Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation.

PubWeight™: 1.15‹?› | Rank: Top 10%

🔗 View Article (PMC 232352)

Published in Mol Cell Biol on September 01, 1997

Authors

W Jongmans1, M Vuillaume, K Chrzanowska, D Smeets, K Sperling, J Hall

Author Affiliations

1: Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, Lyon, France.

Articles citing this

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev (2000) 7.29

AtATM is essential for meiosis and the somatic response to DNA damage in plants. Plant Cell (2003) 1.92

Chk2 activation dependence on Nbs1 after DNA damage. Mol Cell Biol (2001) 1.85

The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response. Am J Hum Genet (1999) 1.73

The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint. Mol Cell Biol (2003) 1.45

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress. Neoplasia (2000) 1.36

Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks. Mol Cell Biol (1999) 1.27

Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol (2008) 1.01

Fine localization of the Nijmegen breakage syndrome gene to 8q21: evidence for a common founder haplotype. Am J Hum Genet (1998) 0.96

Immunodeficiency associated with DNA repair defects. Clin Exp Immunol (2000) 0.91

The Nijmegen breakage syndrome gene and its role in genome stability. Chromosoma (2004) 0.89

The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain. PLoS One (2008) 0.88

Genetic and epigenetic features in radiation sensitivity Part I: cell signalling in radiation response. Eur J Nucl Med Mol Imaging (2005) 0.84

The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes. Nucleic Acids Res (2000) 0.83

Cellular responses to ionising radiation of AT heterozygotes: differences between missense and truncating mutation carriers. Br J Cancer (2004) 0.79

Role of Nijmegen breakage syndrome protein in specific T-lymphocyte activation pathways. Clin Diagn Lab Immunol (2001) 0.76

Meiotic localization of Mre11 and Rad50 in wild type, spo11-1, and MRN complex mutants of Coprinus cinereus. Chromosoma (2009) 0.75

Articles cited by this

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87

Participation of p53 protein in the cellular response to DNA damage. Cancer Res (1991) 16.00

A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20

p53: puzzle and paradigm. Genes Dev (1996) 13.16

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol Cell Biol (1984) 4.83

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev (1994) 4.64

The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J (1996) 4.45

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci U S A (1995) 4.22

A p53-dependent mouse spindle checkpoint. Science (1995) 4.01

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev (1996) 3.70

Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Mol Cell Biol (1993) 2.77

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol Cell Biol (1996) 2.21

A new chromosomal instability disorder: the Nijmegen breakage syndrome. Acta Paediatr Scand (1981) 2.16

Predominance of null mutations in ataxia-telangiectasia. Hum Mol Genet (1996) 2.06

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene (1993) 2.06

Genetic complementation analysis of ataxia telangiectasia and Nijmegen breakage syndrome: a survey of 50 patients. Cytogenet Cell Genet (1988) 1.88

Evidence for a second cell cycle block at G2/M by p53. Oncogene (1995) 1.86

Isolation and characterization of the human MRE11 homologue. Genomics (1995) 1.83

Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. Curr Biol (1996) 1.73

A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene. Proc Natl Acad Sci U S A (1996) 1.60

Mammalian mutants defective in the response to ionizing radiation-induced DNA damage. Mutat Res (1995) 1.59

Nijmegen breakage syndrome. J Med Genet (1996) 1.58

Ataxia-telangiectasia: closer to unraveling the mystery. Eur J Hum Genet (1995) 1.51

A new chromosomal instability disorder confirmed by complementation studies. Clin Genet (1988) 1.45

Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. Genomics (1996) 1.43

The gene for the ataxia-telangiectasia variant, Nijmegen breakage syndrome, maps to a 1-cM interval on chromosome 8q21. Am J Hum Genet (1997) 1.41

DNA damage and p53-mediated cell cycle arrest: a reevaluation. Proc Natl Acad Sci U S A (1996) 1.22

Eleven Polish patients with microcephaly, immunodeficiency, and chromosomal instability: the Nijmegen breakage syndrome. Am J Med Genet (1995) 1.19

ATM gene product phosphorylates I kappa B-alpha. Cancer Res (1997) 1.10

The ataxia-telangiectasia-variant genes 1 and 2 are distinct from the ataxia-telangiectasia gene on chromosome 11q23.1. Am J Hum Genet (1995) 1.06

Nijmegen Breakage syndrome: a progress report. Int J Radiat Biol (1994) 1.02

The role of the Ataxia telangiectasia gene in the p53, WAF1/CIP1(p21)- and GADD45-mediated response to DNA damage produced by ionising radiation. Oncogene (1995) 1.01

The gene for Nijmegen breakage syndrome (V2) is not located on chromosome 11. Am J Hum Genet (1996) 0.98

Severe microcephaly with normal intellectual development: the Nijmegen breakage syndrome. Arch Dis Child (1995) 0.94

Comparative human cellular radiosensitivity: II. The survival following gamma-irradiation of unstimulated (G0) T-lymphocytes, T-lymphocyte lines, lymphoblastoid cell lines and fibroblasts from normal donors, from ataxia-telangiectasia patients and from ataxia-telangiectasia heterozygotes. Int J Radiat Biol (1988) 0.93

Cellular radiosensitivity in ataxia-telangiectasia. Int J Radiat Biol (1994) 0.89

Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome. Clin Immunol Immunopathol (1997) 0.89

Noncomplementation of radiation-induced chromosome aberrations in ataxia-telangiectasia/ataxia-telangiectasia-variant heterodikaryons. Am J Hum Genet (1997) 0.87

Cell checkpoint and radiosensitivity. Nature (1993) 0.79

Articles by these authors

(truncated to the top 100)

Measuring the quality of life of cancer patients: a concise QL-index for use by physicians. J Chronic Dis (1981) 7.00

Serevent nationwide surveillance study: comparison of salmeterol with salbutamol in asthmatic patients who require regular bronchodilator treatment. BMJ (1993) 6.14

Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A (2000) 5.87

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell (1998) 4.72

Effects of organizational change in the medical intensive care unit of a teaching hospital: a comparison of 'open' and 'closed' formats. JAMA (1996) 4.71

A mesoscale phytoplankton bloom in the polar Southern Ocean stimulated by iron fertilization. Nature (2000) 4.36

Epstein-Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells. Proc Natl Acad Sci U S A (1987) 3.98

Toward early diagnosis of myotonic dystrophy: construction and characterization of a somatic cell hybrid with a single human der(19) chromosome. Cytogenet Cell Genet (1986) 3.76

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med (1998) 3.75

Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry (2000) 3.67

Rapid active transport of immunoglobulin A from blood to bile. J Exp Med (1978) 3.62

Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis. N Engl J Med (1992) 3.23

Sex differences in brain maturation during childhood and adolescence. Cereb Cortex (2001) 3.17

Comparison of potency of inhaled beclomethasone and budesonide in New Zealand: retrospective study of computerised general practice records. BMJ (1998) 3.15

A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am J Hum Genet (1999) 2.88

Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics (1997) 2.81

The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1995) 2.74

Practical management of hyperinsulinism in infancy. Arch Dis Child Fetal Neonatal Ed (2000) 2.70

Improved survival in ARDS patients associated with a reduction in pulmonary capillary wedge pressure. Chest (1990) 2.61

Evaluation of anticoagulant control in a pharmacist operated anticoagulant clinic. J Clin Pathol (1995) 2.58

Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J Virol (1993) 2.58

Occurrence of specific antibodies of the IgA class in the bile of rats. Int Arch Allergy Appl Immunol (1979) 2.46

Use of perioperative mupirocin to prevent methicillin-resistant Staphylococcus aureus (MRSA) orthopaedic surgical site infections. J Hosp Infect (2003) 2.40

DNA fingerprinting with the oligonucleotide probe (CAC)5/(GTG)5: somatic stability and germline mutations. Hum Genet (1989) 2.22

The impact of course attendance on the practice of dentists. Br Dent J (2004) 2.08

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther (2006) 2.07

Septicemia caused by Pseudomonas paucimobilis. Am J Clin Pathol (1979) 2.06

Geographical prevalence of two types of Epstein-Barr virus. Virology (1986) 2.05

Screening for subtelomeric rearrangements in 210 patients with unexplained mental retardation using multiplex ligation dependent probe amplification (MLPA). J Med Genet (2004) 2.04

The management of oesophageal carcinoma: radiotherapy or surgery? Cost considerations. Eur J Cancer Clin Oncol (1989) 2.00

Spatial separation of protein domains is not necessary for catalytic activity or substrate binding in a xylanase. Biochem J (1990) 1.93

Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am J Hum Genet (1995) 1.79

The N-terminal region of an endoglucanase from Pseudomonas fluorescens subspecies cellulosa constitutes a cellulose-binding domain that is distinct from the catalytic centre. Mol Microbiol (1990) 1.76

Mutations in the Nijmegen Breakage Syndrome gene (NBS1) in childhood acute lymphoblastic leukemia (ALL). Cancer Res (2001) 1.75

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ (2011) 1.74

The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma. IARC Sci Publ (1985) 1.73

Positional cloning of the gene for Nijmegen breakage syndrome. Nat Genet (1998) 1.73

Predisposition to and late onset of upper airway obstruction following angiotensin-converting enzyme inhibitor therapy. Chest (1992) 1.70

Biogeography and ecological setting of Indian Ocean hydrothermal vents. Science (2001) 1.69

The effects of a neuregulin 1 variant on white matter density and integrity. Mol Psychiatry (2007) 1.68

Characterization of ATM gene mutations in 66 ataxia telangiectasia families. Hum Mol Genet (1999) 1.66

Spontaneous remission of primary hyperparathyroidism from parathyroid apoplexy. J Clin Endocrinol Metab (1996) 1.66

Evidence for a general role for non-catalytic thermostabilizing domains in xylanases from thermophilic bacteria. Biochem J (1995) 1.64

Elevated protease activities in human amnion and chorion correlate with preterm premature rupture of membranes. Am J Obstet Gynecol (1995) 1.62

Nijmegen breakage syndrome. J Med Genet (1996) 1.58

Dark matter search results from the CDMS II experiment. Science (2010) 1.57

Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. Biol Psychiatry (2001) 1.57

Maternal uniparental disomy 7--review and further delineation of the phenotype. Eur J Pediatr (2000) 1.56

Using graded motor imagery for complex regional pain syndrome in clinical practice: failure to improve pain. Eur J Pain (2011) 1.56

Hydrocephalus in achondroplasia: the possible role of intracranial venous hypertension. J Neurosurg (1989) 1.55

Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments. Hum Genet (1982) 1.53

Molecular cloning of multiple xylanase genes from Pseudomonas fluorescens subsp. cellulosa. J Gen Microbiol (1988) 1.53

Incremental change in the Australian health care system. Health Aff (Millwood) (1999) 1.52

The blockade of Fc receptor-mediated clearance of immune complexes in vivo by a monoclonal antibody (2.4G2) directed against Fc receptors on murine leukocytes. J Immunol (1984) 1.48

A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry (2001) 1.46

Lumbar spine surgery in the obese patient. J Spinal Disord (1997) 1.45

A new chromosomal instability disorder confirmed by complementation studies. Clin Genet (1988) 1.45

Accuracy of a portable interpretive ECG machine in diagnosis of acute evolving myocardial infarction. Aust N Z J Med (1992) 1.44

Mutations in the follicle-stimulating hormone receptor and familial dizygotic twinning. Lancet (2001) 1.43

Utilisation as a measure of equity: weighing heat? J Health Econ (1991) 1.43

A general-practitioner survey of the Abortion Act 1967. Practitioner (1971) 1.42

The gene for the ataxia-telangiectasia variant, Nijmegen breakage syndrome, maps to a 1-cM interval on chromosome 8q21. Am J Hum Genet (1997) 1.41

A cost-utility approach to the use of 5-fluorouracil and levamisole as adjuvant chemotherapy for Dukes' C colonic carcinoma. Med J Aust (1993) 1.41

Hypomethylation is restricted to the D4Z4 repeat array in phenotypic FSHD. Neurology (2007) 1.41

Heparin concentrations in neonates during cardiopulmonary bypass. J Thromb Haemost (2012) 1.40

N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD. Am J Psychiatry (2000) 1.40

Effectiveness of topical chlorhexidine powder as an alternative to hexachlorophane for the control of Staphylococcus aureus in neonates. J Hosp Infect (2004) 1.40

Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC. Genes Chromosomes Cancer (1994) 1.40

An unusual complication of central venous catheterization. Chest (1994) 1.39

Counting the costs of mammography screening: first year results from the Sydney study. Med J Aust (1990) 1.39

Reflections on the recommendations of the EWMA Patient Outcome Group document. J Wound Care (2010) 1.39

Whither private health insurance? Aust N Z J Public Health (1997) 1.39

Amylin innocent in essential hypertension? Diabetologia (1999) 1.39

The double 'tails-up' capnograph. Anaesthesia (2004) 1.38

The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics. Clin Pharmacol Ther (2013) 1.37

Iron silicide nanostructure formation on Au induced superstructures on Si(111). Nanotechnology (2009) 1.37

A pilot study of amygdala volumes in pediatric generalized anxiety disorder. Biol Psychiatry (2000) 1.37

Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK). Nat Genet (1994) 1.36

Cerebellar hypoplasia and quadrupedal locomotion in humans as a recessive trait mapping to chromosome 17p. J Med Genet (2005) 1.36

A novel microdeletion, del(2)(q22.3q23.3) in a mentally retarded patient, detected by array-based comparative genomic hybridization. Clin Genet (2004) 1.35

Hypohidrotic ectodermal dysplasia, primary hypothyroidism, and agenesis of the corpus callosum. J Med Genet (1989) 1.34

Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4. Clin Pharmacol Ther (1999) 1.34

Effects of age and sex on auditory brainstem response. Arch Otolaryngol (1980) 1.34

Deficits in facial, body movement and vocal emotional processing in autism spectrum disorders. Psychol Med (2010) 1.33

Possible role of surface Ig in non-random recirculation of small lymphocytes. Nature (1976) 1.33

A unique form of autosomal dominant cataract explained by gene conversion between beta-crystallin B2 and its pseudogene. J Med Genet (2001) 1.31

Use of anorectal manometry during rectal infusion of saline to investigate sphincter function in incontinent patients. Gastroenterology (1983) 1.31

More on marker X chromosomes, mental retardation and macro-orchidism. N Engl J Med (1979) 1.30

The Atlantis platform: a new design and further developments of Buresova's on-demand platform for the water maze. Learn Mem (1999) 1.30

Breastfeeding: prevalence and influencing factors. Can J Public Health (1982) 1.30

mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains. J Gen Physiol (2000) 1.30

Repair of O-alkylpyrimidines in mammalian cells: a present consensus. Proc Natl Acad Sci U S A (1988) 1.30

Increased expression of unmethylated CDKN2D by 5-aza-2'-deoxycytidine in human lung cancer cells. Oncogene (2001) 1.30

Definitive radiotherapy for extramedullary plasmacytomas of the head and neck. Br J Radiol (2003) 1.29

Home or hospital? An evaluation of the costs, preferences, and outcomes of domiciliary chemotherapy. Int J Health Serv (2000) 1.28

Quality of life three months and one year after first treatment for early stage breast cancer: influence of treatment and patient characteristics. Qual Life Res (2000) 1.28

Replication of Epstein-Barr virus: ultrastructural and immunofluorescent studies of P3HR1-superinfected Raji cells. J Virol (1977) 1.26

Analysis of chromosome aberrations and sister chromatid exchanges in peripheral blood lymphocytes of newborns after vitamin K prophylaxis at birth. Pediatr Res (1991) 1.25

Training and use of surgeon's assistants. Surgery (1978) 1.25

Evidence for multiple carboxymethylcellulase genes in Pseudomonas fluorescens subsp. cellulosa. Mol Gen Genet (1987) 1.25