastroenteritis in the United States: clinical, epidemiologic, and laboratory characteristics of sporadic cases. Ann Intern Med (1981) 3.25
Opioids for chronic nonmalignant pain. Attitudes and practices of primary care physicians in the UCSF/Stanford Collaborative Research Network. University of California, San Francisco. J Fam Pract (2001) 3.06
Primary ciliary dyskinesia: diagnosis and standards of care. Eur Respir J (1998) 2.81
Computer assisted management of warfarin treatment. Br Med J (Clin Res Ed) (1984) 2.54
Isolation and complementation of mutants of Anabaena sp. strain PCC 7120 unable to grow aerobically on dinitrogen. J Bacteriol (1988) 2.49
An encyclopedia of mouse genes. Nat Genet (1999) 2.48
Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro. J Clin Invest (1987) 2.40
zA map for sequence analysis of the Arabidopsis thaliana genome. Nat Genet (1999) 2.39
Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res (1997) 2.34
Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol (1998) 2.33
Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries. Circ Res (2000) 2.29
Volunteering for early phase gene transfer research in Parkinson disease. Neurology (2006) 2.27
Comparison of short-term and continuous chemotherapy (mitozantrone) for advanced breast cancer. Lancet (1990) 2.25
Effects of hospitalists on cost, outcomes, and patient satisfaction in a rural health system. Am J Med (2000) 2.23
Illness caused by Vibrio damsela and Vibrio hollisae. Lancet (1982) 2.17
Association mapping of disease loci, by use of a pooled DNA genomic screen. Am J Hum Genet (1997) 2.07
Fourier transform infrared microspectroscopy is a new way to look at plant cell walls. Plant Physiol (1992) 2.07
Rearrangement of immunoglobulin genes. Biochemistry (1979) 2.04
Readers advocate pro-conscience, not pro-choice. Nurse Pract (1992) 2.01
Validation of the St. George's Respiratory Questionnaire in bronchiectasis. Am J Respir Crit Care Med (1997) 2.01
In vivo analysis of Yorkie phosphorylation sites. Oncogene (2009) 2.00
Mercury exposure and risks from dental amalgam in the US population, post-2000. Sci Total Environ (2011) 1.97
Rearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells. Biochemistry (1981) 1.91
Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila. Genes Dev (1998) 1.89
Interaction of Pseudomonas aeruginosa with human respiratory mucosa in vitro. Eur Respir J (1994) 1.87
Risk assessment and comparisons: an introduction. Science (1987) 1.86
Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor. Cell (1986) 1.81
Staphylococcus lugdunensis endocarditis. Aust N Z J Med (1997) 1.81
Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Mol Biol Cell (1999) 1.80
Measuring Friedreich ataxia: Interrater reliability of a neurologic rating scale. Neurology (2005) 1.79
Effect of bacterial products on human ciliary function in vitro. Thorax (1985) 1.78
Proinflammatory interactions of pyocyanin and 1-hydroxyphenazine with human neutrophils in vitro. J Infect Dis (1990) 1.77
Ehlers-Danlos syndrome and "congenital" arteriovenous fistulae. A clinicopathologic study of a family. JAMA (1965) 1.77
Mortality in bronchiectasis: a long-term study assessing the factors influencing survival. Eur Respir J (2009) 1.75
The detection and management of root resorption lesions using intraoral radiography and cone beam computed tomography - an in vivo investigation. Int Endod J (2009) 1.74
A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development (1997) 1.74
Verifiable CPD paper: oral health of remand prisoners in HMP Brixton, London. Br Dent J (2007) 1.71
Digital infrared thermal imaging (DITI) of breast lesions: sensitivity and specificity of detection of primary breast cancers. Clin Radiol (2011) 1.71
Polyclonal Mycobacterium avium complex infections in patients with nodular bronchiectasis. Am J Respir Crit Care Med (1998) 1.71
2-Heptyl-4-hydroxyquinoline N-oxide, an antistaphylococcal agent produced by Pseudomonas aeruginosa. J Antimicrob Chemother (1992) 1.71
Double blind, placebo controlled trial of betamethasone nasal drops for nasal polyposis. Br Med J (Clin Res Ed) (1985) 1.70
Practice choices of graduating family medicine residents. Can Fam Physician (1998) 1.70
Results of CEA-initiated second-look surgery for recurrent colorectal cancer. Am J Surg (1980) 1.69
Evolution of mouse immunoglobulin lambda genes. Proc Natl Acad Sci U S A (1982) 1.68
Transperitoneal versus retroperitoneal approach for aortic reconstruction: a randomized prospective study. J Vasc Surg (1990) 1.64
Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro. Infect Immun (1989) 1.64
The Drosophila protein Dof is specifically required for FGF signaling. Mol Cell (1998) 1.63
Reverse arterial blood flow as a pathway for central nervous system toxic responses following injection of local anesthetics. Anesth Analg (1978) 1.63
Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell (1995) 1.61
Measurement issues in research on social support and health. J Epidemiol Community Health (1994) 1.59
If the NHS introduced a '50 procedures a year' policy, what proportion of consultant firms would be affected? J Public Health Med (2001) 1.59
Interaction of nontypable Haemophilus influenzae with human respiratory mucosa in vitro. J Infect Dis (1991) 1.59
Condom use and HIV risk behaviors among U.S. adults: data from a national survey. Fam Plann Perspect (1999) 1.57
Risk factors for rate of progression of glaucomatous visual field loss: a computer-based analysis. Arch Ophthalmol (1982) 1.56
Age distribution of cancer in mice: the incidence turnover at old age. Toxicol Ind Health (2001) 1.55
Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine inhibit fungal growth. J Clin Pathol (1999) 1.54
Antibiotic-associated pseudomembranous colitis: an epidemiologic investigation of a cluster of cases. J Infect Dis (1982) 1.53
Review of wheat improvement for waterlogging tolerance in Australia and India: the importance of anaerobiosis and element toxicities associated with different soils. Ann Bot (2008) 1.53
Orientation of macromolecules in the walls of elongating carrot cells. J Cell Sci (1993) 1.53
The filamentous type III secretion translocon of enteropathogenic Escherichia coli. Cell Microbiol (2001) 1.53
The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride. Toxicol Appl Pharmacol (2001) 1.51
Interspecies comparison of carcionogenic potency. J Toxicol Environ Health (1979) 1.50
Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium. Am J Respir Cell Mol Biol (1991) 1.50
Strengthening clinical cancer research in the United Kingdom. Br J Cancer (2011) 1.50
Making health care safer II: an updated critical analysis of the evidence for patient safety practices. Evid Rep Technol Assess (Full Rep) (2013) 1.49
Characterisation of Pseudomonas rhamnolipids. Biochim Biophys Acta (1990) 1.47
The use of preoperative plasma CEA levels for the Stratification of patients after curative resection of colorectal cancers. Ann Surg (1980) 1.45
Purification and characterization of factors produced by Aspergillus fumigatus which affect human ciliated respiratory epithelium. Infect Immun (1995) 1.44
A gene for congenital generalized lipodystrophy maps to human chromosome 9q34. J Clin Endocrinol Metab (1999) 1.44
Purification and structural analysis of pyocyanin and 1-hydroxyphenazine. Eur J Biochem (1986) 1.43
Selection bias in clinical trials. J Clin Oncol (1985) 1.42
Zuni Diabetes Project. Public Health Rep (1986) 1.42
Mechanisms of action of Pseudomonas aeruginosa pyocyanin on human ciliary beat in vitro. Infect Immun (1993) 1.42
Years of healthy life. Healthy People 2000 Stat Notes (1995) 1.42
Family illness associated with Shigella infection: the interrelationship of age of the index patient and the age of household members in acquisition of illness. J Infect Dis (1981) 1.41
Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa. Infect Immun (1995) 1.41
Dorsal-ventral signaling in the Drosophila eye. Science (1998) 1.40
Acute phosphine poisoning aboard a grain freighter. Epidemiologic, clinical, and pathological findings. JAMA (1980) 1.39
Lung pathology in high-altitude pulmonary edema. Wilderness Environ Med (1997) 1.39
A low dose atenolol/bendrofluazide combination in patients with mild to moderate hypertension. J Hum Hypertens (1997) 1.39
Multicenter study of target-controlled infusion of propofol-sufentanil or sufentanil-midazolam for coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Anesthesiology (1996) 1.39
Deleterious effects of purulent sputum sol on human ciliary function in vitro: at least two factors identified. Thorax (1987) 1.39
A visit to Chernobyl. Science (1987) 1.39
Association of two different repetitive DNA elements near immunoglobulin light chain genes. Nucleic Acids Res (1983) 1.39
Medical teaching in sioux lookout: primary health care in a cross-cultural setting. Can Fam Physician (1989) 1.38
The effect of Streptococcus pneumoniae pneumolysin on human respiratory epithelium in vitro. Microb Pathog (1990) 1.37
Medico-legal issues in breast imaging. Clin Radiol (2012) 1.37
Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis. Mol Cell Biol (1999) 1.37
Effect of sputum bacteriology on the quality of life of patients with bronchiectasis. Eur Respir J (1997) 1.36